Fabio C L Almeida
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Bioquímica Médica
Departamento:
Gabinete do Diretor do Instituto de Bioquímica Médica
Formação:
-
University of Pennsylvania
| Pós-Doutorado | 1994 - 1996
-
Universidade de São Paulo
Ciências Biológicas (Bioquímica) | Doutorado | 1989 - 1994
-
Universidade de São Paulo
Faculdade de Ciências Farmacêuticas | Graduação | 1984 - 1988
Laboratórios:
Nuvens de Palavras:
Artigos:
(96.35% artigos com DOI)
Titulo | DOI | Ano |
---|---|---|
Toward the mechanism of jarastatin (rJast) inhibition of the integrin αVβ3 | 10.1016/j.ijbiomac.2023.128078 | 2024 |
Self-assembly of dengue virus empty capsid-like particles in solution | 10.1016/j.isci.2023.106197 | 2023 |
Plant defensins as a model to study the thermostability of surface hydrophobic clusters: The Pisum sativum defensin 2 (Psd2) | 10.1016/j.jmro.2023.100106 | 2023 |
rJararacin, a recombinant disintegrin from Bothrops jararaca venom: Exploring its effects on hemostasis and thrombosis | 10.1016/j.abb.2023.109557 | 2023 |
Backbone and sidechain NMR assignments of residues 1-81 from yeast Sis1 in complex with an Hsp70 C-terminal EEVD peptide | 10.1007/s12104-023-10148-0 | 2023 |
1 H, 15 N, and 13 C backbone and side chain resonance assignments of the cold shock domain of the Arabidopsis thaliana glycine-rich protein AtGRP2 | 10.1007/s12104-023-10133-7 | 2023 |
Insights into the Substrate Uptake Mechanism of Mycobacterium Tuberculosis Ribose 5-Phosphate Isomerase and Perspectives on Drug Development | 10.3390/biophysica3010010 | 2023 |
The 1H, 15N and 13C resonance assignments of dengue virus capsid protein with the deletion of the intrinsically disordered N-terminal region | 10.1007/s12104-022-10115-1 | 2023 |
Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein | 10.1080/14756366.2021.2004591 | 2022 |
Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids | 10.1016/j.ijbiomac.2022.01.121 | 2022 |
Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate | 10.1038/s41598-022-14790-x | 2022 |
On the caveats of a multiplex test for SARS-CoV-2 to detect seroconversion after infection or vaccination | 10.1038/s41598-022-14294-8 | 2022 |
The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles | 10.1371/journal.pone.0264643 | 2022 |
Deciphering the Path of S-nitrosation of Human Thioredoxin: Evidence of an Internal NO Transfer and Implication for the Cellular Responses to NO | 10.3390/antiox11071236 | 2022 |
15N, 13C, and 1H resonance assignments of Jarastatin: a disintegrin of Bothrops jararaca | 10.1007/s12104-021-10056-1 | 2022 |
IgA quantification as a good predictor of the neutralizing antibodies levels after vaccination against SARS-CoV-2 | 10.1016/j.jcvp.2022.100121 | 2022 |
Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions | 10.1093/molbev/msac194 | 2022 |
The C-terminal extension of |
10.1002/prot.26344 | 2022 |
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development | 10.1002/anie.202205858 | 2022 |
Hesperetin targets the hydrophobic pocket of the nucleoprotein/phosphoprotein binding site of human respiratory syncytial virus | 10.1080/07391102.2020.1835717 | 2022 |
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications | 10.3389/fmolb.2021.653148 | 2021 |
Unique structural features of flaviviruses? capsid proteins: new insights on structure-function relationship | 10.1016/j.coviro.2021.02.005 | 2021 |
Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction | 10.3389/fmolb.2021.783301 | 2021 |
A systematic structural comparison of all solved small proteins deposited in PDB. The effect of disulfide bonds in protein fold | 10.1016/j.csbj.2021.11.015 | 2021 |
Dynamics of the SARS-CoV-2 nucleoprotein N-terminal domain triggers RNA duplex destabilization | 10.1016/j.bpj.2021.06.003 | 2021 |
Effect of antihistamine-containing syrup on salivary metabolites: an in vitro and in vivo study | 10.1590/1807-3107bor-2021.vol35.0032 | 2021 |
