Luzineide Wanderley Tinoco

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Pesquisas de Produtos Naturais

Departamento:

Gabinete do Diretor do IPPN

e-mail:

luzitinoco@gmail.com

Linkedin:

Google Scholar:

ORCID:

https://orcid.org/0000-0002-1299-6242

Formação:

  • University of California, Riverside (EUA)

    | Pós-Doutorado | 2015 - 2016

  • Instituto Militar de Engenharia

    Química | Doutorado | 1994 - 1998

  • Instituto Militar de Engenharia

    Química | Mestrado | 1992 - 1993

  • Universidade do Estado do Rio de Janeiro

    Licenciatura em Química | Graduação | 1987 - 1991
Laboratórios:
Nuvens de Palavras:
Artigos:

(85.07% artigos com DOI)

Titulo DOI Ano
Insights into nucleoside hydrolase from Leishmania donovani inhibition: A new bioaffinity chromatography-based screening assay and docking studies 10.1016/j.bioorg.2024.107302 2024
Nucleoside Hydrolase immobilized on magnetic particles as a tool for onflow screening and characterization of inhibitors 10.1016/j.jpba.2023.115589 2023
Aspirin Affects MDA-MB-231 Vesicle Production and Their Capacity to Induce Fibroblasts towards a Pro-Invasive State 10.3390/ijms241512020 2023
Advances in screening assays for identifying cholinesterase ligands 10.1016/j.trac.2023.117362 2023
Two new triterpenoid saponins from the flowers of 10.1080/14786419.2022.2031184 2022
Analytical assays to evaluate enzymatic activity and screening of inhibitors for ornithine decarboxylase 10.3389/frans.2022.1018080 2022
High-resolution inhibition profiling and ligand fishing for screening of nucleoside hydrolase ligands in Moringa oleifera Lamarck 10.1016/j.jpba.2022.114614 2022
Zootherapeutic practices in the Amazon Region: chemical and pharmacological studies of Green-anaconda fat (Eunectes murinus) and alternatives for species conservation 10.15451/ec2021-02-10.15-1-27 2021
HSCCC Separations of Rutin Esters Obtained by Enzymatic Reaction Catalyzed by Lipase 10.21577/0103-5053.20200206 2021
Integration of NMR studies, computational predictions, and assays in the search of marine diterpenes with antitumor activity 10.1111/cbdd.13907 2021
Anti-mycobacterial and immunomodulatory activity of n-hexane fraction and spathulenol from Ocotea notata leaves 10.1590/2175-7860202172041 2021
An NMR-Based Chemometric Strategy to Identify Leishmania donovani Nucleoside Hydrolase Inhibitors from the Brazilian Tree Ormosia arborea 10.1021/acs.jnatprod.9b00622 2020
Isolation and characterization of flavonoids from Tapirira guianensis leaves with vasodilatory and myeloperoxidase-inhibitory activities 10.1080/14786419.2020.1784170 2020
Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking 10.1016/j.bioorg.2020.104215 2020
Structure-property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety 10.1039/d0nj01598a 2020
Juice quality traits, potassium content, and 1H NMR derived metabolites of 14 pomegranate cultivars 10.3233/JBR-180344 2019
New nucleoside hydrolase inhibitors from Brazilian flora 10.1039/C9RA02382H 2019
Structural characterization of a complex triterpenoid saponin from Albizia lebbeck and investigation of its permeability property and supramolecular interactions with membrane constituents 10.1016/j.carres.2018.11.015 2018
Phytochemical Study of Tapirira guianensis Leaves Guided by Vasodilatory and Antioxidant Activities 10.3390/molecules22020304 2017
Theoretical and Experimental Characterization of 1,4-N¿¿¿S σ-hole Intramolecular Interactions in Bioactive N-Acylhydrazone Derivatives 10.1039/c7nj03543h 2017
