Mauro Sola-Penna
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Faculdade de Farmácia
Departamento:
Departamento de Biotecnologia Farmacêutica
Formação:
-
Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 1996 - 1997
-
Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 1994 - 1995
-
Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Doutorado | 1992 - 1994
-
Universidade Federal do Rio de Janeiro
Farmácia | Graduação | 1988 - 1991
Laboratórios:
Nuvens de Palavras:
Artigos:
(88.89% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Western diet consumption by host vertebrate promotes altered gene expression on Aedes aegypti reducing its lifespan and increasing fertility following blood feeding | 10.1186/s13071-023-06095-3 | 2024 |
| Novel naphthoquinone-1H-1,2,3-triazole hybrids: Design, synthesis and evaluation as inductors of ROS-mediated apoptosis in the MCF-7 cells | 10.1016/j.bmc.2024.117671 | 2024 |
| 4-oxoquinoline-3-carboxamide acyclonucleoside phosphonates hybrids: Human MCF-7 breast cancer cell death induction by oxidative stress-promoting and in silico ADMET studies | 10.1016/j.molstruc.2022.134542 | 2023 |
| Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6 J mice | 10.1038/s41598-023-30254-2. | 2023 |
| The Role of Interferon Receptors α/β/γ Ablation During Western Diet-Induced Obesity and Insulin Resistance in the Inflectional Model AG129 Mice Strain | 10.1089/jir.2023.0047 | 2023 |
| Mycobacterium leprae is able to infect adipocytes, inducing lipolysis and modulating the immune response | 10.1016/j.micinf.2023.105283 | 2023 |
| Clotrimazole reverses macrophage M2 polarization by disrupting the PI3K/AKT/mTOR pathway | 10.1016/j.bbrc.2023.149455 | 2023 |
| Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice | 10.1016/j.molmet.2022.101437 | 2022 |
| Citrate enrichment in a Western diet reduces weight gain via browning of adipose tissues without resolving diet-induced insulin resistance in mice | 10.1039/d2fo02011d | 2022 |
| Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy | 10.1016/j.lfs.2021.119470 | 2021 |
| Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways | 10.1038/s41419-021-03929-9 | 2021 |
| Dietary citrate acutely induces insulin resistance and markers of liver inflammation in mice | 10.1016/j.jnutbio.2021.108834 | 2021 |
| 3-Bromopyruvate: A new strategy for inhibition of glycolytic enzymes in Leishmania amazonensis | 10.1016/j.exppara.2021.108154 | 2021 |
| Hypocaloric diet with lower meal frequency did not affect weight loss, body composition and insulin responsiveness, but improved lipid profile: a randomized clinical trial | 10.1039/d1fo00484k | 2021 |
| Gene annotation of nuclear receptor superfamily genes in the kissing bug |
10.1111/imb.12696 | 2021 |
| Clotrimazole presents anticancer properties against a mouse melanoma model acting as a PI3K inhibitor and inducing repolarization of tumor-associated macrophages | 10.1016/j.bbadis.2021.166263 | 2021 |
| Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase | 10.1530/rep-19-0502 | 2020 |
| Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively | 10.1038/s41416-019-0640-1 | 2020 |
| Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis | 10.1038/s41598-020-76824-6 | 2020 |
| Design, Synthesis and Biological Evaluation of 1H-1,2,3-Triazole-Linked- 1H-Dibenzo[b,h]xanthenes as Inductors of ROS-Mediated Apoptosis in the Breast Cancer Cell Line MCF-7 | 10.2174/1573406414666180524071409 | 2019 |
| Discrete Fourier Transform based Multivariate Image Analysis: Application to Modeling Aromatase Inhibitory Activity. | 10.1021/acscombsci.7b00155 | 2018 |
| Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway | 10.1007/s10863-018-9750-3 | 2018 |
| Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms | 10.1016/j.biopha.2018.04.033 | 2018 |
| Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis | 10.1016/j.mce.2018.04.005 | 2018 |
| A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties | 10.2174/1568026618666180917100640 | 2018 |
| A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis | 10.2174/1568026618666180821142458 | 2018 |
| Reference genes for quantitative PCR in the adipose tissue of mice with metabolic disease | 10.1016/j.biopha.2017.01.091 | 2017 |
| Phosphofructokinase-P Modulates P44/42 MAPK Levels in HeLa Cells | 10.1002/jcb.25774 | 2017 |
| Effects of Food Additives on Immune Cells As Contributors to Body Weight Gain and Immune-Mediated Metabolic Dysregulation | 10.3389/fimmu.2017.01478 | 2017 |
| Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer | 10.18632/oncotarget.18841 | 2017 |
| Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study | 10.1590/s2175-97902017000216039 | 2017 |
| Exogenous citrate impairs glucose tolerance and promotes visceral adipose tissue inflammation in mice | 10.1017/s0007114516000027 | 2016 |
| Unique PFK regulatory property from some mosquito vectors of disease, and from Drosophila melanogaster | 10.1186/s13071-016-1391-y | 2016 |
| The Use of NMR Metabolite Profiling and Hypoglycemic Assay for Comparison of Unfractionated Aqueous Leaf Extracts of Two Species | 10.1002/cbdv.201500180 | 2016 |
| Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation | 10.1074/jbc.m116.729236 | 2016 |
| SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway | 10.1158/1078-0432.ccr-15-1760 | 2016 |
| Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae | 10.1074/jbc.m116.725283 | 2016 |
| Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells | 10.1371/journal.pone.0130555 | 2015 |
| Phosphatidylinositol-3-kinase as a putative target for anticancer action of clotrimazole | 10.1016/j.biocel.2015.03.004 | 2015 |
| Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma | 10.18632/oncotarget.4910 | 2015 |
| Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study | 10.1016/j.fitote.2013.12.024 | 2014 |
| Therapeutic Nanosystems for Oral Administration of Insulin | 10.2174/1389201015666140915150826 | 2014 |
| Antidiabetic activity of Sedum dendroideum : Metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin | 10.1002/iub.1270 | 2014 |
| Serotonin regulates 6-phosphofructo-1-kinase activity in a PLC¿PKC¿CaMK II- and Janus kinase-dependent signaling pathway | 10.1007/s11010-012-1462-0 | 2013 |
| Amylin induces hypoglycemia in mice | 10.1590/S0001-37652013005000011 | 2013 |
| LIPOPHORIN: LIPID COMPOSITION AND EFFECT OF HIGH TEMPERATURE ON PHYSIOLOGICAL ROLE | 10.1002/arch.21080 | 2013 |
| Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase | 10.1016/j.biochi.2013.02.013 | 2013 |
| Proteomic Analysis of the Secretions of , a Human Fungal Pathogen with Unknown Genome | 10.1021/pr200875x | 2012 |
| Serotonin modulates hepatic 6-phosphofructo-1-kinase in an insulin synergistic manner | 10.1016/j.biocel.2011.10.010 | 2012 |
| Clotrimazole Preferentially Inhibits Human Breast Cancer Cell Proliferation, Viability and Glycolysis | 10.1371/journal.pone.0030462 | 2012 |
| Polymeric particles for the controlled release of human amylin | 10.1016/j.colsurfb.2012.01.021 | 2012 |
| Herpes simplex type 1 activates glycolysis through engagement of the enzyme 6-phosphofructo-1-kinase (PFK-1) | 10.1016/j.bbadis.2012.04.011 | 2012 |
| Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice | 10.1002/iub.1063 | 2012 |
| Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice | 10.1016/j.febslet.2010.11.009 | 2011 |
| Glucuronoxylomannan from Cryptococcus neoformans Down-regulates the Enzyme 6-Phosphofructo-1-kinase of Macrophages | 10.1074/jbc.M110.177030 | 2011 |
