Debora Foguel
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Bioquímica Médica
Departamento:
Programa de Biologia Celular e Biofisica
Formação:
-
Universidade Federal do Rio de Janeiro
Bioquímica | Doutorado | 1991 - 1993
-
Universidade Federal do Rio de Janeiro
Bioquímica | Mestrado | 1988 - 1991
-
Universidade Federal do Rio de Janeiro
Abi - Ciências Biológicas | Graduação | 1983 - 1987
Laboratórios:
Nuvens de Palavras:
Artigos:
(85.83% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| A termiticidal and high denaturation-resistant lectin from Moringa oleifera seed cake | 10.1016/j.napere.2023.100040 | 2023 |
| Connection between MHC class II binding and aggregation propensity: the antigenic peptide 10 (P10) of Paracoccidioides brasiliensis as a benchmark study | 10.1016/j.csbj.2023.02.031 | 2023 |
| Targeting Biomolecular Condensation and Protein Aggregation against Cancer | 10.1021/acs.chemrev.3c00131 | 2023 |
| The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis | 10.1186/s10020-023-00704-8 | 2023 |
| Peripheral nervous system is injured by neutrophil extracellular traps ( |
10.1096/fj.202201904r | 2023 |
| A onda pró-ciência em tempos de negacionismo: percepção da sociedade brasileira sobre ciência, cientistas e universidades na pandemia da COVID-19 | 10.1590/1413-812320232812.20212022 | 2023 |
| Extracellular alpha-synuclein: Sensors, receptors, and responses | 10.1016/j.nbd.2022.105696 | 2022 |
| Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis | 10.1016/j.neurobiolaging.2022.02.010 | 2022 |
| JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species | 10.1007/s12640-022-00559-7 | 2022 |
| Green Tea Polyphenol Microparticles Based on the Oxidative Coupling of EGCG Inhibit Amyloid Aggregation/Cytotoxicity and Serve as a Platform for Drug Delivery | 10.1021/acsbiomaterials.0c00188 | 2021 |
| Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis | 10.1155/2021/9081738 | 2021 |
| Peptides derived from gp43, the most antigenic protein from Paracoccidioides brasiliensis, form amyloid fibrils in vitro: implications for vaccine development | 10.1038/s41598-021-02898-5 | 2021 |
| Green Tea Polyphenol Epigallocatechin-Gallate in Amyloid Aggregation and Neurodegenerative Diseases | 10.3389/fnins.2021.718188 | 2021 |
| Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo | 10.1016/j.ymthe.2021.04.035 | 2021 |
| Neutrophil extracellular trap-enriched supernatants carry microRNAs able to modulate TNF-α production by macrophages | 10.1038/s41598-020-59486-2 | 2020 |
| New Cardiomyokine Reduces Myocardial Ischemia/Reperfusion Injury by PI3K-AKT Pathway Via a Putative KDEL-Receptor Binding | 10.1161/jaha.120.019685 | 2020 |
| Correction: Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice | 10.1038/s41380-020-00873-6 | 2020 |
| Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy | 10.1016/j.neuint.2020.104758 | 2020 |
| α-synuclein oligomers enhance astrocyte-induced synapse formation through |
10.1111/jnc.14710 | 2019 |
| Baseline disease characteristics in Brazilian patients enrolled in Transthyretin Amyloidosis Outcome Survey (THAOS) | 10.1590/0004-282x20180156 | 2019 |
| Geographic distribution of ATTR cases from CEPARM across the Brazilian territory and their clinical aspects, demographics, ethnical and family background | 10.1080/13506129.2019.1582518 | 2019 |
| Inflammatory profiling of patients with familial amyloid polyneuropathy | 10.1186/s12883-019-1369-4 | 2019 |
| Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase | 10.1016/j.str.2017.12.004 | 2018 |
| Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation | 10.1186/s12974-018-1059-y | 2018 |
| The demographic, genetic, and clinical characteristics of Brazilian subjects enrolled in the Transthyretin Amyloidosis Outcomes Survey | 10.1080/13506129.2017.1291423 | 2017 |
| Applying an artificial neural network model for developing a severity score for patients with hereditary amyloid polyneuropathy | 10.1080/13506129.2017.1343714 | 2017 |
| Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson?s disease-like symptoms in mice | 10.1016/j.bbr.2017.06.047 | 2017 |
