Jose Garcia Ribeiro Abreu Junior

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Ciências Biomédicas

Departamento:

Gabinete do Diretor ICB

e-mail:

garciajr@icb.ufrj.br

Linkedin:

Google Scholar:

ORCID:

https://orcid.org/0000-0002-1363-1755

Formação:

  • Childrens Hospital Boston - Harvard Medical School

    | Pós-Doutorado | 2015 - 2015

  • Childrens Hospital Boston - Harvard Medical School

    | Pós-Doutorado | 2008 - 2010

  • University Of California Los Angeles

    | Pós-Doutorado | 1999 - 2002

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Doutorado | 1993 - 1998

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Mestrado | 1991 - 1993

  • Universidade Federal do Rio de Janeiro

    Diferenciacao Celular e Citoesqueleto | Especialização | 1990 - 1991

  • Faculdade de Humanidades Pedro II

    Ciencias Biologicas | Graduação | 1986 - 1990
Laboratórios:
Nuvens de Palavras:
Artigos:

(84.21% artigos com DOI)

Titulo DOI Ano
WNT pathway in focal cortical dysplasia compared to perilesional nonlesional tissue in refractory epilepsies 10.1186/s12883-023-03394-1 2023
Therapeutic Potential of Naturally Occurring Small Molecules to Target the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer 10.3390/cancers14020403 2022
The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway 10.3390/ijms232012078 2022
The Wnt/Beta-Catenin Pathway and Cytoskeletal Filaments Are Involved in the Positioning, Size, and Function of Lysosomes during Chick Myogenesis 10.3390/cells11213402 2022
Establishing embryonic territories in the context of Wnt signaling 10.1387/ijdb.200231ja 2021
UNESCO Chair of Developmental Biology: how an initiative that fostered careers in Developmental Biology impacted Brazilian Science 10.1387/ijdb.200132ja 2021
Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis 10.1016/j.dci.2020.103840 2021
5-Fluorouracil disrupts ovarian preantral follicles in young C57BL6J mice 10.1007/s00280-020-04217-7 2021
Depletion of Ric-8B leads to reduced mTORC2 activity 10.1371/journal.pgen.1008255 2020
Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells 10.1038/s41598-020-68574-2 2020
Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Mediated by Rac1 Glucosylation 10.3389/fmicb.2020.01998 2020
TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis 10.7554/eLife.56793 2020
CUB domain-containing protein 1 (CDCP1) binds transforming growth factor beta family members and increase TGF-β1 signaling pathway 10.1016/j.yexcr.2019.111499 2019
Toxoplasma gondii Impairs Myogenesis in vitro, With Changes in Myogenic Regulatory Factors, Altered Host Cell Proliferation and Secretory Profile 10.3389/fcimb.2019.00395 2019
The Chalcone Lonchocarpin Inhibits Wnt/β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation 10.3390/cancers11121968 2019
GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling 10.1007/s12035-018-1150-5 2018
Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides 10.3390/ijms19092769 2018
N-myc regulates growth and fiber cell differentiation in lens development 10.1016/j.ydbio.2017.07.002 2017
Advances in the use of Xenopus for successful drug screening 10.1080/17460441.2017.1367281 2017
Complexity of the Wnt/β-catenin pathway: Searching for an activation model 10.1016/j.cellsig.2017.08.008 2017
Microglia-glioblastoma interactions: New role for Wnt signaling 10.1016/j.bbcan.2017.05.007 2017
Cholesterol-rich membrane microdomains modulate Wnt/β-catenin morphogen gradient during Xenopus development 10.1016/j.mod.2016.09.001 2016
Developmental aspects of the direct-developing frog A delophryne maranguapensis 10.1002/dvg.22935 2016
Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation 10.1016/j.devcel.2015.02.014 2015
Derricin and Derricidin Inhibit Wnt/β-Catenin Signaling and Suppress Colon Cancer Cell Growth In Vitro 10.1371/journal.pone.0120919 2015
Chick embryo xenograft model reveals a novel perineural niche for human adipose-derived stromal cells 10.1242/bio.010256 2015
Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro 10.1371/journal.pone.0133689 2015
CLOSTRIDIUM DIFFICILE TOXIN A ATTENUATES WNT/ -CATENIN SIGNALING IN INTESTINAL EPITHELIAL CELLS 10.1128/iai.00567-13 2014
New strategy to control cell migration and metastasis regulated by CCN2/CTGF 10.1186/1475-2867-14-61 2014
Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates 10.1387/ijdb.140106ja 2014
Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/ -catenin signaling pathway 10.1074/jbc.M114.621599 2014
Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts 10.1016/j.ydbio.2014.07.025 2014
Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies 10.3390/ijms150712094 2014
Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling 10.2174/1568026611212190008 2013
Connective Tissue Growth Factor (CTGF/CCN2) Is Negatively Regulated during Neuron-Glioblastoma Interaction 10.1371/journal.pone.0055605 2013
