Patrícia Zancan
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Faculdade de Farmácia
Departamento:
Departamento de Biotecnologia Farmacêutica
Formação:
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2006 - 2007
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2005 - 2006
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Universidade Federal do Rio de Janeiro
Química Biológica | Doutorado | 2002 - 2005
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Universidade Federal do Rio de Janeiro
Química Biológica | Mestrado | 2000 - 2002
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Universidade Federal do Rio de Janeiro
Farmácia Habilitação Farmacêutico | Graduação | 1996 - 2000
Laboratórios:
Nuvens de Palavras:
Artigos:
(93.55% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Western Diet Consumption by Host Vertebrate Promotes Altered Gene Expression on Aedes aegypti Reducing its Lifespan and Increasing Fertility Following Blood Feeding | 10.1186/s13071-023-06095-3 | 2024 |
| Clotrimazole reverses macrophage M2 polarization by disrupting the PI3K/AKT/mTOR pathway | 10.1016/j.bbrc.2023.149455 | 2024 |
| Novel Naphthoquinone-1H-1,2,3-triazole Hybrids: Design, Synthesis and Evaluation as Inductors of ROS-Mediated Apoptosis in the MCF-7 Cells | 10.1016/j.bmc.2024.117671 | 2024 |
| 4-oxoquinoline-3-carboxamide acyclonucleoside phosphonates hybrids: human MCF-7 breast cancer cell death induction by oxidative stress-promoting and in silico ADMET studies | 10.1016/j.molstruc.2022.134542 | 2023 |
| Clotrimazole is effective, safe and tolerable for the treatment of endometriosis and functions by downregulating inducible nitric oxide synthase and modulating oxidative stress biomarkers | 10.1016/j.mce.2023.111883 | 2023 |
| Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6J mice | 10.1038/s41598-023-30254-2 | 2023 |
| The role of Interferon receptors α/β/γ ablation during Western diet-induced obesity and insulin resistance in the inflectional model AG129 mice strain | 10.1089/jir.2023.0047 | 2023 |
| Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice | 10.1016/j.molmet.2022.101437 | 2022 |
| Isoquinolines alkaloids and cancer metabolism: pathways and targets to novel chemotherapy | 10.1111/cbdd.14043 | 2022 |
| Viscum album mother tinctures: harvest conditions and host trees influence the metabolome and the glycolytic pathway of breast cancer cells | 10.3389/fphar.2022.1027931 | 2022 |
| Citrate enrichment in a Western diet reduces weight gain via browning of adipose tissues without resolving diet-induced insulin resistance in mice | 10.1039/D2FO02011D | 2022 |
| Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy | 10.1016/j.lfs.2021.119470 | 2021 |
| Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR and EMT pathways | 10.1038/s41419-021-03929-9 | 2021 |
| Dietary citrate acutely induces insulin resistance and markers of liver inflammation in mice | 10.1016/j.jnutbio.2021.108834 | 2021 |
| Clotrimazole presents anticancer properties against a mouse melanoma model acting as a PI3K inhibitor and inducing repolarization of tumor-associated macrophages | 10.1016/j.bbadis.2021.166263 | 2021 |
| Latin America: Reduced S&T Investment Puts Sustainable Development at Risk | 2020 | |
| Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase | 10.1530/REP-19-0502 | 2020 |
| Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis | 10.1038/s41598-020-76824-6 | 2020 |
| Design, Synthesis and Biological Evaluation of 1H-1,2,3-Triazole-Linked- 1H-Dibenzo[b,h]xanthenes as Inductors of ROS-Mediated Apoptosis in the Breast Cancer Cell Line MCF-7 | 10.2174/1573406414666180524071409 | 2019 |
| Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively | 10.1038/s41416-019-0640-1 | 2019 |
| Discrete Fourier Transform based Multivariate Image Analysis: Application to Modeling Aromatase Inhibitory Activity. | 10.1021/acscombsci.7b00155 | 2018 |
| Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms | 10.1016/j.biopha.2018.04.033 | 2018 |
| Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis | 10.1016/j.mce.2018.04.005 | 2018 |
| Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway | 10.1007/s10863-018-9750-3 | 2018 |
| A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis | 10.2174/1568026618666180821142458 | 2018 |
| A novel triazole derivative drug presenting in vitro and in vivo anticancer properties | 10.2174/1568026618666180917100640 | 2018 |
| Phosphofructokinase-P Modulates P44/42 MAPK Levels in HeLa Cells | 10.1002/jcb.25774 | 2017 |
| Effects of Food Additives on Immune Cells As Contributors to Body Weight Gain and Immune-Mediated Metabolic Dysregulation | 10.3389/fimmu.2017.01478 | 2017 |
