Russolina Benedeta Zingali

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Bioquímica Médica

Departamento:

Gabinete do Diretor do Instituto de Bioquímica Médica

e-mail:

lzingali@bioqmed.ufrj.br

Linkedin:

Google Scholar:

ORCID:

não disponível no Lattes

Formação:
  • Institut Pasteur

    | Pós-Doutorado | 1993 - 1993
  • Universidade Federal do Rio de Janeiro

    Química Biológica | Doutorado | 1989 - 1993
  • Universidade Federal de São Paulo

    Ciências Biológicas (Biologia Molecular) | Mestrado | 1987 - 1989
  • Instituto Butantan

    Estágio Em Laboratório de Pesquisa | Especialização | 1986 - 1986
  • Universidade de São Paulo

    Farmácia Bioquímica | Graduação | 1981 - 1986
Laboratórios:
Nuvens de Palavras:
Artigos:

(84.42% artigos com DOI)

Titulo DOI Ano
Toward the mechanism of jarastatin (rJast) inhibition of the integrin αVβ3 10.1016/j.ijbiomac.2023.128078 2024
Anti-hemostatic, antithrombotic, and chemical profiles of a curly-leaf variety of Petroselinum crispum (Apiaceae), a food and medicinal aromatic herb 10.1016/j.fitote.2024.105894 2024
Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis 10.3390/toxins16030142 2024
rJararacin, a recombinant disintegrin from Bothrops jararaca venom: Exploring its effects on hemostasis and thrombosis 10.1016/j.abb.2023.109557 2023
The Brazilian Atlantic Bushmaster Lachesis (Linnaeus, 1766) Mitogenome With Insights On Snake Evolution And Divergence (Serpentes: Viperidae: Crotalinae) 10.1590/0001-3765202320220973 2023
15N, 13C, and 1H resonance assignments of Jarastatin: a disintegrin of Bothrops jararaca 10.1007/s12104-021-10056-1 2022
Pharmacological Screening of Venoms from Five Brazilian Micrurus Species on Different Ion Channels 10.3390/ijms23147714 2022
The recombinant disintegrin, jarastatin, inhibits platelet adhesion and endothelial cell migration 10.1016/j.toxicon.2022.08.010 2022
Proteomic Analysis of HCC-1954 and MCF-7 Cell Lines Highlights Crosstalk between αv and β1 Integrins, E-Cadherin and HER-2 10.3390/ijms231710194 2022
BmooMPα-I, a Metalloproteinase Isolated from Bothrops moojeni Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension 10.3390/toxins14110766 2022
Extracellular Vesicles from Bothrops jararaca Venom Are Diverse in Structure and Protein Composition and Interact with Mammalian Cells 10.3390/toxins14110806 2022
Monoclonal-Based Antivenomics Reveals Conserved Neutralizing Epitopes in Type I PLA2 Molecules from Coral Snakes 10.3390/toxins15010015 2022
Three-Finger Toxins from Brazilian Coral Snakes: From Molecular Framework to Insights in Biological Function 10.3390/toxins13050328 2021
Widow spiders in the New World: a review on Latrodectus Walckenaer, 1805 (Theridiidae) and latrodectism in the Americas 10.1590/1678-9199-jvatitd-2021-0011 2021
Cellular Growth Arrest and Efflux Pumps Are Associated With Antibiotic Persisters in Streptococcus pyogenes Induced in Biofilm-Like Environments 10.3389/fmicb.2021.716628 2021
Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction 10.3389/fmolb.2021.783301 2021
Polyclonal F(ab?)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency 10.1016/j.isci.2021.103315 2021
Chalcones identify cTXNPx as a potential antileishmanial drug target 10.1371/journal.pntd.0009951 2021
Quantitative proteomic analysis reveals altered enzyme expression profile in Zea mays roots during the early stages of colonization by Herbaspirillum seropedicae 10.1002/pmic.202000129 2021
Polysaccharide composition of an anticoagulant fraction from the aqueous extract of Marsypianthes chamaedrys (Lamiaceae) 10.1016/j.ijbiomac.2019.12.176 2020
Oral treatment with a chemically characterized parsley (Petroselinum crispum var. neapolitanum Danert) aqueous extract reduces thrombi formation in rats 10.1016/j.jtcme.2020.04.003 2020
Evaluation of the Enzymatic Arsenal Secreted by Myceliophthora thermophila During Growth on Sugarcane Bagasse With a Focus on LPMOs 10.3389/fbioe.2020.01028 2020
Schinus terebinthifolia leaf lectin (SteLL) is an immunomodulatory agent by altering cytokine release by mice splenocytes 10.1007/s13205-020-2137-2 2020
