Alexandre Morrot Lima

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Faculdade de Medicina

Departamento:

Departamento de Clínica Médica/FM

ORCID:

https://orcid.org/0000-0001-9432-9701


Formação:
  • National Institute Of Health

    | Pós-Doutorado | 2006 - 2007
  • Johns Hopkins University

    | Pós-Doutorado | 2003 - 2006
  • New York University

    | Pós-Doutorado | 2000 - 2003
  • Instituto de Biofísica Carlos Chagas Filho, UFRJ

    Biofísica, área de concentração em imunologia | Doutorado | 1994 - 2000
  • Departamento de Genética

    Biologia, Bacharelado em Genética | Graduação | 1990 - 1994
Laboratórios:
Nuvens de Palavras:
Artigos:
Nenhum artigo cadastrado
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Immunogenic properties of a recombinant fusion protein containing the c-terminal (F3) of Nucleoside Hydrolase and the innate immunity agonist FliC flagelin of Salmonella typhimurium 2015
DCs transferred from mice vaccinated with the C-terminal moiety (F3) of Nucleoside Hydrolase NH36 reduce the parasite load of L.(L.) chagasi infected mice 2015
The natural cysteine peptidase inhibitor of the african trypanosome plays a role in brain endothelial activation and parasite virulence 2012
A novel strategy to develop a vaccine against Chagas disease based on the generation of a Trypanosoma cruzi line induced by the cell reprogramming technique 2012
Trypanosoma cruzi subverts thymic homeostasis by altering intrathymic and systemic endocrine status 2012
Role of prolactin and glucocorticoid receptor interactions in the thymus atrophy occurring during experimental Trypanosoma cruzi infection 2011
Partial contribution of the B2 receptor of the kinin inflammation pathway in protection against murine visceral leishmaniasis by the C-terminal domain of Nucleoside hydrolase vaccine 2011
Trans-sialidase from Trypanosoma cruzi mediates immature thymocyte release into the peripheral lymph nodes 2011
Bradykinin B2 receptors are critical for the development of protective type-1 in visceral leishmaniasis 2011
Angiotensin II/AT1 receptor axis mediates naive T cell homing and activation 2011
P2X7 Purinergic receptors and its role on the transmembrane transport mechanisms in bone-marrow-derived dendritic cells 2011
Partial contribution of the B2 receptor of the kinin inflammation pathway in mice vaccinated with the C-terminal domain of nucleoside hydrolase and saponin against visceral leishmaniasis 2011
Immature thymocytes are released into the periphery of Trypanosoma cruzi acutely infected by a S1P-dependet mechanism 2010
Blockade of ACE and AT1 receptor in T cells during malaria infection: further mechanisms of T cell regulation mediated by angiotensis II 2010
Blockade of angiotensin converting enzyme and AT1 receptor in T cells during malaria infection: further mechanisms of T cell regulation mediated by angiotensin II 2010
Regulation of T-cell functions by Angiotensin II 2009
IMMUNOENDOCRINE IMBALANCE IN MURINE AND HUMAN CHAGAS DISEASE 2009
Thymocyte depletion induced by tran-sialidase from Trypanosoma cruzi is mediated by carbohydrate-lectin interaction 2009
Abnormal T cell traffic in experimental Chagas disease 2008
Subversion of MHC class I cross-presentation by Leishmania 2007
In vivo targeting of dendritic cells with synthetic bradykinin : a novel strategy improving vaccine adjuvanticity 2007
Activation of the innate kinin pathway is critical for type-1 immunity development and host resistance to acute infection with Trypanosoma cruzi 2007
Activation of the innate kinin pathway is critical for development of host resistance to acute intraperitoneal infection with Trypanosoma cruzi 2006
IL-4 induces a wide-spectrum signaling in CD8+ T cells 2006
IL-4 induces a wide-spectrum signaling in CD8+T cells 2006
Pathway of Memory CD8+ T Cell Development 2006
Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites 2006
Induction of malaria-specific CD8+ T cell response 2006
Initiation of anti-sporozoite immunity in malaria is extra-hepatic, while the effector phase operates within the liver 2006
Effective boosting vectors for malaria immunization evade the CD8 T cell response generated by priming 2006
Kinins liberated by Trypanosoma cruzi link innate to adaptative immunity by activating dendritic cells via bradykinin B2 receptor 2005
Evaluation of the impact of helminth co-infection on malaria transmission in a murine model 2005
B Cells Induce Anergy on Memory CD4+ T Cells 2005
Bradykinin-driven activation of dendritic cells: new strategies for adjuvant development and vaccine production 2004
Kinin-driven inflammation and its modulation by the angiotensin converting enzyme: a molecular pathway linking innate and adptive immunity in experimental Chagas disease 2004
Expresion of the IL-4 receptor on CD8+ T cells is critical to the development of protective memory against malaria liver stages 2004
Regulation of the CD8+ T cell responses against Plasmodium liver stages in mice 2004
CD4/CD8 cross-talk int the immune response against malaria-specific CD8+ T cell response 2001
Short-term antigen-induced CD8´s T cell activation generates long-lasting memory responses against malaria liver stages 2001
CD4+/CD8+ cross-talk in the immune response against malaria liver stages 2001
Swift development of protective effector functions in naive CD8+ T cells against malaria liver stages. 2001
Self-regulatory CD8+ T cell responses on Plasmodium liver stages 2001
MOLECULAR BASIS OF ACTIVATION OF VASCULAR ENDOTHELIUM BY TRYPANOSOMA CRUZI: ROLE OF KININOGENS, KININS AND BRADYKININ-RECEPTORS 2000
Trypanosoma cruzi invasion of endothelial cells is potentiated by kinin-induced stimulation of G protein-coupled bradykinin receptors 1999
Trypanosoma cruzi INVASION OS ENDOTHELIAL CELLS IS POTENTIATED BY KININ-INDUCED STIMULATION OF G-PROTEIN COUPLED BRADYKININ RECEPTORS 1999
Trypanosoma cruzi resistance to synthetic inhibitors of cysteine-proteinases correlates with changes in the expression of target enzymes and membrane permeability 1998
TRYPANOSOMA CRUZI RESISTANCE TO SYNTHETIC INHIBITORS OF CYSTEINE PROTEINASES CORRELATES WITH CHANGES IN THE EXPRESSION OF TARGET ENZYMES AND MEMBRANES PERMEABILITY 1998
r-CHAGASIN, A POTENT INHIBITOR OF PAPAIN-LIKE CYSTEINE PROTEINASES, REDUCES HOST CELL SUSCEPTIBILITY TO INVASION BY TRYPANOSOMA CRUZI TRYOPOMASTYGOTES 1998
Endothelial cell interactions with Trypanosoma cruzi cysteine proteinases: possible role in microvascular pathology 1997
Chronic Chagas Myocardiopathy in Humans: Identification of Cruzipain Antigens in Inflammatory Sites 1996
Sialic acid is a cell surface component of Cryptococcus neoformans and influences the interaction of the fungus with mouse resident macrophages 1996
Human T Cell Responses Against T.Cruzi Cysteine-Proteinases: Uptake by Monocyte alpha-2-Macroglobulin Receptors Enhances Antigen-Presenting Cell Function 1995
Respostas de células T humanas contra a principal cisteíno-proteinase do T. cruzi: função do receptor de alpha-2-macroglobulina 1995
Human T Cell Responses Against T. cruzi Cysteine-Proteinase (Cruzipain): Uptake by Monocyte a2-Macroglobulin Receptors Enhances Antigen-Presenting Cell Function 1995
The Major Cysteine Proteinase Of Trypanosoma Cruzi: Biochemical Characterization With The Human Plasma Inhibitor alpha-2-Macroglobulin 1994
The major T. cruzi cysteine proteinase (cruzipain): involvement of the alpha-2-macroglobulin receptor in antigen presentation to human T lymphocytes 1994
Interaction Between the Major T.cruzi Cysteine Proteinase (Cruzipain) Antigen and the Human Plasma Inhibitor alpha-2-Macroglobulin 1994
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