Carlos Rangel Rodrigues

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Faculdade de Farmácia

Departamento:

Departamento de Fármacos e Medicamentos

ORCID:

não disponível no Lattes


Formação:

  • Universidade Federal do Rio de Janeiro

    Química | Doutorado | 1996 - 1999

  • Universidade Federal do Rio de Janeiro

    Química | Mestrado | 1992 - 1995

  • Universidade Federal do Rio de Janeiro

    Farmácia | Graduação | 1988 - 1991
Laboratórios:
Nuvens de Palavras:
Artigos:

(89.55% artigos com DOI)

Titulo DOI Ano
Synthesis, in silico, and in vitro evaluation of 7-chloro-quinolines designed as myeloperoxidase inhibitors 10.1016/j.molstruc.2024.138528 2024
Evaluation of Silybin Nanoparticles against Liver Damage in Murine Schistosomiasis mansoni Infection 10.3390/pharmaceutics16050618 2024
Novel naphthoquinone-1H-1,2,3-triazole hybrids: Design, synthesis and evaluation as inductors of ROS-mediated apoptosis in the MCF-7 cells 10.1016/j.bmc.2024.117671 2024
4-oxoquinoline-3-carboxamide acyclonucleoside phosphonates hybrids: Human MCF-7 breast cancer cell death induction by oxidative stress-promoting and in silico ADMET studies 10.1016/j.molstruc.2022.134542 2023
Development of SEDDS formulation containing caffeine for dermal delivery 10.1111/ics.12841 2023
Aryl hydrocarbon receptor as a therapeutical target of environmentally induced skin conditions 10.1124/molpharm.122.000627 2023
Physiologically based pharmacokinetic modelling of semaglutide in children and adolescents with healthy and obese body weights 10.1111/bcp.15816 2023
Chitosan-based hydrotalcite nanostructured membranes containing sodium alendronate for guided bone regeneration therapy 10.7324/japs.2023.40064 2023
Use of In silico Methodologies to Predict the Bioavailability of OralSuspensions: A Regulatory Approach 10.2174/0113816128257028231030113156 2023
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis 10.1016/j.bmc.2021.116506 2022
Molecular modelling and dynamics simulations of single-wall carbon nanotube as a drug carrier: New insights into the drug-loading process 10.1016/j.jmgm.2022.108145 2022
Applying in silico Approaches to Nanotoxicology: Current Status and Future Potential 10.1016/j.comtox.2022.100225 2022
Eugenia sulcata (Myrtaceae) Nanoemulsion Enhances the Inhibitory Activity of the Essential Oil on P2X7R and Inflammatory Response In Vivo 10.3390/pharmaceutics14050911 2022
Evaluation of biological activities of quinone-4-oxoquinoline derivatives against pathogens of clinical importance 10.2174/1568026622666220504124710 2022
Development of novel montmorillonite-based sustained release system for oral bromopride delivery. 10.1016/j.ejps.2022.106222 2022
Alternative Methods for Pulmonary-Administered Drugs Metabolism: a Breath of Change 10.2174/1389557522666220620125623 2022
Preparation and evaluation of red propolis and nystatin cyclodextrin inclusion complexes against oral microbiome opportunistic microorganisms 10.1590/fst.118022 2022
Toxicological assessment of SGLT2 inhibitors metabolites using in silico approach 10.1590/0001-3765202220211287 2022
Ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane: Toxicological effects on marine biota and human concerns 10.1002/jat.4210 2022
In silico phytochemicals analysis as inhibitors of the SARS-COV-2 main protease 10.17352/ijpsdr.000041 2022
Application of in silico methods in clinical research and development of drugs and their formulation, a scoping review (Pub Med Central). 10.1079/searchrxiv.2022.00006 2022
Nanoemulsion of Sideroxylon obtusifolium as an Alternative to Combat Schistosomiasis 10.3389/fpls.2022.853002 2022
Triazoles with inhibitory action on P2X7R impaired the acute inflammatory response in vivo and modulated the hemostatic balance in vitro and ex vivo 10.1007/s00011-022-01664-1 2022
Inventive step assessment of top selling monoclonal antibodies in Brazil 10.1080/13543776.2021.1873955 2021
Benign prostatic hyperplasia therapy through liquisolid technology composed of polymer-layered nanocomposites based on silicate that contain babassu oil and copaiba oil-resin 10.1016/j.jddst.2021.102586 2021
Clofazimine functionalized polymeric nanoparticles for brain delivery in the tuberculosis treatment 10.1016/j.ijpharm.2021.120655 2021
Structural insights into the allosteric site of Arabidopsis NADP-malic enzyme 2: role of the second sphere residues in the regulatory signal transmission 10.1007/s11103-021-01176-2 2021
Evaluation of chloroquine and hydroxychloroquine as ACE-2 Inhibitors By In Silico Approaches: Cardiac Arrhythmia Cause? 10.1016/j.molstruc.2021.130946 2021
Development of rivaroxaban microemulsion-based hydrogel for transdermal treatment and prevention of venous thromboembolism 10.1016/j.colsurfb.2021.111978 2021
