Alexandre Morrot Lima
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Faculdade de Medicina
Departamento:
Departamento de Clínica Médica/FM
Formação:
-
National Institute Of Health
| Pós-Doutorado | 2006 - 2007
-
Johns Hopkins University
| Pós-Doutorado | 2003 - 2006
-
New York University
| Pós-Doutorado | 2000 - 2003
-
Instituto de Biofísica Carlos Chagas Filho, UFRJ
Biofísica, área de concentração em imunologia | Doutorado | 1994 - 2000
-
Departamento de Genética
Biologia, Bacharelado em Genética | Graduação | 1990 - 1994
Laboratórios:
Nuvens de Palavras:
Artigos:
(98.53% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Inhibition of Microbicidal Activity of Canine Macrophages DH82 Cell Line by Capsular Polysaccharides from Cryptococcus neoformans | 10.3390/jof10050339 | 2024 |
| A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants | 10.3390/microorganisms12040720 | 2024 |
| Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 | 10.1111/bph.16013 | 2023 |
| Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages | 10.1007/s12026-022-09321-9 | 2023 |
| Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response | 10.3390/ijms24010656 | 2023 |
| The Blessed Union of Glycobiology and Immunology: A Marriage That Worked | 10.3390/medicines10020015 | 2023 |
| Increased expression of the pathological O-glycosylated form of oncofetal fibronectin in the multidrug resistance phenotype of cancer cells | 10.1016/j.matbio.2023.03.002 | 2023 |
| Special Issue: -Parasitic Infection and Host Immunity-: Editorial | 10.3390/microorganisms11041027 | 2023 |
| Increased Trypanosoma cruzi Growth during Infection of Macrophages Cultured on Collagen I Matrix | 10.3390/life13041063 | 2023 |
| Non-self glycan structures as possible modulators of cancer progression: would polysaccharides from Cryptococcus spp. impact this phenomenon? | 10.1007/s42770-023-00936-0 | 2023 |
| Correction to: Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages | 10.1007/s12026-022-09338-0 | 2023 |
| Bittersweet Sugars: How Unusual Glycan Structures May Connect Epithelial-to-Mesenchymal Transition and Multidrug Resistance in Cancer | 10.3390/medicines10060036 | 2023 |
| Bone Marrow Granulocytes Downregulate IL-1β and TNF Production and the Microbicidal Activity of Inflammatory Macrophages | 10.1139/bcb-2021-0460 | 2022 |
| Immune Responses in Leishmaniasis: An Overview | 10.3390/tropicalmed7040054 | 2022 |
| Eryptosis as a New Insight in Malaria Pathogenesis | 10.3389/fimmu.2022.855795 | 2022 |
| Glycobiology of Cancer: Sugar Drives the Show | 10.3390/medicines9060034 | 2022 |
| The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation | 10.3390/medicines9060037 | 2022 |
| SARS-CoV-2?s Variants of Concern: A Brief Characterization | 10.3389/fimmu.2022.834098 | 2022 |
| Cellular Stress and Senescence Induction during Trypanosoma cruzi Infection | 10.3390/tropicalmed7070129 | 2022 |
| Humoral response in Leishmaniasis | 10.3389/fcimb.2022.1063291 | 2022 |
| Pulmonary Fibrosis and Hypereosinophilia in TLR9-/- Mice Infected by Cryptococcus gattii | 10.3390/pathogens11090987 | 2022 |
| The role of Toll-like receptor 9 in a murine model of Cryptococcus gattii infection | 10.1038/s41598-021-80959-5 | 2021 |
| Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach | 10.1099/acmi.0.000220 | 2021 |
| The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection | 10.3390/cells10081891 | 2021 |
| Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection | 10.1093/infdis/jiab425 | 2021 |