| Muscle-type 6-phosphofructo-1-kinase and aldolase associate conferring catalytic advantages for both enzymes | 10.1002/iub.464 | 2011 |
| Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues | 10.1016/j.ymgme.2011.04.003 | 2011 |
| Serotonin regulates an acyl-CoA-binding protein (ACBP) gene expression in the midgut of Rhodnius prolixus | 10.1016/j.ibmb.2010.01.002 | 2010 |
| Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse | 10.1016/j.abb.2010.01.013 | 2010 |
| Filamentous actin and its associated binding proteins are the stimulatory site for 6-phosphofructo-1-kinase association within the membrane of human erythrocytes | 10.1016/j.biochi.2010.01.023 | 2010 |
| Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase | 10.1016/j.abb.2010.03.013 | 2010 |
| Microcapsules of alginate/chitosan containing magnetic nanoparticles for controlled release of insulin | 10.1016/j.colsurfb.2010.07.008 | 2010 |
| Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism | 10.1002/iub.393 | 2010 |
| A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence | 10.1093/glycob/cwq065 | 2010 |
| Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells | 10.1016/j.ymgme.2010.04.006 | 2010 |
| Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity | 10.1016/j.bcp.2008.09.020 | 2009 |
| Calmodulin upregulates skeletal muscle 6-phosphofructo-1-kinase reversing the inhibitory effects of allosteric modulators | 10.1016/j.bbapap.2009.02.006 | 2009 |
| ATP and fructose-2,6-bisphosphate regulate skeletal muscle 6-phosphofructo-1-kinase altering its quaternary structure | 10.1002/iub.58 | 2008 |
| Metabolic Regulation by Lactate | 10.1002/iub.97 | 2008 |
| Crude ethanolic extract from babassu (Orbignya speciosa): cytotoxicity on tumoral and non-tumoral cell lines | 10.1590/S0001-37652008000300008 | 2008 |
| Betaine protects urea-induced denaturation of myosin subfragment-1 | 10.1111/j.1742-4658.2008.06487.x | 2008 |
| High dilutions of Euphorbia tirucalli L. (AVELOZ) modify the viability and glycolitic metabolism of cell lines | 2008 | |
| Fructose-2,6-bisphosphate counteracts guanidinium chloride-, thermal- and ATP-induced dissociation of skeletal muscle key glycolytic enzyme 6-phosphofructo-1-kinase: a structural mechanism for ATP allosteric regulation | 10.1016/j.abb.2007.08.032 | 2007 |
| Serotonin stimulates mice skeletal muscle 6-phosphofructo-1-kinase through tyrosine-phosphorylation of the enzyme altering its intracellular localization | 10.1016/j.ymgme.2007.07.010 | 2007 |
| Lactate favors the dissociation of skeletal muscle 6-phophofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis | 10.1042/BJ20070687 | 2007 |
| Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase | 10.1016/j.bcp.2007.01.018 | 2007 |
| Allosteric regulation of 6-phosphofructo-1-kinase activity of fat body and flight muscle from the bloodsucking bug Rhodnius prolixus | 10.1590/S0001-37652007000100008 | 2007 |
| Modulation of 6-phosphofructo-1-kinase oligomeric equilibrium by calmodulin: formation of active dimmers | 10.1016/j.ymgme.2005.11.002 | 2006 |
| Opposing effects of two osmolytes - trehalose and glycerol - on thermal denaturation of rabbit muscle 6-phosphofructo-1-kinase | 10.1007/s11010-005-3090-4 | 2005 |
| Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes | 10.1016/j.ymgme.2004.11.012 | 2005 |
| Calcium influx: a possible role for insulin modulation of intracellular distribution and activity of 6-phosphofructo-1-kinase in human erythrocytes | 10.1016/j.ymgme.2005.07.005 | 2005 |
| Trehalose and gycerol stabilize and renature yeast inorganic pyrophosphatase inactivated by very high temperatures | 10.1016/j.abb.2005.09.014 | 2005 |