Antiviral drug discovery and development for Mayaro Fever - What do we have so far? 10.2174/1389557520666200316160425 2020
Forced degradation studies of norepinephrine and epinephrine from dental anesthetics: Development of stability-indicating HPLC method and in silico toxicity evaluation 10.1002/bmc.4832 2020
Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors 10.1016/j.ejmech.2020.112255 2020
Correction to: Molecular modeling as a design tool for sunscreen candidates: a case study of bemotrizinol 10.1007/s00894-019-4271-5 2020
Development of inhaled formulation of modified clofazimine as an alternative to treatment of tuberculosis 10.1016/j.jddst.2020.101805 2020
Full-factorial design for statistical planning of attritor milling parameters and evaluation of effects on particle size and structure of sodium-montmorillonite 10.1088/2631-8695/ab7d85 2020
Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi 10.1007/s10863-020-09834-8 2020
Synthesis, In Vitro and In Silico Studies of Indolequinone Derivatives against Clinically Relevant Bacterial Pathogens 10.2174/1568026620666191223110518 2020
Molecular dynamic simulations of full-length human purinergic receptor subtype P2X7 bonded to potent inhibitors 10.1016/j.ejps.2020.105454 2020
In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension 10.1590/0001-3765202020191445 2020
Nanoparticles Loaded with a New Thiourea Derivative: Development and In Vitro Evaluation Against Leishmania Amazonensis 10.2174/1567201817666200704132348 2020
Vancomycin-loaded nanoparticles against vancomycin intermediate and methicillin resistant Staphylococcus aureus strains 10.1088/1361-6528/ab97d7 2020
Structure-activity relationship, molecular docking, and molecular dynamic studies of diterpenes from marine natural products with anti-HIV activity 10.1080/07391102.2020.1845977 2020
Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens 10.1016/j.jphotobiol.2019.03.003 2019
8-Hydroxy-2-(1H-1,2,3-triazol-1-yl)-1,4-naphtoquinone derivatives inhibited P2X7 Receptor-Induced dye uptake into murine Macrophages 10.1016/j.bmc.2018.11.036 2019
Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors 10.3389/fchem.2019.00261 2019
Arylboronic acids inhibit P2X7 receptor function and the acute inflammatory response 10.1007/s10863-019-09802-x 2019
Molecular modeling for the investigation of UV absorbers for sunscreens: Triazine and benzotriazole derivatives 10.1016/j.jphotochem.2017.12.036 2018
1,4-Naphthoquinones potently inhibiting P2X7 receptor activity 10.1016/j.ejmech.2017.10.033 2018
A promising oral fucoidan-based antithrombotic nanosystem: development, activity and safety 10.1088/1361-6528/aaae5b 2018
A comprehensive review of chalcone derivatives as antileishmanial agents 10.1016/j.ejmech.2018.03.047 2018
Development and Characterization of Dapsone Cocrystal Prepared by Scalable Production Methods 10.1208/s12249-018-1101-5 2018
A synergistic nanoformulation of babassu and copaiba oils as natural alternative for prevention of benign prostatic hyperplasia 10.1016/j.jddst.2018.07.013 2018
Pharmaceutical excipients properties and screw feeder performance in continuous processing lines: a Quality by Design (QbD) approach 10.1080/03639045.2018.1513024 2018
Pyrazolyl-Tetrazoles and Imidazolyl-Pyrazoles as Potential Anticoagulants and their Integrated Multiplex Analysis Virtual Screening 10.21577/0103-5053.20180150 2018
Identification, characterization and in silico ADMET prediction of Roflumilast degradation products 10.1016/j.jpba.2017.02.012 2017
Analysis of worldwide sequence mutations in Zika virus proteins E, NS1, NS3 and NS5 from a structural point of view 10.1039/C6MB00645K 2017
Targeting CYP51 for drug design by the contributions of molecular modeling 10.1111/fcp.12230 2017
Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor 10.1016/j.bmcl.2016.11.051 2017
Synthesis and mechanistic evaluation of novel N ?-benzylidene-carbohydrazide-1 H -pyrazolo[3,4 -b ]pyridine derivatives as non-anionic antiplatelet agents 10.1016/j.ejmech.2017.04.023 2017
Development and characterization of clay-polymer nanocomposite membranes containing sodium alendronate with osteogenic activity 10.1016/j.clay.2017.06.033 2017
Asymmetric bioreduction of β-ketoesters derivatives by Kluyveromyces marxianus: influence of molecular structure on the conversion and enantiomeric excess 10.1590/0001-3765201720170118 2017
Antileishmanial Thioureas: Synthesis, Biological Activity and in Silico Evaluations of New Promising Derivatives 10.1248/cpb.c17-00293 2017
1-Aryl-1 H - and 2-aryl-2 H -1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo 10.1016/j.ejmech.2017.08.034 2017