| X-linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection | 10.1038/s41598-021-97041-9 | 2021 |
| Autoimmune Disorders & COVID-19 | 10.3390/medicines8100055 | 2021 |
| COVID-19 Infection and Neuropathological Features | 10.3390/medicines8100059 | 2021 |
| How to B(e)-1 Important Cell During Leishmania Infection | 10.3389/fcimb.2019.00424 | 2020 |
| Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-related Events in Human Lung Adenocarcinoma Cells | 10.3390/medicines7040019 | 2020 |
| Cancer immunotherapy: lessons from the parasites to improve fighting against tumors | 10.21037/pcm.2020.02.02 | 2020 |
| Editorial: Immune Evasion Strategies in Protozoan-Host Interactions | 10.3389/fimmu.2020.609166 | 2020 |
| Maternal SARS-CoV-2 infection associated to systemic inflammatory response and pericardial effusion in the newborn: a Case-Report | 10.1093/jpids/piaa133 | 2020 |
| The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19) | 10.1038/s41598-020-76781-0 | 2020 |
| Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation | 10.3389/fimmu.2019.00164 | 2019 |
| Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host | 10.3389/fmicb.2019.00305 | 2019 |
| Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans | 10.3389/fmed.2019.00129 | 2019 |
| B-1 lymphocytes are able to produce IL-10, but is not pathogenic during Leishmania (Leishmania) amazonensis infection | 10.1016/j.imbio.2019.10.006 | 2019 |
| Immunotherapy approaches to beat tumors | 10.21037/pcm.2019.12.03 | 2019 |
| Circulating Plasma MicroRNA-208a as Potential Biomarker of Chronic Indeterminate Phase of Chagas Disease | 10.3389/fmicb.2018.00269 | 2018 |
| Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection | 10.3389/fmed.2018.00025 | 2018 |
| Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses | 10.3389/fonc.2018.00081 | 2018 |
| Antibody Repertoires Identify β-Tubulin as a Host Protective Parasite Antigen in Mice Infected With Trypanosoma cruzi | 10.3389/fimmu.2018.00671 | 2018 |
| NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis | 10.3389/fimmu.2018.00967 | 2018 |
| Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions | 10.3389/fendo.2018.00334 | 2018 |
| Developing effective vaccines: cues from natural infection | 10.1080/08830185.2018.1471479 | 2018 |
| Trypanosoma cruzi Infection Induces Cellular Stress Response and Senescence-Like Phenotype in Murine Fibroblasts | 10.3389/fimmu.2018.01569 | 2018 |
| Human Kinetoplastid Protozoan Infections: Where Are We Going Next? | 10.3389/fimmu.2018.01493 | 2018 |
| Immunomodulating role of IL-10-Producing B cells in Leishmania amazonensis infection | 10.1016/j.cellimm.2018.08.014 | 2018 |
| Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection | 10.1038/s41598-018-34649-4 | 2018 |
| A Chimera Containing CD4+ and CD8+ T-Cell Epitopes of the Leishmania donovani Nucleoside Hydrolase (NH36) Optimizes Cross-Protection against Leishmania amazonesis Infection | 10.3389/fimmu.2017.00100 | 2017 |
| Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host | 10.4331/wjbc.v8.i1.57 | 2017 |
| Leishmania donovani Nucleoside Hydrolase (NH36) Domains Induce T-Cell Cytokine Responses in Human Visceral Leishmaniasis | 10.3389/fimmu.2017.00227 | 2017 |
| Human stem memory T cells (TSCM) as critical players in the long-term persistence of immune responses | 10.21037/atm.2017.02.28 | 2017 |
| Asymmetric cell division regulates the transcriptional balance controlling memory fate decisions in T cells | 10.21037/atm.2017.02.29 | 2017 |
| Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues | 10.1371/journal.pntd.0005507 | 2017 |
| Timing of lymphocyte trafficking is regulated by the circadian clock | 10.21037/atm.2017.03.27 | 2017 |
| Self-renewal capacity of semi-differentiated CD8+ T cells sustains long-term protective responses in chronic persistent infection | 10.21037/atm.2017.03.14 | 2017 |
| Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection | 10.3389/fimmu.2017.00518 | 2017 |
| Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis | 10.3389/fmicb.2017.00978 | 2017 |
| Canine Macrophage DH82 Cell Line As a Model to Study Susceptibility to Trypanosoma cruzi Infection | 10.3389/fimmu.2017.00604 | 2017 |
| B-1 cells modulate the murine macrophage response to Leishmania major infection | 10.4331/wjbc.v8.i2.151 | 2017 |
| Decoding the Role of Glycans in Malaria | 10.3389/fmicb.2017.01071 | 2017 |
| Multiple Myeloma Cells Express Key Immunoregulatory Cytokines and Modulate the Monocyte Migratory Response | 10.3389/fmed.2017.00092 | 2017 |
| Therapeutic Approaches Blocking Glycan Synthesis as Targeting Strategy for Malaria | 10.2174/1574884711666161220152827 | 2017 |
| Role of Inactive and Active Trypanosoma cruzi Trans-sialidases on T Cell Homing and Secretion of Inflammatory Cytokines | 10.3389/fmicb.2017.01307 | 2017 |
| Host-Toxoplasma gondii Coadaptation Leads to Fine Tuning of the Immune Response | 10.3389/fimmu.2017.01080 | 2017 |
| Host resistance to visceral leishmaniasis: prevalence and prevention | 10.1586/14787210.2016.1160779 | 2016 |
| The Sweet Side of Immune Evasion: Role of Glycans in the Mechanisms of Cancer Progression | 10.3389/fonc.2016.00054 | 2016 |
| Role of Trypanosoma cruzi Trans-sialidase on the Escape from Host Immune Surveillance | 10.3389/fmicb.2016.00348 | 2016 |
| Role of Small RNAs in Trypanosomatid Infections | 10.3389/fmicb.2016.00367 | 2016 |
| The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis | 10.3389/fimmu.2016.00153 | 2016 |
| Modulation of Cell Sialoglycophenotype: A Stylish Mechanism Adopted by Trypanosoma cruzi to Ensure Its Persistence in the Infected Host | 10.3389/fmicb.2016.00698 | 2016 |
| Evasion and Immuno-Endocrine Regulation in Parasite Infection: Two Sides of the Same Coin in Chagas Disease? | 10.3389/fmicb.2016.00704 | 2016 |
| Lifelong protection mediated by stem cell-like CD8+ T memory subset cells (Tscm) induced by vaccination | 10.21037/atm.2016.05.38 | 2016 |
| Immune Escape Strategies of Malaria Parasites | 10.3389/fmicb.2016.01617 | 2016 |
| Live-attenuated vaccination increases the diversity of pathogen-specific T cell repertoire triggered in chronic infection responses | 10.21037/atm.2016.09.44 | 2016 |
| Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils | 10.1038/srep08008 | 2015 |
| Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis | 10.1186/s13071-015-0721-9 | 2015 |
| Macrophage Polarization in Infectious Diseases | 10.4172/2155-9899.1000294 | 2015 |
| Renin-angiotensin system contributes to naive T-cell migration in vivo | 10.1016/j.abb.2015.02.035 | 2015 |
| The PGE2/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection | 10.1371/journal.pone.0124888 | 2015 |
| Ouabain Modulates Zymosan-Induced Peritonitis in Mice | 10.1155/2015/265798 | 2015 |
| The sterile and tolerogenic fetal niche does not restrict the generation of CD4 T memory cells | 10.3978/j.issn.2305-5839.2015.02.02 | 2015 |
| Immune Evasion Strategies of | 10.1155/2015/178947 | 2015 |
| Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease | 10.1155/2015/709846 | 2015 |