Investigation of the ability of the oviposition-stimulant lectin from Moringa oleifera seeds (WSMoL) to bind with membrane proteins present in the legs of Aedes aegypti 10.1016/j.ijbiomac.2020.06.189 2020
Portulaca elatior root contains a trehalose-binding lectin with antibacterial and antifungal activities 10.1016/j.ijbiomac.2018.12.188 2019
Evaluation of the effects of humic acids on maize root architecture by label-free proteomics analysis 10.1038/s41598-019-48509-2 2019
Protective factors in mature human milk: a look into the proteome and peptidome of adolescent mothers? breast milk 10.1017/s0007114519002447 2019
Binding targets of termiticidal lectins from the bark and leaf of Myracrodruon urundeuva in the gut of Nasutitermes corniger workers 10.1002/ps.4847 2018
Purification and characterization of a protease from the visceral mass of Mytella charruana and its evaluation to obtain antimicrobial peptides 10.1016/j.foodchem.2017.11.044 2018
Protein Profile of Blood Monocytes is Altered in HTLV-1 Infected Patients: Implications for HAM/TSP Disease 10.1038/s41598-018-32324-2 2018
Pain-like behaviors and local mechanisms involved in the nociception experimentally induced by Latrodectus curacaviensis spider venom 10.1016/j.toxlet.2018.09.008 2018
Recombinant and Chimeric Disintegrins in Preclinical Research 10.3390/toxins10080321 2018
Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms? 10.1186/s40409-017-0105-z 2017
The costa of trichomonads: A complex macromolecular cytoskeleton structure made of uncommon proteins 10.1111/boc.201600050 2017
Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine 10.1186/s40409-017-0118-7 2017
The antithrombotic and haemostatic effects of LASSBio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats 10.1111/jphp.12771 2017
Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms 10.1016/j.thromres.2017.09.019 2017
A trypsin inhibitor from Moringa oleifera flower extract is cytotoxic to Trypanosoma cruzi with high selectivity over mammalian cells 10.1080/14786419.2017.1389932 2017
Differences between renal effects of venom from two Bothrops jararaca populations from southeastern and southern Brazil 10.1016/j.toxicon.2016.11.249 2017
Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma 10.1016/j.urolonc.2015.07.016 2016
Differential proteomic analysis of outer membrane enriched extracts of Bacteroides fragilis grown under bile salts stress 10.1016/j.anaerobe.2016.03.003 2016
Proteomics of cell-cell interactions in health and disease 10.1002/pmic.201500341 2016
Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest 10.1016/j.jprot.2015.04.029 2016
A proteomic approach to compare saliva from individuals with and without oral leukoplakia 10.1016/j.jprot.2016.07.029 2016
Exploiting the antithrombotic effect of the (pro)thrombin inhibitor bothrojaracin 10.1016/j.toxicon.2016.05.007 2016
Metaproteomics reveals metabolic transitions between healthy and diseased stony coral 10.1111/mec.13775 2016
Evaluation of antimicrobial, cytotoxic, and hemolytic activities from venom of the spider Lasiodora sp. 10.1016/j.toxicon.2016.09.019 2016
Proteomic analysis of the secretome of HepG2 cells indicates differential proteolytic processing after infection with dengue virus 10.1016/j.jprot.2016.07.011 2016
Biotechnological value of Moringa oleifera seed cake as source of insecticidal lectin against Aedes aegypti 10.1016/j.procbio.2016.06.026 2016
Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil 10.1016/j.jprot.2014.11.011 2015
Isoforms of Hsp70-binding human LDL in adult Schistosoma mansoni worms 10.1007/s00436-014-4292-z 2015
Ecotin: Exploring a feasible antithrombotic profile 10.1016/j.ijbiomac.2015.03.071 2015
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus 10.1590/S1677-5538.IBJU.2014.0051 2015
Molecular Characterization of Rhodnius prolixus´ embryonic cuticle 10.1016/j.ibmb.2013.12.005 2014
Purification and Characterization of the Lectin from Taro (Colocasia esculenta) and Its Effect on Mouse Splenocyte Proliferation In Vitro and In Vivo 10.1007/s10930-013-9541-y 2014
Four conventional [Glycine max (L.) Merrill] soybean seeds exhibit different protein profiles as revealed by proteomic analysis. 10.1021/jf404351g 2014
New insights on the Golgi complex of Tritrichomonas foetus 10.1017/s0031182013001455 2014
