Mychael Vinícius da Costa Lourenço
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Bioquímica Médica
Departamento:
Programa de Biologia Molecular e Biotecnologia
e-mail:
mychael@bioqmed.ufrj.br
Linkedin:
https://www.linkedin.com/in/mychael-lourenco-333808b5/
Google Scholar:
https://scholar.google.com/citations?user=fig3DLgAAAAJ
ORCID:
https://orcid.org/0000-0002-1078-0296
Formação:
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2016 - 2018
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Universidade Federal do Rio de Janeiro
Química Biológica | Doutorado | 2012 - 2016
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Universidade Federal do Rio de Janeiro
Química Biológica | Mestrado | 2010 - 2012
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Universidade Federal do Rio de Janeiro
Ciências Biológicas (Genética) | Graduação | 2007 - 2010
Laboratórios:
Nuvens de Palavras:
Artigos:
(92.68% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Irisin limits amyloid-β buildup in Alzheimer?s disease | 10.1016/j.tem.2023.11.006 | 2024 |
| Effects of gestational exercise on nociception, BDNF, and irisin levels in an animal model of ADHD | 10.1016/j.neuroscience.2024.02.008 | 2024 |
| Cross-species comparative hippocampal transcriptomics in Alzheimer?s disease | 10.1016/j.isci.2023.108671 | 2024 |
| Brain FNDC5/irisin expression in patients and mouse models of major depression | 10.1523/ENEURO.0256-22.2023 | 2023 |
| Promoting diversity and overcoming publication barriers in Latin American neuroscience and Alzheimer's disease research: A call to action | 10.1002/trc2.12378 | 2023 |
| The unfolded protein response transcription factor XBP1s ameliorates Alzheimer?s disease by improving synaptic function and proteostasis | 10.1016/j.ymthe.2023.03.028 | 2023 |
| Emerging concepts towards a translational framework in Alzheimer?s disease | 10.1016/j.neubiorev.2023.105246 | 2023 |
| Preface: Special issue ¿Brain Proteostasis in Health and Disease¿ | 10.1111/jnc.15879 | 2023 |
| Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia | 10.1002/alz.12893 | 2023 |
| : Interview with Brain Proteostasis Special Issue Guest Editor Mychael Lourenco | 10.1111/jnc.15888 | 2023 |
| Association of the fibronectin type III domain-containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans | 10.1093/braincomms/fcad216 | 2023 |
| Synaptic proteasome is inhibited in Alzheimer?s disease models and associates with memory impairment in mice | 10.1038/s42003-023-05511-9 | 2023 |
| Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD | 10.1016/j.pnpbp.2022.110555 | 2022 |
| Editorial: Honouring John Hardy - A true pioneer in research | 10.1111/jnc.15593 | 2022 |
| Irisin stimulates protective signaling pathways in rat hippocampal neurons | 10.3389/fncel.2022.953991 | 2022 |
| Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans | 10.1038/s41398-022-02208-1 | 2022 |
| Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease | 10.1126/scisignal.abc5429 | 2021 |
| Cerebrospinal Fluid Neurotransmitters, Cytokines, and Chemokines in Alzheimer?s and Lewy Body Diseases | 10.3233/JAD-210147 | 2021 |
| How does the skeletal muscle communicate with the brain in health and disease? | 10.1016/j.neuropharm.2021.108744 | 2021 |
| The Next 50 Years of Neuroscience | 10.1523/JNEUROSCI.0744-19.2019 | 2020 |
| Cerebrospinal fluid irisin correlates with amyloid¿β, BDNF, and cognition in Alzheimer's disease | 10.1002/dad2.12034 | 2020 |
| Protective actions of exercise¿related FNDC5/Irisin in memory and Alzheimer?s disease | 10.1111/jnc.15039 | 2020 |
| Amyloid-β oligomers in cellular models of Alzheimer?s disease | 10.1111/jnc.15030 | 2020 |
| Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer?s models | 10.1038/s41591-018-0275-4 | 2019 |
| Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects | 10.3389/fnins.2018.00037 | 2018 |
| Metabolic Dysfunction in Alzheimer?s Disease: From Basic Neurobiology to Clinical Approaches | 10.3233/jad-179911 | 2018 |
| Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice | 10.1074/jbc.m116.761189 | 2017 |
| Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons | 10.1074/jbc.m116.753525 | 2017 |
| The malleable brain: plasticity of neural circuits and behavior | 2017 | |
| Integrated Stress Response: Connecting ApoE4 to Memory Impairment in Alzheimer's Disease | 10.1523/jneurosci.4110-15.2016 | 2016 |
| Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students | 10.1111/jnc.13713 | 2016 |
| d-serine levels in Alzheimer's disease: implications for novel biomarker development | 10.1038/tp.2015.52 | 2015 |
| Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer?s disease | 10.3389/fncel.2015.00191 | 2015 |
| Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer?s disease | 10.3389/fnagi.2015.00094 | 2015 |
| Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes | 10.1016/j.pneurobio.2015.03.003 | 2015 |
| How does brain insulin resistance develop in Alzheimer?s disease? | 10.1016/j.jalz.2013.12.004 | 2014 |
| Targeting Alzheimer's pathology through PPARγ signaling: modulation of microglial function | 10.1523/JNEUROSCI.0172-13.2013 | 2013 |
| 2,4-dinitrophenol induces neural differentiation of murine embryonic stem cells | 10.1016/j.scr.2013.09.016 | 2013 |
| TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer?s β-amyloid oligomers in mice and monkeys | 10.1016/j.cmet.2013.11.002 | 2013 |
| Parâmetros de avaliação de patologias em obras-de-arte especiais | 2009 | |
| Verificação da corrosão e de outras patologias em pontes metálicas | 2009 |
Eventos:
(3.12% eventos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| FNDC5/irisin links physical exercise to neuroprotection in mouse models of Alzheimer?s disease | 2019 | |
| Neuroprotective actions of physical exercise in mouse models of Alzheimer?s disease | 2016 | |
| D-serine levels in Alzheimer's disease: implications for novel biomarker development | 2015 | |
| Increased D-serine levels as a potential biomarker in Alzheimer's disease | 2015 | |
| An inflammatory pathway towards synapse and cognitive impairment triggered by amyloid-β oligomers | 2014 | |
| Alzheimer-linked amyloid-β oligomers deregulate brain AMPK in mice and monkeys | 2014 | |
| PKR-dependent stress signaling underlies memory impairment caused by Alzheimer?s disease-linked amyloid-β oligomers | 2014 | |
| PKR-dependent phosphorylation of eIF2α is linked to impaired neuronal insulin signaling in Alzheimer's disease | 2013 | |
| TNF-α/PKR-dependent eIF2α phosphorylation and insulin signaling inhibition are linked to memory impairment triggered by Aβ oligomers in Alzheimer?s disease | 2013 | |
| TNF-α- and PKR-dependent phosphorylation of eIF2α is linked to defective brain insulin signaling and memory impairment caused by Alzheimer?s Aβ oligomers | 2013 | |
| Endoplasmic reticulum stress links impaired insulin signaling and Alzheimer's disease | 2012 | |
| Endoplasmic reticulum stress links impaired insulin signaling and Alzheimer?s disease | 2012 | |
| Amyloid-β peptide oligomers impair neuronal energy metabolism disrupting AMPK signaling | 2012 | |
| Endoplasmic reticulum stress links impaired insulin signaling and Alzheimer's disease | 2011 | |
| Characterization of primary and secondary injury in experimental compressive encephalic trauma | 2011 | |
| Alzheimer's toxic amyloid-beta oligomers induce endoplasmic reticulum stress in mature hippocampal neuronal cultures | 10.1111/j.1471-4159.2011.07325.x | 2011 |
| Oligômeros do peptídeo beta-amilóide induzem estresse de retículo endoplasmático em neurônios hipocampais | 2011 | |
| Disfunção da sinalização de insulina no cérebro de um modelo transgênico para a doença de Alzheimer | 2011 | |
| Investigação histológica, bioquímica e comportamental na lesão secundária ao trauma encefálico experimental e possíveis correlações com a fisiopatologia da doença de Alzheimer | 2011 | |
| Estratégias anti-diabetes bloqueiam o estresse de retículo endoplasmático induzido pelos oligômeros tóxicos do peptídeo beta-amilóide em neurônios hipocampais | 2011 | |
| Alzheimer's toxic amyloid-beta oligomers induce endoplasmic reticulum stress in mature hippocampal neuronal cultures | 2011 | |
| 2,4-dinitrophenol induces neural differentiation of murine embryonic stem cells | 2011 | |
| Impacto sobre o controle da produção de D-serina em modelos da doença de Alzheimer | 2011 | |
| Metabolic reprogramming of lung cancer cell induced by sodium butyrate: studies on mitochondrial physiology and bioenergetics | 2010 | |
| Characterization of compressive brain trauma: possible participation of Alzheimer's beta-amyloid oligomers in the secondary injury | 2010 | |
| 2,4-dinitrophenol induces neural differentiation in embryonic stem cells | 2010 | |
| Análise ultraestrutural, bioquímica e transcriptômica do trauma crânio encefálico extra-axial | 2010 | |
| Diferenciação neuronal de células-tronco embrionárias induzida pelo 2,4-dinitrofenol | 2010 | |
| Investigação histológica, bioquímica e comportamental na injúria cerebral secundária ao trauma experimental e possíveis correlações com a fisiopatologia da doença de Alzheimer | 2010 | |
| Metabolic reprogramming of lung cancer cell induced by sodium butyrate: studies on mitochondrial physiology and bioenergetics | 2010 | |
| Corrosion in Brazilian reinforced concrete bridges | 2008 | |
| Análise do impacto ambiental da construção de pontes e viadutos sobre ambientes aquáticos e ambientes terrestres nativos | 2007 |