Ana Paula Cabral de Araujo Lima

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Biofísica Carlos Chagas Filho

Departamento:

Programa de Biofísica/I Biof

ORCID:

https://orcid.org/0000-0003-4631-2694


Formação:

  • University of Glasgow

    | Pós-Doutorado | 2008 - 2008

  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 1996 - 1997

  • McGill University

    Molecular Control of Cell Growth | Especialização | 1992 - 1992

  • McGill University

    Recent Advances in Molecular Genetics | Especialização | 1992 - 1992

  • McGill University

    Physiology of Blood I | Especialização | 1992 - 1992

  • McGill University

    Topics in Molecular Biology | Especialização | 1991 - 1991

  • McGill University

    Biology of Cancer | Especialização | 1991 - 1991

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Doutorado | 1990 - 1996

  • Universidade Federal do Rio de Janeiro

    | Graduação | 1986 - 1989
Laboratórios:
Nuvens de Palavras:
Artigos:

(73.13% artigos com DOI)

Titulo DOI Ano
The ecotin-like peptidase inhibitor of Trypanosoma cruzi prevents TMPRSS2-PAR2-TLR4 crosstalk downmodulating infection and inflammation 10.1096/fj.202302091rr 2024
A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas? disease 10.1016/j.pt.2024.02.002 2024
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response 10.3390/ijms24010656 2023
Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages 10.3389/fimmu.2022.801182 2022
Tissue Specific Dual RNA-Seq Defines Host-Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum 10.1128/spectrum.00679-22 2022
Subtilisin of Leishmania amazonensis as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor 10.3390/cimb44050141 2022
Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis 10.1128/iai.00324-22 2022
Bone marrow granulocytes downregulate IL-1β and TNF production and the microbicidal activity of inflammatory macrophages 10.1139/bcb-2021-0460 2022
Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host 10.1371/journal.pntd.0009526 2021
The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites 10.1038/s41598-021-97490-2 2021
Venom alkaloids against Chagas disease parasite: search for effective therapies 10.1038/s41598-020-67324-8 2020
Leishmanicidal therapy targeted to parasite proteases 10.1016/j.lfs.2019.01.015 2019
Neutrophil elastase promotes Leishmania donovani infection via interferon-β 10.1096/fj.201900524r 2019
Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects 10.1021/acsinfecdis.7b00244 2018
Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers 10.1074/jbc.m117.807180 2017
Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells 10.1096/fj.201700797r 2017
Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion 10.1371/journal.pone.0124832 2015
Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity 10.1371/journal.pntd.0003945 2015
Natural cysteine protease inhibitors in protozoa: Fifteeen years of the chagasin family 10.1016/j.biochi.2015.11.002 2015
Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNF  and IFN  10.1096/fj.13-245126 2014
Crovirin, a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania 10.1371/journal.pntd.0003252 2014
Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells 10.1016/j.bbadis.2012.12.003 2013
Cysteine Peptidase Inhibitors in Trypanosomatid Parasites 10.2174/0929867311320250009 2013
Yolk hydrolases in the eggs of Anticarsia gemmatalis Hubner (Lepidoptera: Noctuidae): A role for inorganic polyphosphate towards yolk mobilization 10.1016/j.jinsphys.2013.09.008 2013
Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L 10.1016/j.bbapap.2011.12.006 2012
Toll-Like Receptors in Leishmania Infections: Guardians or Promoters? 10.1155/2012/930257 2012
Cruzipain Promotes Trypanosoma cruzi Adhesion to Rhodnius prolixus Midgut 10.1371/journal.pntd.0001958 2012
Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation 10.1111/j.1462-5822.2012.01798.x 2012
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy 10.1111/j.1476-5381.2011.01609.x 2012
Leishmania INHIBITOR OF SERINE PEPTIDASE2 PREVENTS TOLL-LIKE 4 RECEPTOR ACTIVATION BY NEUTROPHIL ELASTASE PROMOTING PARASITE SURVIVAL IN MURINE MACROPHAGES 10.4049 2011
Cysteine Proteases in Differentiation of Embryonic Stem Cells into Neural Cells. 10.1089/scd.2010.0186 2011
Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection 10.1007/s00430-011-0216-z 2011
Detection of matrix metallopeptidase-9-like proteins in Trypanosoma cruzi 10.1016/j.exppara.2010.01.023 2010
Trypanosomatid-Encoded Inhibitors of Peptidases: Unique Structural Features and Possible Roles as Virulence Factors 10.2174/1874421401004010132 2010
Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major 10.1111/j.1462-5822.2008.01243.x 2009
Sorting of phosphoglucomutase to glycosomes in Trypanosoma cruzi is mediated by an internal domain 10.1093/glycob/cwp121 2009
Protease Activated Receptor Signaling Is Required for African Trypanosome Traversal of Human Brain Microvascular Endothelial Cells 10.1371/journal.pntd.0000479 2009
Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi. 2008
The role of conserved residues of chagasin in the inhibition of cysteine peptidases 10.1016/j.febslet.2008.01.008 2008
Interplay between acid phosphatase and cysteine proteases in mediating vitellin degradation during early embryogenesis of Periplaneta americana 10.1016/j.jinsphys.2008.04.005 2008
The propeptide of cruzipain-−-a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin-F 10.1111/j.1742-4658.2007.05666.x 2007
Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence 10.1111/j.1365-2958.2007.05970.x 2007
Calcium-regulated fusion of yolk granules is important for yolk degradation during early embryogenesis of Rhodnius prolixus Stahl 10.1242/jeb.02652 2007
1H, 15N and 13C assignments of the cysteine protease inhibitor Chagasin from Trypanosoma cruzi. 2006
The Substrate Specificity of Cruzipain 2, a Cysteine Protease Isoform from Trypanosoma cruzi. 2006
Effects of dibucaine on the endocytic/exocytic pathways on Trypanosoma cruzi. 2006
Blood brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease. 2006
Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi 10.4049/jimmunol.177.9.6325 2006
Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex 10.1016/j.micinf.2005.06.016 2006
Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa 10.1007/s00436-006-0195-y 2006
Solution Structure and Backbone Dynamics of the Trypanosoma cruzi Cysteine Protease Inhibitor Chagasin 10.1016/j.jmb.2006.01.064 2006
Chagasin, the endogenous cysteine protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and mammalian cell invasion. 2005
Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant. 2005
A New Cruzipain-Mediated Pathway of Human Cell Invasion by Trypanosoma cruzi Requires Trypomastigote Membranes 10.1128/IAI.72.10.5892-5902.2004 2004
Recombinant cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inactivation by inhibitors. 2001
Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi. 2001
Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi 10.1046/j.0014-2956.2001.02612.x 2001
Heparan Sulfate Modulates Kinin Release by Trypanosoma cruzi through the Activity of Cruzipain 10.1074/jbc.m108518200 2001
Altered expression of cruzipain and a cathepsin-B like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases. 2000
Identification and properties of two extracellular proteases from Brevundimonas diminuta. 2000
Host cell invasion by Trypanosoma cruzi is potentiated by activation of Bradykinin B2-receptors 2000
Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi. 1997
Identification of new cysteine protease gene isoforms in Trypanosoma cruzi. 1994
Analysis and partial epitope mapping of human T Cell responses to Trypanosoma cruzi cysteinyl proteinase. 1993
Use of Trypanosoma cruzi purified glycoprotein (Gp57/51) or trypomastigote shed antigens to access cure for human Chagas' Disease. 1993
Structural and enzymatic properties of the major cysteinyl proteinase from Trypanosoma cruzi. 1992
Temperature-dependent substrate inhibition of the cysteine protease (Gp57/51) from Trypanosoma cruzi. 1992
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Inhibitor of serine peptidase 2 (ISP2) of Leishmania major modulates parasite interaction with neutrophils 2011
Substrate inhibition and allosteric modulation of brucipain by heparan sulfate 2011
The inhibition of cysteine cathepsins in embryonic stem cells promotes neual differentiation 2011
Leishmania major inhibitor of serine peptidases, ISP2, prevents the activation of mammalian PKR, promoting parasite survival in macrophages 2011
Substrate inhibition and allosteric modulation of brucipain by heparan sulfate 2011
Cruzipain promotes Trypanosoma cruzi adhesion to Rhodnius prolixus midgut 2011
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathwayleading to chagasic vasculopathy 2011
Characterization of serine peptidase inhibitor (ISP2) of Trypanosoma cruzi 2011
Characterisation of the putative sialoglyco metallopeptidase-like gene of Leishmania major 2011
Cruzipain promotes Trypanosoma cruzi adhesion to Rhodnius prolixus explanted midguts 2010
Leishmania major encoded inhibitors of serine peptidase (ISPs) modulate de uptake and release of parasite from murine neutropils 2010
