Marcius da Silva Almeida

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Centro Nacional de Biologia Estrutural e Bioimagem

Departamento:

Diretoria Adjunta de Ensino

e-mail:

msalmeida@bioqmed.ufrj.br

Linkedin:

https://br.linkedin.com/in/marcius-almeida-4675a53b?trk=people-guest_people_search-card&challengeId=AQFf2sT6AoItQAAAAXMZp2d3qKxOKT0eqvbjTIBv-aZoR1QAJlse4U0WNszpxzz1dKUE-N8fMOJIbEQprfHU7i-V_RaK9T6cVg&submissionId=74c1a48f-328a-1e16-13b1-4928e2726664

Google Scholar:

ORCID:

https://orcid.org/0000-0003-4921-8185

Formação:

  • Centre de RMN à très hauts champs

    | Pós-Doutorado | 2013 - 2013

  • The Scripps Research Institute

    | Pós-Doutorado | 2003 - 2006

  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2002 - 2003

  • Universidade Federal do Rio de Janeiro

    Química Biológica | Doutorado | 1997 - 2001

  • Universidade Federal do Rio de Janeiro

    Farmacia | Graduação | 1993 - 1997
Laboratórios:
Nuvens de Palavras:
Artigos:

(98.08% artigos com DOI)

Titulo DOI Ano
Development and assessment of a multiepitope synthetic antigen for the diagnosis of Dengue virus infection 10.1016/j.bjid.2024.103746 2024
Mutations in asparaginase II from E. coli and implications for inactivation and PEGylation 10.1016/j.bpc.2023.107041 2023
Accuracy of a raw saliva-based COVID-19 RT-LAMP diagnostic assay 10.1016/j.bjid.2023.102790 2023
Modified Asparaginase For Treatment Of CancerHistorical appraisal and future perspectives 10.2174/2452271606666230104143806 2023
Copper drives prion protein phase separation and modulates aggregation 10.1126/sciadv.adi7347 2023
Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids 10.1016/j.ijbiomac.2022.01.121 2022
Phase separation of the mammalian prion protein: physiological and pathological perspectives 10.1111/jnc.15586 2022
Formation of subvisible particles in commercial insulin formulations 10.1016/j.colsurfb.2022.112566 2022
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development 10.1002/anie.202205858 2022
Novel Method for the Production, Purification, and Characterization of Recombinant Lunasin: Identification of Disulfide Cross-Linked Dimers 10.1007/s10989-022-10466-2 2022
Biophysical characterization of two commercially available preparations of the drug containing Escherichia coli L-Asparaginase 2 10.1016/j.bpc.2021.106554 2021
Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo 10.1016/j.ymthe.2021.04.035 2021
Three-Finger Toxins from Brazilian Coral Snakes: From Molecular Framework to Insights in Biological Function 10.3390/toxins13050328 2021
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications 10.3389/fmolb.2021.653148 2021
The 1H, 15N, and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus 10.1007/s12104-021-10027-6 2021
New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells 10.3390/ijms222312885 2021
Unambiguous characterization of site on human amylin by two-dimensional nuclear magnetic resonance spectroscopy 10.1002/pep2.24252 2021
Phase Separation and Disorder-to-Order Transition of Human Brain Expressed X-Linked 3 (hBEX3) in the Presence of Small Fragments of tRNA 10.1016/j.jmb.2020.02.030 2020
Brazilian three-finger toxins: What can we learn? From molecular framework to insights in biological function 10.1016/j.toxicon.2019.12.129 2020
Liquid-liquid phase separation and fibrillation of the prion protein modulated by a high-affinity DNA aptamer 10.1096/fj.201901897R 2019
