Robson de Queiroz Monteiro
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Ciências Biomédicas
Departamento:
Docentes/ICB
Formação:
-
Universidade do Estado do Rio de Janeiro
| Pós-Doutorado | 2002 - 2002
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Universidade Federal do Rio de Janeiro
Química Biológica | Doutorado | 1997 - 2001
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Universidade Federal do Rio de Janeiro
Química Biológica | Mestrado | 1995 - 1997
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Universidade Federal do Rio de Janeiro
Farmácia | Graduação | 1990 - 1993
Laboratórios:
Nuvens de Palavras:
Artigos:
(92.37% artigos com DOI)
Titulo | DOI | Ano |
---|---|---|
TF/PAR2 Signaling Axis Supports the Protumor Effect of Neutrophil Extracellular Traps (NETs) on Human Breast Cancer Cells | 10.3390/cancers16010005 | 2024 |
Aspirin Affects MDA-MB-231 Vesicle Production and Their Capacity to Induce Fibroblasts towards a Pro-Invasive State | 10.3390/ijms241512020 | 2023 |
Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo | 10.3390/ph15010021 | 2022 |
Detachment of Hexokinase II From Mitochondria Promotes Collateral Sensitivity in Multidrug Resistant Chronic Myeloid Leukemia Cells | 10.3389/fonc.2022.852985 | 2022 |
Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way | 10.1093/jmcb/mjac039 | 2022 |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 | 10.1182/bloodadvances.2021006680 | 2022 |
Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications | 10.1590/1414-431x202010754 | 2021 |
Recombinant human DNase I for the treatment of cancer-associated thrombosis: A pre-clinical study | 10.1016/j.thromres.2021.04.028 | 2021 |
Intracerebral hemorrhage associated with vaccine-induced thrombotic thrombocytopenia following ChAdOx1 nCOVID-19 vaccine in a pregnant woman | 10.3324/haematol.2021.279407 | 2021 |
Fundamentals in Covid-19-Associated Thrombosis: Molecular and Cellular Aspects | 10.3389/fcvm.2021.785738 | 2021 |
Pisum sativum Defensin 1 Eradicates Mouse Metastatic Lung Nodules from B16F10 Melanoma Cells | 10.3390/ijms21082662 | 2020 |
Neutrophil Extracellular Traps (NETs) Promote Pro-Metastatic Phenotype in Human Breast Cancer Cells through Epithelial-Mesenchymal Transition | 10.3390/cancers12061542 | 2020 |
Development of 131I-ixolaris as a theranostic agent: metastatic melanoma preclinical studies | 10.1007/s10585-020-10036-0 | 2020 |
Characterization and internalization of small extracellular vesicles released by human primary macrophages derived from circulating monocytes | 10.1371/journal.pone.0237795 | 2020 |
β-Lapachone enhances the antifungal activity of fluconazole against a Pdr5p-mediated resistant Saccharomyces cerevisiae strain | 10.1007/s42770-020-00254-9 | 2020 |
Extracellular vesicle fingerprinting: the next generation for cancer diagnosis? | 10.1038/s41392-020-00385-3 | 2020 |
Cellular and Molecular Immunology Approaches for the Development of Immunotherapies against the New Coronavirus (SARS-CoV-2): Challenges to Near-Future Breakthroughs | 10.1155/2020/8827670 | 2020 |
Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer | 10.3389/fonc.2020.557280 | 2020 |
Ectophosphatase activity in the triple-negative breast cancer cell line MDA-MB-231 | 10.1002/cbin.11497 | 2020 |
Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement | 10.3389/fimmu.2019.01073 | 2019 |
H+-dependent inorganic phosphate transporter in breast cancer cells: Possible functions in the tumor microenvironment | 10.1016/j.bbadis.2019.04.015 | 2019 |
Novel Aspects of Extracellular Vesicles as Mediators of Cancer-Associated Thrombosis | 10.3390/cells8070716 | 2019 |
NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition | 10.1182/blood.2018889493 | 2019 |
IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model | 10.3389/fimmu.2019.02088 | 2019 |