| Differential Expression of microRNAs in Thymic Epithelial Cells from Trypanosoma cruzi Acutely Infected Mice: Putative Role in Thymic Atrophy | 10.3389/fimmu.2015.00428 | 2015 |
| Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis | 10.1371/journal.pntd.0004297 | 2015 |
| A comparison of virulence patterns and in vivo fitness between hospital- and community-acquired methicillin-resistant Staphylococcus aureus related to the USA400 clone | 10.1007/s10096-014-2253-1 | 2015 |
| Neutrophils increase or reduce parasite burden in Trypanosoma cruzi-infected macrophages, depending on host strain: role of neutrophil elastase | 10.1371/journal.pone.0090582 | 2014 |
| Thymic Atrophy during Infection as a Host Response to Avoid Tolerance to Persistent Pathogens | 10.9734/IJTDH/2014/6481 | 2014 |
| Cross-Protective Immunity to Leishmania amazonensis is Mediated by CD4+ and CD8+ Epitopes of Leishmania donovani Nucleoside Hydrolase Terminal Domains | 10.3389/fimmu.2014.00189 | 2014 |
| Leishmania donovani Nucleoside Hydrolase Terminal Domains in Cross-Protective Immunotherapy Against Leishmania amazonensis Murine Infection | 10.3389/fimmu.2014.00273 | 2014 |
| Vaccination with Nucleoside hydrolase (NH36) of L.(L.) donovani or its C-terminal portion (F3) in formulation with saponin prevents the increase of the proportions of spleen dendritic cells in murine experimental visceral leishmaniasis | 10.1016/j.provac.2014.07.010 | 2014 |
| Expression of ganglioside 9-O acetyl GD3 in undifferentiated embryonic stem cells | 10.1002/cbin.10335 | 2014 |
| Stress Related Hormonal Circuitry in Chagas Disease | 10.3233/NIB-140094 | 2014 |
| Early Double-Negative Thymocyte Export in Trypanosoma cruzi Infection Is Restricted by Sphingosine Receptors and Associated with Human Chagas Disease | 10.1371/journal.pntd.0003203 | 2014 |
| Tissue signatures influence the activation of intrahepatic CD8+ T cells against malaria sporozoites | 10.3389/fmicb.2014.00440 | 2014 |
| Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes | 10.1016/j.micinf.2013.02.003 | 2013 |
| Angiotensin II Is a New Component Involved in Splenic T Lymphocyte Responses during Plasmodium berghei ANKA Infection | 10.1371/journal.pone.0062999 | 2013 |
| Effects of 5-Fluorouracil in Nuclear and Cellular Morphology, Proliferation, Cell Cycle, Apoptosis, Cytoskeletal and Caveolar Distribution in Primary Cultures of Smooth Muscle Cells | 10.1371/journal.pone.0063177 | 2013 |
| The Development of Unconventional Extrathymic Activated CD4+CD8+ T Cells in Chagas Disease | 10.5402/2013/801975 | 2013 |
| Inhibitory Effects of Trypanosoma cruzi Sialoglycoproteins on CD4+ T Cells Are Associated with Increased Susceptibility to Infection | 10.1371/journal.pone.0077568 | 2013 |
| Trypanosoma cruzi Disrupts Thymic Homeostasis by Altering Intrathymic and Systemic Stress-Related Endocrine Circuitries | 10.1371/journal.pntd.0002470 | 2013 |
| The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host | 10.1155/2013/965856 | 2013 |
| Multiple Myeloma and its role in immunosupression | 10.5281/zenodo.816319 | 2013 |
| Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance | 10.1111/j.1749-6632.2012.06627.x | 2012 |
| Thymic atrophy in acute experimental Chagas disease is associated with an imbalance of stress hormones | 10.1111/j.1749-6632.2012.06601.x | 2012 |
| Cholesterol depletion by methyl-β-cyclodextrin enhances cell proliferation and increases the number of desmin-positive cells in myoblast cultures | 10.1016/j.ejphar.2012.07.035 | 2012 |
| Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs | 10.1155/2012/747185 | 2012 |
| Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors | 10.1186/1756-3305-5-261 | 2012 |
| Thymus atrophy and double-positive escape are common features in infectious diseases | 10.1155/2012/574020 | 2012 |
| AT1 receptor-mediated angiotensin II activation and chemotaxis of T lymphocytes | 10.1016 | 2011 |
| Chagasic Thymic Atrophy Does Not Affect Negative Selection but Results in the Export of Activated CD4+CD8+ T Cells in Severe Forms of Human Disease | 10.1371/journal.pntd.0001268 | 2011 |
| Differential Regional Immune Response in Chagas Disease | 10.1371/journal.pntd.0000417 | 2009 |
| Anergy in memory CD4+ T cells is induced by B cells | 10.4049/jimmunol.181.5.3221 | 2008 |
| IL-4 induces a wide-spectrum intracellular signaling cascade in CD8+ T cells | 10.1189/jlb.0906583 | 2007 |
| Bradykinin B2 Receptors of Dendritic Cells, Acting as Sensors of Kinins Proteolytically Released by Trypanosoma cruzi, Are Critical for the Development of Protective Type-1 Responses | 10.1371/journal.ppat.0030185 | 2007 |
| Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses | 10.1084/jem.20051639 | 2006 |
| Protective CD8+ T Cells Induced by Malaria Sporozoites Do Not Undergo Modulation of Interleukin-7 Receptor Expression | 10.1128/IAI.74.4.2495-2497.2006 | 2006 |
| Priming of CD8+ T-cell responses following immunization with heat-killedPlasmodiumsporozoites | 10.1002/eji.200535712 | 2006 |
| Leishmania Antigens Are Presented to CD8+ T Cells by a Transporter Associated with Antigen Processing-Independent Pathway In Vitro and In Vivo | 10.4049/jimmunol.177.6.3525 | 2006 |
| Cooperative activation of TLR2 and Bradykinin B2 Receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi | 10.4049/jimmunol.177.9.6325 | 2006 |
| IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites | 10.1084/jem.20042463 | 2005 |
| Effector and memory CD8+ T cells as seen in immunity to malaria | 10.1111/j.0105-2896.2004.00175.x | 2004 |
| Regulation of the CD8+ T cell responses against Plasmodium liver stages in mice | 10.1016/j.ijpara.2004.10.001 | 2004 |
| Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria | 10.4049/jimmunol.171.2.964 | 2003 |
| IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages | 10.1038/nm0202-166 | 2002 |
| Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages | 10.1073/pnas.182189999 | 2002 |
| Swift Development of Protective Effector Functions in Naive CD8+ T Cells Against Malaria Liver Stages | 2001 | |
| Chemokines Fail to Up-Regulate 1 Integrin-Dependent Adhesion in Human Th2 T Lymphocytes | 10.4049/jimmunol.164.6.3292 | 2000 |
| Host Cell Invasion by Trypanosoma cruzi is Potentiated by Activation of Bradykinin B2 Receptors | 10.1084/jem.192.9.1289 | 2000 |
| A role for extracellular amastigotes in the immunopathology of Chagas disease | 10.1590/s0074-02761999000700005 | 1999 |
| Human T cell responses against the major cysteine proteinase (cruzipain) of Trypanosoma cruzi: role of the multifunctional alpha 2- macroglobulin receptor in antigen presentation by monocytes | 10.1093/intimm/9.6.825 | 1997 |
| Resposta proliferativa das células T contra a cruzipaina na cardiopatia chagásica crônica | 10.1590/S0037-86821996000400004 | 1996 |
| The MHC Class II restricted immune response against parasitic proteinases: Clearence-receptors as an alternative pathway for their endocytic uptake into antigen presenting cells. | 1994 |
Eventos:
(0.00% eventos com DOI)