Pedro Lagerblad de Oliveira
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Bioquímica Médica
Departamento:
Programa de Biologia Estrutural
Formação:
-
Universidade Federal do Rio de Janeiro
| Doutorado | 1985 - 1990
-
Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Mestrado | 1983 - 1985
-
Universidade Federal do Rio de Janeiro
| Graduação | 1979 - 1982
Laboratórios:
Nuvens de Palavras:
Artigos:
(91.49% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Immunometabolic crosstalk in Aedes fluviatilis and Wolbachia pipientis symbiosis | 10.1016/j.jbc.2024.107272 | 2024 |
| Export of heme by the feline leukemia virus C receptor regulates mitochondrial biogenesis and redox balance in the hematophagous insect Rhodnius prolixus | 10.1096/fj.202301671rr | 2024 |
| Juvenile Hormone as a contributing factor in establishing midgut microbiota for fecundity and fitness enhancement in adult female Aedes aegypti | 10.1038/s42003-024-06334-y | 2024 |
| The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme-induced peroxidase | 10.1371/journal.ppat.1011149 | 2023 |
| Alterations in energy metabolism of Rhodnius prolixus induced by Trypanosoma rangeli infection | 10.1016/j.ibmb.2023.103987 | 2023 |
| eIF3 subunit M regulates blood meal digestion in Rhodnius prolixus affecting ecdysis, reproduction, and survival | 10.1111/1744-7917.13174 | 2023 |
| Exploring dose-response relationships in Aedes aegypti survival upon bacteria and arbovirus infection | 10.1016/j.jinsphys.2023.104573 | 2023 |
| Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes | 10.1016/j.ibmb.2022.103720 | 2022 |
| Coxiella Endosymbiont of Rhipicephalus microplus Modulates Tick Physiology With a Major Impact in Blood Feeding Capacity | 10.3389/fmicb.2022.868575 | 2022 |
| Sexual Dimorphism in Immune Responses and Infection Resistance in Aedes aegypti and Other Hematophagous Insect Vectors | 10.3389/fitd.2022.847109 | 2022 |
| Atypical strategies for cuticle pigmentation in the blood-feeding hemipteran Rhodnius prolixus | 10.1093/genetics/iyac064 | 2022 |
| Wolbachia pipientis modulates metabolism and immunity during Aedes fluviatilis oogenesis | 10.1016/j.ibmb.2022.103776 | 2022 |
| Zika virus infection drives epigenetic modulation of immunity by the histone acetyltransferase CBP of Aedes aegypti | 10.1371/journal.pntd.0010559 | 2022 |
| A fat body transcriptome analysis of the immune responses of Rhodnius prolixus to artificial infections with bacteria | 10.1186/s13071-022-05358-9 | 2022 |
| Metal ions in the physiology of insects | 10.1016/j.cois.2022.100965 | 2022 |
| Characterization of the Temporal Pattern of Blood Protein Digestion in Rhodnius prolixus: First Description of Early and Late Gut Cathepsins | 10.3389/fphys.2020.509310 | 2021 |
| Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis | 10.1371/journal.pbio.3000796 | 2021 |
| Rhodnius prolixus uses the peptidoglycan recognition receptor rpPGRP-LC/LA to detect Gram-negative bacteria and activate the IMD pathway | 10.1016/j.cris.2020.100006 | 2021 |
| An insight into the functional role of antioxidant and detoxification enzymes in adult Rhipicephalus microplus female ticks | 10.1016/j.parint.2020.102274 | 2021 |
| -Urate and NOX5 Control Blood Digestion in the Hematophagous Insect Rhodnius prolixus- | 10.3389/fphys.2021.633093 | 2021 |
| Non-immune Traits Triggered by Blood Intake Impact Vectorial Competence | 10.3389/fphys.2021.638033 | 2021 |
| Chloroquine inhibits pro-inflammatory effects of heme on macrophages and in vivo | 10.1016/j.freeradbiomed.2021.07.028 | 2021 |
| Aedes fluviatilis cell lines as new tools to study metabolic and immune interactions in mosquito-Wolbachia symbiosis | 10.1038/s41598-021-98738-7 | 2021 |
| On the use of inhibitors of 4-hydroxyphenylpyruvate dioxygenase as a vector-selective insecticide in the control of mosquitoes | 10.1002/ps.6679 | 2021 |
| Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector | 10.1042/bcj20210428 | 2021 |
| Poor Unstable Midgut Microbiome of Hard Ticks Contrasts With Abundant and Stable Monospecific Microbiome in Ovaries | 10.3389/fcimb.2020.00211 | 2020 |
| A physiologic overview of the organ-specific transcriptome of the cattle tick Rhipicephalus microplus | 10.1038/s41598-020-75341-w | 2020 |
| The relationship between oxidant levels and gut physiology in a litter-feeding termite | 10.1038/s41598-018-37043-2 | 2019 |
| Haem Biology in Metazoan Parasites - `The Bright Side of Haem? | 10.1016/j.pt.2019.01.001 | 2019 |
| DOPA decarboxylase is essential for cuticle tanning in Rhodnius prolixus (Hemiptera: Reduviidae), affecting ecdysis, survival and reproduction | 10.1016/j.ibmb.2019.03.006 | 2019 |
| Rhodnius prolixus: Identification of missing components of the IMD immune signaling pathway and functional characterization of its role in eliminating bacteria | 10.1371/journal.pone.0214794 | 2019 |
| Non-canonical transcriptional regulation of heme oxygenase in Aedes aegypti | 10.1038/s41598-019-49396-3 | 2019 |
| Silencing of Iron and Heme-Related Genes Revealed a Paramount Role of Iron in the Physiology of the Hematophagous Vector Rhodnius prolixus | 10.3389/fgene.2018.00019 | 2018 |
| Regulation of midgut cell proliferation impacts Aedes aegypti susceptibility to dengue virus | 10.1371/journal.pntd.0006498 | 2018 |
| The redox-sensing gene Nrf2 affects intestinal homeostasis, insecticide resistance and Zika virus susceptibility in the mosquito Aedes aegypti | 10.1074/jbc.ra117.001589 | 2018 |
| Transcriptomic analyses uncover emerging roles of mucins, lysosome/secretory addressing and detoxification pathways in insect midguts | 10.1016/j.cois.2018.05.015 | 2018 |
| NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function | 10.1161/JAHA.118.009388 | 2018 |
| Ticks as potential vectors of Mycobacterium leprae: Use of tick cell lines to culture the bacilli and generate transgenic strains | 10.1371/journal.pntd.0007001 | 2018 |
| Editorial overview: Molecular physiology: from omics data encyclopedia to physiology `short stories? | 10.1016/j.cois.2018.08.004 | 2018 |
| Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase | 10.1186/s12862-017-0940-0 | 2017 |
| Microbiota activates IMD pathway and limits Sindbis infection in Aedes aegypti | 10.1186/s13071-017-2040-9 | 2017 |
| Catalase protects Aedes aegypti from oxidative stress and increases midgut infection prevalence of Dengue but not Zika | 10.1371/journal.pntd.0005525 | 2017 |
| Developmental roles of tyrosine metabolism enzymes in the blood-sucking insect | 10.1098/rspb.2016.2607 | 2017 |
| The Dose Makes the Poison: Nutritional Overload Determines the Life Traits of Blood-Feeding Arthropods | 10.1016/j.pt.2017.04.008 | 2017 |
| Immune-related redox metabolism of embryonic cells of the tick Rhipicephalus microplus (BME26) in response to infection with Anaplasma marginale | 10.1186/s13071-017-2575-9 | 2017 |
| A Coxiella mutualist symbiont is essential to the development of Rhipicephalus microplus | 10.1038/s41598-017-17309-x | 2017 |
| Amino acids trigger down regulation of superoxide via TORC pathway in the midgut of Rhodnius prolixus | 10.1042/bsr20160061 | 2016 |
| Acquisition of exogenous haem is essential for tick reproduction | 10.7554/elife.12318 | 2016 |
| Identification of a selenium-dependent glutathione peroxidase in the blood-sucking insect Rhodnius prolixus | 10.1016/j.ibmb.2015.08.007 | 2016 |
| Experimental Infection of Rhodnius prolixus (Hemiptera, Triatominae) with Mycobacterium leprae Indicates Potential for Leprosy Transmission | 10.1371/journal.pone.0156037 | 2016 |
| Tyrosine Detoxification Is an Essential Trait in the Life History of Blood-Feeding Arthropods | 10.1016/j.cub.2016.06.025 | 2016 |
| Polyphenol-Rich Diets Exacerbate AMPK-Mediated Autophagy, Decreasing Proliferation of Mosquito Midgut Microbiota, and Extending Vector Lifespan | 10.1371/journal.pntd.0005034 | 2016 |
