Flavia Regina Souza Lima

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Ciências Biomédicas

Departamento:

Instituto de Ciências Biomédicas/ICB

ORCID:

não disponível no Lattes


Formação:

  • Instituto de Ciências Biomédicas , UFRJ

    | Pós-Doutorado | 2006 - 2007

  • Instituto Ludwig de Pesquisa sobre o Câncer

    | Pós-Doutorado | 2002 - 2006

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Doutorado | 1995 - 2000

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Mestrado | 1992 - 1994

  • Universidade Santa Úrsula

    Ciências Biológicas | Graduação | 1987 - 1990
Laboratórios:
Nuvens de Palavras:
Artigos:

(76.56% artigos com DOI)

Titulo DOI Ano
Targeting the reprogrammed metabolism in H3.3K27M pediatric high-grade gliomas 10.1016/j.bbadis.2024.167248 2024
CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma 10.1007/s00018-023-04788-7 2023
TLR4 mutation protects neurovascular function and cognitive decline in high-fat diet-fed mice 10.1186/s12974-022-02465-3 2022
The multiple functions of PrPC in physiological, cancer and neurodegenerative contexts 10.1007/s00109-022-02245-9 2022
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies 10.1038/s41392-020-00367-5 2021
The multiple functions of the co-chaperone stress inducible protein 1 10.1016/j.cytogfr.2020.06.003 2021
SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia 10.1172/jci141083 2021
Microglial lysophosphatidic acid promotes glioblastoma proliferation and migration via LPA 1 receptor 10.1111/jnc.15097 2021
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion 10.1186/s12974-020-01771-y 2020
Fatal Dengue Cases Reveal Brain Injury and Viral Replication in Brain-Resident Cells Associated with the Local Production of Pro-Inflammatory Mediators 10.3390/v12060603 2020
Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers 10.1016/j.isci.2020.100820 2020
Design, synthesis, molecular modeling and neuroprotective effects of a new framework of cholinesterase inhibitors for Alzheimer’s disease 10.1080/07391102.2020.1796796 2020
Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking 10.1016/j.bioorg.2020.104215 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives 10.1016/j.bbih.2020.100127 2020
Glioblastoma Therapy in the Age of Molecular Medicine 10.1016/j.trecan.2018.11.002 2019
In-vitro evaluation studies of 7-chloro-4-aminoquinoline Schiff bases and their copper complexes as cholinesterase inhibitors 10.1016/j.jinorgbio.2018.11.019 2019
Dengue infection in mice inoculated by the intracerebral route: neuropathological effects and identification of target cells for virus replication 10.1038/s41598-019-54474-7 2019
Combination Therapy with Sulfasalazine and Valproic Acid Promotes Human Glioblastoma Cell Death Through Imbalance of the Intracellular Oxidative Response 10.1007/s12035-018-0895-1 2018
Perinatal Asphyxia and Brain Development: Mitochondrial Damage Without Anatomical or Cellular Losses 10.1007/s12035-018-1019-7 2018
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system 10.1038/s41598-018-28137-y 2018
GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling 10.1007/s12035-018-1150-5 2018
Microglia/ astrocytes - glioblastoma crosstalk: crucial molecular mechanisms and microenvironmental factors 10.3389/fncel.2018.00235 2018
Evidence for a cell surface role for Hsp90 complex proteins mediating neuroblast migration in the subventricular zone 10.3389/fncel.2017.00138 2017
Microglia-glioblastoma interactions: New role for Wnt signaling 10.1016/j.bbcan.2017.05.007 2017
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs 10.1038/s41598-017-16197-5 2017
The availability of the embryonic TGF-β protein Nodal is dynamically regulated during glioblastoma multiform tumorigenesis 10.1186/s12935-016-0324-3 2016