Properties of novel surfactin-derived biosurfactants obtained through solid-phase synthesis 10.1002/psc.3129 2018
Monitoring asparaginase activity 10.1016/s1470-2045(18)30656-9 2018
Comprehensive structural analysis of designed incomplete polypeptide chains of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus 10.1371/journal.pone.0182132 2017
1H, 13C and 15N chemical shift assignment of lissencephaly-1 homology (LisH) domain homodimer of human two-hybrid-associated protein 1 with RanBPM (Twa1) 10.1007/s12104-017-9787-y 2017
Ligand-free method to produce the anti-angiogenic recombinant Galectin-3 carbohydrate recognition domain 10.1016/j.pep.2017.11.006 2017
The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role Against α-Synuclein Oligomers 10.1074/jbc.M115.662254 2015
Biophysical Studies on BEX3, the p75NTR-Associated Cell Death Executor, Reveal a High-Order Oligomer with Partially Folded Regions 10.1371/journal.pone.0137916 2015
1H-, 13C- and 15N-NMR assignment of the N-terminal domain of human cerebral dopamine neurotrophic factor (CDNF) 10.1007/s12104-012-9388-8 2013
Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species 10.1021/ja106725p 2011
Structural and Functional Study of Yer067w, a New Protein Involved in Yeast Metabolism Control and Drug Resistance 10.1371/journal.pone.0011163 2010
Heterologous expression and purification of a biologically active legume lectin from Cratylia mollis seeds (CRAMOLL 1) 10.1016/j.bbapap.2010.06.004 2010
Mapping the Interactions between a Major Pollen Allergen and Human IgE Antibodies 10.1016/j.str.2010.05.012 2010
Sequence-specific 1H, 15N and 13C resonance assignments of Art v 1: a proline-rich allergen of Artemisia vulgaris pollen 10.1007/s12104-009-9151-y 2009
Improved biocontrol of fruit decay fungi with Pichia pastoris recombinant strains expressing Psd1 antifungal peptide 10.1016/j.postharvbio.2007.06.010 2008
Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cells 10.1074/jbc.M802102200 2008
Evolutionary relationship between defensins in the Poaceae family strengthened by the characterization of new sugarcane defensins 10.1007/s11103-008-9372-y 2008
Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus. 10.1128/jvi.01939-06 2007
NMR Structure and Functional Characterization of a Human Cancer-related Nucleoside Triphosphatase. 10.1016/j.jmb.2007.01.001 2007
Structure of the Ebola fusion peptide in a membrane-mimetic environment and the interaction with lipid rafts. 10.1074/jbc.M611864200 2007
NMR Structure of the N-terminal Domain of the Nonstructural Protein 3 from the SARS Coronavirus. 10.1128/JVI.00969-07 2007
NMR assignment of the SARS-CoV protein nsp1. 10.1007/s10858-006-9018-9 2006
NMR assignment of the protein nsp3a from SARS-CoV 10.1007/s10858-006-9017-x 2006
NMR assignment of a human cancer-related nucleoside triphosphatase 10.1007/s10858-006-9042-9 2006
NMR structure of the conserved hypothetical protein TM0487 from Thermotoga maritima: Implications for 216 homologous DUF59 proteins 10.1110/ps.051755805 2005
1H-, 13C- and 15N-NMR Assignment of the Conserved Hypothetical Protein TM0487 from Thermotoga Maritima 10.1023/b:jnmr.0000032522.43753.f1 2004
Expression of Pisum sativum defensin 1 (Psd1) in shaking flasks and bioreactor cultivations of recombinant Pichia pastoris at different pHs 10.1590/s0104-66322004000200004 2004