| Genetically Modifying the Insect Gut Microbiota to Control Chagas Disease Vectors through Systemic RNAi | 10.1371/journal.pntd.0003358 | 2015 |
| Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme | 10.1016/j.abb.2015.03.007 | 2015 |
| Heme Signaling Impacts Global Gene Expression, Immunity and Dengue Virus Infectivity in Aedes aegypti | 10.1371/journal.pone.0135985 | 2015 |
| ATP Binding Cassette Transporter Mediates Both Heme and Pesticide Detoxification in Tick Midgut Cells | 10.1371/journal.pone.0134779 | 2015 |
| Functional studies of TcRjl, a novel GTPase of Trypanosoma cruzi, reveals phenotypes related with MAPK activation during parasite differentiation and after heterologous expression in Drosophila model system | 10.1016/j.bbrc.2015.09.110 | 2015 |
| Monitoring of the Parasite Load in the Digestive Tract of Rhodnius prolixus by Combined qPCR Analysis and Imaging Techniques Provides New Insights into the Trypanosome Life Cycle | 10.1371/journal.pntd.0004186 | 2015 |
| Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection | 10.1073/pnas.1506226112 | 2015 |
| The use of a chemically defined artificial diet as a tool to study Aedes aegypti physiology | 10.1016/j.jinsphys.2015.11.007 | 2015 |
| An Insight into the Transcriptome of the Digestive Tract of the Bloodsucking Bug, Rhodnius prolixus | 10.1371/journal.pntd.0002594 | 2014 |
| Silencing of Maternal Heme-binding Protein Causes Embryonic Mitochondrial Dysfunction and Impairs Embryogenesis in the Blood Sucking Insect Rhodnius prolixus | 10.1074/jbc.m113.504985 | 2013 |
| Ovarian Dual Oxidase (Duox) Activity Is Essential for Insect Eggshell Hardening and Waterproofing | 10.1074/jbc.m113.522201 | 2013 |
| The Role of Reactive Oxygen Species in Anopheles aquasalis Response to Plasmodium vivax Infection | 10.1371/journal.pone.0057014 | 2013 |
| OKB, a novel family of brain-gut neuropeptides from insects | 10.1016/j.ibmb.2012.03.003 | 2012 |
| The Antioxidant Role of Xanthurenic Acid in the Aedes aegypti Midgut during Digestion of a Blood Meal | 10.1371/journal.pone.0038349 | 2012 |
| Mitochondrial Reactive Oxygen Species Modulate Mosquito Susceptibility to Plasmodium Infection | 10.1371/journal.pone.0041083 | 2012 |
| Multi-antigenic vaccine against the cattle tick Rhipicephalus (Boophilus) microplus: A field evaluation | 10.1016/j.vaccine.2012.08.078 | 2012 |
| Energy metabolism affects susceptibility of Anophelesgambiae mosquitoes to Plasmodium infection. | 10.1016/j.ibmb.2011.02.001 | 2011 |
| Blood Meal-Derived Heme Decreases ROS Levels in the Midgut of Aedes aegypti and Allows Proliferation of Intestinal Microbiota | 10.1371/journal.ppat.1001320 | 2011 |
| Transcriptome and gene expression profile of ovarian follicle tissue of the triatomine bug Rhodnius prolixus | 10.1016/j.ibmb.2011.06.004 | 2011 |
| Heme-Oxygenases during Erythropoiesis in K562 and Human Bone Marrow Cells | 10.1371/journal.pone.0021358 | 2011 |
| Sn-protoporphyrin inhibits both heme degradation and hemozoin formation in Rhodnius prolixus midgut | 10.1016/j.ibmb.2010.08.005 | 2010 |
| Antioxidant pathways are up-regulated during biological nitrogen fixation to prevent ROS-induced nitrogenase inhibition in Gluconacetobacter diazotrophicus. | 10.1007/s00203-010-0609-1 | 2010 |
| On the physico-chemical and physiological requirements of hemozoin formation promoted by perimicrovillar membranes in Rhodnius prolixus midgut. | 10.1016/j.ibmb.2009.12.013 | 2010 |
| In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells. | 10.1042/CBI20090427 | 2010 |
| Trypanosoma brucei brucei: Effects of ferrous iron and heme on ecto-nucleoside triphosphate diphosphohydrolase activity? | 10.1016/j.exppara.2008.10.018 | 2009 |
| On the fate of extracellular hemoglobin and heme in brain | 10.1038/jcbfm.2009.34 | 2009 |