Exploring 1,2,3-triazole derivatives by using in vitro and in silico assays to target new antifungal agents and treat Candidiasis 10.1007/s00044-017-1789-x 2017
Molecular modeling and dynamic simulations of agglutinin-like family members from Candida albicans : New insights into potential targets for the treatment of candidiasis 10.1080/07391102.2017.1417159 2017
Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment 10.1208/s12249-016-0477-3 2016
Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization 10.3109/14756366.2016.1158712 2016
The antihemostatic profile of vitamin C: Mechanisms that underlie the technical application of a physiological molecule 10.2298/abs150413024s 2016
New approaches in tail-bleeding assay in mice: improving an important method for designing new anti-thrombotic agents 10.1111/iep.12182 2016
Design, Synthesis and Evaluation of New Fluoroamodiaquine Analogues 10.1248/cpb.c15-01001 2016
Oligopeptidase B and B2: comparative modelling and virtual screening as searching tools for new antileishmanial compounds 10.1017/s0031182016002237 2016
Sodium Montmorillonite/Amine-Containing Drugs Complexes: New Insights on Intercalated Drugs Arrangement into Layered Carrier Material 10.1371/journal.pone.0121110 2015
Hologram QSAR Models of a Series of 6-Arylquinazolin-4-Amine Inhibitors of a New Alzheimer?s Disease Target: Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase-1A Enzyme 10.3390/ijms16035235 2015
Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease 10.3390/molecules200610689 2015
Synthesis and Antiplatelet Activity of Antithrombotic Thiourea Compounds: Biological and Structure-Activity Relationship Studies 10.3390/molecules20047174 2015
Antimycobacterial and Anti-Inflammatory Activities of Substituted Chalcones Focusing on an Anti-Tuberculosis Dual Treatment Approach 10.3390/molecules20058072 2015
Molecular modeling study of a series of amodiaquine analogues with antimalarial activity 10.1007/s00044-015-1403-z 2015
Probing insulin bioactivity in oral nanoparticles produced by ultrasonication-assisted emulsification/internal gelation 10.2147/ijn.s86313 2015
Preparation and Evaluation of Chitosan Submicroparticles Containing Pilocarpine for Glaucoma Therapy 10.2174/1567201812666150901113240 2015
Molecular Dynamics Simulations of the Free and Inhibitor-Bound Cruzain Systems in Aqueous Solvent: Insights on the Inhibition Mechanism in Acidic pH 10.1080/07391102.2015.1100139 2015
Aqueous Molecular Dynamics Simulations of the M. tuberculosis Enoyl-ACP Reductase-NADH System and Its Complex with a Substrate Mimic or Diphenyl Ethers Inhibitors 10.3390/ijms161023695 2015
Crystalline forms of nonprotein drugs filed in Brazil from 1995-2005 10.4155/ppa.14.5 2014
Structural model of haptoglobin and its complex with the anticoagulant ecotin variants: structure-activity relationship study and analysis of interactions 10.3109/14756366.2013.774389 2014
Therapeutic Nanosystems for Oral Administration of Insulin 10.2174/1389201015666140915150826 2014
Intestinal Uptake of Insulin Nanoparticles: Facts or Myths? 10.2174/1389201015666140915151319 2014
Assessment of analytical techniques for characterization of crystalline clopidogrel forms in patent applications 10.1590/s1984-82502014000200001 2014
Titanium Dioxide-Montmorillonite Nanocomposite as Photoprotective Agent Against Ultraviolet B Radiation-Induced Mutagenesis in Saccharomyces cerevisiae : A Potential Candidate for Safer Sunscreens 10.1002/jps.24057 2014
Preparation and characterization of polymer/layered silicate pharmaceutical nanobiomaterials using high clay load exfoliation processes 10.1016/j.jiec.2013.12.110 2014
Exploring N-Acylhydrazone Derivatives Against Clinical Resistant Bacterial Strains 10.1007/s00284-014-0591-y 2014
Intestinal absorption of insulin nanoparticles: contribution of M cells 10.1016/j.nano.2014.02.014 2014
In vitro and in vivo analysis of the antithrombotic and toxicological profile of new antiplatelets N-acylhydrazone derivatives and development of nanosystems 10.1016/j.thromres.2014.05.009 2014
Novel isomannide-based peptide mimetics containing a tartaric acid backbone as serine protease inhibitors 10.1007/s00044-014-1058-1 2014
Development of New Babassu Oil Lipidic Nanostructured Systems; Potential Alternative for Benign Prostatic Hyperplasia Therapy 10.2174/1573413710666140806005930 2014
Effect of 9-hydroxy-a- and 7-hydroxy-pyran Naphthoquinones on Trypanosoma cruzi and Structure-activity Relationship Studies 10.2174/1573406410666131229151303 2014
Molecular Modeling of a Phenyl-Amidine Class of NMDA Receptor Antagonists and the Rational Design of New Triazolyl-Amidine Derivatives 10.1111/cbdd.12056 2013
Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia 10.2147/ijn.s47731 2013
Efavirenz Dissolution Enhancement I: Co-Micronization 10.3390/pharmaceutics5010001 2013
Hologram quantitative structure–activity relationship and comparative molecular field analysis studies within a series of tricyclic phthalimide HIV-1 integrase inhibitors 10.2147/dddt.s47057 2013
Tuberculosis, an Old Disease Lacking New Therapeutic Drugs 10.2174/1574885511308020003 2013
Molecular Docking Studies of Marine Diterpenes as Inhibitors of Wild-Type and Mutants HIV-1 Reverse Transcriptase 10.3390/md11114127 2013
Alginate-Based Micro and Nanoparticles Coated with Chitosan 10.1166/jcc.2013.1025 2013
In Vitro-In Vivo Correlation of Efavirenz Tablets Using GastroPlus® 10.1208/s12249-013-0016-4 2013
Human thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel 10.3109/14756366.2013.817403 2013
Development of a Doxazosin and Finasteride Transdermal System for Combination Therapy of Benign Prostatic Hyperplasia 10.1002/jps.23715 2013
Searching for new antileishmanial lead drug candidates: Synthesis, biological and theoretical evaluations of promising thieno[2,3-b] pyridine derivatives 10.5897/JMA11.109 2012
Application of 4D-QSAR Studies to a Series of Raloxifene Analogs and Design of Potential Selective Estrogen Receptor Modulators 10.3390/molecules17067415 2012
Residue-Ligand Interaction Energy (ReLIE) on a Receptor-Dependent 3D-QSAR Analysis of S- and NH-DABOs as Non-Nucleoside Reverse Transcriptase Inhibitors 10.3390/molecules17077666 2012
HIV-1 Reverse Transcriptase: a potential target for marine products 2012
Tuberculosis: Finding a New Potential Antimycobacterium Derivative in a Aldehyde¿Arylhydrazone¿Oxoquinoline Series 10.1007/s00284-012-0176-6 2012
Novel peptide mimetics based on N-protected amino acids derived from isomannide as potential inhibitors of NS3 serine protease of Hepatitis C virus 2012
Hologram QSAR Models of 4-[(Diethylamino)methyl]-phenol Inhibitors of Acetyl/Butyrylcholinesterase Enzymes as Potential Anti-Alzheimer Agents 10.3390/molecules17089529 2012
Development and in silico bioavailability studies of dapsone oral nanoemulsion systems: perameability and in silico bioavailibity studies 2012
Rational use of antioxidants in solid oral pharmaceutical preparations 2012
4-(1H-Pyrazol-1-yl) Benzenesulfonamide Derivatives: Identifying New Active Antileishmanial Structures for Use against a Neglected Disease 10.3390/molecules171112961 2012
Sulphonamide and sulphonyl-hydrazone cyclic imide derivatives: Antinociceptive activity, molecular modeling and In Silico ADMET screening 10.1007/s12272-012-1002-1 2012
Molecular Modeling Studies of the Structural, Electronic, and UV Absorption Properties of Benzophenone Derivatives 10.1021/jp306130y 2012
Receptor-Dependent 4D-QSAR Analysis of Peptidemimetic Inhibitors of Trypanosoma cruzi Trypanothione Reductase with Receptor-Based Alignment 10.1111/j.1747-0285.2012.01338.x 2012
Looking at the proteases from a simple perspective 10.1002/jmr.1091 2011
Preparation and Evaluation of a New Nano Pharmaceutical Excipients and drug Delivery System Based in Polyvinylpyrrolidone and Silicates 2011
Identification of Nor-?-Lapachone Derivatives as Potential Antibacterial Compounds against Enterococcus faecalis Clinical Strain 10.1007/s00284-010-9763-6 2011
Trypanosoma cruzi: Insights into naphthoquinone effects on growth and proteinase activity 10.1016/j.exppara.2010.07.007 2011
Synthesis and Antileishmanial Activity of New 1-Aryl-1H-Pyrazole-4-Carboximidamides Derivatives 2011
Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE) 10.1016/j.ejmech.2010.10.009 2011
Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones 10.1016/j.ejmech.2011.01.066 2011
Preparation and evaluation of lidocaine hydrochloride in cyclodextrin inclusion complexes for development of stable gel in association with chlorhexidine gluconate for urogenital use 10.2147/IJN.S20409 2011
Oxoquinoline Derivatives: Identification and Structure¿Activity Relationship (SAR) Analysis of New Anti-HSV-1 Agents 10.1007/s00284-010-9860-6 2011
Trimethoxy-Chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, Biological Evaluation, Molecular Modeling and Structure Activity Relationship (SAR) 10.1016/j.bmc.2011.06.023 2011
Comparative Analysis of Viperidae Venoms Antibacterial Profile: a Short Communication for Proteomics 10.1093/ecam/nen052 2011
The study of vancomycin use and its adverse reactions associated to patients of a brazilian university hospital 10.1186/1756-0500-4-236 2011
Synthesis, antitubercular activity, and SAR study of N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides 10.1016/j.bmc.2011.07.035 2011
Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts 10.4236/jbnb.2011.23039 2011
A universidade, a escola e as necessidades especiais: Como melhorar? Como contribuir? 2011
Preparation and evaluation of antimicrobial activity of nanosystems for the control of oral pathogens Streptococcus mutans and Candida albicans 10.2147/ijn.s25667 2011
Antiplatelet activity and structure-activity relationship study of Pyrazolopyridine Derivatives as potential series for treating thrombotic diseases. 2010
Development of methodologies for dimethylaminoethanol glycolate assay in association with sunscreens in dermocosmetic formulation 10.1590/S1984-82502010000400012 2010
Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1,2,3-triazole derivatives of carbohydrates 10.1016/j.ejmech.2008.02.047 2009
Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity 10.1016/j.ejmech.2008.04.016 2009
Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series 10.1016/j.bmc.2008.10.085 2009
Brown Seaweed Defensive Chemicals: a Structure-activity Relationship Approach for the Marine Environment 2009
Integrin inhibitors from snake venom: Exploring the relationship between the structure and activity of RGD-peptides 10.1016/j.abb.2008.11.023 2009
Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides 10.1016/j.bmc.2009.03.053 2009
Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives 10.1016/j.bmc.2009.06.037 2009
Bioequivalence studies and sugar-based excipients effects on the properties of new generic ketoconazole tablets formulations and stability evaluation by using direct compression method 10.1080/10837450902832877 2009
Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms 10.2174/092986609788923365 2009
Leishmania amazonensis Growth Inhibitors: Biological and Theoretical Features of Sulfonamide 4-Methoxychalcone Derivatives 10.1007/s00284-009-9447-2 2009
Synthesis, biological, and theoretical evaluations of new 1,2,3-triazoles against the hemolytic profile of the Lachesis muta snake venom 10.1016/j.bmc.2009.09.031 2009
Molecular docking of a series of peptidomimetics in the trypanothione binding site of T. cruzi Trypanothione Reductase 10.1016/j.jmgm.2009.08.011 2009
Antiophidian Sera Sterility Control: Topics in Perspective 2009
SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series 10.1016/j.bmc.2007.09.032 2008
Identification and characterization of a new member of snake venom thrombin inhibitors from Bothrops insularis using a proteomic approach 10.1016/j.toxicon.2007.11.026 2008
Leishmaniasis Treatment - A Challenge that Remains 10.1007/s00436-008-0943-2 2008
Speciation of antimony (III) and antimony (V) using hydride generation for meglumine antimoniate pharmaceutical formulations quality control 10.1590/S0074-02762008000200002 2008
Just working with the cellular machine : A high school game for teaching molecular biology 10.1002/bmb.20164 2008
Preparation and Evaluation of Inclusion Complexes of Commercial Sunscreens in Cyclodextrins and Montmorillonites: Performance and Substantivity Studies 10.1080/03639040701831769 2008
Avaliação da adequação técnica de indústrias de medicamentos fitoterápicos e oficinais do Estado do Rio de Janeiro 10.1590/S1413-81232008000700025 2008
DNA methylation: A promising target for the twenty-fi rst century 10.1517/14728222.12.8.1035 2008
3D-QSAR CoMFA of a Series of DABO Derivatives as HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors 10.1021/ci8001217 2008
Identification of a Potential Lead Structure for Designing New Antimicrobials to Treat Infections Caused by Staphylococcus epidermidis-Resistant Strains 10.1007/s00284-008-9234-5 2008
Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure¿activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives 10.1016/j.bmc.2008.07.035 2008
Synthesis of new 4-(phenylamino)thieno[2,3-b]pyridines and derivatives of the novel benzo[b]thieno[3,2-h]-1,6-naphthyridine tetracyclic system 2008
The Preparation and Evaluation of Sodium and Alkylammonium Montmorillonite and Polysaccharide Nanocomposites as Sustained Release Excipients 10.1080/03602550802497727 2008
Expression of B7-1 costimulatory molecules in patients with multibacillary leprosy and reactional states 10.1111/j.1365-2230.2006.02291.x 2007
Current Understanding of the Role of Dendritic Cells and Their Co-Stimulatory Molecules in Generating Efficient T Cell Responses in Lepromatous Leprosy 2007
Synthesis, in vitro Evaluation and SAR studies of a Potential Antichagasic 1H-pyrazolo[3,4-b]pyridine Series 10.1016/j.bmc.2006.09.067 2007
Staphylococcus aureus: visitando uma cepa de importância hospitalar 10.1590/S1676-24442007000600005 2007