| Exogenous citrate impairs glucose tolerance and promotes visceral adipose tissue inflammation in mice | 10.1017/s0007114516000027 | 2016 |
| Targeted Nanosystems to Prostate Cancer | 10.2174/1381612822666160715131359 | 2016 |
| Phosphatidylinositol-3-kinase as a putative target for anticancer action of clotrimazole | 10.1016/j.biocel.2015.03.004 | 2015 |
| Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells | 10.1371/journal.pone.0130555 | 2015 |
| Anti-diabetic activity of Sedum dendroideum: metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin | 10.1002/iub.1270 | 2014 |
| Therapeutic Nanosystems for Oral Administration of Insulin | 10.2174/1389201015666140915150826 | 2014 |
| Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma | 10.18632/oncotarget.4910 | 2014 |
| H3N2 homeopathic influenza virus solution modifies cellular and biochemical aspects of MDCK and J774G8 cell lines | 10.1016/j.homp.2012.10.003 | 2013 |
| Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase | 10.1016/j.biochi.2013.02.013 | 2013 |
| Clotrimazole Preferentially Inhibits Human Breast Cancer Cell Proliferation, Viability and Glycolysis | 10.1371/journal.pone.0030462 | 2012 |
| AMP-Activated Protein Kinase Upregulates Glucose Uptake in Thyroid PCCL3 Cells Independent of Thyrotropin | 10.1089/thy.2012.0041 | 2012 |
| Characterization of ecto-ATPase activity in the surface of LLC-PK1 cells and its modulation by ischemic conditions | 10.1016/j.bbagen.2012.09.009 | 2012 |
| Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice | 10.1002/iub.1063 | 2012 |
| Muscle type 6-phosphofructo-1-kinase and aldolase associate conferring catalytic advantages for both enzymes | 10.1002/iub.464 | 2011 |
| Glucuronoxylomannan from Cryptococcus neoformans down-regulates the enzyme 6-phosphofructo-1-kinase of macrophages | 10.1074/jbc.M110.177030 | 2011 |
| Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse | 10.1016/j.abb.2010.01.013 | 2010 |
| Filamentous actin and its associated binding proteins are the stimulatory site for 6-phosphofructo-1-kinase association within the membrane of human erythrocytes | 10.1016/j.biochi.2010.01.023 | 2010 |
| Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase | 10.1016/j.abb.2010.03.013 | 2010 |
| Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells | 10.1016/j.ymgme.2010.04.006 | 2010 |
| Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism | 10.1002/iub.393 | 2010 |
| Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity | 10.1016/j.bcp.2008.09.020 | 2009 |
| Calmodulin upregulates 6-phosphofructo-1-kinase reversing the inhibitory effects of allosteric modulators | 10.1016/j.bbapap.2009.02.006 | 2009 |
| Crude ethanolic extract from babassu (Orbignya speciosa): cytotoxicity on tumoral and non-tumoral cell lines. | 10.1590/s0001-37652008000300008 | 2008 |
| ATP and fructose-2,6-bisphosphate regulate skeletal muscle 6-phosphofructo-1-kinase by altering its quaternary structure | 10.1002/iub.58 | 2008 |
| Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase | 10.1016/j.bcp.2007.01.018 | 2007 |
| Lactate favors the dissociation of skeletal muscle 6-phophofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis. | 10.1042/bj20070687 | 2007 |
| Fructose-2,6-bisphosphate counteracts guanidinium chloride-, thermal- and ATP-induced dissociation of skeletal muscle key glycolytic enzyme 6-phosphofructo-1-kinase: a structural mechanism for PFK allosteric regulation | 10.1016/j.abb.2007.08.032 | 2007 |
| Modulation of 6-phosphofructo-1-kinase oligomeric equilibrium by calmodulin: formation of active dimmers. | 10.1016/j.ymgme.2005.11.002 | 2006 |
| Regulation of human erythrocytes metabolism by insulin: cellular distribution of 6-phosphofructo-1-kinase and its implications to red blood cells functions | 10.1016/j.ymgme.2005.06.011 | 2005 |
| Calcium influx: a possible role for insulin modulation of intracellular distribution and activity of 6-fosfofructo-1-kinase in human erythrocytes | 10.1016/j.ymgme.2005.07.005 | 2005 |
| Trehalose and Glycerol stabilize and renature yeast inorganic pyrophosphatase inactivated by very high temperatures | 10.1016/j.abb.2005.09.014 | 2005 |
| Venous and arterial thrombosis in rat models: dissociation of the antithrombotic effects of glycosaminoglycans | 2004 | |
| Unbalanced effects of dermatan sulfate with different sulfation patterns on coagulation, thrombosis and bleeding | 2001 | |
| Different antithrombotic mechanisms among glycosaminoglycans revealed with a new fucosylated chondroitin sulfate from echinoderm | 2000 |
Eventos:
(0.00% eventos com DOI)