Protein Surface Interactions-Theoretical and Experimental Studies | 10.3389/fmolb.2021.706002 | 2021 |
The 1H, 15N, and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus | 10.1007/s12104-021-10027-6 | 2021 |
1H, 15N and 13C backbone and side-chain assignments of reduced and S-nitrosated C62only mutant of human thioredoxin | 10.1007/s12104-021-10015-w | 2021 |
1H, 15N and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the endemic human coronavirus HKU1 | 10.1007/s12104-020-09998-9 | 2021 |
1H, 15N, and 13C resonance assignments of the SH3-like tandem domain of human KIN protein | 10.1007/s12104-021-10044-5 | 2021 |
Backbone assignment of ribose-5-phosphate isomerase of Mycobacterium tuberculosis (MtRpiB) | 10.1007/s12104-020-09931-0 | 2020 |
The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions | 10.1038/s41598-020-70034-w | 2020 |
Biophysical and Dynamic Characterization of Fine-Tuned Binding of the Human Respiratory Syncytial Virus M2-1 Core Domain to Long RNAs | 10.1128/jvi.01505-20 | 2020 |
Osteoarthritic Synovial Fluid Modulates Cell Phenotype and Metabolic Behavior In Vitro | 10.1155/2019/8169172 | 2019 |
Backbone and side chain 1H, 15N and 13C assignments of a putative peptidyl prolyl cis-trans isomerase FKBP12 from Mycobacterium tuberculosis | 10.1007/s12104-019-09884-z | 2019 |
Expression, purification and spectrophotometric analysis of nucleoside hydrolase from Leishmania chagasi (LcNH) | 10.1016/j.pep.2019.04.009 | 2019 |
Fast NMR method to probe solvent accessibility and disordered regions in proteins | 10.1038/s41598-018-37599-z | 2019 |
NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition | 10.1182/blood.2018889493 | 2019 |
Retinoic Acid Binding Leads to CRABP2 Rigidification and Dimerization | 10.1021/acs.biochem.9b00672 | 2019 |
Solution NMR investigation on the structure and function of the isolated J-domain from Sis1: Evidence of transient inter-domain interactions in the full-length protein | 10.1016/j.abb.2019.05.020 | 2019 |
1 H NMR metabolomics reveals increased glutaminolysis upon overexpression of NSD3s or Pdp3 in Saccharomyces cerevisiae | 10.1002/jcb.27816 | 2019 |
Dynamics of Zika Virus Capsid Protein in Solution: The Properties and Exposure of the Hydrophobic Cleft Are Controlled by the α-Helix 1 Sequence | 10.1021/acs.biochem.9b00194 | 2019 |
NMR assignment of free 1H, 15N and 13C-Grb2-SH2 domain | 10.1007/s12104-019-09894-x | 2019 |
Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1 | 10.1038/s41598-018-28358-1 | 2018 |
Monitoring asparaginase activity | 10.1016/S1470-2045(18)30656-9 | 2018 |
Oligomeric transition and dynamics of RNA binding by the HuR RRM1 domain in solution | 10.1007/s10858-018-0217-y | 2018 |
Conformational Dynamics of a Cysteine-Stabilized Plant Defensin Reveals an Evolutionary Mechanism to Expose Hydrophobic Residues | 10.1021/acs.biochem.8b00753 | 2018 |
1H, 15N and 13C resonance assignments of the J-domain of co-chaperone Sis1 from Saccharomyces cerevisiae | 10.1007/s12104-018-9823-6 | 2018 |
Structure and membrane interactions of the homodimeric antibiotic peptide homotarsinin | 10.1038/srep40854 | 2017 |
1H, 13C and 15N chemical shift assignments of Saccharomyces cerevisiae type 1 thioredoxin in the oxidized state by solution NMR spectroscopy | 10.1007/s12104-017-9752-9 | 2017 |
Metabolomic Analysis Reveals Vitamin D-induced Decrease in Polyol Pathway and Subtle Modulation of Glycolysis in HEK293T Cells | 10.1038/s41598-017-10006-9 | 2017 |
Salivary metabolic profile of children and adolescents after hemodialysis | 10.1007/s11306-017-1283-y | 2017 |
DIADECOMP: A new approach to analyze decompositions from projection spectroscopy | 10.1016/j.jmr.2016.10.002 | 2016 |
Regulation of the assembly and amyloid aggregation of murine amylin by zinc | 10.1016/j.bpc.2016.09.008 | 2016 |