1 H NMR Metabolic Profiling of Earthworm ( Eisenia fetida ) Coelomic Fluid, Coelomocytes, and Tissue: Identification of a New Metabolite-Malylglutamate 10.1021/acs.jproteome.7b00439 2017
Ingasaponin, a complex triterpenoid saponin with immunological adjuvant activity from Inga laurina 10.1016/j.carres.2015.11.008 2016
The Use of NMR Metabolite Profiling and Hypoglycemic Assay for Comparison of Unfractionated Aqueous Leaf Extracts of Two Species 10.1002/cbdv.201500180 2016
Characterization of a Ternary System Based on Hybrid Nanoparticles 10.1166/jnn.2016.11771 2016
Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery 10.1039/c6ra15143d 2016
Structural characterization and gastroprotective property of a novel glucofructan from Allium ampeloprasum var. porrum 10.1016/j.carres.2014.10.022 2015
Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Ocotea notata from Brazilian Restinga 10.1155/2015/947248 2015
Hypoglycemic Effect of the Methanol flower Extract of Piper Claussenianum and the Major Constituent 2′,6′-dihydroxy-4′-methoxychalcone in Streptozotocin Diabetic Rats 2015
Sphingolipids: Bioactive Metabolites and Models for Drug Design 10.5935/1984-6835.20150076 2015
New Alkaloids from Margaritopsis carrascoana (Rubiaceae) 10.5935/0103-5053.20150079 2015
Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study 10.1016/j.fitote.2013.12.024 2014
Structural characterization of a neuroblast-specific phosphorylated region of MARCKS 10.1016/j.bbapap.2014.02.016 2014
Production of Saturated Esters from Hydrolysis and Hydrogenation Simultaneous Process 2014
Structural characterization of an acetylated glucomannan with antiinflammatory activity and gastroprotective property from Cyrtopodium andersonii 10.1016/j.carres.2014.03.021 2014
In Vitro Microsomal Hepatic Metabolism of Antiasthmatic Prototype LASSBio-448 10.2174/1568026614666140506123718 2014
Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B 10.1128/aac.00093-14 2014
Haemolytic Activity and Immunological Adjuvant Effect of a New Steroidal Saponin from Allium ampeloprasum var. porrum 10.1002/cbdv.201100005 2012
Flowers from Kalanchoe pinnata are a Rich Source of T Cell-Suppressive Flavonoids 2012
Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain 10.1039/c1md00223f 2012
Flavonoids from Mimosa xanthocentra (Leguminosae: Mimosoideae) and molecular modeling studies for isovitexin-2--O-α-l-rhamnopyranoside rotamers 10.1016/j.phytol.2012.03.015 2012
Kinetics and docking studies of two potential new inhibitors of the nucleoside hydrolase from Leishmania donovani 10.1016/j.ejmech.2012.07.052 2012
1,2,4-thiadiazol-5(4 H )-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition 10.3109/14756366.2012.700928 2012
Development of second generation amidinohydrazones, thio- and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1,3-dioxide core scaffolds 10.1039/c0md00085j 2010
Antiradical activity, nutritional potential and flavonoids of the cladodes of Opuntia monacantha (Cactaceae) 10.1016/j.foodchem.2010.05.074 2010
Efficient kinetic resolution of (±)-1,2-O-isopropylidene-3,6-di-O-benzyl-myo-inositol with the lipase B of Candida antarctica 10.1016/j.tetasy.2010.12.006 2010
Chiral Recognition of 2-Hydroxypropyl-alpha-cyclodextrin Towards DLTryptophan 10.2174/157017809787893091 2009
Two New Oleanane Saponins from Chiococca alba (L.) Hitch 2009
Spin-Lattice Relaxation Time in Drug Discovery and Design 10.2174/156802609789207082 2009
Homology Modeling of Leishmania donovani Nucleoside Hydrolase and Molecular Dynamics Studies for the Design of Potential Inhibitors 2008
Recognition mechanism of D- and L-tryptophan enantiomers using 2-hydroxypropyl-a- or b-cyclodextrins as chiral selectors 10.1016/j.tetasy.2008.04.035 2008