Microglia in Cancer: For Good or for Bad? 2016
Ontogeny of CX3CR1-EGFP expressing cells unveil microglia as an integral component of the postnatal subventricular zone 10.3389/fncel.2015.00037 2015
Thyroid hormone and astroglia: endocrine control of the neural environment 10.1111/jne.12283 2015
Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis 10.1007/s12035-014-8868-5 2015
Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages 10.1016/j.jneuroim.2014.06.021 2014
The impact of microglial activation on blood-brain barrier in brain diseases 10.3389/fncel.2014.00362 2014
The reciprocal interactions between astrocytes and prostate cancer cells represent an early event associated with brain metastasis 10.1007/s10585-014-9640-y 2014
The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model 10.1186/1471-2407-14-923 2014
Glioblastoma cells inhibit astrocytic p53-expression favoring cancer malignancy 10.1038/oncsis.2014.36 2014
Equinatoxin II Potentiates Temozolomide- and Etoposide-Induced Glioblastoma Cell Death 10.2174/1568026611212190006 2013
The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles 10.1007/s00018-013-1328-y 2013
Membrane Elastic Properties and Cell Function 10.1371/journal.pone.0067708 2013
Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve 10.1111/ejn.12161 2013
Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis 10.1038/cddis.2013.325 2013
Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells 10.1016/j.neuroscience.2011.10.025 2012
Glioblastoma: Therapeutic challenges, what lies ahead 10.1016/j.bbcan.2012.05.004 2012
High levels of cellular prion protein improve astrocyte development 10.1016/j.febslet.2012.11.032 2012
Glioblastoma cells: A heterogeneous and fatal tumor interacting with the parenchyma 10.1016/j.lfs.2011.04.022 2011
Identity of the cells recruited to a lesion in the central nervous system of a decapod crustacean 10.1007/s00441-010-1045-x 2010
Prion protein and its ligand stress inducible protein 1 regulate astrocyte development 10.1002/glia.20861 2009
STI1 promotes glioma proliferation through MAPK and PI3K pathways 10.1002/glia.20579 2007
Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation 10.1111/j.1471-4159.2007.04904.x 2007
Soluble factors released by Toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration 10.1128/IAI.71.4.2047-2057.2003 2003
Regulation of microglial development: a novel role for thyroid hormone 2002
New insights into the role of thyroid hormone in the CNS: the microglial track 10.1038/sj.mp.4000988 2002
Regulation of microglial development: a novel role for thyroid hormone 2001
Thyroid hormone role on nervous system morphogenesis 2001
A Novel role for thyroid hormone: modulation of microglial development 2001
Patterns of synthesis and secretion of sulfated glycosaminoglycans in primary cortical and cerebellar astrocytes in vitro. (1o E 2o AUTORES CONTRIBUÍRAM IGUALMENTE) 2000
Thyroid hormones actions on microglial development 2000
Thyroid hormone action on astroglial cells from distinct brain regions during development 1998
Thyroid hormone induces secretion of factors and progressive morphological changes on primary and subcultured astrocytes 1998
Thyroid hormone induces protein secretion and morphological changes on astroglial cells with increase in GFAP expression 1997
Effects of the thyroid hormone (T3) on astrocytes (Review) 1996
Triiodothyronine effects on astrocytes differentiation during brain development 1995
Evidences of an Active Extrusion Pump Associated with the Multidrug Resistance Phenotype in Some Drug Resistant Leishmania amazonensis Cell Lines 1993
Multidrug Resistance Phenotype in Leishmania Amazonensis Resistant to Vinblastine: Reversal by Calcium Channel Antagonist 1992
Multidrug Resistance Phenotype in Leishmania amazonensis 1991