1 H NMR metabolomics of plasma unveils liver dysfunction in dengue patients | 10.1128/jvi.00187-16 | 2016 |
Salivary metabolite fingerprint of type 1 diabetes in young children | 10.1021/acs.jproteome.6b00007 | 2016 |
Dissection of the water cavity of yeast Thioredoxin 1: the effect of a hydrophobic residue in the cavity. | 10.1021/acs.biochem.5b00082 | 2015 |
A Cross-Reactive Human Single-Chain Antibody for Detection of Major Fish Allergens, Parvalbumins, and Identification of a Major IgE-Binding Epitope | 10.1371/journal.pone.0142625 | 2015 |
NMR investigation of domain III of Dengue virus E protein: antibody binding modulates conformational exchange in the antigen | 10.1128/jvi.02314-15 | 2015 |
Biophysical Studies on BEX3, the p75NTR-Associated Cell Death Executor, Reveal a High-Order Oligomer with Partially Folded Regions | 10.1371/journal.pone.0137916 | 2015 |
Structures of the reduced and oxidized state of the mutant D24A of yeast thioredoxin 1: insights into the mechanism for the closing of the water cavity | 10.1007/s10858-015-9996-6 | 2015 |
1H, 13C and 15N resonance assignments and second structure information of Fag s 1: Fagales allergen from Fagus sylvatica | 10.1007/s12104-015-9634-y | 2015 |
Hydration and Conformational Equilibrium in Yeast Thioredoxin 1: Implication for H + Exchange | 10.1021/bi401542v | 2014 |
Peptide:lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional studies | 10.1016/j.bbamem.2014.04.004 | 2014 |
1H, 15N and 13C resonance assignments of the RRM1 domain of the key post-transcriptional regulator HuR | 10.1007/s12104-014-9592-9 | 2014 |
Longitudinal evaluation of salivary profile from children with dental caries before and after treatment | 10.1007/s11306-014-0717-z | 2014 |
Understanding Dengue Virus Capsid Protein Disordered N-Terminus and pep14-23-Based Inhibition | 10.1021/cb500640t | 2014 |
Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity | 10.1016/j.bmcl.2014.04.072 | 2014 |
Bet v 1 - a Trojan horse for small ligands boosting allergic sensitization? | 10.1111/cea.12361 | 2014 |
Solution and high-pressure NMR studies of the structure, dynamics and stability of the cross-reactive allergenic cod parvalbumin Gad m 1 | 10.1002/prot.24664 | 2014 |
1H, 13C and 15N resonance assignments and second structure information of Gad m 1: a β-parvalbumin allergen from Atlantic cod (Gadus morhua) | 10.1007/s12104-012-9393-y | 2013 |
Modeling the Interaction of Dodecylphosphocholine Micelles with the Anticoccidial Peptide PW2 Guided by NMR Data | 10.3390/molecules180810056 | 2013 |
Revealing the Properties of Plant Defensins through Dynamics | 10.3390/molecules180911311 | 2013 |
Dengue Virus Capsid Protein Interacts Specifically with Very Low Density Lipoproteins | 10.1016/j.nano.2013.06.004 | 2013 |
Structural Basis for the Interaction of Human β-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles | 10.1016/j.jmb.2013.08.001 | 2013 |
Structural meta-analysis of regular human insulin in pharmaceutical formulations | 10.1016/j.ejpb.2013.05.005 | 2013 |
Salivary metabolite signatures of children with and without dental caries lesions | 10.1007/s11306-012-0484-7 | 2013 |
PHD domain from human SHPRH | 10.1007/s10858-013-9758-2 | 2013 |
The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif | 10.1042/bj20112219 | 2012 |
Herpes simplex type 1 activates glycolysis through engagement of the enzyme 6-phosphofructo-1-kinase (PFK-1) | 10.1016/j.bbadis.2012.04.011 | 2012 |
Identification of Regions Involved in Substrate Binding and Dimer Stabilization within the Central Domains of Yeast Hsp40 Sis1 | 10.1371/journal.pone.0050927 | 2012 |
Moniliophthora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Metastable Dimer in Solution: Structural and Functional Implications | 10.1371/journal.pone.0045620 | 2012 |
Heat stability of Proteobacterial PII protein facilitate purification using a single chromatography step | 10.1016/j.pep.2011.09.008 | 2012 |