| An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils. | 10.1021/acschemneuro.7b00017 | 2017 |
| Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation | 10.1038/srep44709 | 2017 |
| Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and Macular Degeneration | 10.1002/1873-3468.12093 | 2016 |
| Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity | 10.1073/pnas.1606791113 | 2016 |
| Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid- Oligomers in Mice | 10.1523/jneurosci.1269-16.2016 | 2016 |
| Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core | 10.1038/srep37990 | 2016 |
| Brazilian Science and Research Integrity: Where are We? What Next? | 10.1590/0001-3765201520150165 | 2015 |
| A metabolic shift towards pentose phosphate pathway is necessary for amyloid fibril- and phorbol 12-myristate 13-acetate -induced neutrophil extracellular trap (NET) formation | 10.1074/jbc.m115.640094 | 2015 |
| The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role Against α-Synuclein Oligomers | 10.1074/jbc.m115.662254 | 2015 |
| Identification of a new variant of TTR involved in familial amyloid cardiomyopathy (FAC) in Brazil: from the patient to the protein | 10.1186/1750-1172-10-S1-P55 | 2015 |
| The importance of a gatekeeper residue on the aggregation of transthyretin: implications to transthyretin-related amyloidoses | 10.1074/jbc.M114.563981 | 2014 |
| High-Pressure Chemical Biology and Biotechnology | 10.1021/cr400204z | 2014 |
| Conformational Changes in Human Hsp70 Induced by High Hydrostatic Pressure Produce Oligomers with ATPase Activity but without Chaperone Activity | 10.1021/bi500004q | 2014 |
| Insights into the Intramolecular Coupling between the N- and C-Domains of Troponin C Derived from High-Pressure, Fluorescence, Nuclear Magnetic Resonance, and Small-Angle X-ray Scattering Studies | 10.1021/bi301139d | 2013 |
| Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis | 10.1038/cddis.2013.325 | 2013 |
| Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer | 10.1016/j.bpc.2013.06.002 | 2013 |
| Inhibition of Human Transthyretin Aggregation by Non-Steroidal Anti-Inflammatory Compounds: A Structural and Thermodynamic Analysis | 10.3390/ijms14035284 | 2013 |
| Structure-Based Analysis of A19D, a Variant of Transthyretin Involved in Familial Amyloid Cardiomyopathy | 10.1371/journal.pone.0082484 | 2013 |
| 1H-, 13C- and 15N-NMR assignment of the N-terminal domain of human cerebral dopamine neurotrophic factor (CDNF) | 10.1007/s12104-012-9388-8 | 2013 |
| Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis | 10.1016/j.jsb.2012.07.008 | 2012 |
| Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice | 10.1038/mp.2012.168 | 2012 |
| Amyloid Fibrils Trigger the Release of Neutrophil Extracellular Traps (NETs), Causing Fibril Fragmentation by NET-associated Elastase | 10.1074/jbc.M112.369942 | 2012 |
| The binding of synthetic triiodo l-thyronine analogs to human transthyretin: Molecular basis of cooperative and non-cooperative ligand recognition | 10.1016/j.jsb.2010.10.003 | 2011 |
| The Anti-Parkinsonian Drug Selegiline Delays the Nucleation Phase of ?-Synuclein Aggregation Leading to the Formation of Nontoxic Species | 10.1016/j.jmb.2010.10.027 | 2011 |
| Protein refolding at high pressure: Optimization using eGFP as a model | 10.1016/j.procbio.2010.10.002 | 2011 |
| Snake venomics and venom gland transcriptomic analysis of Brazilian coral snakes, Micrurus altirostris and M. corallinus | 10.1016/j.jprot.2011.04.003 | 2011 |
| Characterization of the unfolding process of the tetrameric and dimeric forms of Cratylia mollis seed lectin (CRAMOLL 1): effects of natural fragmentation on protein stability | 10.1021/bi200320x | 2011 |
| Dissecting the Structure, Thermodynamic Stability, and Aggregation Properties of the A25T Transthyretin (A25T-TTR) Variant Involved in Leptomeningeal Amyloidosis: Identifying Protein Partners That Co-Aggregate during A25T-TTR Fibrillogenesis in Cerebrospinal Fluid | 10.1021/bi201365r | 2011 |
| Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins | 10.1021/ar900179t | 2010 |
| Identification of a novel ligand binding motif in the transthyretin channel | 10.1016/j.bmc.2009.11.025 | 2010 |