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
O PAPEL DA QUIMIOCINA CCL21 NA INTERAÇÃO NEURÔNIO-GLIA DURANTE A SEPSE 2024
AVALIAÇÃO DO PAPEL DA 6-FOSFOFRUTOQUINASE-2/FRUTOSE 2,6 BIFOSFATASE NA PROGRESSÃO DO GLIOBLASTOMA 2024
A INFLUÊNCIA DO SUPRESSOR DE TUMOR P53 NA INTERAÇÃO ENTRE ASTRÓCITOS E CÉLULAS DE GLIOBLASTOMA 2024
A EXPRESSÃO DA PROTEÍNA PRION CELULAR (PRPC) AUMENTA O PROCESSO NEURODEGENERATIVO TÍPICO DA DOENÇA DE PARKINSON EM CAMUNDONGOS 2024
The expression of Cellular Prion Protein (PrPC) increases Parkinson's Disease neurodegeneration in mice 2024
EVALUATION OF THE ROLE OF 6-PHOSPHOFRUTOKINASE-2/FRUCTOSE 2,6 BIPHOSPHATASE IN THE GLIOBLASTOMA PROGRESSION 2024
Neuron-microglia interaction during Parkinson's disease: the role of the cytokine CCL21 2023
CCL21-CCR7 PATHWAY INDUCE MICROGLIAL REACTIVITY AND NEURODEGENERATION IN A NOVEL 3,4-DIHYDROXYPHENYLACETOADEHYDE INDUCED PARKINSON?S DISEASE MODEL 2023
GLIOBLASTOMA MICROENVIRONMENT IS REMODELLED BY ZIKA VIRUS INFECTION IN VITRO AND IN VIVO 2022
Intrastriatal injection of 3,4-dihydroxyphenylacetaldehyde (DOPAL) induce motor and non-motor Parkinson-like deficit in mice 2022
The role of the CCL21 chemokine in neuron-glia interaction during sepsis 2021
Microglia-Neuron Interaction in Parkinson's Disease: The Role of Cytokine CCL21 2021
Role of PFKFB3 in glioblastoma progression 2021
Genomic Integrity in the context of H3.3K27M Diffuse Midline Gliomas 2021
The role of CCL21-CCR7 via during microglia-neuron interaction in Parkinson?s Disease 2021
EVALUATION OF MIR-181 FAMILY MEMBERS IN ORAL CANCER 2020
Microglia-Neuron Interaction in Parkinson's Disease: The Role of Cytokine CCL21 2020
The role of cellular prion protein in the regulation pf angiogenesis in the developing central nervous system 2020
The role of CCL21 in the microglia-glioma interaction - Oral Presentation 2019
Alpha 7 Nicotinic Acetylcholine Receptors in Macrophages and Microglia 2019
Anti-neuroinflammatory and neuroprotective effects of CLA in LPS-activated microglial cells 2019
Role of PrPc in Microglia During Central Nervous System Development 2018
Evaluation of MIR-181 family members in oral cancer 2018
GBM-microglia interaction modulated by Wnt pathway 2017
The role of parenchymal cellular prion protein during glioblastoma progression 2017
The role of Lisophosphatidic Acid in the microglia-glioblastoma interaction 2017
The Role of LPA in the microglia-GBM interaction 2017
Análise do perfil de expressão de MGMT no cancer oral e dos mecanismos epigenéticos envolvidos em sua regulação 2016
GBM-Microglia interaction modulated by Wnt pathway 2016
Estudo dos mecanismos epigenéticos na regulação do gene O(6)-metilguanina-DNA metiltransferase (MGMT) no câncer oral 2016
THE ROLE OF LYSOPHOSPHATIDIC ACID IN THE MICROGLIA- GLIOBLASTOMA INTERACTION 2015
The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model 2015
The Role of Stress Inducible Protein 1 (STI1) in the Microglia-Glioblastoma Interaction 2015
GBM-Microglia interaction modulated by Wnt pathway 2015
Brain tumors and interactions with parenchyma-Poster 2014
Papel do LPA na interação microglia-glioblastoma 2014
Prion-like aggregation of p53 in breast cancer and glioblastoma: New targets for antitumoral drugs-Conferência 2014
Glioblastoma: a fatal and heterogeneous tumor interacting with the parenchyma 2013
Papel do ácido lisofosfatídico na interação microglia-glioblastoma 2013
Apresentação ORAL - Progression of human glioblastoma in the brain parenchyma from immunocompetent mice 2013
Synaptic deficits in sepsis 2013
Equinotoxina potencializa a morte celular induzida por temozolomida e etoposídeo em células de glioblastoma humano 2013
Progression of human glioblastoma in the brain parenchyma from immunocompetent mice 2012
The role of p53 in the tumor-microenvironment interaction 2012