Structure of the Ebola Fusion Peptide in a Membrane-mimetic Environment and the Interaction with Lipid Rafts 10.1074/jbc.m611864200 2007
Structural Biology of Membrane-Acting Peptides: conformational plasticity of anticoccidial peptide PW2 probed by solution NMR 10.1016/j.bbamem.2007.08.022 2007
Effect of Micelle Interface on the Binding of Anticoccidial PW2 Peptide 10.1007/s10858-007-9202-6 2007
Structural insights into the interaction between prion protein and nucleic acid 10.1021/bi060532d 2006
Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis 10.1016/j.vaccine.2006.02.034 2006
The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata 10.1016/j.phytochem.2006.06.027 2006
Solvent effects in the 2JHH, 3JHH, 1JNC and 2JNC coupling constants in the NMR spectrum of acetylcholine chloride 10.1016/j.molstruc.2006.03.012 2006
NMR Study of the Leaving Ligand and Solvent Effects on the Solvolysis of (u-Oxo)bis(u-acetato)diruthenium(III) Complexes 10.1016/j.chemphys.2004.07.026 2004
Protective Vaccination Against Murine Visceral Leishmaniasis using Aldehyde-containing Quillaja saponaria sapogenins 10.1016/j.vaccine.2004.01.072 2004
Formation of p-Cresol:Piperazine Complex in Solution Monitored by Spin Lattice Relaxation Times and Pulsed Gradient NMR Diffusion Measurements 10.1016/S1090-7807(03)00252-0 2003
NMR Structure of PW2 Bound to SDS Micelles: A Tryptophan-rich Anticoccidial Peptide Selected from Phage Display Libraries 10.1074/jbc.M204225200 2002
Study of the Interaction Between Trypanocide 3-Nitrobenzaldeyde Guanyl Hydrazone and Bovine Serum Albumin by Equilibrium Dialysis and NMR 1999
Determination of Correlation Times From Selective and non-Selective Spin-Lattice Relaxation Rates and Their Use in Drug-Drug and Drug-Albumin Interaction Studies 1999
Estudos da Interação da Guanil Hidrazona do 3-Nitrobenzaldeído com BSA Utilizando T1, T1 Seletivo e T2 1997
Weak Drug-Biopolymer Interactions by Relaxatio Times in Low Magnetic Fields 1996
Aromatic Guanyl Hydrazones:Synthesis, Structural Studiesand in vitro Activity Against Trypanosoma cruzi 10.1016/0960-894X(95)00541-5 1995
Ressonância Magnética Nuclear de Aminoguanidina e Derivados 1993
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
AVALIAÇÃO DA COMPOSIÇÃO DO LÍQUIDO CELOMÁTICO DE MINHOCA APÓS EXPOSIÇÃO EM SOLO CONTAMINADO COM CEFALEXINA 2018
Interaction studies of Yersinia pestis Plasmin (Bubonic Plague Agent) and Human Plasminogen by Circular Dichroism and NMR 2014
THE ENDOGENOUS BUFADIENOLIDE MARINOBUFAGIN: REAPPRAISAL OF ITS CLAIMED SELECTIVITY FOR THE ALPHA ISOFORM OF NA+/K+-ATPASE 2014
NMR Analysis of intermolecular interactions of catechins in green tea (Camellia sinensis) 2013
Contributions of LC-NMR analysis for the quality control of green tea(Camellia sinensis) 2013
Análise por RMN da esfingosina-1-fosfato: supressão do sinal da água e seu efeito nos sinais dos hidrogênios lábeis 2013
Análise por RMN das interações intermoleculares das catequinas no chá verde (Camellia sinensis) 2013
DESENVOLVIMENTO DE PROTOCOLO PARA TESTES DE INIBIÇÃO DE TOPOISOMERASES EXTRAÍDAS DE CÉLULAS DE MAMÍFEROS 2013
QUANTIFICAÇÃO DE CAPSAICINA POR RMN EM EXTRATOS DE FRUTOS DE HÍBRIDOS DE Capsicum chinense E C. annum 2013
Structural Analysis of Human Plasminogen Peptide Interacting with Yersinia pestis Plasmin 2012
APLICAÇÃO DE CLAE-DAD-RMN NA IDENTIFICAÇÃO E CARACTERIZAÇÃO DE NEOLIGNANAS DE PIPER RIVINOIDES 2012
Busca de Inibidores da Acetilcolinesterase a partir de Extratos da Flora Fluminense 2012