| Blood-Feeding Induces Reversible Functional Changes in Flight Muscle Mitochondria of Aedes aegypti Mosquito | 10.1371/journal.pone.0007854 | 2009 |
| BYC, an atypical aspartic endopeptidase from Rhipicephalus (Boophilus) microplus eggs | 10.1016/j.cbpb.2007.12.007 | 2008 |
| An extraovarian aspartic protease accumulated in tick oocytes with vitellin-degradation activity | 10.1016/j.cbpb.2008.08.008 | 2008 |
| Heme crystallization in the midgut of triatomine insects. | 10.1016/j.cbpc.2006.12.007 | 2007 |
| Oxidative stress impairs heme detoxification in the midgut of the cattle tick, | 10.1016/j.molbiopara.2006.10.008 | 2007 |
| Perimicrovillar membranes promote hemozoin formation into Rhodnius prolixus midgut | 10.1016/j.ibmb.2007.01.001 | 2007 |
| Biglutaminyl-Biliverdin IX Alpha as a Heme Degradation Product in the Dengue Fever Insect-Vector Aedes aegypti | 10.1021/bi700011d | 2007 |
| Characterization of Heme as Activator of Toll-like Receptor 4 | 10.1074/jbc.M610737200 | 2007 |
| Extracellular lipid droplets promote hemozoin crystallization in the gut of the blood fluke Schistosoma mansoni | 10.1016/j.febslet.2007.03.054 | 2007 |
| Heme requirement and intracellular trafficking in Trypanosoma cruzi epimastigotes | 10.1016/j.bbrc.2006.12.238 | 2007 |
| A novel heme degradation pathway in a blood-sucking insect | 10.1073/pnas.0602224103 | 2006 |
| Identification of the Aedes aegypti Peritrophic Matrix Protein AeIMUCI as a Heme-Binding Protein | 10.1021/bi0605991 | 2006 |
| Adaptations against heme toxicity in blood-feeding arthropods. | 10.1016/j.ibmb.2006.01.009 | 2006 |
| Vaccination of bovines with recombinant Boophilus Yolk pro-Cathepsin | 10.1016/j.vetimm.2006.08.011 | 2006 |
| Purification and antigenicity of two recombinant forms of Boophilus microplus yolk pro-cathepsin expressed in inclusion bodies | 10.1016/j.pep.2005.07.009 | 2006 |
| Tracing heme in a living cell: hemoglobin degradation and heme traffic in digest cells of the cattle tick Boophilus microplus. | 2005 | |
| Oxidized tissue proteins after intestinal reperfusion injury in rats | 10.1590/s0102-86502005000600007 | 2005 |
| Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus | 10.1016/j.febslet.2005.09.035 | 2005 |
| A comparative study of patenting activity in U.S. and Brazilian scientific institutions | 10.1023/B:SCIE.0000045113.27221.bf | 2004 |
| Crystallization and preliminary X-ray diffraction analysis of HeLp, a heme lipoprotein from the hemolymph of the cattle tick Boophilus microplus | 10.1107/s0907444904016245 | 2004 |
| Inhibition of Heme Aggregation by Chloroquine Reduces Schistosoma mansoni Infection | 10.1086/422759 | 2004 |
| Proteolytic activity of Boophilus microplus Yolk pro-Cathepsin D (BYC) is coincident with cortical acidification during embryogenesis | 10.1016/j.ibmb.2004.01.006 | 2004 |
| HeLp, a heme-transporting lipoprotein with an antioxidant role | 10.1016/j.ibmb.2003.09.005 | 2004 |
| A new intracellular pathway of haem detoxification in the midgut of the cattle tick Boophilus microplus: aggregation inside a specialized organelle, the hemosome. | 2003 | |
| Heparan sulfate glycosaminoglycan expression in the intestinal tract and ovary of fully engorged adult females of the cattle tick Boophilus microplus and in their laid eggs | 10.1016/s0166-6851(03)00169-5 | 2003 |
| Changes in salivary nitrophorin profile during the life cycle of the blood-sucking bug Rhodnius prolixus | 10.1016/s0965-1748(02)00163-7 | 2003 |
| Rhodnius heme-binding protein (RHBP) is a heme source for embryonic development in the blood-sucking bug Rhodnius prolixus (Hemiptera, Reduviidae) | 10.1016/s0965-1748(01)00163-1 | 2002 |
| On the pro-oxidant effects of haemozoin | 2002 | |
| Neutrophil activation by hemin: role of protein kinase C and implication in the inflammatory processes. | 2002 | |