The role of lysophosphatidic acid in the microglia-glioblastoma interaction 2012
The subcellular distribution of the asymmetric proteinNodal in glial cells plays a key role during development and physiopathology of the central nervous system 2012
Unraveling a new cellular mechanism behind trnsthyretin-related leptomeningeal amyloidosis using as model a highly unstable trnsthyretin mutant 2012
Wallerian degeneration in galectin-3 knockout mice 2012
Membrane nanotubes: mechanisms of formation and functions in cells 2012
Wallerian degeneration in galectin-3 knockout mice 2012
THE LACK OF GALECTIN-3 PROTEIN ENHANCES WALLERIAN DEGENERATION BY INCREASING MYELIN PHAGOCYTOSIS AND CYTOKINE PRODUCTION AFTER SCIATIC NERVE INJURY IN MICE 2011
THE ROLE OF LYSOPHOSPHATIDIC ACID IN THE MICROGLIA-GLIOBLASTOMA INTERACTION 2011
Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells 2011
Unraveling a new cellular mechanism behind transthyretin-related leptomeningeal amyloidosis using as model a highly unstable transthyretin mutant. 2011
Science on Wheels - The ICB goes to school / Ciência sobre Rodas - O ICB vai à Escola 2011
O ICB vai à Escola - Ciência sobre Rodas 2011
The role of prion protein during the development of glioblastoma multiforme in vivo 2010
The role of stress inducible protein 1 (STI1) in the microglia-glioblastoma interaction 2010
Ciência sobre Rodas - parte 1 2010
Ciência sobre Rodas - parte 2 2010
Prion protein and stress inducible protein 1 modulate astrocyte development 2009
Unraveling the possible cellular mechanism behind leptomeningeal amyloidosis using as model a highly unstable transthyretin tetramer 2009
Ativação microglial induzida por oligômeros solúveis da proteína prion celular 2009
Desvendando um possível mecanismo celular associado à amiloidose leptomeningeal utilizando como modelo o tetrâmero mais instável da transtirretina 2009
STI1 uncoventional secretion by astrocytes is lipid dependent and activates the ERK signaling pathway 2009
Ciência sobre Rodas 2009
The role of PrPc and STI1 in the microglia-glioblastoma interaction 2008
Amyloid aggregates induce an inflammatory response - APRESENTAÇÂO ORAL 2008
Astrocyte secrete STI1 modulating neuronal MAPK in a cellular prion dependent manner 2008
The Role of STI1 in the microglia-glioblastoma interaction 2008
Stress inducible protein-1 as an important player in subventricular zone neuroblast migration 2008
Activation of microglia cells by the aggregates formed from the A25T variant of transthyretin: implication in central nervous system Amyloidosis 2008
Cellular prion modulates astrocyte functions 2008
Exossome dependent trafficking of stress inducible protein-1 in association with cellular prion protein 2007
Role of cellular prion protein in neuron-astrocyte crosstalk 2007
A possible role of stress inducible protein - 1 in neuroblast migration from the subventricular zone - MENÇÂO HONROSA 2007
STI-1 promotes glioma proliferation through MAPK and PI3K pathways 2007
Astrocyte proliferation, differentiation and survival: involvement of cellular prion protein and its ligand STI1 2006
Cellular prion protein engagement to its ligand STI1 promotes neuronal and astrocytic survival 2006
Interaction between PrPc and STI1 in astrocyte development - ORAL 2006
Cellular prion expression in astrocytes regulates survival and differentiation 2006
Interação do gangliosídeo 9-O-acetil GD3 com integrina beta1 e PrPc: possível papel na migração neuronal 2006
Astrocytes regulate neuronal survival and differentiation via cellular prion protein-PREMIADO 2006
Role of Cellular prion protein - Stress inducible protein 1 interaction in astrocyte development 2006
Stress inducible protein 1 as a new regulator for subventricular zone neuroblast migration 2006