Production of the active antifungal Pisum sativum defensin 1 (Psd1) in Pichia pastoris: overcoming the inefficiency of the STE13 protease 10.1016/s1046-5928(03)00136-0 2003
Optimized expression of a thermostable xylanase from Thermomyces lanuginosus in Pichia pastoris. 10.1128/aem.69.10.6064-6072.2003 2003
Solution structure of Pisum sativum defensin 1 by high resolution NMR: plant defensins, identical backbone with different mechanisms of action. 10.1006/jmbi.2001.5252 2002
Como Purificar Proteínas? 2002
cDNA cloning and heterologous expression of Pisum sativum defensin 1 (Psd1) in Pichia pastoris 10.1006/abbi.2001.2564 2001
CARACTERIZATION OF TWO NOVEL DEFENSE PEPTIDES FROM PEA (Pisum sativum) SEEDS 10.1006/abbi.2000.1824 2000
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
STRUCTURAL AND FUNCTIONAL STUDIES OF ERLIN-2: AN ENDOPLASMIC RETICULUM MEMBRANE PROTEIN INVOLVED IN HUMAN BREAST CANCER 2013
Functional Characterization of Two Hybrid Associated Protein 1 with RanBPM (Twa1), a New Nuclear Protein Related to Cancer 2012
Toward the structure determination of Erlin-2: an ER-membrane protein related to breast cancer pathogenesis 2012
Characterization of the Interaction of GDNF mimetic peptides with its co-receptor GFRalfa1. 2011
The effect of heparin length on interaction with the prion protein 2011
STRUCTURAL CHARACTERIZATION OF BEX3 (AN INTRINSICALLY UNSTRUCTURED P75NTR-ASSOCIATED CELL DEATH EXECUTOR) 2011
Functional Characterization of a new Conserved Dopamine Neurotrophic Factor with Important Role in the Protection of the Parkinson ?s Disease Progression 2011
Proteomic Characterization of Molecular Changes in Breast Cancer 2011
STRUSCTURAL STUDIES WITH THE CEREBRAL DOPAMINE NEUROTROPHIC FACTOR (CDNF) AND ITS NEUROPROTECTIVE EFFECTS AGAINST THE TOXICITY OF ALPHA-SYNUCLEIN AGGREGATES. 2011
STRUCTURAL CHARACTERIZATION OF NADE (AN INTRINSICALLY UNSTRUCTURED P75NTR-ASSOCIATED CELL DEATH EXECUTOR) 2010
STRUCTURAL STUDIES WITH CONSERVED DOPAMINE NEUROTROPHIC FACTOR, A NOVEL NEUROTROPHIC FACTOR IN PARKINSON?S DISEASE 2010
Prion protein interaction with low molecular weight heparin. 2010
Engineering of Human Cancer-related Proteins for NMR spectroscopy 2009
STRUCTURAL BIOLOGY REVEALS A NEW PROTEIN FAMILY FROM S.CEREVISIAE WITH A NOVEL FOLD AND IMPLICATED IN THE METABOLISM CONTROL AND DRUG RESISTANCE 2009
Expression of Active Cratylia mollis Seed Lectin (CRAMOLL 1) in Escherichia coli 2009
Prion protein interaction with heparin 2009
SOLUTION NMR STUDIES OF PSD1: CORRELATION BETWEEN BACKBONE DYNAMICS AND MEMBRANE INTERACTION 2008
HOW STABLE IS AN ENZYME FROM A THERMOPHILIC ORGANISM? DENATURATION STUDIES WITH THE ESTERASE FROM PYROCOCCUS FURIOSUS ? IMPLICATIONS IN BIOTECHNOLOGY 2008
A NOVEL FOLD AND A NEW PROTEIN FAMILY: STRUCTURAL CHARATERIZATION OF YER067W PROTEIN OF S. cerevisiae 2008
BEYOND GENOMES: STRUCTURE AND FUNCTION OF HUMAN CANCER-RELATED PROTEINS 2008
INVESTIGATION OF THE EFFECT OF HEPARIN ON PRION PROTEIN STRUCTURE 2008
CHARACTERIZATION OF THE PRP:RNA COMPLEX: STRUCTURAL INSIGHTS AND TOXICITY STUDIES 2008
Solution structure of Art v1: a pollen allergen with defensin fold 2008
Beyond Genomes: Structure and Function of Human Cancer Related Proteins 2007
SUGAR-CANE DEFENSINS SD3, SD4 AND SD6: ACTIVITY AND STRUCTURAL FEATURES 2007
BEYOND GENOMES: STRUCTURE AND FUNCTION OF HUMAN CANCER-RELATED PROTEINS 2007
FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF TWO DEFENSINS FROM SUGARCANE: Sd1 AND Sd5 2007