| Resistência a insulina, alterações no metabolismo energético da lipoproteína VLDL e desenvolvimento da hipertrigliceridemia | 2005 | |
| Regulation of human erythrocyte metabolism by insulin: Cellular distribution of 6-phosphofructo-1-kinase and its implication for red blood cell function | 10.1016/j.ymgme.2005.06.011 | 2005 |
| Inhibition of yeast glutatione reductase by trehalose: possible implications in yeast survival and recovery from stress | 10.1016/j.biocel.2003.10.006 | 2004 |
| Effects of Insulin and Actin on Phosphofructokinase Activity and Cellular Distribution in Skeletal Muscle | 10.1590/S0001-37652004000300008 | 2004 |
| Mayaro virus infection alters glucose metabolism in cultured cells through activation of the enzyme 6-phosphofructo-1-kinase | 10.1023/B:MCBI.0000049154.17866.00 | 2004 |
| Inactivation of yeast inorganic pyrophosphatase by organic solvents | 10.1590/S0001-37652004000400006 | 2004 |
| Epinephrine modulates cellular distribution of muscle phosphofructokinase | 10.1016/S1096-7192(03)00037-4 | 2003 |
| Cellular distribution of phosphofructokinase activity and implications to metabolic regulation in human breast cancer | 10.1016/S1096-7192(03)00117-3 | 2003 |
| Co-localization of phosphofructokinase and actin in human breast cancer and implications to metabolic regulation. | 2003 | |
| A radioassay for phosphofructokinase-1 activity in cell extracts and purified enzyme. | 10.1016/S0165-022X(01)00180-4 | 2002 |
| Couteracting effects of urea and methylamines in function and structure of skeletal muscle myosin | 10.1016/S0003-9861(02)00565-9 | 2002 |
| p-Nitrophenylphosphatase activity catalyzed by plasma membrane (Ca2++Mg2+)ATPase: correlation with structural changes modulated by glycerol and Ca2+ | 10.1023/A:1010477916631 | 2001 |
| Urea increases tolerance of yeast inorganic pyrophosphatase activity to ethanol | 10.1006/abbi.2001.2529 | 2001 |
| Cellular distribution of phosphofructokinase-1 and implications to metabolic regulation in human breast cancer | 2001 | |
| Effects Of Trehalose And Ethanol On Yeast Cytosolic Pyrophosphatase | 1999 | |
| Protection Against Thermal Denaturation By Trehalose On The Plasma Membrane H-Atpase From Yeast: Synergetic Effect Between Trehalose And Phospholipid Environment | 10.1046/j.1432-1327.1999.00916.x | 1999 |
| Structure and biosynthesis of mucins in Trypanosoma cruzi | 1999 | |
| Stabilization Promoted By Sugars On Enzyme Structure And Function Against Thermal Inactivation: Why Is Trehalose More Effective Than Other Sugars? | 10.1006/abbi.1998.0906 | 1998 |
| Biosynthesis Of O-N-Acetylglucosamine-Linked Glycans In Trypanosoma Cruzi. Characterization Of The Novel Udp-N-Acetylglucosamine: Polypeptide N-Acetylglucosaminyltransferase Catalyzing Formation Of N-Acetylglucosamine A1®O-Threonine | 10.1074/jbc.273.24.14982 | 1998 |
| Carbohydrate Protection Of Enzymes Structure And Function Against Guanidinium Chloride Depends On The Nature Of Both, Carbohydrate And Enzyme | 10.1111/j.1432-1033.1997.00024.x | 1997 |
| Trehalose Protects Yeast Pyrophosphatase Against Structural And Functional Damage Induced By Guanidinium Chloride | 1996 | |
| Glycerol Inhibits Or Uncouples The Plasma Membrane (Ca2++Mg2+)Atpase Of Kidney Proximal Tubules Depending On The Ca2+ Concentration | 1995 | |
| Polyols That Accumulate In Renal Tissue Uncouple The Plasma Membrane Calcium Pump And Counteract The Inhibition By Urea And Guanidine Hydrochloride | 1995 | |
| Protective Role Of Trehalose On Thermal Denaturation Of Yeast Pyrophosphatase | 1994 | |
| Uncoupling By Trehalose Of Calcium Transport And Atp Hydrolysis By The Plasma Membrane Ca2+-Atpase Of Kidney Proximal Tubules | 1994 | |
| Mosaccharides And Disaccharides Decrease The Km For Pi Of A Membrane Bound Enzyme Atpase | 1991 |
Eventos:
(0.00% eventos com DOI)