Characterization of inorganic phosphate transport in the triple-negative breast cancer cell line, MDA-MB-231 | 10.1371/journal.pone.0191270 | 2018 |
Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis | 10.1038/s41598-018-22780-1 | 2018 |
Blood coagulation abnormalities in multibacillary leprosy patients | 10.1371/journal.pntd.0006214 | 2018 |
Tissue factor mediates microvesicles shedding from MDA-MB-231 breast cancer cells | 10.1016/j.bbrc.2018.05.136 | 2018 |
Positive crosstalk between EGFR and the TF-PAR2 pathway mediates resistance to cisplatin and poor survival in cervical cancer | 10.18632/oncotarget.25748 | 2018 |
Protease-activated receptor 2 (PAR2) upregulates granulocyte colony stimulating factor (G-CSF) expression in breast cancer cells | 10.1016/j.bbrc.2018.08.169 | 2018 |
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia | 10.1016/j.exphem.2018.07.008 | 2018 |
Inorganic phosphate transporters in cancer: Functions, molecular mechanisms and possible clinical applications | 10.1016/j.bbcan.2018.05.001 | 2018 |
Pyrazolyl-Tetrazoles and Imidazolyl-Pyrazoles as Potential Anticoagulants and their Integrated Multiplex Analysis Virtual Screening | 10.21577/0103-5053.20180150 | 2018 |
Recombinant expression of Ixolaris, a Kunitz-type inhibitor from the tick salivary gland, for NMR studies | 10.1016/j.pep.2017.07.012 | 2017 |
Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis | 10.1038/s41598-017-06893-7 | 2017 |
Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms | 10.1016/j.thromres.2017.09.019 | 2017 |
1H, 15N and 13C resonance assignments of Ixolaris, a tissue factor pathway inhibitor from the tick salivary gland | 10.1007/s12104-017-9766-3 | 2017 |
TR47, a PAR1-based peptide, inhibits melanoma cell migration in vitro and metastasis in vivo | 10.1016/j.bbrc.2017.11.174 | 2017 |
In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus | 10.1371/journal.pntd.0004298 | 2016 |
Exploiting the antithrombotic effect of the (pro)thrombin inhibitor bothrojaracin | 10.1016/j.toxicon.2016.05.007 | 2016 |
Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model | 10.3892/ol.2016.4593 | 2016 |
Evoking picomolar binding in RNA by a single phosphorodithioate linkage | 10.1093/nar/gkw725 | 2016 |
Protease-activated receptor 1 (PAR1): a promising target for the treatment of glioblastoma? | 10.21037/tcr.2016.11.30 | 2016 |
Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators | 10.1155/2015/313842 | 2015 |
99mTc-ixolaris targets glioblastoma-associated tissue factor: In vitro and pre-clinical applications | 10.1016/j.thromres.2015.05.032 | 2015 |
Salivary Thromboxane A2-Binding Proteins from Triatomine Vectors of Chagas Disease Inhibit Platelet-Mediated Neutrophil Extracellular Traps (NETs) Formation and Arterial Thrombosis | 10.1371/journal.pntd.0003869 | 2015 |
Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin | 10.1371/journal.pone.0133991 | 2015 |
Thrombomodulin modulates cell migration in human melanoma cell lines | 10.1097/CMR.0000000000000035 | 2014 |
Expression of tissue factor signaling pathway elements correlates with the production of vascular endothelial growth factor and interleukin-8 in human astrocytoma patients | 2014 | |
Structural and Functional Analysis of a Platelet-Activating Lysophosphatidylcholine of Trypanosoma cruzi | 10.1371/journal.pntd.0003077 | 2014 |
Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis | 10.1371/journal.ppat.1004338 | 2014 |
Aegyptin inhibits collagen-induced coagulation activation in vitro and thromboembolism in vivo | 10.1016/j.bbrc.2013.05.082 | 2013 |
Activation of blood coagulation in cancer: implications for tumor progression | 10.1042/BSR20130057 | 2013 |
Intercellular transfer of tissue factor via the uptake of tumor-derived microvesicles | 10.1016/j.thromres.2013.07.026 | 2013 |