Thermodynamic and Structural Characterization of Zwitterionic Micelles of the Membrane Protein Solubilizing Amidosulfobetaine Surfactants ASB-14 and ASB-16 | 10.1021/la1037525 | 2011 |
Portrayal of Complex Dynamic Properties of Sugarcane Defensin 5 by NMR: Multiple Motions Associated with Membrane Interaction | 10.1016/j.str.2010.11.011 | 2011 |
Energy Metabolism in H460 Lung Cancer Cells: Effects of Histone Deacetylase Inhibitors | 10.1371 | 2011 |
Backbone dynamics of the antifungal Psd1 pea defensin and its correlation with membrane interaction by NMR spectroscopy | 10.1016/j.bbamem.2009.07.013 | 2010 |
From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway | 10.1073/pnas.0915141107 | 2010 |
Mapping the Interactions between a Major Pollen Allergen and Human IgE Antibodies | 10.1016/j.str.2010.05.012 | 2010 |
Novel Zn2+-binding Sites in Human Transthyretin: IMPLICATIONS FOR AMYLOIDOGENESIS AND RETINOL-BINDING PROTEIN RECOGNITION | 10.1074/jbc.m110.157206 | 2010 |
Conformational selection, dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI. | 10.1016 | 2010 |
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1 | 10.1042/bj20080805 | 2009 |
Structure and Membrane Interactions of the Antibiotic Peptide Dermadistinctin K by Multidimensional Solution and Oriented 15N and 31P Solid-State NMR Spectroscopy | 10.1016/j.bpj.2008.11.063 | 2009 |
Sequence-specific 1H, 15N and 13C resonance assignments of Art v 1: a proline-rich allergen of Artemisia vulgaris pollen | 10.1007/s12104-009-9151-y | 2009 |
Interaction of the Dengue Virus Fusion Peptide with Membranes Assessed by NMR: The Essential Role of the Envelope Protein Trp101 for Membrane Fusion | 10.1016/j.jmb.2009.07.035 | 2009 |
Ferromagnetic Levan Composite: An Affinity Matrix to Purify Lectin | 10.1155/2009/179106 | 2009 |
A minor β-structured conformation is the active state of a fusion peptide of vesicular stomatitis virus glycoprotein | 10.1002/psc.934 | 2008 |
Spectroscopic characterization of a truncated hemoglobin from the nitrogen-fixing bacterium Herbaspirillum seropedicae | 10.1007/s00775-008-0394-3 | 2008 |
Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: The role of charges and hydrogen bonding interactions in stabilizing helix conformations | 10.1016/j.peptides.2008.06.022 | 2008 |
A Ligand Peptide Motif Selected from a Cancer Patient Is a Receptor-Interacting Site within Human Interleukin-11 | 10.1371/journal.pone.0003452 | 2008 |
NMR solution structure of the reduced form of thioredoxin 1 from Sacharomyces cerevisiae | 10.1002/prot.21693 | 2008 |
Evolutionary relationship between defensins in the Poaceae family strengthened by the characterization of new sugarcane defensins | 10.1007/s11103-008-9372-y | 2008 |
NMR solution structure of the reduced form of thioredoxin 2 from Saccharomyces cerevisiae | 10.1007/s10858-007-9144-z | 2007 |
Structure of the Ebola Fusion Peptide in a Membrane-mimetic Environment and the Interaction with Lipid Rafts | 10.1074/jbc.m611864200 | 2007 |
Structural biology of membrane-acting peptides: Conformational plasticity of anticoccidial peptide PW2 probed by solution NMR | 10.1016/j.bbamem.2007.08.022 | 2007 |
Effect of micelle interface on the binding of anticoccidial PW2 peptide | 10.1007/s10858-007-9202-6 | 2007 |
In-Cell NMR Spectroscopy: Inhibition of Autologous Protein Expression Reduces Escherichia coli Lysis | 10.1385/cbb:44:3:497 | 2006 |
Structure of a Membrane-binding Domain from a Non-enveloped Animal Virus: INSIGHTS INTO THE MECHANISM OF MEMBRANE PERMEABILITY AND CELLULAR ENTRY | 10.1074/jbc.m604689200 | 2006 |
Implications of Protein Conformational Diversity for Binding and Development of New Biological Active Compounds | 10.2174/092986706779026147 | 2006 |
Prediction of the amount of secondary structure of proteins using unassigned NMR spectra: a tool for target selection in structural proteomics | 10.1590/s1415-47572006000400030 | 2006 |
