Ana Paula Canedo Valente
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Centro Nacional de Biologia Estrutural e Bioimagem
Departamento:
Coordenadoria do Centro Nacional de RMN Jiri Jonas/CENABIO
Formação:
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University of Pennsylvania
| Pós-Doutorado | 1994 - 1996
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Universidade de São Paulo
Ciências Biológicas (Bioquímica) | Doutorado | 1989 - 1994
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Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Mestrado | 1986 - 1989
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Universidade Federal do Rio de Janeiro
Farmácia | Graduação | 1983 - 1986
Laboratórios:
Nuvens de Palavras:
Artigos:
(66.92% artigos com DOI)
Titulo | DOI | Ano |
---|---|---|
A Decrease in Branched-Chain Amino Acids after a Competitive Male Professional Volleyball Game-A Metabolomic-Based Approach | 10.3390/metabo14020115 | 2024 |
Understanding the Enzyme ( S )-Norcoclaurine Synthase Promiscuity to Aldehydes and Ketones | 10.1021/acs.jcim.3c01773 | 2024 |
Conformational dynamics and kinetics of protein interactions by nuclear magnetic resonance | 10.1016/j.jmro.2023.100093 | 2023 |
Salivary Metabolomic Analysis Reveals Amino Acid Metabolism Shift in SARS-CoV-2 Virus Activity and Post-Infection Condition | 10.3390/metabo13020263 | 2023 |
NMR-Based Metabolomics Demonstrates a Metabolic Change during Early Developmental Stages from Healthy Infants to Young Children | 10.3390/metabo13030445 | 2023 |
Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects | 10.1021/acs.jproteome.3c00014 | 2023 |
Integrated NMR and MS Analysis of the Plasma Metabolome Reveals Major Changes in One-Carbon, Lipid, and Amino Acid Metabolism in Severe and Fatal Cases of COVID-19 | 10.3390/metabo13070879 | 2023 |
Comparison of the effects of pea protein and whey protein on the metabolic profile of soccer athletes: a randomized, double-blind, crossover trial | 10.3389/fnut.2023.1210215 | 2023 |
Chronic alcohol and nicotine consumption as catalyst for systemic inflammatory storm and bone destruction in apical periodontitis | 10.1111/iej.13994 | 2023 |
Salivary Metabolites in Patients with Mucopolysaccharidosis | 10.1590/pboci.2024.011 | 2023 |
Metabolomic Signatures of In Vitro Biofilm Maturation of Streptococcus mutans | 10.1007/s00284-022-02778-9 | 2022 |
Impact of Precompetitive Training on Metabolites in Modern Pentathletes | 10.1123/ijspp.2020-0836 | 2022 |
A critical review on the association of hyposalivation and dental caries in children and adolescents | 10.1016/j.archoralbio.2022.105545 | 2022 |
Salivary metabolomic profile in adolescents with juvenile systemic lupus erythematosus | 10.1590/1807-3107bor-2022.vol36.0128 | 2022 |
The Bacterial Microbiome and Metabolome in Caries Progression and Arrest | 10.1080/20002297.2021.1886748 | 2021 |
Effect of antihistamine-containing syrup on salivary metabolites: an in vitro and in vivo study | 10.1590/1807-3107bor-2021.vol35.0032 | 2021 |
Mapping conformational epitopes by NMR spectroscopy | 10.1016/j.coviro.2021.04.001 | 2021 |
Analysis of Salivary Metabolites by Nuclear Magnetic Resonance Before and After Oral Mucosa Cleaning of Infants in the Pre-dental Period | 10.3389/fdmed.2021.667365 | 2021 |
Conformational dynamics of Tetracenomycin aromatase/cyclase regulate polyketide binding and enzyme aggregation propensity | 10.1016/j.bbagen.2021.129949 | 2021 |
Salivary metabolome of children and adolescents under peritoneal dialysis | 10.1007/s00784-020-03557-1 | 2021 |
Cytocompatibility of filling pastes by primary teeth root simulating model | 10.1007/s10266-020-00541-9 | 2021 |