Structural Basis for the Interaction of Human β-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles | 10.1016/j.jmb.2013.08.001 | 2013 |
Desmolaris, a novel Factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo | 10.1182/blood-2013-08-517474 | 2013 |
Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva | 10.1590/0074-0276108062013002 | 2013 |
Allosteric activation of human ¿-thrombin through exosite 2 by suramin analogs | 10.1016/j.abb.2012.02.001 | 2012 |
Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria | 10.1161/ATVBAHA.111.240291 | 2012 |
Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines | 10.1016/j.bbrc.2012.03.140 | 2012 |
Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma | 10.1016/j.thromres.2012.05.021 | 2012 |
Lufaxin, a Novel Factor Xa Inhibitor From the Salivary Gland of the Sand Fly Lutzomyia longipalpis Blocks Protease-Activated Receptor 2 Activation and Inhibits Inflammation and Thrombosis In Vivo | 10.1161/ATVBAHA.112.253906 | 2012 |
The tick-derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells | 10.1111/j.1538-7836.2012.04864.x | 2012 |
Glycoinositolphospholipids from Trypanosomatids Subvert Nitric Oxide Production in Rhodnius prolixus Salivary Glands | 10.1371/journal.pone.0047285 | 2012 |
Structure and Behavior of Human ¿-Thrombin upon Ligand Recognition: Thermodynamic and Molecular Dynamics Studies | 10.1371/journal.pone.0024735 | 2011 |
Malignant transformation in melanocytes is associated with increased production of procoagulant microvesicles | 10.1160/TH11-03-0143 | 2011 |
Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity | 10.1074/jbc.M111.247924 | 2011 |
Tissue factor as a target for the treatment of disseminated intravascular coagulation | 10.1016/j.thromres.2011.04.006 | 2011 |
Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias | 10.1016/j.bcmd.2010.12.005 | 2011 |
Platelet Activating Factor Blocks Interkinetic Nuclear Migration in Retinal Progenitors through an Arrest of the Cell Cycle at the S/G2 Transition | 10.1371/journal.pone.0016058 | 2011 |
Venous thrombosis risk: Effects of palm oil and hydrogenated fat diet in rats | 10.1016/j.nut.2009.11.027 | 2011 |
Tissue factor expression on monocytes from patients with severe dengue fever | 10.1016/j.bcmd.2010.08.004 | 2010 |
Nitrophorin 2, a factor IX(a)-directed anticoagulant, inhibits arterial thrombosis without impairing haemostasis | 10.1160/TH10.1160/TH10-03-0186 | 2010 |
Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinoma | 10.1590/S0100-879X2010007500017 | 2010 |
Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation | 10.1111/j.1742-4658.2009.07494.x | 2010 |
Anticoagulant activity of a sulfated galactan: Serpin-independent effect and specific interaction with factor Xa | 10.1160/TH09-04-0273 | 2009 |
Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model | 10.1111/j.1538-7836.2009.03553.x | 2009 |
Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner | 10.1016/j.canlet.2009.03.041 | 2009 |
Simultaneous tissue factor expression and phosphatidylserine exposure account for the highly procoagulant pattern of melanoma cell lines | 10.1097/CMR.0b013e32832e40fe | 2009 |
Lung adenocarcinoma and antiphospholipid antibodies | 10.1016/j.autrev.2009.01.010 | 2009 |
Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases | 10.1016/j.bbapap.2009.03.011 | 2009 |
Evidence for increased expression of tissue factor and protease-activated receptor-1 in human esophageal cancer | 10.3892/or_00000393 | 2009 |
Blood Coagulation, Inflammation, and Malaria | 10.1080/10739680701451516 | 2008 |
Serpin-independent anticoagulant activity of a fucosylated chondroitin sulfate | 10.1160/TH08-04-0210 | 2008 |