SCREENING UNCHARACTERIZED HYDROSTATIC PRESSURE STRESS PROTEINS FROM SACCHAROMYCES CEREVISIAE FOR STRUCTURE DETERMINATION BY SOLUTION NMR 2007
Biocontrol activity of recombinant Pichia pastoris constitutively secreting Psd1 defensin against blue mold of apple 2006
Structural genomics using solution NMR 2005
Backbone dynamics of recombinant 15N-Psd1 (Pisum sativum defensin 1) studied by 15N relaxation NMR parameters 2005
Purification and structural characterization of two putative defensins (sd1 and sd4) from sugarcane 2005
The use of solution nmr to study the protein-membrane interaction 2005
Targeting Novel Proteins For Cancer Therapy: Target Selection And Establishment of Protocols 2004
Backbone Dynamics of Psd1 Studied by N Relaxation NMR Parameters 2004
Heterologus Expression and Characterization of Putative Defensin from Sugarcane (SD1) In. P. Pastoris and E. coli 2004
Heterologous Expression And Characterization Of Sd1: A Novel Putative Defensin Identified From The Sucest Ests Data Bank 2003
Morphological Aspect of Filamentous Fungi in the Presence of Pea Defensins Psd1 and Psd2. 2003
cDNA cloning of human rotavirus spike-protein (VP8*) 2002
Assigning function from 3D homology: the strategy used for Pisum sativum defensin 1 2002
Cloning and heterologous expression of Pisum sativum defense protein 2 (Psd2) in Pichia pastoris 2002
cDNA cloning of human rotavirus spike-protein (VP8*) 2002
Expressão Em Fermentador De Defensina 1 De Pisum SATIVUM (Psd1) Empregando Pichia Pastoris Recombinante 2002
Solution structure of Pisum sativum defensin 1 (Psd1) by high resolution NMR 2001
expression of a Thermomyces xylanase in Pichia pastoris 2001
Fermentor expression of the recombinant Pisum sativum defensin 1 (PSD1) in Pichia pastoris 2001
Heterologous expression of thermomyces xylanase cDNA in pichia pastoris 2001
Characterization of antifungal activity of Psd2 defensin 2001
Cloning of Pisum sativum defense protein 1 (Psd1) 2000
The effect of rhodnius prolixus eggshell derived proteins on fungi growth 2000
Caracterização da atividade antifúngica antifúngica da defensina Psd2 isolada de semente de ervilha 2000
Cloning of Plant defensin psdf1 from pea (Pisum sativum) seeds 1999
Solution structure of defense peptide isolated from seeds of pea (Pisum sativum) determined by high resolution NMR 1998
Characterization of two defense peptides isolated from pea (Pisum sativum) seeds. 1998
Immunolocalization and cross reactivity of pea defensins 1998
Isolation and Characterization of two defense Peptides from pea (Pisum sativum) seeds 1997
Isolation and functional characterization of two defense peptides from pea (Pisum sativum) seeds. 1997
Cross-reactivity between inducible Nitric Oxide Sinthase and Pea Defensins 1997
Purification and sequencing of a toxic peptide from seeds of pea (Pisum sativum). 1996
Purificação e Caracterização de uma proteína de Defesa Isolada de Sementes de Ervilha (Pisum sativum) 1996
Purification and Biological Characterization of a Toxic Protein from seeds of pea (Pisum sativum). 1995
Purificação Parcial e Caracterização Biológica de uma Proteína Tóxica de Sementes de Ervilha (Pisum sativum) 1995
Contruction of a plasmid carrying the rat m1 muscarinic receptor subtype cDNA for expression in yeast 1994
Construção de um Plasmídeo Contendo o cDNA de Receptor Muscarínico Subtipo m1 de Rato para Expressão em Leveduras 1994
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