Backbone 1H, 15N, and 13C resonance assignments of the non-structural protein NS2B of Zika virus | 10.1007/s12104-021-10055-2 | 2021 |
Saliva NMR-Based Metabolomics in the War Against COVID-19 | 10.1021/acs.analchem.0c04679 | 2020 |
Evaluation of polymathy methacrylate containing chlrorhexidin reveals an evolutionary mechanism to expose hydrophobic residues | 2019 | |
Longitudinal Evaluation of Salivary Iga-S in Children with Early Childhood Caries Before and After Restorative Treatment | 10.17796/1053-4625-43.4.3 | 2019 |
NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition | 10.1182/blood.2018889493 | 2019 |
Zika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against Zika virus infection? | 10.1590/1678-9199-jvatitd-2019-0013 | 2019 |
Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1 | 10.1038/s41598-018-28358-1 | 2018 |
A unique fucosylated chondroitin sulfate type II with strikingly homogeneous and neatly distributed α-fucose branches | 10.1093/glycob/cwy048 | 2018 |
A Dynamic Overview of Antimicrobial Peptides and Their Complexes | 10.3390/molecules23082040 | 2018 |
Conformational Dynamics of a Cysteine-Stabilized Plant Defensin Reveals Evolutionary Mechanism to Expose Hydrophobic Residues | 10.1021/acs.biochem.8b00753 | 2018 |
Insights into CC chemokine ligand 2 - chemokine receptor 2 molecular recognition: a step forward towards anti-chemotactic agents | 10.1021/acs.biochem.7b00129 | 2017 |
Recombinant expression of Ixolaris, a Kunitz-type inhibitor from the tick salivary gland, for NMR studies | 10.1016/j.pep.2017.07.012 | 2017 |
PAMAM dendrimer hydrogel film-biocompatible material to an efficient dermal delivery of drugs | 10.1007/s11051-017-3965-9 | 2017 |
1H, 15N and 13C resonance assignments of Ixolaris, a tissue factor pathway inhibitor from the tick salivary gland | 10.1007/s12104-017-9766-3 | 2017 |
Salivary metabolic profile of children and adolescents after hemodialysis | 10.1007/s11306-017-1283-y | 2017 |
Salivary metabolite fingerprint of type 1 diabetes in young children | 10.1021/acs.jproteome.6b00007 | 2016 |
DIADECOMP: A new approach to analyze decompositions from projection spectroscopy | 10.1016/j.jmr.2016.10.002 | 2016 |
Structural and Dynamic Insights of the Interaction between Tritrpticin and Micelles: An NMR Study | 10.1016/j.bpj.2016.10.034 | 2016 |
Epitope mapping by solution NMR spectroscopy | 10.1002/jmr.2454 | 2015 |
A Cross-Reactive Human Single-Chain Antibody for Detection of Major Fish Allergens, Parvalbumins, and Identification of a Major IgE-Binding Epitope | 10.1371/journal.pone.0142625 | 2015 |
Dissection of the water cavity of yeast Thioredoxin 1: the effect of a hydrophobic residue in the cavity. | 10.1021/acs.biochem.5b00082 | 2015 |
Structures of the reduced and oxidized state of the mutant D24A of yeast thioredoxin 1: insights into the mechanism for the closing of the water cavity | 10.1007/s10858-015-9996-6 | 2015 |
NMR investigation of domain III of Dengue virus E protein: antibody binding modulates conformational exchange in the antigen | 10.1128/jvi.02314-15 | 2015 |
1H, 13C and 15N resonance assignments and second structure information of Fag s 1: Fagales allergen from Fagus sylvatica | 10.1007/s12104-015-9634-y | 2015 |
Peptide:lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional studies | 10.1016/j.bbamem.2014.04.004 | 2014 |
Hydration and conformational equilibrium in yeast thioredoxin 1: implication for H+ exchange | 10.1021/bi401542v | 2014 |
Bet v 1 - a Trojan horse for small ligands boosting allergic sensitization? | 10.1111/cea.12361 | 2014 |
