Alcides José Monteiro da Silva

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Pesquisas de Produtos Naturais

Departamento:

Programa de Produtos Naturais/IPPN

ORCID:

https://orcid.org/0000-0002-3200-0318


Formação:

  • Queen's University

    | Pós-Doutorado | 2009 - 2010

  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 1998 - 2000

  • Universidade Federal do Rio de Janeiro

    Química | Doutorado | 1993 - 1996

  • Universidade Federal do Rio de Janeiro

    Química de Produtos Naturais | Mestrado | 1990 - 1993

  • Universidade Federal do Rio de Janeiro

    Farmácia | Graduação | 1985 - 1989
Laboratórios:
Nuvens de Palavras:
Artigos:

(100.00% artigos com DOI)

Titulo DOI Ano
Regio- and Chemoselective Synthesis of Polyaryl Flavones by Combination of C-O/C-H Activation and Suzuki-Miyaura Cross Coupling Reactions 10.1016/j.molstruc.2023.137067 2024
Synthesis and evaluation of hybrid sulfonamide-chalcones with potential antileishmanial activity 10.1002/ardp.202300440 2024
Flavonoids as Inspiration for the Design and Synthesis of New Antiproliferative, Antiparasitic and Antiviral Compounds: An Account 10.21577/0103-5053.20240056 2024
Synthesis, Characterization and Computational Studies of New Naphthoquinones Fused Isoxazoles by the Regiospecific Tandem Sonogashira-Cyclization Reaction 10.1016/j.2023.135186 2023
Low doses of 3-phenyl-lawsone or meglumine antimoniate delivery by tattooing route are successful in reducing parasite load in cutaneous lesions of Leishmania (Viannia) braziliensis-infected hamsters 10.3389/fcimb.2023.1025359 2023
Aurones: A Promising Scaffold to Inhibit SARS-CoV-2 Replication 10.1021/acs.jnatprod.3c00249 2023
Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms 10.1371/journal.pone.0211229 2019
Snake venom activities as a tool to develop new metalloproteinase inhibitors from synthetic derivatives of lapachol 10.1016/j.toxicon.2019.06.133 2019
Second generation of the pterocarpanquinones: synthesis and antileishmanial activity 10.1186/s40409-018-0174-7 2018
Chemoselective Ruthenium-Catalyzed C-O Bond Activation: Orthogonality of Nickel- and Palladium-Catalyzed Reactions for the Synthesis of Polyaryl Fluorenones 10.1055/s-0036-1590985 2017
Anti-Inflammatory Properties of Pterocarpanquinone LQB-118 in Mice 10.1016/j.bmc.2016.07.046 2016
Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities 10.21577/0103-5053.20160326 2016
Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro 10.1016/j.parint.2015.08.010 2015
Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters 10.1371/journal.pone.0109672 2014
The Therapeutical Potential of a Novel Pterocarpanquinone LQB-118 to Target Inhibitor of Apoptosis Proteins in Acute Myeloid Leukemia Cells 10.2174/1871520611313020019 2013
LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis 10.1093/jac/dks498 2013
The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway 10.1097/cad.0b013e3283592da8 2013
Palladium-catalyzed arylation of enoates with iodobenzene: stereoselective synthesis of trisubstituted olefins 10.1590/S0103-50532013000300018 2013
Purification of a synthetic pterocarpanquinone by countercurrent chromatography 10.1590/s0103-50532012000600016 2012
A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro 10.1016/j.vetpar.2011.11.008 2012
214. Evaluation of the Antiophidic Activity of Lapachol and Synthetic Analogues 10.1016/j.toxicon.2012.04.215 2012
LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells 10.1007/s10637-010-9453-z 2011
Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis 10.1093/jac/dkr158 2011
Comparison of the Cytotoxic Effect of Lapachol, α-Lapachone and Pentacyclic 1,4- Naphthoquinones on Human Leukemic Cells 10.1007/s10637-009-9231-y 2010
NEW PTEROCAPANQUINONES:SYNTHESIS, ANTINEOPLASIC ACTIVITYON CULTURED HUMAN MALIGNANT CELL LINES AND TNF-a MODULATION IN HUMAN PBMC CELLS 10.1016/j.bmc.2009.12.073 2010
Ability of a synthetic coumestan to antagonize Bothrops snake venom activities 10.1016/j.toxicon.2009.09.021 2010
Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry 10.1016/j.jorganchem.2010.05.014 2010
Palladium-Catalyzed Tandem Heck-Lactonization from o -Iodophenols and Enoates: Synthesis of Coumarins and the Study of the Mechanism by Electrospray Ionization Mass Spectrometry 10.1021/jo1010922 2010
Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives 10.1590/s0103-50532009000100026 2009
Iodination of phenols in water using easy to handle amine-iodine complexes 10.1590/s0103-50532009001000021 2009
(±)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: Cytotoxic effect on human leukemia cell lines 10.1016/j.ejmech.2008.01.027 2009