Infuence of Ecotin-like serine peptidase inhibitors of Leishmania major in parasite internalization and survival in murine dendritic cells 2010
Role of natural inhibitor of cysteine peptidase in Trypanosoma brucei. 2009
Influence on host cell invasion by serine peptidase inhibitor (ISP2) of Trypanosoma cruzi. 2008
Influence of inhibitors of serine peptidases of Leishmania major in the early stage of infection. 2008
Intracellular sorting of phosphoglucomutase to glycosomes in Trypanosoma cruzi. 2008
ICP regulation of Trypanosoma brucei cysteine peptidases: influence on parasite traversal of the blood brain barrier. 2007
Modulation of host neutrophil elastase by ecotin-like serine peptidase inhibitors (ISP) of Leishmania major: influence on parasite infectivity and survival. 2007
Characterization of Trypanosoma cruzi p67: a putative reservosome marker. 2007
The phosphoglucomutase (PGM) of Trypanosoma cruzi: mapping the import motifs responsible for the intracellular sorting to glycosomes. 2007
Characterization of the serine peptidase inhibitor (ISP2) of Trypanosoma cruzi. 2007
Distinct pathways of smooth muscle invasion by Trypanosoma cruzi Dm28 trypomastigotes: Differential roles of G Protein-coupled receptors, adenylyl cyclase and PI3 kinase mediated signaling. 2006
African trypanosomes traversal of the human blood-brain barrier requires cysteine protease mediated calcium signaling. 2006
Structural basis for the inhibitory function of chagasin: Different requirements for the inhibition of parasite versus host cysteine proteases. 2006
Role of ecotin-like serine peptidase inhibitors of Leishmania major in parasite internalization and survival in murine macrophages. 2006
Phosphoglucomutase (PGM) is located in the glycosomes of Trypanosoma cruzi. 2006
Molecular and biochemical characterization of the acyl-CoA-dependent ceramide synthase gene in Trypanosoma cruzi. 2006
Antileishmanial chalcones with increased in vitro activity against African trypanosomes. 2006
Trypanosomatid drug resistance: some cellular facets. 2006
Studies on the sub-cellular localization of phosphoglucomutase (PGM) in Trypanosoma cruzi. 2005
Alterations in traffic and pro-cruzipain maturation in Trypanosoma cruzi overexpressing chagasin. 2005
Studies on the chagasin family of cysteine peptidase inhibitors. 2005
Alterations in Traffic, Lipid Biosynthesis and Pro-Cruzipain Maturation in Trypanosoma cruzi Overexpressing Chagasin. 2005
The Substrate specificity of the cysteine peptidase of Trypanosoma b. brucei, brucipain and its inactivation by natural cysteine peptidase inhibitors. 2005
Potent inhibition of cathepsin F and of cysteine proteases from trypanosomes (cruzipain and brucipain) by the propeptide of cruzipain. 2005
Interplay between parasite cysteine proteases and the host kinin system modulates vascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex. 2005
Brucipain takes a tryp across the Blood-Brain Barrier. 2005
Chagasin contributes to post-transcriptional regulation of cruzipain function. 2004
Cloning and heterologous expression of the cysteine protease from Trypanosoma brucei brucei (brucipain) and characterization of temperature dependent substrate inhibition. 2004
High affinity inhibition of cysteine proteases from diverse pathogenic trypanosomatids by the pro domain of cruzipain. 2004
Heterologous expression of Trypanosoma cruzi phosphoglucomutase (PGM) in Saccharomyces cerevisiae and functional complementation of yeast pgm null mutant. 2004
The activation of precursor forms of the T. cruzi main cysteine protease, cruzipain, is modulated by glycosaminoglicans and by mildly acidic pH. 2004
Modulation of the cysteine protease of T. brucei brucei (brucipain) by glycosaminoglicans and enzyme inactivation by the N-terminal domain (pro domain) of cruzipain. 2004
Role of dibucaine in the endocytic and exocytic pathway of epimastigote forms of Trypanosoma cruzi. 2004
Analysis of the phosphoglucomutase (PGM) gene among different stocks of T. cruzi. 2004
Chronic heart fibrosis is attenuated in B1 knockout mice infected by Trypanosoma cruzi. 2004
Cloning and expression of a recombinant cysteine protease (TFCP1) from Thrithrichomonas foetus. 2003
Post-Transcriptional regulation of cruzipain by the endogenous inhibitor chagasin 2003
Cloning, expression and characterization of the cysteine proteases from Trypanosoma brucei brucei (brucipain) and Leishmania donovani. 2003
Potent inhibition of trypanosomatid cysteine proteases by the pro domain of cruzipain. 2003
Cloning and characterization of the phosphoglucomutase (PGM) gene from Trypanosoma cruzi. 2003