Unique properties of human -defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site | 10.1074/jbc.m114.572529 | 2014 |
Impact of sulfation pattern on the conformation and dynamics of sulfated fucan oligosaccharides as revealed by NMR and MD | 10.1093/glycob/cwu184 | 2014 |
Solution and high-pressure NMR studies of the structure, dynamics and stability of the cross-reactive allergenic cod parvalbumin Gad m 1 | 10.1002/prot.24664 | 2014 |
Longitudinal evaluation of salivary profile from children with dental caries before and after treatment | 10.1007/s11306-014-0717-z | 2014 |
1H, 13C and 15N resonance assignments and second structure information of Gad m 1: a β-parvalbumin allergen from Atlantic cod (Gadus morhua) | 10.1007/s12104-012-9393-y | 2013 |
Salivary metabolite signatures of children with and without dental caries lesions | 10.1007/s11306-012-0484-7 | 2013 |
Structural Basis for the Interaction of Human |
10.1016/j.jmb.2013.08.001 | 2013 |
Intramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membrane | 10.1074/jbc.m113.500926 | 2013 |
Modeling the Interaction of Dodecylphosphocholine Micelles with the Anticoccidial Peptide PW2 Guided by NMR Data | 10.3390/molecules180810056 | 2013 |
Revealing the Properties of Plant Defensins through Dynamics | 10.3390/molecules180911311 | 2013 |
Heat stability of Proteobacterial PII protein facilitate purification using a single chromatography step | 10.1016/j.pep.2011.09.008 | 2012 |
Moniliophthora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Metastable Dimer in Solution: Structural and Functional Implications | 10.1371/journal.pone.0045620 | 2012 |
Portrayal of Complex Dynamic Properties of Sugarcane Defensin 5 by NMR: Multiple Motions Associated with Membrane Interaction | 10.1016/j.str.2010.11.011 | 2011 |
Backbone dynamics of the antifungal Psd1 pea defensin and its correlation with membrane interaction by NMR spectroscopy | 10.1016/j.bbamem.2009.07.013 | 2010 |
The p53 Core Domain Is a Molten Globule at Low pH: FUNCTIONAL IMPLICATIONS OF A PARTIALLY UNFOLDED STRUCTURE | 10.1074/jbc.m109.075861 | 2010 |
From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway | 10.1073/pnas.0915141107 | 2010 |
Structural elucidation of n galactan from the eggs of mollusc Pomacea lineata | 2010 | |
Sulfated {alpha}-L-galactans from the sea urchin ovary: selective 6-desulfation as eggs are spawned. | 10.1093/glycob/cwq017 | 2010 |
Mapping the Interactions between a Major Pollen Allergen and Human IgE Antibodies | 10.1016/j.str.2010.05.012 | 2010 |
Sequence-specific 1H, 15N and 13C resonance assignments of Art v 1: a proline-rich allergen of Artemisia vulgaris pollen | 10.1007/s12104-009-9151-y | 2009 |
Structure and Membrane Interactions of the Antibiotic Peptide Dermadistinctin K by Multidimensional Solution and Oriented 15N and 31P Solid-State NMR Spectroscopy | 10.1016/j.bpj.2008.11.063 | 2009 |
Ferromagnetic Levan Composite: An Affinity Matrix to Purify Lectin | 10.1155/2009/179106 | 2009 |
Interaction of the Dengue Virus Fusion Peptide with Membranes Assessed by NMR: The Essential Role of the Envelope Protein Trp101 for Membrane Fusion | 10.1016/j.jmb.2009.07.035 | 2009 |
NMR solution structure of the reduced form of thioredoxin 1 from Sacharomyces cerevisiae | 10.1002/prot.21693 | 2008 |
Minor beta-structured conformation of a fusion peptide of vesicular stomatitis virus glycoprotein | 2008 | |
Spectroscopic characterization of a truncated hemoglobin from the nitrogen-fixing bacterium Herbaspirillum seropedicae | 10.1007/s00775-008-0394-3 | 2008 |
Evolutionary relationship between defensins in the Poaceae family strengthened by the characterization of new sugarcane defensins | 10.1007/s11103-008-9372-y | 2008 |
Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: The role of charges and hydrogen bonding interactions in stabilizing helix conformations | 10.1016/j.peptides.2008.06.022 | 2008 |
A Ligand Peptide Motif Selected from a Cancer Patient Is a Receptor-Interacting Site within Human Interleukin-11 | 10.1371/journal.pone.0003452 | 2008 |
NMR solution structure of the reduced form of thioredoxin 2 from Saccharomyces cerevisiae | 2007 | |
Structure of the ebola fusion peptide in a membrane-mimetic environment and the interaction with lipid rafts | 2007 | |
Structural biology of membrane acting peptides: conformational plasticity of anticcocidal peptide PW2 by NMR | 2007 | |
Effect of micelle interface on the binding of anticoccidial PW2 peptide | 2007 | |
A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum | 10.1093/glycob/cwm139 | 2007 |
Ca(2+) and Mg(2+) binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament. | 2006 | |
1 H, 13 C and 15 N Resonance Assignments for the Reduced Forms of Thioredoxin 1 and 2 from S. cerevisiae | 10.1007/s10858-006-0025-7 | 2006 |
In-Cell NMR Spectroscopy: Inhibition of Autologous Protein Expression Reduces Escherichia coli Lysis | 10.1385/cbb:44:3:497 | 2006 |
Structure of a membrane-binding domain from a non-enveloped animal virus: Insights into the mechanism of membrane permeability and cellular entry | 2006 | |
Implications of protein conformational diversity for binding and development of new biological active compounds | 2006 | |
Prediction of the amount of secondary structure of proteins using unassigned NMR spectra: A tool for target selection in structural proteomics | 2006 | |
A new steroidal saponin from | 10.1080/14786410500045564 | 2006 |
Study of the effect of the peptide loading and solvent system in SPPS by HRMAS-NMR | 10.1002/psc.659 | 2005 |
Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity. | 2005 | |
Occurrence of sulfated galactans in marine angiosperms: evolutionary implications. | 2005 | |
Structural and haemostatic activities of a sulfated galactofucan from the brown alga spatoglossum schrdelta ederi. An ideal antithrombotic agent? | 2005 | |
Controlling beta amyloid oligomerization by the use of naphthalene sulfonates: Trapping low-molecular-weight oligomeric species. | 2005 | |
Structure and anticoagulant activity of a sulfated galactan from the red alga, Gelidium crinale. Is there a specific structural requirement for the anticoagulant action? | 2005 | |
Structural Basis for the Interaction of a Vascular Endothelial Growth Factor Mimic Peptide Motif and Its Corresponding Receptors | 10.1016/j.chembiol.2005.07.008 | 2005 |
Mild acid hydrolysis of sulfated fucans: a selective 2-desulfation reaction and an alternative approach for preparing tailored sulfated oligosaccharides | 10.1093/glycob/cwj030 | 2005 |
Acharan sulfate, the new glycosaminoglycan from Achatina fulica Bowdish 1822 | 2004 | |
Correlation between conformation and antibody binding:NMR structure of cross reactive peptides from T. cruzi, human, L. braziliensis | 2004 | |
The bZIP Region of the Plant Transcription Factor Opaque-2 Forms Stable Homodimers in Solution and Retains Its Helical Structure upon Subunit Dissociation | 10.1021/bi035905e | 2004 |
Reversible aggregation plays a crucial role on the folding landscape of p53 core domain | 2004 | |
A new bioactive steroidal saponin from Sansevieria cylindrica. | 2003 | |
Structural Studies of MS2 Bacteriophage Virus Particle Disassembly by Nuclear Magnetic Resonance Relaxation Measurements. | 2003 | |