Glial STI-1 and laminin modulate neuronal development via prion cellular protein 2005
Involvement of the cellular prion protein and its ligant STI1 in the astrocyte development-PREMIADO 2005
Cellular prion protein in neuronal signalling networks and neuron-glia crosstalk: compensatory mechanisms 2005
Proliferation, Differentiation and Apoptosis: Involvement of Cellular Prion Protein-PREMIADO 2005
Involvement of the cellular prion protein in the neuron-glia interaction 2004
Involvement of the cellular prion protein in the neuron-glia interaction 2004
Involvement of cellular prion protein in the neuron-glia interaction-Apresentação ORAL 2004
Association between cellular prion protein and glial fibrilary acidic protein in the astrocyte differentiation 2004
The PrPc-STI1 interaction in peripheral nerve: Studies in axon transport and regeneration 2004
Involvement of cellular prion protein in the astrocyte differentiation 2004
STI1 binding to cellular prion protein modulates glioma proliferation 2004
STI1 modulates glioma proliferation 2004
Involvement of the cellular prion protein in the neuron-glia interaction 2003
Toxoplasma gondii pode impedir neurodegeneração no sistema nervoso central inibindo a produção de óxido nítrico 2003
Cellular prion protein deleted glia impairs neurite growtn 2002
A novel role for thyroid hormone: modulation of microglial development 2001
Vesicular stomatitis virus X neuron-glial interactions 2001
Regulation of microglial development: a novel role for thyroid hormone 2001
Growth factors promoting microglial development: a role for thyroid hormones 2000
Thyroid hormones control astrocyte morphology and release of growth factors 2000
Patterns of synthesis and secretion of sulfated glycosaminoglycans in primary cortical and cerebellar astrocyte in vitro 2000
Thyroid hormones actions on microglial development 2000
Influences of thyroid hormones on the development of microglia 1999
Influences des hormones thyroidiennes sur le développement de la microglie-ORAL 1999
Sulfated glycosaminoglycans from cortical and cerebellar astroglial cultures 1998
Distribution of sulfated glycosaminoglycans in cortical and cerebellar astroglial cultures 1997
Thyroid hormone (T3) induces morphological changes affecting GFAP and laminin organization in cortical astrocytes 1996
Thyroid hormone effects on glial and neuronal cells differentiation 1996
Triiodothyronine action in astrocyte cultures of rat cerebral hemisphere, mesencephalon and cerebellum 1995
Triiodothyronine effects on astrocytes differentiation during brain development-Apresentação ORAL, PREMIADO 1995
Hormone de la thyroide induit prolifération et differentiation des astrocytes avec changement d'expression de GFAP 1995
Triiodothyronine Effects on Astrocytes Cultures of Rat Cerebral Hemisphere, Mesencephalon and Cerebellum 1995
Efeito diferencial do hormônio da Tireóide sobre astrócitos provenientes de mesencéfalo, cortex e cerebelo de rato 1994
Different effects of triiodothyronine in astrocytes cultured of rats cerebral hemisphere, mesencephalon and cerebellum 1994
Diferentes efeitos do hormônio da tireóide sobre astrócitos provenientes de córtex, mesencéfalo e cerebelo de rato 1994
Ação diferencial do hormônio da tireóide sobre astrócitos provenientes de mesencéfalo, córtex e cerebelo de rato 1993
Evidences of an active extrusion pump associated with the multidrug resistance phenotype in some drug resistant Leishmania amazonensis cell lines 1993
Multidrug Resistance Phenotype in Leishmania amazonensis resistant to vinblastine: reversal by calcium channel antagonist 1992
Reversão da resistência de Leishmania amazonensis à droga por antagonista de canais de cálcio 1991
Multidrug resistance phenotype in Leishmania amazonensis 1991
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