| Immunome and venome of Bothrops jararacussu: A proteomic approach to study the molecular immunology of snake toxins. | 10.1016/j.toxicon.2009.12.018 | 2010 |
| Subunit-subunit interactions and overall topology of the dimeric mitochondrial ATP synthase of Polytomella sp. | 10.1016/j.bbabio.2010.02.024 | 2010 |
| Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: Implications to tetramer stability and ligand-binding | 10.1016/j.jsb.2010.03.002 | 2010 |
| Heterologous expression and purification of a biologically active legume lectin from Cratylia mollis seeds (CRAMOLL 1) | 10.1016/j.bbapap.2010.06.004 | 2010 |
| Identification of archaeal proteins that affect the exosome function in vitro | 10.1186/1471-2091-11-22 | 2010 |
| Novel Zn2+-binding Sites in Human Transthyretin: IMPLICATIONS FOR AMYLOIDOGENESIS AND RETINOL-BINDING PROTEIN RECOGNITION | 10.1074/jbc.M110.157206 | 2010 |
| Trapping the monomer of a non-amyloidogenic variant of transthyretin: exploring its possible use as a therapeutic strategy against transthyretin amyloidogenic diseases. | 10.1074/jbc.M807100200 | 2009 |
| Predictions suggesting a participation of beta-sheet configuration in the M2 domain of the P2X(7) receptor: a novel conformation? | 10.1016/j.bpj.2008.10.043 | 2009 |
| Hydration, cavities and volume in protein folding, aggregation and amyloid assembly | 10.1088/1478-3975/6/1/015002 | 2009 |
| The fully-active and structurally-stable form of the mitochondrial ATP synthase of Polytomella sp. is dimeric | 10.1007/s10863-009-9203-0 | 2009 |
| A Fluorescent Mutant of the NM Domain of the Yeast Prion Sup35 Provides Insight into Fibril Formation and Stability | 10.1021/bi9000276 | 2009 |
| Reciprocal remodeling upon binding of the Prion Protein to its signaling partner hop/STI1 | 10.1096/fj.09-138974 | 2009 |
| Intriguing nucleic-acid-binding features of mammalian prion protein. | 10.1016/j.tibs.2007.11.003 | 2008 |
| Volume and Free Energy of Folding for Troponin C C-Domain: Linkage to Ion Binding and N-Domain Interaction. | 10.1021/bi702058t | 2008 |
| Free-Energy Linkage between Folding and Calcium Binding in EF-Hand Proteins | 10.1529/biophysj.108.135715 | 2008 |
| Sulfated galactan is a catalyst of antithrombin-mediated inactivation of ?-thrombin | 10.1016/j.bbagen.2008.05.006 | 2008 |
| Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein | 10.1021/bi061871+ | 2007 |
| An Aggregation-Prone Intermediate Species Is Present in the Unfolding Pathway of the Monomeric Portal Protein of Bacteriophage P22: Implications for Portal Assembly | 10.1021/bi700006d | 2007 |
| An Intermediate Structure in the Thermal Unfolding of the GTPase Domain of Human Septin 4 (SEPT4/Bradeion-?) Forms Amyloid-like Filaments in Vitro | 10.1021/bi700702w | 2007 |
| Ca2+ and Mg2+ binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament | 10.1016/j.biocel.2005.08.009 | 2006 |
| Tetramerization of the LexA repressor in solution: Implications for gene regulation of the E. Coli SOS system at acidic pH | 10.1016/j.jmb.2006.03.069 | 2006 |
| FT-IR spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin | 10.1529/biophysj.106.085928 | 2006 |
| Structural insights into the interaction between prion protein and nucleic acid | 10.1021/bi060532d | 2006 |
| Protein folding and aggregation: Two sides of the same coin in the condensation of proteins revealed by pressure studies | 10.1016/j.bbapap.2005.11.012 | 2006 |
| HIGH PRESSURE STUDIES ON TRANSTHYRETIN | 2005 | |
| Controlling b amyloid oligomerization by the use of naphtalene sulfonates: Trapping low molecular weight oligomeric species | 10.1074/jbc.M501651200 | 2005 |
| The amino-terminal PrP domain is crucial to modulate prion misfolding and aggregation | 10.1529/biophysj.105.067603 | 2005 |
| Highlights of the 3rd International Conference on High Pressure Bioscience and Biotechnology | 10.1590/S0100-879X2005000800001 | 2005 |
| New Insights into the Mechanisms of Protein Misfolding and Aggregation in Amyloidogenic Diseases derived from Pressure Studies | 10.1021/bi048864a | 2004 |
| Modulation of Prion Protein Oligomerization, Aggregation, and Beta-sheet Conversion by 4,4'-Dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS) | 10.1074/jbc.M312262200 | 2004 |