Wnt Stabilization of  -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies 10.1126/science.1232389 2013
Plasma membrane cholesterol depletion disrupts prechordal plate and affects early forebrain patterning 10.1016/j.ydbio.2012.03.003 2012
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation 10.1016/j.cell.2012.04.039 2012
Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development 10.1016/j.cell.2012.11.014 2012
Kinin-B2 Receptor Activity Determines the Differentiation Fate of Neural Stem Cells 10.1074/jbc.M112.407197 2012
CCN2/CTGF silencing blocks cell aggregation in embryonal carcinoma P19 cell 10.1590/S0100-879x2011007500019 2011
Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer 10.1016/j.lfs.2011.05.003 2011
CTGF/CCN2 has a chemoattractive function but a weak adhesive property to embryonic carcinoma cells 10.1016/j.bbrc.2011.09.005 2011
Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family 10.1073/pnas.0906764107 2010
Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer 10.1242/dev.043257 2010
The Wnt signaling pathway regulates Nalm-16 b-cell precursor acute lymphoblastic leukemic cell line survival and etoposide resistanceâ¿¿ 10.1016/j.biopha.2009.09.005 2010
Inhibition of GSK3 Phosphorylation of ?-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6 10.1371/journal.pone.0004926 2009
Ccn2/Ctgf Overexpression Induced by Cigarette Smoke during Cutaneous Wound Healing is Strain Dependent 10.1177/0192623308328134 2009
Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes ?-catenin cellular localization 10.1097/CAD.0b013e32832d1149 2009
Dynamic analysis of the expression of TGFß/SMAD2 pathway and CCN2/CTGF during early steps of tooth development (published on line) 10.1159/000112640 2008
Amyloid-  Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/ -Catenin Signaling 10.1074/jbc.M707108200 2008
Wnt/beta-catenin pathway activation is induced by cholesterol depletion in cultured chick myoblasts. 10.1111/j.1432-0436.2006.00129.x 2007
Interactive properties of human glioblastoma cells with brain neurons culture and neuronal modulation of glial laminin organization 10.1111/j.1432-0436.2006.00090.x 2006
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of A  oligomerization 10.1096/fj.04-1764com 2004
Scientific aid to Brazil is strangled by red tape 10.1038/428601a 2004
Concentration-dependent actions of glial chondroitin sulfate on the neuritic growth of midbrain neurons 10.1016/S0165-3806(03)00036-1 2003
Sulfated proteoglycans as modulators of neuronal migration and axonal decussation in the developing midbrain 10.1590/S0100-879X2003000800005 2003
P-glycoprotein-like protein contributes to cadmium resistance in Euglena gracilis 10.1007/s00360-003-0365-5 2003
Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems 10.1016/s0378-1119(01)00827-7 2002
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-? 10.1038/ncb826 2002
Modulators of axonal growth and guidance at the brain midline with special reference to glial heparan sulfate proteoglycans 10.1590/S0001-37652002000400010 2002
Astroglial cells derived from lateral and medial midbrain sectors differ in their synthesis and secretion of sulfated glycosaminoglycans 10.1590/S0100-879X2001000200014 2001
Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer 2001
Inhibition of Alzheimer's disease b-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy 10.1096/fj.00-0676fje 2001
Contribution of heparan sulfate to the non-permissive role of the midline glia to the growth of midbrain neurites. 2000
Glial cells with differential neurite growth-modulating properties probed by atomic force microscopy 2000
Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures 1999
Neurons induce GFAP gene promoter and differentiation of cultured astrocytes from transgenic mice 1999
Regulatory roles of microtubule-associated proteins in neuronal morphogenesis. Involvement of the extracellular matrix 1999
Heterogeneity of median and lateral midbrain radial glia and astrocytes 1997
Complementary hydropathy identifies a cellular prion protein receptor 10.1038/nm1297-1376 1997
The extracellular matrix of the midline and non-midline midbrain glia: Correlations with neurite growth-supporting abilities. 1996
Compartmental distribution of sulfated glycossaminoglycans in lateral and medial midbrain astroglial cultures 1996
Effects of thyroid hormone (T3) on astrocytes 1996
Regionally-specific properties of midbrain glia. I. Interactions with midbrain neurons. 1995
Differential patterns of laminin expression in lateral and medial midbrain glia. 1995
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
CTNNB1 L388P mutation compromises Wnt/β-catenin signalling and affects anterior development in Xenopus embryos 2017
Effects on cholesterol synthesis inhibition on early Xenopus development 2017
Caspases activation and compensatory prolifaration in Xenopus laevis' tail regeneration 2017