Identificação e Quantificação de Artemisinina por RMN em Extratos de Arthemísia Annua L. Obtidos sob Diferentes Condições de Luz 2012
Identificação das Condições Adequadas para o Correto Enovelamento da Proteína Plasmina de Yersinia pestis 2012
Construção de uma biblioteca de fragmentos moleculares para o desenvolvimento de novos fármacos 2011
Seleção Rápida de Fragmentos Moleculares na Busca por Novos Fármacos 2011
Caracterização Estrutural e do Estado de Agregação da Esfingosina em Solução Aquosa por Ressonância Magnética Nuclear 2011
Estudo do Enovelamento da Protease Pla de Yersinia pestis por Dicroísmo Circular 2011
Conformational changes induced by phosphorylation out of Effector Domain favors MARCKS antibody interaction 2010
Cloning, Expression and Purification of Dihydrofolate Reductase of Plasmodium falciparum 2009
Identification, Isolation and Cloning of the Nucleoside Hydrolase of Leishmania amazonensis 2009
Obtention of Dihydrofolate Reductase from Mycobacterium leprae: A Target for the Development of New Drugs for Leprosy Treatment 2009
Structural Studies of Phosphorylated N-Terminal Peptide of MARCKS Protein and the Monoclonal Antibody 3C3 2009
Interação da Região N-terminal da Proteína MARCKS com o Anticorpo mAb3C3: Estudos por RMN e Dicroísmo Circular 2009
INTERACTION STUDIES OF PHOSPHORYLATED N-TERMINAL PEPTIDE OF MARCKS PROTEIN AND THE MONOCLONAL ANTIBODY 3C3: NMR AND CIRCULAR DICHROISM STUDIES 2009
NMR Structural Analysis of the Chicken MARCKS N-terminal Peptide: Phosphorylation Influence and Antibody Binding 2008
Estudo de Interações entre oximas e Albumina do Soro Bovino e Acetilcolinesterase por RMN 2008
Análise Por RMN do Peptídeo da Região de Interação da Proteína MARCKS com o Anticorpo mAb 3C3 2008
Avaliação de Potenciais Inibidores da Nucleosídeo Hidrolase de Leishmania donovani por Ressonância Magnética Nuclear 2008
Kinetic Studies and Evaluation of Potential Compounds for the Chemotherapy of Leishmaniasis Using LdNH-MBP 2008
The Use of NMR-Derived Restrained Molecular Dynamics to Study Binding of Peptides to Membranes 2008
NMR in Drug Discovery 2008
Docking Studies of Inhibitors of Protozoan Nucleoside Hydrolases 2008
DSS usado como referência interna em experimentos de RMN interfere na interação de ribonucleosídeo com albumina 2007
Chiken Marks N-terminal peptide: structural analysis of the phosphorilation influence in ser25 and atibody biding 2007
Design of Yersinia pestis invasion inhibitors: structural studies of PK2 peptide using T-ROESY experiments 2007
Chiocca alba Saponin structure elucidation by nmr 2007
Structural Studies of PK2 Peptide: A Human Plasminogen Region that Interacts with Yersinia Pestis 2007
Potencial Fitoterapêutico de Kalanchoe pinnata (Crassulaceae) no Tratamento da Leishmaniose 2006
NMR Structural Analysis of PK2 Peptide:The Target of Yersinia pestis Plasmin 2006
STRUCTURAL BASIS FOR NUCLEIC ACID BINDING AND CONFORMATIONAL CONVERSION OF PRION PROTEIN 2005
NMR STUDY OF PIPERAZINE-P-CRESOL COMPLEXES: INFLUENCE OF MOLECULAR ENVIRONMENT ON HYDROGEN NMR STUDY OF PIPERAZINE-P-CRESOL COMPLEXES: INFLUENCE OF MOLECULAR ENVIRONMENT ON HYDROGEN BONDING 2005
THEORETICAL AND EXPERIMENTAL NMR STUDY ON THE INTERACTION OF RADIOSENSITIZERS WITH DNA 2005
THE USE OF SOLUTION NMR TO STUDY THE PROTEIN-MEMBRANE INTERACTION 2005
STRUCTURAL STUDIES OF THE ANTICOCCIDIAL PEPTIDE (PW2) WITH PHOSPHOLIPID MEMBRANES BY NUCLEAR MAGNETIC RESONANCE. 2005
Rational Design of New Potential Drugs for Leishmaniasis Using Molecular Modeling 2005
Structural Studies of Anti-Microbial Peptides PW2 and Tritrpticin Interacting with Phospholipid Vesicles by Nuclear Magnetic Resonance. 2005