HIV-1 Reverse Transcriptase: a therapeutical target in the spotlight 10.2174/092986706775476089 2006
Current Status of Snake Venom Thrombin-like Enzymes 10.1080/15569540600567321 2006
Trypanocidal agents with low cytotoxicity to mammalian cell line: A comparison of the theoretical and biological features of lapachone derivatives. 10.1016/j.bmc.2006.04.046 2006
Design, Synthesis, SAR, and Biological Evaluation of New 4-(phenylamino)thieno[2,3-b]pyridine Derivatives 10.1016/j.bmc.2006.03.013 2006
Plaquetas: Ainda um Alvo Terapêutico 10.1590/s1676-24442006000500004 2006
Structure-Function Inferences Based On Molecular Modeling, Sequence-Based Methods and Biological Data Analysis of Snake Venom Lectins 10.1016/j.toxicon.2006.08.006 2006
Synthesis, Tuberculosis Inhibitory Activity and SAR study of N-Substituted-Phenyl-1,2,3-triazole Derivatives 10.1016/j.bmc.2006.08.019 2006
Snake venom: any clue for antibiotics. 10.1093/ecam/neh063 2005
The Development and validation of a HPLC-UV method for the determination of didanosine tablets. 10.1016/j.jpba.2005.02.004 2005
Tourette: por dentro da síndrome 10.1590/S0101-60832005000400004 2005
Bioinformática na Era Pós-Genômica: métodos de dinâmica molecular, docking e qsar-3D/4D no planejamento de novos fármacos antiparasitários 2005
Avaliação da Adequação Técnicas de Indústrias de Medicamentos Fitoterápicos e Oficinais do Estado do Rio de janeiro 2005
Snake Venom thrombin-like enzyme:from reptilase to now 10.1007/s00018-003-3325-z 2004
Solving an Ethical Issue In A Brazilian Teaching Laboratory. 10.1002/bmb.2004.494032060404 2004
The Role of the Undergraduate Student Research Assistant for the New Millennium. 10.1187/cbe.04-02-0032 2004
Selective PGHS-2 Inhibitors: A Rational Approach for Treatment of the Inflammation 2004
Chiral separation of gamma-butyrolactone derivatives by gas chromatography on 2,3-di-O-methyl-6-O-tert.-butyldimethylsilyl-beta-cyclodextrin 10.1016/S0040-4039(02)00074-6 2003
Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-d]pyridine and Pyrazolo[3,4-b][1,8]naphthyridine Isosteres: A New Class of Potent and Selective Acetylcholinesterase Inhibitors 10.1021/jm020391n 2003
A QUÍMICA MEDICINAL DE N-ACILIDRAZONAS: NOVOS COMPOSTOS-PROTÓTIPOS DE FÁRMACOS ANALGÉSICOS, ANTIINFLAMATÓRIOS E ANTI-TROMBÓTICOS 10.1590/s0100-40422002000100022 2002
Molecular Modeling of Novel 1H-Pyrazolo[3,4-b]pyridine Derivatives Designed as Isosters of the Antimalarial Mefloquine 10.1016/S0166-1280(01)00677-7 2002
CoMFA and HQSAR of Acylhydrazide Cruzain Inhibitors 10.1016/S0960-894X(02)00189-0 2002
Higly Diastereoselective Mercury Mediated Synthesis of Functionalyzed 2-Azabicyclo[3.3.0]octane Derivatives 10.1016/S0040-4039(02)00074-6 2002
Selective PGHS-2 Inhibitors: A Rational Approach for Treatment of the Inflammation 2002
Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 6. The Development of Predictive In Vitro Potency Models Using CoMFA and HQSAR Methodologies 10.1021/jm0100234 2002
Novel Phthalimide Derivatives, Designed as Leukotriene D4 Receptor Antagonists 10.1016/S0960-894X(02)00203-2 2002
Processos Modernos no desenvolvimento de Fármacos 2001
Estratégias em Química Medicinal para o planejamento de fármacos 2001
Chiral Gas Chromatographic Separation of 2-Oxabicyclo[3.3.0]octane Derivatives and Their Synthetic Precursors 10.1021/ac9912101 2000
A possible molecular mechanism for the inhibition of cysteine Proteases by salicylaldehyde N-Acylhydrazones and related compounds 10.1016/s0166-1280(99)00307-3 2000
Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolyl N-Acylarylhydrazone Derivatives 10.1016/s0968-0896(00)00152-8 2000
Synthesis and Pharmacological Evaluation of Novel Heterotricyclic Acylhydrazone Derivatives, Designed as PAF Antagonist Candidates 10.1016/S0928-0987(00)00102-0 2000
Proposal of a New Paf Pharmacophore Map by AM1 Method. 10.1016/S0928-0987(99)00029-9 1999
On the Modeling of Some Anti-inflammatory and Anti-thrombotic Drugs by AM1 1997
Modelagem molecular: uma ferramenta para o planejamento racional de fármacos em química medicinal 1997
A semiempirical study of pyrazole acylhydrazones as potential antimalarial agents 10.1002/(SICI)1097-461X(1996)60:8<1835::AID-QUA11>3.0.CO;2-Z 1996
Design of New Potential 5-Lipoxygenase Inhibitors, Dual Thromboxane Synthase Inhibitors, and Thromboxane A2 Receptor Antagonists By AM1 1995
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Barnettlysin-I: homology modeling and structural studies for exploring a snake venom biotechnological target 2016
Toxicity risks predictions and in silico structural-toxicity relationship evaluation of new amodiaquine analogues with antimalarial activity 2015