A inibição da biossíntese de colesterol induz defeitos axiais em embriões de Xenopus laevis 2016
Effects of cholesterol synthesis inhibition on early Xenopus development 2015
The natural compound A7 synergistically activates Wnt/beta-catenin signaling pathway 2015
Xenopus laevis embryos as model system for screening chemical compounds targeting wnt/β-catenin 2015
Lipidomic analysis during Xenopus laevis development 2009
Expression patter of genes related to lipid rafts formation during Xenopus laevis development 2009
Emerging role for cholesterol-rich microdomains during head formation in Xenopus 2007
CTGF PROMOVE DIFERENCIAÇÃO GLIAL E MODULAÇÃO DA MATRIZ EXTRACELULAR MODULANDO A VIA DE MAPK 2007
FATOR DE CRESCIMENTO DE TECIDO CONJUNTIVO (CTGF) PROMOVE AGREGAÇÃO E MIGRAÇÃO EM CÉLULAS P19 ATRAVÉS DA ATIVAÇÃO DAS VIAS DE SINALIZAÇÃO P38 MAPK E AKT 2007
PAPEL DOS MICRODOMÍNIOS DE MEMBRANA RICOS EM COLESTEROL NO DESENVOLVIMENTO EMBRIONÁRIO 2007
O Flavonoide isoquercitina promove a diminuicao da proliferacao de glioblastoma multiforme humano 2007
Reprogramacao de Astrocitos por Determinantes Citoplasmaticos 2007
Cholesterol Depletion disrupts formation of anterior structures 2006
CTGF is co-expressed with members of the TGF-beta signaling in the inductors centers of the tooth developoment 2004
Xenopus nodal relacted-1 induces connective tissue growth factor gene expression and protein secretion 2004
Influência da Interação Neurônio-Glioblastoma na expressão de CTGF 2004
Efeito quimiotático de CTGF em células P19 2004
Interação do fator de crescimento do tecido conectivo com a via de sinalização do fator de crescimento transformante beta (TGF-beta) 2004
Expressao de CTGF nos centros indutores da odonogenese, interacao com TGF-beta e relacao entre esses fatores na interacao epitelio-mesenquimal 2004
Connective tissue growth factor may modulates CTGF-beta signaling pathway by interaction with soluble and membrane-bound betaglycan 2004
Expression of CTGF and Components of TGF-beta signaling cascade during early tooth development 2004
Chemotatic Role of CTGF in P19 Cells 2004
The role of CTGF in the determination of mesoderm derivatives 2003
Expressão ontogenética de componentes da via de sinalização TGF-beta durante a odontogênese 2003
regulação da expressão de CTGF e TGF-beta1 Durante a Interação Entre Glioblastoma Multiforme e Neurônios 2003
The role of CTGF in the determination of mesoderm derivatives 2003
Connective tissue growth factor modulates cell signaling by binding to BMP2/4 and TGFbeta1 in the extracellular space 2002
Chordin-like cysteine-repeat of CTGF binds BMP4 and TGF-beta1 2001
CTGF binds BMP4 and TGF-beta1 2001
Chordin-like CR domains as signaling units in the extracellular space 2001
Expression cloning of novel proteins that interact with nodal and cerberus 2001
Expression cloning of novel proteins that interact with nodal and cerberus using secretion-trapping 2000
Characterization of compounds that prevent aggregation and neurotoxicity of Alzeheimer's disease A beta peptide 2000
Characterization of compounds that prevent aggregation and neurotoxicity of Alzheimer's disease A beta peptide. 2000
Expression cloning of novel proteins that interact with nodal and cerberus using secretion-trapping 2000
Glycosaminoglycans are partially responsible for the neurite growth-modulating properties of the midline and non-midline midbrain glia. 1998
Soluble factors present in lateral and medial midbrain astrocyte conditioned medium modulate neurite growth of midbrain neurons. 1998
Propriedades regionalmente específicas da glia do mesencéfalo: O papel dos fatores solúveis. 1997
Characterization of soluble factors present in lateral and medial midbrain astrocyte conditioned medium. 1997
Efeito do Meio Condicionado Astroglial Lateral e Medial Sobre Neurônios Laterais e Mediais Mesencefálicos. 1996
Compartmental distribution of sulfated glycosaminoglycans in lateral and medial midbrain astroglial cultures. 1996
Acoplamento juncional entre neurônios e astrócitos em cultura 1996
Regional heterogeneity of glia : Correlation between soluble factors and extracellular matrix. 1996
Expression of sulfated glycosaminoglycans in lateral and medial midbrain astroglial cultures. 1996
Identification of the cellular receptor for prion protein and a specific interaction with a basement membrane component. 1996
Increased expression of Glial Fibrillary Acidic Protein (GFAP) due to neuron-glia interaction 1996
Compartmental distribution of sulfated glycosaminoglycans in lateral and medial midbrain astroglial cultures. 1996
Effects of lateral and medial midbrain glial conditioned medium on midbrain neurons 1996
Alterações morfológicas induzidas por hormônio tireoidiano em cultura de células ependimárias humanas. 1995
Efeito do Meio Condicionado Astroglial Lateral e Medial Sobre Neurônios Laterais e Mediais Mesencefálicos. 1995
Regional Heterogeneity of Midbrain Glia 1995
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