Influência da Acidez do Fenol na Estabilidade de Complexos de Piperazina com Fenóis 2005
Models of 3D Structures Based on Homology Modeling for Nucleoside Hydrolase from Leishmania donovani: A Promissing Target to Drug Design Against Visceral Leishmaniosis 2004
Análise por RMN da Interação da Guanil Hidrazona do Bromo Piperonal com o Fragmento de DNA d(CGCCGAATTCGCG)2 2004
Estudos Estruturais de Peptídeos dos HPVs 9, 16 e 30 Contendo o domínio de Ligação LXCXE na presença e na Ausência da pRB 2004
RMN e Modelagem Molecular Explicam Resultados Inesperados nas Solvólises de Complexos Dinucleares de Rutênio 2004
Immunoptherapy agaisnt canine visceral leishmanaiasis with the FML-vaccine 2004
NMR Study of the Leaving Ligand and Solvent Effects on the Solvolysis of (u-Oxo)Bis(u-Acetato)Diruthenium(III) Complexes 2003
Study of the Interaction of SDS Micelles With Aromatic Guanyl Hydrazones by NMR 2003
Effect of the Phenol Acidity on the Strucuture of Phenol-Piperazine 2:1 Complexes Using NMR 2003
Structure of the Avian Anticocidial Peptide PW2: Differences Between PW2 Bound to Dodecylphosphocoline and Sodium Dodecyl Sulphate 2003
The FML Vaccine on Imunotherapy of Canine Visceral Leishmaniasis 2003
The FML Vaccine on Immunoprophylaxis and Immunotherapy of Canine visceral leishmaniasis 2003
NMR Strategies to Structure-Function Analysis of the E7 oncoprotein from High Risk Human Papillomavirus (HPV16) 2002
NMR Structure of a Tryptophan-Rich Peptide with Avian Anticoccidial Activity Selected from Phage Display Libraries 2002
Estrutura por Ressonância Magnética Nuclear de um Novo Peptídeo com Atividade Anticoccidial 2002
Estudo de Complexos Orgânicos de Derivados Fenóis com Piperazina por RMN e Cálculos ab initio 2002
Análise por RMN do Sítio de Ligação da Proteína E7 do Papilomavírus Humano a Proteína Retinoblastoma 2002
Strctural Studies of HPV16 E7 Oncogenic Protein by Solution Nuclear Magnetic Resonance. 2001
The Addition of Trifluorethanol Decreases Conformational Fluctuations on the Human Papillomavirus(HPV 16) E7 Protein 2001
Structural Determination Of the Nine Residue Human Papillomavirus (HPV 16) E7 Peptide by NMR 2001
Characterization of HPV-16 E7 Protein in Solution by Nuclear Magnetic Resonance. 2000
Aspectos Estruturais da Proteína E7 do Papilomavírus Humano por Ressonância Magnética Nuclear 2000
Determination of Correlation Times from Selective and Non Selective Spin-Lattice Relaxation Rates and Their Use in Drug-Drug and Drug-Albumin Interaction Studies 1999
Relação entre a Atividade Anti-Tripanosoma cruzi e as Interações Intermoleculares das Nitro Guanil Hidrazonas aromáticas 1998
Estudo por RMN das Interações de Nitro Guanil Hidrazonas Aromáticas com a Albumina do Soro Bovino 1998
Efeito dos contra-ânions nos Tensores de Blindagem e tempos de relaxação de guanil Hidrazonas com atividade Anti-Tripanossoma cruzi 1997
Study of Interaction Between Trypanocide 3-Nitrobenzaldehyde Guanyl Hydrazone and Bovine Serum Albumin by Equilibrium Dialysis and NMR 1997
Guanyl Hydrazones. Syntesis, Structural Studies and In Vitro Activity Agains Trypanosoma cruzi 1994
Correlação dos Parâmetros Espectrais e de Hammett com Atividade Anti-Trypanosoma cruzi de Mono Guanil Hidrazonas Aromáticas 1994
Análise Conformacional de Bis-Guanil Hidrazonas Tripanocidas por RMN 1994
Estudo das Interações Intra e Intermoleculares em Nitroguanil Hidrazonas por RMN 1994
Síntese e RMN do o,o'-Difenil-Dicarboxialdeído-bis-Guanil-Hidrazona 1993
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