| Antithrombin-mediated anticoagulant activity of sulfated polysaccharides: Different mechanisms for heparin and sulfated galactans | 10.1074/jbc.M308688200 | 2004 |
| High Pressure Applications in Medicine and Pharmacology | 10.1088/0953-8984/16/14/002 | 2004 |
| Hydration and packing effects on prion folding and beta-sheet conversion: High-pressure spectroscopy and pressure perturbation calorimetry studies. | 10.1074/jbc.M404295200 | 2004 |
| New insights into conformational and functional stability of human alpha-thrombin probed by high hydrostatic pressure | 10.1111/j.0014-2956.2004.04295.x | 2004 |
| Subunit dissociation, unfolding, and inactivation of bothrojaracin, a C-type lectin-like protein from snake venom | 10.1021/bi020571z | 2003 |
| Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease | 10.1016/S0022-2836(03)00368-1 | 2003 |
| Role of hydration in the closed to-open transition involved in Ca2+-binding by Troponin C | 10.1021/bi027102h | 2003 |
| Dissociation of amyloid fibrils of a-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities | 10.1073/pnas.1734009100 | 2003 |
| Fibrillar aggregates of tumor suppressor p53 core domain | 10.1021/bi034218k | 2003 |
| Pressure Induces Folding Intermediates that are Crucial for Protein-DNA Recognition and Virus Assembly | 10.1016/S0167-4838(01)00348-X | 2002 |
| Hydrostatic pressure induces the fusion-active state of enveloped viruses | 10.1074/jbc.M106096200 | 2002 |
| Pressure Provides New Insights into Protein Folding, Dynamics and Structure | 10.1016/S0968-0004(01)01949-1 | 2001 |
| The Metastable State of Nucleocapsids of Enveloped Viruses as Probed by High Hydrostatic Pressure | 10.1074/jbc.M010037200 | 2001 |
| Pressure induces the formation of fusion-active states of membrane-enveloped viruses | 2001 | |
| DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation | 10.1074/jbc.M106707200 | 2001 |
| LexA Repressor Forms Stable Dimers in Solution: The Role of Specific DNA in Tightening Protein-Protein Interactions | 10.1074/jbc.275.7.4708 | 2000 |
| The Pre-Aggregated State of an Amyloidogenic Protein: Hydrostatic Pressure Converts Native Transthyretin into the Amyloidogenic State | 10.1073/pnas.97.12.6445 | 2000 |
| DNA tightens the dimeric DNA binding domain of human papillomavirus E2 protein without changes in volume. | 10.1073/pnas.250352197 | 2000 |
| Hydrostatic Pressure Rescues Native Protein From Aggregates | 1999 | |
| Cavity-Deffects In The Procapsid Of Bacteriophage P22 And The Mechanism Of Capsid Maturation | 1999 | |
| Effects Of High Pressure And Temperature On The Wildtype And F29w Mutant Of The N-Domain Of Avian Troponin C | 1999 | |
| Characterization Of A Partially Folded Monomer Of The Dna-Binding Domain Of Human Papillomavirus E2 Protein Obtained At High Pressure | 1998 | |
| Hydrostatic Pressure Rescues Native Protein From Aggregates | 1998 | |
| International symposium on protein condensation | 1998 | |
| The Use Of Hydrostatic Pressure As A Tool To Study Viruses And Other Macromolecular Assemblages | 1996 | |
| Mimicry Of The Calcium-Induced Conformational State Of Troponin C By Low Temperature Under Pressure | 1996 | |
| The Role Of Entropic Interaction In Viral Capsids:Single Amino Acid Substitution In P22 Bacteriophage Coat Protein Resulting In Loss Of Capsid Stability | 1995 | |
| Cold Denaturation Of Ab Subunits Of Allophycocyanin At Subzero Temperatures And High Pressure | 1995 | |
| Single Amino Acid Substitution In P22 Bacteriophage Coat Protein Result In Loss Of Pressure Stability Of The Shells | 1995 | |
| Low Temperature Drives The Conformation Of F29w/N-Domain Of Troponin C Mutant Toward The Calcium-Bound Form | 1995 | |
| Cold Denaturation Of A Repressor-Operator Complex: The Role Of Entropy In Protein-Dna Recogniiton | 1994 | |
| Effects of the alkaloid gramine on the light harvesting, energy transfer, and growth of Anabaena sp (PCC 7119) | 1993 | |
| Pressure and Low Temperature Effects on the Fluorescence Emission Spectra and Lifetime of the Photosyhthetic Components of Cyanobacteria | 1992 |
Eventos:
Nenhum evento cadastrado