High speed countercurrent chromatography as a valuable tool to isolate C-glycosylfalvones from Cecropia lyratiloba Miquel | 2003 | |
High-throughput Screening of Structural Proteomics Targets Using NMR | 2003 | |
Conversion of wild-type p53 domain into a corformation that mimics a hot spot mutant | 2003 | |
{beta}-Galactofuranose-containing O-linked oligosaccharides present in the cell wall peptidogalactomannan of Aspergillus fumigatus contain immunodominant epitopes | 2003 | |
Production of the active antifungal Pisum sativum defensin 1 (Psd1) in Pichia pastoris: overcoming the inefficiency of the STE 13 protease | 2003 | |
Solution Structure of Plant Defensin 1 from Pisum sativum: Plant Defensins, identical backbone with different mechanism | 2002 | |
Sulfated Fucans from Strongylocentruotus droebachiensis and strongylocentrotus pallidus ensure species-specific fertilization | 2002 | |
NMR Structure of PW2 bound to SDS micelles: Triptophan rich peptide with avian anticoccidial activity | 2002 | |
A 2-sulfated, 3-linked alpha-L-galactan is an anticoagulant polysaccharide. | 2002 | |
Espectrometria de massa e RMN multidimensional e multinuclear: Revolução no estudo de macromoléculas biológicas | 2002 | |
Selectively labeling the heterologous protein in E. coli for NMR studies: A strategy to speed up NMR spectroscopy | 2001 | |
Embryos of the sea urchim Strongylocentrus purpuratus synthesize a dermatan sulfate enriched in 4-O- and 6-O-disulfated galactosamine units | 2001 | |
cDNA cloning and Heterologous Expression of functional Cys-rich Antifungal Protein Psd1 in the Yeast Pichia pastoris | 2001 | |
Virus maturation targets the capsid to concerted disassembly and unfolding | 2000 | |
NMR structural studies using selective labeling of the heterologous protein | 2000 | |
Structure and anticoagulant activity of sulfated galactans. Isolation os a unique sulfated galactan from the red algae botrycladia occidentalis and comparison of its anticoagulant action with that of a sulfated galactans from invertebrates | 2000 | |
Occurence of heparin in the invertebrate styela plicata (Tunicata is restricted to cell layers facing the outside environment: an ancient role in defence? | 2000 | |
Hydrostatic Pressure As A Tool To Study Virus Assembly: Pressure-Inactivation Of Viruses By Formation Of Fusion Intermediate States. | 1999 | |
Structure Of Sulfated Al-Fucan From The Egg Jelly Coat Of The Sea Urchin Strongylocentrotus Franciscanus: Pattenr Of Preferencial 2-O And 4-O Sulfation Determine Sperm Cell Recognition | 1999 | |
Dilute Spin-Exchange Assignment Of Solid State Nmr Spectra Of Oriented Proteins: Acetylcholine M2 In Bilayers | 10.1023/A:1008391823293 | 1999 |
Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy | 10.1038/7610 | 1999 |
Stability and activity modulation of chymotrypsins in AOT reversed micelles by protein¿interface interaction: Interaction of α-chymotrypsin with a negative interface leads to a cooperative breakage of a salt bridge that keeps the catalytic active conformation (Ile16¿Asp194) | 10.1002/(SICI)1097-0290(19980805)59:3<360::AID-BIT12>3.0.CO;2-I | 1998 |
Highly Sulfates Dermatan Sulfates From Ascidians. Structure Versus Anticoagulant Activity Of These Glycosaminoglycans | 1998 | |
Two-Dimensional NMR Spectroscopy of Peptides on Beads | 10.1006/jmre.1996.1099 | 1997 |
Structural Studies Of The Pore Lining Segments Of Neurotransmitter-Gated Channels | 1997 | |
NMR structural studies of channel forming peptides in membrane enviroments | 1996 | |
Isolation and characterization of the Mg2+-ATPase from rabbit skeletal muscle sarcoplasmic reticulum membrane preparations | 10.1016/0167-4838(90)90262-e | 1990 |
Eventos:
(0.00% eventos com DOI)