Crovirin, a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania 10.1371/journal.pntd.0003252 2014
Functional Variability of Snake Venom Metalloproteinases: Adaptive Advantages in Targeting Different Prey and Implications for Human Envenomation 10.1371/journal.pone.0109651 2014
Modulation of α-Enolase Post-Translational Modifications by Dengue Virus: Increased Secretion of the Basic Isoforms in Infected Hepatic Cells 10.1371/journal.pone.0088314 2014
The Molecular and Structural Characterization of Two Vitellogenins from the Free-Living Nematode Oscheius tipulae 10.1371/journal.pone.0053460 2013
Feather keratin hydrolysates obtained from microbial keratinases: effect on hair fiber 10.1186/1472-6750-13-15 2013
Investigation of Thrombin Activity with PAR 1-based Fluorogenic Peptides 10.2174/09298665113209990001 2013
Pyruvate decarboxylase activity is regulated by the Ser/Thr protein phosphatase SIT4 in the yeast Saccharomyces cerevisiae 10.1111/1567-1364.12052 2013
Structural features in neuropsin as potential target for pharmacological inhibition in brain diseases 2013
Keratinases and sulfide from Bacillus subtilis SLC to recycle feather waste 10.1007/s11274-011-0930-0 2012
Proteomic analysis of the ventral disc of Giardia lamblia 10.1186/1756-0500-5-41 2012
Oral Antithrombotic Effects of Acylhydrazone Derivatives 10.5551/jat.14886 2012
Label-free quantitative proteomics reveals differentially regulated proteins in the latex of sticky diseased Carica papaya L. plants 10.1016/j.jprot.2012.03.021 2012
Snake venomics and venom gland transcriptomic analysis of Brazilian coral snakes, Micrurus altirostris and M. corallinus 10.1016/j.jprot.2011.04.003 2011
Proteomic analysis of papaya (Carica papaya L.) displaying typical sticky disease symptoms 10.1002/pmic.201000757 2011
Immobilized Cratylia mollis lectin: An affinity matrix to purify a soybean (Glycine max) seed protein with in vitro platelet antiaggregation and anticoagulant activities 10.1016/j.procbio.2010.07.017 2011
A new exogen anticoagulant with high selectivity to intrinsic pathway of coagulation 10.1016/j.thromres.2011.06.005 2011
Phenolic Chemical Composition of Petroselinum crispum Extract and Its Effect on Haemostasis 2011
Biodegradation of feather waste by extracellular keratinases and gelatinases from Bacillus spp. 10.1007/s11274-010-0586-1 2011
Analysis of the salivary proteome in gingivitis patients 10.1111/j.1600-0765.2011.01378.x 2011
Production, purification and characterization of a thermostable β-1,3-glucanase (laminarinase) produced by Moniliophthora perniciosa 10.1590/S0001-37652011005000007 2011
Purification, characterization and structural determination of UDP-N-acetylglucosamine pyrophosphorylase produced by Moniliophthora perniciosa 10.1590/S0103-50532011000600003 2011
Keratinolytic activity of Bacillus subtilis AMR using human hair 10.1111/j.1472-765X.2009.02760.x 2010
Comparative proteomic analysis of whole saliva from chronic periodontitis patients 10.1016/j.jprot.2010.02.018 2010
Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: Assessment of geographic variation and its implication on snakebite management 10.1016/j.jprot.2010.06.001 2010
Immunome and venome of Bothrops jararacussu: A proteomic approach to study the molecular immunology of snake toxins 10.1016/j.toxicon.2009.12.018 2010
Engineering Ecotin for Identifying Proteins with a Trypsin Fold 10.1007/s12010-009-8711-z 2010
Guest editor do volume especial "Highlights in Toxinology: Biodiversity in Toxins - Tools for Biological Research and Drug Development" 2010
Metabólitos Secundários de Origem Vegetal: Uma Fonte Potencial de Fármacos Antitrombóticos. 2010
Bothrops insularis venomics: A proteomic analysis supported by transcriptomic-generated sequence data 10.1016/j.jprot.2009.01.001 2009
Integrin inhibitors from snake venom: Exploring the relationship between the structure and activity of RGD-peptides 10.1016/j.abb.2008.11.023 2009
A TonB-dependent outer membrane protein as a Bacteroides fragilis fibronectin-binding molecule. 10.1111/j.1574-695X.2009.00532.x 2009
Evaluation of sample preparation methods for the analysis of papaya leaf proteins through two-dimensional gel electrophoresis 10.1002/pca.1147 2009
