Newton Gonçalves de Castro
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Ciências Biomédicas
Departamento:
Docentes/ICB
Formação:
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Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Doutorado | 1991 - 1994
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University System of Maryland
| Pós-Doutorado | 1991 - 1994
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Universidade Federal do Rio de Janeiro
Engenharia Biomédica | Mestrado | 1988 - 1991
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Universidade Federal do Rio de Janeiro
Medicina | Graduação | 1981 - 1986
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Universidade Federal do Rio de Janeiro
| Ensino Médio (2o grau) | 1978 - 1980
Laboratórios:
Nuvens de Palavras:
Artigos:
(84.91% artigos com DOI)
Titulo | DOI | Ano |
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NMDA Receptor Activation and Ca2+/PKC Signaling in Nicotine-Induced GABA Transport Shift in Embryonic Chick Retina | 10.1007/s11064-023-03870-7 | 2023 |
Age-dependent memory impairment induced by co-exposure to nicotine and a synthetic cannabinoid in mice | 10.1016/j.pnpbp.2023.110821 | 2023 |
P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels | 10.3389/fimmu.2022.752105 | 2022 |
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation | 10.1039/d1md00374g | 2022 |
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer?s disease | 10.1016/j.bmc.2022.116952 | 2022 |
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer?s Disease | 10.3390/molecules25143165 | 2020 |
Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice | 10.1007/s00213-020-05485-0 | 2020 |
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice | 10.1038/s41467-019-11866-7 | 2019 |
Live Cell Imaging Supports a Key Role for Histone Deacetylase as a Molecular Target during Glioblastoma Malignancy Downgrade through Tumor Competence Modulation | 10.1155/2019/9043675 | 2019 |
Design, synthesis and pharmacological evaluation of N -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates | 10.1016/j.ejmech.2018.01.066 | 2018 |
Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists | 10.3389/fnmol.2018.00277 | 2018 |
Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation | 10.1038/srep40912 | 2017 |
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease | 10.1016/j.ejmech.2017.02.043 | 2017 |
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease | 10.1016/j.ejmech.2015.12.024 | 2016 |
Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase | 10.3109/14756366.2015.1094468 | 2016 |
Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson?s disease | 10.3389/fncel.2015.00097 | 2015 |
Waveform Similarity Analysis: A Simple Template Comparing Approach for Detecting and Quantifying Noisy Evoked Compound Action Potentials | 10.1371/journal.pone.0136992 | 2015 |
Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling | 10.1002/glia.22713 | 2014 |
Erythrina mulungu Alkaloids Are Potent Inhibitors of Neuronal Nicotinic Receptor Currents in Mammalian Cells | 10.1371/journal.pone.0082726 | 2013 |
Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient | 10.3727/096368911X600957 | 2012 |
Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors | 10.1590/s0103-50532012000100023 | 2012 |
Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor Signaling through Modulation of D-Serine Levels in Cerebral Cortex Neurons | 10.1074/jbc.M112.380824 | 2012 |
Colchicine inhibits cationic dye uptake induced by ATP in P2X2- and P2X7-expressing cells: implication for its therapeutic action | 10.1111/j.1476-5381.2011.01254.x | 2011 |
Estudo etnofarmacognóstico da saracuramirá (Ampelozizyphus amazonicus Ducke), uma planta medicinal usada por comunidades quilombolas do Município de Oriximiná-PA, Brasil | 10.1590/S0044-59672011000300008 | 2011 |
LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation | 10.1111/j.1476-5381.2010.00672.x | 2010 |
Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates | 10.1016/j.bmc.2008.12.045 | 2009 |
New potential AChE inhibitor candidates | 10.1016/j.ejmech.2009.03.045 | 2009 |
Geissospermum vellosii stembarkAnticholinesterase activity and improvement of scopolamine-induced memory deficits | 10.1016/j.pbb.2009.01.024 | 2009 |
CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline | 10.1016/j.ejphar.2007.11.035 | 2008 |
The Magnitude of 7 Nicotinic Receptor Currents in Rat Hippocampal Neurons Is Dependent upon GABAergic Activity and Depolarization | 10.1124/jpet.106.106385 | 2006 |
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids | 10.1016/j.bmc.2005.04.030 | 2005 |
Binding of [3H]-MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors | 10.1016/j.bcp.2005.03.005 | 2005 |
Characterization of 2-methoxy-3,8,9-trihydroxy coumestan, a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor | 10.1016/j.ejphar.2004.05.026 | 2004 |
Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon | 10.1016/j.neuro.2004.01.007 | 2004 |
Stereoselective synthesis and preliminary evaluation of new D-3-heteroarycarbonylalanines as ligands of the NMDA receptor | 10.1016/j.bmcl.2004.06.062 | 2004 |
Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: Involvement of muscarinic receptors | 10.1124/jpet.102.043109 | 2003 |
Design, synthesis and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: A new class of potent and selective acetylcholinesterase inhibitors | 10.1021/jm020391n | 2003 |
Synthesis and preliminary pharmacological evaluation of new 1,4-naphthoquinones structurally related to lapachol | 10.1016/S0968-0896(02)00100-1 | 2002 |
A novel thienylhydrazone, (2-thienylidene) 3,4-methylenedioxybenzohydrazine, increases inotropism and decreases fatigue of skeletal muscle | 2001 | |
Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons | 10.1016/S0006-8993(00)02863-8 | 2000 |
Kinetic properties of alpha 7 nicotinic acetylcholine receptor channels of rat hippocampal neurons activated by choline and acetylcholine | 2000 | |
Direct inhibition of the N-methyl-d-aspartate receptor channel by dopamine and (+)-SKF38393 | 10.1038/sj.bjp.0702479 | 1999 |
Properties of the neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function. http://jpet.aspetjournals.org/content/280/3/1117.full | 1997 | |
Neuronal nicotinic receptors: Function, modulation and structure | 10.1006/smns.1995.0011 | 1995 |
alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability | 10.1016/S0006-3495(95)80213-4 | 1995 |
Nicotinic receptor function in the mammalian central nervous system | 10.1111/j.1749-6632.1995.tb17464.x | 1995 |
Calcium permeability of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons | 1994 | |
Function and modulation of hippocampal nicotinic acetylcholine receptors | 1994 | |
Brief-lifetime, fast-inactivating ion channels account for the alpha-bungarotoxin-sensitive nicotinic response in hippocampal neurons | 10.1016/0304-3940(93)90876-M | 1993 |
A novel agonist binding site on nicotinic acetylcholine receptors | 10.3109/10799899309073670 | 1993 |
Fast-desensitizing single channel currents correlated with the nicotinic whole-cell response in hippocampal neurons | 1993 | |
Nonstationary single channel currents analysed by point process modeling | 1991 | |
Análise de correntes iônicas unitárias por modelagem ponto-evento. http://www.rbejournal.org/article/5889fba95d01231a018b4728 | 1990 |
Eventos:
(0.00% eventos com DOI)