1 H, 13 C and 15 N Resonance Assignments for the Reduced Forms of Thioredoxin 1 and 2 from S. cerevisiae | 10.1007/s10858-006-0025-7 | 2006 |
Study of the effect of the peptide loading and solvent system in SPPS by HRMAS-NMR | 10.1002/psc.659 | 2005 |
Controlling β-Amyloid Oligomerization by the Use of Naphthalene Sulfonates | 10.1074/jbc.m501651200 | 2005 |
Structural Basis for the Interaction of a Vascular Endothelial Growth Factor Mimic Peptide Motif and Its Corresponding Receptors | 10.1016/j.chembiol.2005.07.008 | 2005 |
The bZIP Region of the Plant Transcription Factor Opaque-2 Forms Stable Homodimers in Solution and Retains Its Helical Structure upon Subunit Dissociation - | 10.1021/bi035905e | 2004 |
Letter to Editor: Solution structure of the HPV-16 E2 DNA binding domain, a transcriptional regulator with a dimeric β-barrel fold | 10.1023/b:jnmr.0000048942.96866.76 | 2004 |
Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis | 2004 | |
Structural Studies of MS2 Bacteriophage Virus Particle Disassembly by Nuclear Magnetic Resonance Relaxation Measurements | 10.1016/s0006-3495(03)75117-0 | 2003 |
Production of the active antifungal Pisum sativum defensin 1 (Psd1) in Pichia pastoris: overcoming the inefficiency of the STE13 protease, | 10.1016/s1046-5928(03)00136-0 | 2003 |
Conversion of Wild-type p53 Core Domain into a Conformation that Mimics a Hot-spot Mutant | 10.1016/j.jmb.2003.08.026 | 2003 |
High-throughput screening of structural proteomics targets using NMR | 10.1016/s0014-5793(03)00926-8 | 2003 |
Solution structure of Pisum sativum defensin 1 by high resolution NMR: plant defensins, identical backbone with different mechanisms of action | 10.1006/jmbi.2001.5252 | 2002 |
High-Risk (HPV16) Human Papillomavirus E7 Oncoprotein Is Highly Stable and Extended, with Conformational Transitions that Could Explain Its Multiple Cellular Binding Partners - | 10.1021/bi025579n | 2002 |
Espectrometria de massa e o RMN multidimensional e multinuclear: evolução no estudo de macromoléculas biológicas | 2002 | |
NMR Structure of PW2 Bound to SDS Micelles | 10.1074/jbc.m204225200 | 2002 |
Selectively Labeling the Heterologous Protein in Escherichia coli for NMR Studies: A Strategy to Speed Up NMR Spectroscopy | 10.1006/jmre.2000.2213 | 2001 |
cDNA Cloning and Heterologous Expression of Functional Cysteine-Rich Antifungal Protein Psd1 in the Yeast Pichia pastoris, | 10.1006/abbi.2001.2564 | 2001 |
NMR Structural Studies using selective labeling of the heterologous protein | 2000 | |
Virus Maturation Targets the Protein Capsid to Concerted Disassembly and Unfolding | 10.1074/jbc.m910145199 | 2000 |
Stability and activity modulation of chymotrypsins in AOT reversed micelles by protein-interface interaction: Interaction of α-chymotrypsin with a negative interface leads to a cooperative breakage of a salt bridge that keeps the catalytic active conformation (Ile16-Asp194) | 10.1002/(sici)1097-0290(19980805)59:3<360::aid-bit12>3.0.co;2-i | 1998 |
Measurement of1HT1ρin a Uniformly15N-Labeled Protein in Solution with Heteronuclear Two-Dimensional Spectroscopy | 10.1006/jmre.1996.1091 | 1997 |
fd coat protein structure in membrane environments: structural dynamics of the loop between the hydrophobic trans-membrane helix and the amphipathic in-plane helix | 10.1006/jmbi.1997.1114 | 1997 |
Membrane Protein Structure and Topology by NMR spectroscopy | 1996 | |
Electron Spin Resonance Study of the Effect of Urea on the Properties of AOT Reverse Micelles in Isooctane | 10.1021/la00018a028 | 1994 |
Solvent-induced changes in the photophysical properties of N-alkylphthalimides II. Temperature and acidity effects | 10.1016/1010-6030(91)87047-y | 1991 |
Potencially Antimalarial Heterocyclic Thyosemicarbazones. I.Structural Aspects | 1985 |
Eventos:
(0.00% eventos com DOI)