The interaction of Bacteroides fragilis with components of the human fibrinolytic system 10.1111/j.1574-695X.2009.00546.x 2009
Pharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts 10.1017/S0031182009990618 2009
Effect of Moringa oleifera lectin on development and mortality of Aedes aegypti larvae 10.1016/j.chemosphere.2009.08.022 2009
Synthesis and anti-platelet activity of novel arylsulfonate-acylhydrazone derivatives, designed as antithrombotic candidates. 10.1016/j.ejmech.2007.03.032 2008
Identification and characterization of a new member of snake venom thrombin inhibitors from Bothrops insularis using a proteomic approach 10.1016/j.toxicon.2007.11.026 2008
Molecular characterization of BjussuSP-I, a new thrombin-like enzyme with procoagulant and kallikrein-like activity isolated from Bothrops jararacussu snake venom. 10.1016/j.biochi.2007.10.005 2008
Secretome of HepG2 cells infected with dengue virus: Implications for pathogenesis 10.1016/j.bbapap.2008.06.015 2008
Suramin counteracts the haemostatic disturbances produced by Bothrops jararaca snake venom. 10.1016/j.toxicon.2007.01.002 2007
Effect of RGD-disintegrins on melanoma cell growth and metastasis: Involvement of the actin cytoskeleton, FAK and c-Fos 10.1016/j.toxicon.2007.07.016 2007
Couteracting effect of Glycyrrhizin on the hemostatic abnormalities induced by Bothrops jararaca snake venom 10.1038/sj.bjp.0706786 2006
Interaction of Snake-Venom Protein with Blood coagulation Factors. Mechanisms of Anticoagulant Activity. 10.1080/15569540600567412 2006
Ecotin Modulates Thrombin Activity Through Exosite Interactions 10.1016/j.biocel.2006.05.001 2006
Molecular diversity of disintegrin-like domains within metalloproteinase precursors of Bothrops jararaca 10.1016/j.toxicon.2006.07.010 2006
Bothrops jararaca venom gland transcriptome: Analysis of the gene expression pattern 10.1016/j.toxicon.2006.07.008 2006
Partial purification of tightly bound mitochondrial hexokinase from maize (Zea mays L.) root membranes 10.1590/S0100-879X2006000900003 2006
Fast Analysis Of Low-Molecular-Mass Compounds Present In Snake Venom: Identification Of Ten New Pyroglutamate-Containing Peptides 10.1002/rcm.1973 2005
Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom Toxicon. 10.1016/j.toxicon.2005.03.006 2005
Bothrojaracin, a Bothrops jararaca snake venom-derived (pro)thrombin inhibitor, as an anti-thrombotic molecule. 10.1159/000092416 2005
RGD- and MLD-disintegrins, jarastatin and EC3, activate integrin-mediated signaling modulating the human neutrophils chemotaxis, apoptosis and IL-8 gene expression 10.1016/j.yexcr.2003.09.013 2004
Cloning, characterization and structural analysis of a C-type lectinfrom Bothrops insularis (BiL) venom 10.1016/j.abb.2004.08.018 2004
Snake venom thrombin-like enzymes: from reptilase to now. 10.1007/s00018-003-3325-z 2004
New insights into conformational and functional stability of human alpha-thrombin probed by high hydrostatic pressure. 10.1111/j.0014-2956.2004.04295.x 2004
Subunit Dissociation, unfolding, and inactivation of bothrojaracin, a C-type lectin-like protein from snake venom. 10.1021/bi020571z 2003
Changes in salivary nitrophorin profile during the life cycle of the blood-sucking bug Rhodnius prolixus 10.1016/S0965-1748(02)00163-7 2003
Preliminary in vitro studies on the marsypianthes chamaedrys (boia-caá) extracts at fibrinoclotting induced by snake venoms. 10.1016/S0041-0101(03)00087-4 2003
Comparative evaluation of immunological and structural similarities of snake venom C-type lectin proteins. 10.1016/S0041-0101(02)00358-6 2003
Antiplatelet Properties of NovelN-Substituted-phenyl-1, 2, 3-trizole-4-acylhydrazone Derivatives. 10.1016/S0968-0896(03)00055-5 2003
Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor In Press 10.1016/j.thromres.2003.10.014 2003
Bothrojaracin, a Proexosite I Ligand, Inhibits Factor Va-Accelerated Prothrombin Activation 2002
Purification and characterization of a phospholipase A(2) isoenzyme isolated from Lachesis muta snake venom. 10.1016/S0006-2952(02)00873-0 2002
Proteolytic action of Bothrops jararaca venom upon its own constituents 10.1016/S0041-0101(00)00208-7 2001