Virtual screening as a search tool for new antileishmanial compounds 2014
Design, Synthesis and Antimalarial Activity of New Fluororamodiaquine Analogues 2014
In Silico Toxicity Evaluation of Marine Molecules with Antifungal Profile 2014
Molecular Docking of Benzoxazinones and HSV-1 Protease as a Strategy for Drug Design 2012
Docking studies on the binding interactions between benzophenone derivatives and strogen receptor 2012
Structure-activity relationship and molecular docking studies of new Amodiaquine analogues into heme: an approach to malaria treatment 2012
Molecular Docking Studies of New HIV-1 Inhibitors Based on Natural Products 2012
Ability of Swelling the Organically Modified Montmorillonite in diferent solvents: Molecular modeling and molecular dynamics study 2012
HQSAR, CoMFA, In Silico Physico-chemical and Toxicological Analyses of a Series of HIV-1 Integrase Inihibitors 2012
Docking Studies of 4-[(Diethylamino)Methyl]-Phenol Derivatives as Acetylcholinestarase Inhibitors 2012
Theoretical Studies of The Structural and Spectral Properties of Benzophenone Derivatives 2011
Inhibition of HIV-1 by Diterpenes Isolated from Brazilian Brown Seaweeds: a structural relationship Study 2011
In Vitro and in Silico Approaches to the Identification of New Compunds with Antibacterial Profile 2011
In silico analysis of the binding mode of lapachone derivatives into cruzain 2008
Structural Basis for Enantioselectivity of Candida antarctica Lipase B (CaLB) in the Optical Resolution of 1-Phenyl-Ethanol 2008
Docking of the Anti-Retroviral Dolabelladienetriol into the Wild-Type and Y181C Mutant HIV-1 Reverse Transcriptase 2008
Molecular modeling of a phenyl-amidine class of NMDA receptor antagonists and the rational design of new triazolyl-amidine derivatives 2008
Theoretical SAR based on DFT Descriptors of a series of acyl-hydrazones with in vitro inhibitory activity against T. cruzi 2008
Theoretical Evaluation of 1H-pyrazole-4-carbohydrazides derivatives as trypanocidal agents. 2008
Molecular Dynamics Simulation of a DABO Analogue: A non-nucleoside HIV Reverse Transcriptase Inhibitor 2007
ANTIBIOTIC AND THEORETICAL PROFILES OF 4-ANILINE-1H-PIRAZOLO[3,4-b]PIRIDINES AND 4-ANILINE-TIENE[2,3-B]PIRIDINES DERIVATIVES 2007
LAPACHONE DERIVATIVES AS TRIPANOCIDAL AND LOW CITOTOXICITY AGENTS: A MOLECULAR MODELING STUDYi 2007
NMDA RECEPTOR: MOLECULAR MODELING OF A POTENTIAL TARGET 2007
Modelos de Complexos de Inclusão de Esteróides em Ciclodrextrinas 2006
Modelos de QSAR-4D de Inibidores Peptídicos da Tripanotiona Redutase 2006
Estudo por SAR de compostos candidatos a antibióticos contra Staphylococcus aureus 2006
Relação Estrutura-Atividade de derivados da lapachona como agentes tripanossomicidas de baixa citotoxicidade 2006
Structure-Activity Relationships of Thieno[2,3-b]pyridine derivatives as potential anti-Giardia drugs 2006
MOLECULAR MODELING EVALUATION OF A SERIES OF OXOQUINOLINE ANALOGS AS POTENCIAL HIV-1 REVERSE TRANSCRIPATASE INHIBITORS 2006
Structure-Activity Relationship Studies of a Series of NR2B-selective NMDA receptor Antagonists Using Molecular Modeling 2006
SAR studies of a new antibacterial candidate against Staphylococcus aureus 2006
Identification of a new series of carbohydrate-substituted triazoles derivatives presenting antiplatelet activity 2006
Molecules of synthetic, animal or vegetal origin: the search for new antibiotic archetype 2006
Neuropsin, u-PA and thrombin: structural comparison within three serine-proteases of central neurons system 2006
Just working with the cellular machine 2006
Sintese de novos derivados do sistema tieno[2,3-b]piridina com potencial atividade antiparasitária 2006
Síntese e atividade biológica de novos derivados 4-(fenilamino)tieno[2,3-b]piridina. 2006
PERFIL DA ATIVIDADE ANTIBIÓTICA DE LIGANTES DERIVADOS DE CARBOIDRATOS 2006
Biologia Interdisciplinar: Realidade Ou Utopia ?. 2005
Comparing Neuropsin To Other Serine Proteases 2005
Construction And Characterization Of Defensin Psd1 Protein Mutants - Structure-Activity Relationship Study 2005
Síntese e caracterização de nanocompósitos derivados de montmorilonita visando sua utilização como novas matrizes mistas para a liberação controlada. 2005
Desenvolvimento de uma nova classificação farmacotécnica de riscos em desvios da qualidade de medicamentos 2005
Preparação e avaliação de novos compósitos poliméricos para liberação prolongada de fármacos - uso de PVP e montmorilonita organofílica 2005
Docking of a Dolabellane Diterpene Derivative on the Non-Nucleoside Binding Site of the HIV-1 Reverse Transcriptase 2005
Structure-Activity Relationships (SAR) studies of antiplatelet Pyrazolopyridine derivatives 2005