| Cyclic nucleotide-independent phosphorylation of Vitellin by casein kinase II purified from Rhodnius prolixus oocytes | 10.1016/s0965-1748(01)00173-4 | 2002 |
| Vampires, Pasteur and reactive oxygen species. Is the switch from aerobic to anaerobic metabolism a preventive antioxidant defence in blood-feeding parasites? | 2002 | |
| On the biosynthesis of Rhodnius prolixus heme-binding protein | 10.1016/s0965-1748(02)00074-7 | 2002 |
| Binding and storage of heme by vitellin from the cattle tick, Boophilus microplus | 10.1016/s0965-1748(02)00162-5 | 2002 |
| Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion | 10.1016/s0965-1748(01)00130-8 | 2002 |
| Heme biosynthesis and oogenesis in the blood-sucking bug, Rhodnius prolixus | 10.1016/s0965-1748(00)00129-6 | 2001 |
| Hydrogen peroxide detoxification in the midgut of the blood-sucking insect,Rhodnius prolixus | 10.1002/arch.1058 | 2001 |
| Crystallization and preliminary X-ray study of haem-binding protein from the bloodsucking insect Rhodnius prolixus | 10.1107/s0907444901004437 | 2001 |
| Production of reactive oxygen species by hemocytes from the cattle tick Boophilus microplus. | 2001 | |
| The Brazilian investment in Science and Technology | 2001 | |
| HeLp, a hemeliporotein from the hemolymph of the cattle tick, Boophilus microplus. | 2000 | |
| A heme-binding aspartic proteinase from the eggs of the hard tick Boophilus microplus | 2000 | |
| Haemozoin formation in the midgut of the blood-sucking insect Rhodnius prolixus | 10.1016/s0014-5793(00)01786-5 | 2000 |
| Haemozoin in Schistosoma mansoni | 10.1016/s0166-6851(00)00299-1 | 2000 |
| Vacina contra carrapato | 2000 | |
| Extracellular glutathione peroxidase from the blood-sucking bug,Rhodnius prolixus | 10.1002/(sici)1520-6327(1999)41:4<171::aid-arch1>3.0.co;2-5 | 1999 |
| A missing metabolic pathway in the cattle tick Boophilus microplus | 10.1016/S0960-9822(99)80312-1 | 1999 |
| Urate Synthesis In The Blood-Sucking Insect Rhodnius Prolixus ( Stimulation By Hemin Is Mediated By Protein Kinase C) | 1999 | |
| Haem detoxification by an insect | 10.1038/22910 | 1999 |
| Immunization Of Bovines With An Aspartic Proteinase Precursor Isolated From Eggs Of Boophilus Microplus | 1998 | |
| Isolation of an aspartic proteinase precursor from the egg of a hard tick, Boophilus microplus | 10.1017/s0031182098002698 | 1998 |
| Uptake ofRhodnius heme-binding protein (RHBP) by the ovary ofRhodnius prolixus | 10.1002/(sici)1520-6327(1998)39:4<133::aid-arch1>3.0.co;2-d | 1998 |
| Urate Protects a Blood-Sucking Insect Against Hemin-Induced Oxidative Stress | 10.1016/s0891-5849(96)00293-6 | 1997 |
| Role of Phospholipids in the Protein Stability of an Insect Lipoprotein, Lipophorin from Rhodnius prolixus - | 10.1021/bi9706069 | 1997 |
| A Heme-binding Protein from Hemolymph and Oocytes of the Blood-sucking Insect, Rhodnius prolixus | 10.1074/jbc.270.18.10897 | 1995 |
| Antioxidant Role of Rhodnius prolixus Heme-binding Protein | 10.1074/jbc.270.18.10893 | 1995 |
| Protein phosphorylation in Rhodnius prolixus oocytes: Identification of a type II casein kinase | 10.1016/0965-1748(93)90070-9 | 1993 |
| Identification of yolk platelet-associated hydrolases in the oocytes ofRhodnius prolixus | 10.1002/arch.940210402 | 1992 |
| Vitellin processing and degradation during embryogenesis in Rhodnius prolixus | 10.1016/0020-1790(89)90031-0 | 1989 |
| Lipophorin from Rhodnius prolixus: Purification and partial characterization | 10.1016/0020-1790(89)90086-3 | 1989 |
| Lipophorin and oögenesis in Rhodnius prolixus: Transfer of phospholipids | 10.1016/0022-1910(89)90032-2 | 1989 |
| The roles of haemolymphatic lipoproteins in the oogenesis of Rhodnius prolixus | 10.1590/S0074-02761987000700018 | 1987 |
| Uptake of yolk proteins in Rhodnius prolixus | 10.1016/0022-1910(86)90101-0 | 1986 |
| Characterization of vitellin and vitellogenin from Rhodnius prolixus | 10.1016/0020-1790(85)90068-X | 1985 |
Eventos:
Nenhum evento cadastrado