Inhibition of the alfa1beta1 Isoform of the Na,K-ATPase by 8- methoxycoumestrol without positive ionotropic effect in human myocardium - novel aspects of Cardiac glycoside pharnacology 10.1097/FJC.0b013e3181a95ab2 2009
A tandem palladium-catalyzed Heck-lactonization through the reaction of ortho-iodophenols with β-substituted acrylates: synthesis of 4,6-substituted coumarins 10.1016/j.tetlet.2008.03.037 2008
Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors 10.1093/nar/gkm1178 2008
Insights into the mechanism of Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan 10.1016/j.bmc.2008.09.007 2008
Synergistic interaction between ouabain and 8-methoxy-3,9-dihydroxy coumestan, a non-steroidal synthetic inhibitor of Na+,K+-ATPase 10.1016/j.lfs.2007.08.021 2007
Structure-activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na+,K+-ATPase and binding to the central benzodiazepine receptor 10.1016/j.bmc.2006.07.053 2006
Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom 10.1016/j.bmcl.2003.10.044 2004
The first synthesis of (±)-3,4-dihydroxy-8,9-methylenedioxypterocarpan, an antitumoral agent and its coumestan derivative 10.1590/s0103-50532004000600029 2004
Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor 10.1016/j.ejphar.2004.05.026 2004
2-Methoxy-3,8,9-trihydroxy coumestan: a new synthetic inhibitor of Na+,K+-ATPase with an original mechanism of action 10.1016/j.bcp.2003.08.005 2003
Synthesis and preliminary pharmacological evaluation of new (±) 1,4-naphthoquinones structurally related to lapachol 10.1016/S0968-0896(02)00100-1 2002
Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation 10.1016/s0960-894x(00)00621-1 2001
Regioselective lithiations of a pterocarpan skeleton: the first synthesis of (±)-4--dehydroxycabenegrin A-I 10.1016/s0040-4039(01)00682-7 2001
The reaction of safrole derivatives with aluminum chloride: improved procedures for the preparation of catechols or their mono-O-Methylated Derivatives and a mechanistic interpretation 10.1590/s0103-50532001000300005 2001
Directed ortho metalation - cross coupling links. Carbamoyl rendition of the baker-venkataraman rearrangement. Regiospecific route to substituted 4-hydroxycoumarins 10.1016/S0040-4039(98)00977-0 1998
Phenylboronic Acid-Mediated Synthesis of 2H-Chromenes 10.1055/s-1998-2042 1998
Variable Chemo-selective Electrophilic Attack on Silylated Aromatic Aldehydes 10.1055/s-1996-5530 1996
Synthesis of Dimethoxyfuranonaftoquinones 10.1080/00397918808081336 1988
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
In vivo Preventive and Protective action of new syunthetic pterocarpan and coumestans against snake venoms (gen Crotalus) 2004
Pterocarpanquinones with antiproliferative action in erytroleukemia (K562 and Lucena I cells) in culture 2004
Preliminary Study on Catalytic Michael Reaction Promoted by a Lithium-Binol Complex to 1-boc-1,5-Dihydro-Pirrol-2-one 2003
Adição Conjugada do Dianio de a-N-benzoilaminoacetinitrila a enoat6os Preparados a partir do D(+)-Manitol visando a Síntese de Pirrolidinas 2002
Effect of PCALC 36, A New Synthethic Coumestan, on Na,K ATPase 2001
Effect of PCALC 36, a new shynthetic coumestan, on GABAa receptor 2001
Primeira Síntese da +/-4'-desidroxicabenegrina A-I via um novo modo de saubstituição regiosseletiva em esqueletos pterocarpânicos 2001
Síntese Convergente de Cromenos e organomercurias: Intermediários na Síntese de Pterocarpanos e Cumestanos 2000
Síntese e Avaliação Farmacológica de Cumestanos com Diferentes Padrões de substituição nos Anéis A e D. 2000
Novel Ligands of the benzodiazepine site of GABA A receptor channels 2000
Preliminary pharmacological evaluation of new coumestans with diferent patterns of oxygenation 2000
Contribution of the pharmacological profile of PCALC19, a newly synthesized antiophidic drug 1999
Regioselective Lithiation of Maackiain Derivatives: A New Aproach to the Total Synthesis of Prenylated Pterocarpans 1998
Synthesis of New Crhomenes and Prganomercurials: Toward the Preperation of New Pterocarpans with Diferent Patersns of Oxygenatiojn at Rings A and D 1998
Directed ortho Methalation-Cross Coupling, Carbamonyl Reedition of the Baker-Venkataraman Rearrangement. Regiospecific Route to Substituted 4- hidroxycoumarins 1998
Phenylboronic Acid Mediated Synthesis of 2H-Chromens 1998
Palladium-Catalized Arylation of ZnCl-Vinyl Ether with Aryl Triflates 1994
Aryl Triflate-Zinc Vinyl Ether Cross coupling Connected to DoM. An Anionic Fridel-Crafts Equivalent for Regiospecific Acylation 1994
Aryl Triflate - Zinc Vinyl Ether Cross Coupling Coonected to DoM. An Anionic Friedel-Crafts Equivalent for Regiospecific Acylation 1994
A Vanilina como matperia-prima para as síntese de Ftalidos 1987
Publicações:
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