Structure-Activity Relationship (Sar) Of New Antiviral Candidates 2005
Neuropsin: structural comparison with enzymes of the family of the serine-proteases 2005
Neuropsin, trypsin and Lm-TL: structural comparison of three serine-proteases 2005
Psd1: Construction Characterization Of Defensin Mutants 2005
Homology extended to the inhibitor interaction? Looking at a non-enzymatic protein through an enzyme inhibitor perspective. 2005
Perfil Da Atividade Antibiótica De Derivados 4-Anilino-1h-Pirazolo[3,4-B]Piridinas E 4-Anilino-Tieno[2,3-B]Piridinas. 2005
JORNADA DE INICIAÇÃO CIENTÍFICA DA FACULDADE DE MEDICINA DA UFF 2004
Identification of a new series of acylhydrazone derivatives presenting antiplatelet activity 2004
Modelos de QSAR-4D para Acilidrazonas com Atividade Tripanocida 2004
Ambiente Virtual para o ensino da Dengue 2004
Química Interdisciplinar: Realidade ou Utopia 2004
Snake venom Lectins: structure-function inferences based on a bioinformatic approach 2004
Síntese e Avaliação da Atividade Farmacológica de 4-Acil-Hidrazona-1-H-Pirazolo[3,4-b]piridinas como Agentes Antitrombóticos 2004
Uso do Graphos no combate a dengue 2004
Desenvolvimento de Bancos de Dados para Implementação de softwares Educativos na Área de Endemias Usando a Dengue como Modelo. 2003
Desenvolvimento e avaliação do ambiente virtual de aprendizagem para doenças tropicais usando a dengue como modelo 2003
Erradicação da Dengue pela Educação: Desenvolvimento e avaliação do ambiente virtual de aprendizagem para doenças tropicais usando a dengue como modelo 2003
Theoretical analysis of a C-type lectin from Bothrops insularis (BiL) venom 2003
Diastereosseletividade em Reações de heteromercuração 2002
Design, Synthesis and Pharmacological Profile of Novel Dopamine D2 Receptor Ligands 2002
Síntese, Avaliação farmacológica e Desenvolvimento de Modelo Farmacofórico de Novos Análogos da Talidomida 2001
Planejamento, síntese e avaliação farmacológica de novos derivados ftalimídicos como candidatos a antagonistas de receptores 2001
Planejamento, síntese e avaliação farmacológica de novos compostos heterocíclicos candidatos a protótipos de agentes anti-psicóticos. 2001
Estudos de interação COX-2 ligantes: o papel do encaixe induzido na proposição de novos candidatos a agentes antiinflamatórios 2001
Modelagem Molecular de novos mode los Heterocíclicos Isosteros ao Antimalárico Mefloquina 2001
MODELAGEM MOLECULAR DE DERIVADOS N-ACILHIDRAZÔNICOS COM AÇÃO ANTINOCICEPTIVA 2000
SÍNTES, MODELAGEM MOLECULAR E AVALIAÇÃO FARMACOLÓGICA DE NOVOS ANÁLOGOS DE PIPERAMIDAS NATURAIS PLANEJADOS COMO NOVOS AGENTES CARDIODEPRESSORES 2000
DINÂMICA MOLECULAR DAS INTERAÇÕES DE NOVOS ANÁLOGOS DA TACRINA (THA) COM A ACETILCOLINESTERASE 2000
HOLOGRAM QSAR (HQSAR) OF ARTEMISININ ANALOGS 1999
MÉTODOS DE QSAR - ANÁLISE COMPARATIVA DE CAMPO MOLECULAR (CoMFA) E FRAGMENTOS ESTRUTURAIS (HQSAR) DE DERIVADOS ACILHIDRAZONA COMO INIBIDORES DE CRUZAÍNA 1999
PROPOSTA DE UM NOVO MODELO FARMACOFÓRICO 3D PARA O RECEPTOR DO PAF 1999
MODELAGEM MOLECULAR DE DERIVADOS PIRAZOLO[3,4-B] PIRIDINA CANDIDATOS A AGENTES ANTIMALÁRICOS 1999
A SEMIEMPIRICAL STUDY OF PYRAZOLE ACYLHYDRAZONES AS POTENTIAL ANTIMALARIAL AGENTS 1997
ESTUDO AM1 DE DERIVADOS PIRAZOLOPIRIDINA COMO PROVÁVEIS AGENTES ANTIMALÁRICOS. 1997
MODELAGEM MOLECULAR DE DERIVADOS ACIL-HIDRAZONAS COM POTENCIAL AÇÃO ANTIMALARIAL 1996
PROGRESSOS RECENTES NA DESCOBERTA DE NOVOS PROTÓTIPOS DE INIBIDORES ENZIMÁTICOS 1996
EFEITO ANTIINFLAMATÓRIO DE DERIVADOS ARIL-HIDRAZÔNICOS SOBRE A PLEURISIA INDUZIDA POR CARREGININA EM RATOS NORMAIS E SENSIBILIZADOS 1996
DRUG DESIGN OF NEW POTENTIAL 5-LIPOXIGENASE INHIBITORS AND DUAL THROMBOXANE SYNTHASE A2 RECEPTOR ANTAGONISTS BY AM1 1995
MOLECULAR MODELING STUDIES ON DRUGS RELATED TO THE THERAPY OF INFLAMMATORY AND CARDIOVASCULAR DISEASES 1995
Congresso de Físico-Química Orgânica, 1995
MODELAGEM MOLECULAR DE INIBIDORES NITROGENADOS DE 5-LIPOXIGENASE PELO MÉTODO AM1 1995
EFEITO ANTIINFLAMATÓRIO DE DERIVADOS ARIL-HIDRAZÔNICOS SOBRE A PLEURISIA RATOS NORMAIS E SENSIBILIZADOS 1995
Molecular Modeling Studies on Drugs Related to the Therapy of Inflammatory and Cardiovascular Diseases 1994
Estudo AM1 de Derivados 5-Tiofenilpirazolo e Proposta de Novos Inibidores da Enzima 5-LO 1994
Estudo AM1 de Derivados 5-Tiofenilpirazolo e Proposta de Novos Inibidores da Enzima 5-LO 1994
Um Estudo Conformacional da 5-Hidrazona Pirazola 1993
An AM1 Study of 5-Hydrazonepyrazole of Biological Interest 1993
Estudo Conformacional de derivados 5-Tiofenilpirazóis por Mecânica Molecular 1993
Síntese Estereosseletiva de Cis-2-Metil-5,6-Metilenodioxi-Indanol a partir do Safrol 1992
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