Prothrombin fragments containing kringle domains induce migration and activation of human neutrophils | 10.1016/j.biocel.2007.09.002 | 2008 |
Procoagulant properties of human MV3 melanoma cells | 10.1590/S0100-879X2008005000003 | 2008 |
Sulfated galactan is a catalyst of antithrombin-mediated inactivation of α-thrombin | 10.1016/j.bbagen.2008.05.006 | 2008 |
Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer | 10.1016/j.cell.2008.01.016 | 2008 |
Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite | 10.1110/ps.073016308 | 2007 |
Suramin counteracts the haemostatic disturbances produced by Bothrops jararaca snake venom | 10.1016/j.toxicon.2007.01.002 | 2007 |
Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes | 10.1111/j.1538-7836.2006.02232.x | 2007 |
On the molecular mechanisms for the highly procoagulant pattern of C6 glioma cells | 10.1111/j.1538-7836.2006.01985.x | 2006 |
Counteracting effect of glycyrrhizin on the hemostatic abnormalities induced by Bothrops jararaca snake venom | 10.1038/sj.bjp.0706786 | 2006 |
Antithrombotic properties of ixolaris, a potent inhibitor of the extrinsic pathway of the coagulation cascade | 10.1160/TH06-02-0105 | 2006 |
Ecotin modulates thrombin activity through exosite-2 interactions | 10.1016/j.biocel.2006.05.001 | 2006 |
Platelet-activating factor-like activity isolated from Trypanosoma cruzi | 10.1016/j.ijpara.2005.09.016 | 2006 |
TARGETING EXOSITES ON BLOOD COAGULATION PROTEASES | 2005 | |
Bothrojaracin, a <i>Bothrops jararaca</i> Snake Venom-Derived (Pro)Thrombin Inhibitor, as an Anti-Thrombotic Molecule | 10.1159/000092416 | 2005 |
Assembly and regulation of prothrombinase complex on B16F10 melanoma cells | 10.1016/j.thromres.2004.08.001 | 2005 |
Ixolaris: a Factor Xa heparin-binding exosite inhibitor | 10.1042/BJ20041738 | 2005 |
NEW INSIGHTS INTO CONFORMATIONAL AND FUNCTIONAL STABILITY OF HUMAN alpha-THROMBIN PROBED BY HIGH HYDROSTATIC PRESSURE | 2004 | |
Suramin interaction with human α-thrombin: inhibitory effects and binding studies | 10.1016/j.biocel.2004.03.007 | 2004 |
ASSEMBLY AND REGULATION OF PROTHROMBINASE COMPLEX ON B16F10 MELANOMA CELLS | 2003 | |
PROEXOSITE I LIGANDS AS PROBES FOR THE STUDY OF PROTHROMBIN ACTIVATION | 2003 | |
Lysophosphatidylcholine Acts as an Anti-hemostatic Molecule in the Saliva of the Blood-sucking Bug Rhodnius prolixus | 10.1074/jbc.M212421200 | 2003 |
Mechanisms of ouabain toxicity | 10.1096/fj.02-0937fje | 2003 |
Subunit Dissociation, Unfolding, and Inactivation of Bothrojaracin, a C-Type Lectin-like Protein from Snake Venom | 10.1021/bi020571z | 2003 |
Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor | 10.1016/j.thromres.2003.10.014 | 2003 |
BOTHROJARACIN, A PROEXOSITE I LIGAND, INHIBITS FACTOR Va ACCELERATED PROTHROMBIN ACTIVATION | 2002 | |
BOTHROJARACIN INTERACTION WITH PROTHROMBIN | 2001 | |
Characterization of bothrojaracin interaction with human prothrombin | 10.1110/ps.09001 | 2001 |
Proteolytic action of Bothrops jararaca venom upon its own constituents | 10.1016/S0041-0101(00)00208-7 | 2001 |
Inhibition of Prothrombin Activation by Bothrojaracin, a C-Type Lectin from Bothrops jararaca Venom | 10.1006/abbi.2000.2006 | 2000 |
Allosteric Changes of Thrombin Catalytic Site Induced by Interaction of Bothrojaracin with Anion-Binding Exosites I and II | 10.1006/bbrc.1999.1297 | 1999 |
BOTHROPS JARARACA SNAKES PRODUCE SEVERAL BOTHROJARACIN ISOFORMS FOLLOWING AN INDIVIDUAL PATTERN | 1998 | |
Variability of bothrojaracin isoforms and other venom principles in individual jararaca (Bothrops jararaca) snakes maintained under seasonally invariant conditions | 10.1016/s0041-0101(97)00061-5 | 1998 |
DISTINCT BOTHROJARACIN ISOFORMS PRODUCED BY INDIVIDUAL JARARACA (Bothrops jararaca) SNAKES | 1997 | |
Identification of Glycyrrhizin as a Thrombin Inhibitor | 10.1006/bbrc.1997.6735 | 1997 |
Eventos:
(0.00% eventos com DOI)