Chagasin regulates cruzipain activity, maturation and intracellular traffic in Trypanosoma cruzi. 2003
Targeting of Trypanosoma cruzi cysteine proteinases by synthetic inhibitors depends on endocytosis. 2002
Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain. 2002
Maturation of pro-cruzipain1 by cruzipain2: Evidence for trans-activation "in vivo". 2002
Over-expression of chagasin, a cysteine protease inhibitor of T. cruzi, modulates the maturation of pro-cruzipain and the suceptibility of epimastigotes to synthetic cysteine protease inhibitors. 2002
Characterization of chagasin-like cysteine protease inhibitors in Leishmania amazonensis, Leishmania donovani and Tritrichomonas foetus. 2001
Heparan sulfate modulates kinin-release by Trypanosoma cruzi through the activity of cruzipain. 2001
Activation of the inducible B1-kinin receptor (B1) by Trypanosoma cruzi: host cell susceptibility. 2001
Infectivity of Trypanosoma cruzi trypomastigotes depends on the activity of extracellular cruzipain. 2001
Correlation between cruzipain expression and Trypanosoma cruzi infectivity "in vitro" 2000
Signaling through the inducible bradykinin receptor (B1R) increases host cell suceptibility to invasion by Trypanosoma cruzi. 2000
Specificity determinants of cruzipain isoforms 2000
Protozoa cystine-proteases as markers for the study of endocytic function in primitive eucaryotic cells 2000
Substrate specificity of a major cysteine proteinase from Plasmodium falciparum (falcipain) characterized by fluorescent internally quenched substrates. 2000
Molecular dynamics simulation of cruzain and cruzipain 2: the S2 specificity pocket. 2000
Molecular basis of activation of vascular endothelium by Trypanosoma cruzi: role of kininogens, kinins and bradykinin receptors. 2000
Characterization of the substrate specificity of cysteine protease isoforms from Trypanosoma cruzi: a comparative study between cruzipain 2 and cruzain. 1999
Expression of cruzipain and of a cathepsin B like target (Tc-cb) is inverted in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine proteinases. 1999
Gene transfection of Trypanosoma cruzi with a minor cysteine proteinase isoform (cruzipain 2) but not cruzain, potentiates trypomastigote infectivity in mammalian cells "in vitro". 1999
Molecular modeling of the inhibition of cysteine proteases from Trypanosoma cruzi by E-64. 1998
Molecular characterization of chagasin, a Trypanosoma cruzi inhibitor of papain like cysteinyl proteinases. 1998
The transfection of Trypanosoma cruzi cell lines with the gene of the cysteine protease isoform cruzipain 2 enhances parasite infectivity in host cells. 1998
Trypanosoma cruzi resistance to synthetic inhibitors of cysteine-proteinases correlates with changes in the expression of target enzymes and membrane permeability. 1998
Recombinant cysteine protease isoforms from Trypanosoma cruzi (Cruzain and cruzipain 2) show marked differences to inhibitor sensitivity. 1998
Inhibition studies of cysteine proteases from Trypanosoma cruzi by molecular modeling. 1998
Immunochemical characterization of cruzipain isoforms during Trypanosoma cruzi development. 1998
Preliminary characterization of Trypanosoma cruzi cell lines transfected with the cysteine protease isoform cruzipain 2. 1997
Multiple mechanisms determine drug resistance against peptidyl-based inhibitors of Trypanosoma cruzi. 1997
Characterization of a Trypanosoma cruzi population resistant to synthetic irreversible cysteine protase inhibitors. 1996
The kinin releasing activity of cysteinyl proteinases from Trypanosoma cruzi: a factor of parasite virulence and pathogenicity ? 1996
The Major Cysteine Proteinase From Trypanosoma Cruzi: Phenotypic Cha- Racterization Of A Parasite Sub-Population Selected For Resistance Against Irreversible Synthetic Inhibitors. 1995
The Minor Cysteine Proteinase From Trypanosoma Cruzi:Identification Inparasite Population Selected For Resistance To Synthetic Inhibitors. 1995
Synthesis cf coumarin-containing peptides and their hydrolysis by cysteine proteases. 1995
Preliminary Characterization Of Recombinant Cruzipain 2, A New Cystei-Ne Protease Isoform From Trypanosoma Cruzi. 1994
Structure And Functional Diversities In Trypanosoma Cruzi Cysteinyl Protease. 1994
Genetic Diversity Of Cysteinyl Proteinases From Trypanosoma Cruzi. 1993
Temperature dependent substrate inhibition of the cysteine protease (Gp57/51) from Trypanosoma cruzi. 1992
Cloning and expression of cruzipain 2, a new cysteine protease of Trypanosoma cruzi. 1992
Cloning Of Cruzipain 2, A New Cysteine Protease From Trypanosoma Cruzi 1992
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