Structural Features Of A Snake Venom Thrombin-Like Enzyme: Thrombin And Trypsin On A Single Catalytic Platform? 10.1016/S0167-4838(01)00177-7 2001
Interaction of disintegrins with human neutrophils induces cytoskeleton reorganization, focal adhesion kinase activation and extracellular-regulated kinase-2 nuclear translocation, interfering with the chemotactic function 10.1096/fj.00-0812fje 2001
Characterization of bothrojaracin interaction with human prothrombin. 10.1110/ps.09001 2001
Canatoxin, a toxic protein of jack beans (Canavalia ensiformis), is a variant form of urease (EC3.5.1.5). Biological effects of urease independent of its ureolytic 2001
Interaction of Bothrojaracin with Prothrombin 10.1159/000048073 2001
BOTHROJARACIN INTERACTION WITH PROTHROMBIN 2001
Myotoxic activity of an acidic phospholipase A2 isolated from Lachesis muta (Bushmaster) snake venom. 2001
Myotoxic activity of an acidic phospholipase A2 isolated from Lachesis muta (Bushmaster) snake venom 2000
Characterization of two novel defensins from pea (Pisum sativum) seeds. 2000
A Heme binding Aspartic Proteinase from the eggs of the hard tick Boophilus Microplus 10.1006/abbi.2000.2120 2000
Inhibition of prothrombin activation by bothrojaracin, a C-type lectin from Bothrops jararaca venom 10.1006/abbi.2000.2006 2000
The Disintegrin-like Domain of the Snake Venom Metalloprotease Alternagin inhibits a2b1 Integrin- Mediated Cell Adhesion 2000
Identification of Bothrojaracin-like proteins in snake venoms from Bothrops species and Lachesis muta 10.1016/S0041-0101(99)00087-2 1999
Allosteric Changes of Thrombin Catalytic Site Induced by Interaction of Bothrojaracin with Anion-Binding Exosites I And II 1999
Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics 1999
Variability Of Bothrojaracin Isoforms And Other Venom Principles In Individual Jararaca (Bothrops Jararaca) Snakes Maintained In A Seasonally Invariable Condition 10.1016/S0041-0101(97)00061-5 1998
Bothrops Sp Snake Venoms: Comparison Of Some Biochemical And Physicochemical Properties And Interference In Platelet Funcions 1998
Bothrops Jararaca Snakes Produce Several Bothrojaracin Isoforms Following An Individual Pattern 1998
Bothroalternin, a Thrombin inhibitor from the venom of Bothrops alternatus 10.1016/S0041-0101(98)00111-1 1998
Isolation of na Aspartic proteinase precursor from the egg of a hard tick, Boophilus microplus 1998
Isolation and properties of a new kallikrein inhibitor from Tityus serrulatus venom 10.1023/A:1020778302161 1998
Isolation, characterization and biological properties of two kinin-like peptides (peptide-S and peptide-R) from Scaptocosa raptoria venom 10.1016/s0041-0101(97)00059-7 1998
Molecular Clonning And Expression Of Bothrojaracin A Potent Thrombin Inhibitor From Snake Venom 1997
Distinct Bothrojaracin Isoforms Produced By Individual Bothrops Jararaca Snakes. 10.1016/S0041-0101(96)00176-6 1997
Isolation Of A Calcium-Binding Phosphoprotein From The Oocytes And Hemolymph Of The Blood Sucking Bug, Rhodnius Prolixus. 1996
Bothrojaracin: A Potent Two-Site-Directed Thrombin Inhibitor 1996
Cerastocytin, a new thrombin-like platelet activator from the venom of the Tunisian viper Cerastes cerastes 10.1016/0304-4165(94)00216-K 1995
Bothrojaracin, A New Thrombin Inhibitor Isolated From Bothrops Jararaca Venom: Characterization And Mechanism Of Thrombin Inhibition 1993
Partial purification and some physicochemical properties of phospholipases A2 from the venom of the bushmaster snake (Lachesis muta). 1993
Purification , physicochemical caracterization and N-terminal-amino acid sequence of a phospholipase A2 from Bothrops jararaca venom. 1993
Les protéines de venins de serpents agissant sur les plaquettes sangüínes 1991
snake venom: Effects on platelet aggregation 10.1016/0049-3848(90)90100-q 1990
Purification and some characteristics of a zinc metaloprotease from venom of Bothrops jararaca (Jararaca). 10.1016/0041-0101(89)90041-X 1989
Biochemical And Pharmacological Screening Of Snake (Bothrops) Venons: Characterization Of Components Acting On Blood Coagulation And Platelet Aggregation. 1988
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