Francois Germain Noel
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Ciências Biomédicas
Departamento:
Docentes/ICB
Formação:
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Université Catholique de Louvain
| Pós-Doutorado | 1997 - 1997
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Université Catholique de Louvain
| Pós-Doutorado | 1989 - 1990
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 1983 - 1986
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Université Catholique de Louvain
Pharmacien D'industrie | Especialização | 1982 - 1982
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Université Catholique de Louvain
Sciences Pharmaceutiques | Doutorado | 1978 - 1982
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Université Catholique de Louvain
Sciences Pharmaceutiques | Graduação | 1973 - 1978
Laboratórios:
Nuvens de Palavras:
Artigos:
(44.96% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses | 10.1590/1414-431x2023e13258 | 2024 |
| L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke | 10.1007/s43440-023-00451-x | 2023 |
| Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice | 10.1016/j.bbr.2021.113582 | 2022 |
| Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases | 10.3390/biom12081112 | 2022 |
| Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca2+-ATPase | 10.1002/jcb.30150 | 2021 |
| Implications of Synthetic Modifications of the Cardiotonic Steroid Lactone Ring on Cytotoxicity | 10.1007/s00232-021-00186-x | 2021 |
| Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A2A Receptor | 10.3390/molecules26237364 | 2021 |
| SCREENER, an educational game for teaching the Drug Discovery and Development process | 10.1590/1414-431x2021e11786 | 2021 |
| Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study | 10.1016/j.bcp.2019.113679 | 2020 |
| New α-hydroxy-1,2,3-triazoles and 9H-fluorenes-1,2,3-triazoles: synthesis and evaluation as Glycine Transporter 1 Inhibitors | 10.21577/0103-5053.20200011 | 2020 |
| Pharmacological aspects and clues for the rationale use of Chloroquine/Hydroxychloroquine facing the therapeutic challenges of COVID-19 pandemic | 2020 | |
| Ivermectin and COVID-19: a report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses | 10.1016/j.antiviral.2020.104805 | 2020 |
| Suggesting Treatments for COVID-19. Beware! Expectations cannot Replace Good Science | 2020 | |
| Effects of doxycycline in Swiss mice predictive models of schizophrenia | 10.1007/s12640-020-00268-z | 2020 |
| Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin | 10.2174/1871527319999200817153150 | 2020 |
| Evaluation of functional selectivity of haloperidol, clozapine, and LASSBio-579, an experimental compound with antipsychotic-like actions in rodents, at G protein and arrestin signaling downstream of the dopamine D2 receptor | 10.3389/fphar.2019.00628 | 2019 |
| Revisiting the Pharmacodynamic Uroselectivity of α 1 -Adrenergic Receptor Antagonists | 10.1124/jpet.119.260216 | 2019 |
| The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by EGF receptor inhibition | 10.1016/j.lfs.2019.117048 | 2019 |
| A NEW PIPERAZINE DERIVATIVE: 1-(4-(3,5-DI-TERT-BUTYL-4- HYDROXYBENZYL) PIPERAZIN-1-YL)-2-METHOXYETHAN-1-ONE WITH ANTIOXIDANT AND CENTRAL ACTIVITY | 10.1007/s00210-017-1451-7 | 2018 |
| The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment | 2018 | |
| Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides | 10.3390/ijms19092769 | 2018 |
| Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+,K+-ATPase (α1β1): Methodological considerations | 10.1016/j.vascn.2018.09.001 | 2018 |
| LASSBio-1422 | 10.1097/fbp.0000000000000267 | 2017 |
| Effects of Cardiotonic Steroids on Isolated Perfused kidney and NHE3 Activity in Renal Proximal Tubules | 10.1016/j.bbagen.2017.05.012 | 2017 |
| LASSBio-897 reduces lung injury induced by silica particles in mice: potential interaction with the A2A receptor | 10.3389/fphar.2017.00778 | 2017 |
| New multi-target antagonists of 1A-, 1D-adrenoceptors and 5-HT1A receptors reduce human hyperplastic prostate cell growth and the increase of intraurethral pressure | 10.1124/jpet.115.227066 | 2016 |
| Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery | 10.1039/C6RA15143D | 2016 |
| ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia | 10.1590/1414-431x20165542 | 2016 |
| Na+-shift binding assay for estimation of the intrinsic efficacy of ligands at the A2A adenosine receptor | 10.1016/j.vascn.2016.10.009 | 2016 |
| Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na+/K+-ATPase activity | 10.1016/j.toxicon.2015.11.015 | 2016 |
| Effects of Diene Valepotriates from Valeriana glechomifolia on Na+/K+-ATPase Activity in the Cortex and Hippocampus of Mice | 10.1055/s-0034-1396200 | 2015 |
| Biosynthesis of human diazepam and clonazepam metabolites | 10.1016/j.bmcl.2015.01.025 | 2015 |
| Novel Orally Active Analgesic and Anti-Inflammatory Cyclohexyl-N-Acylhydrazone Derivatives | 10.3390/molecules20023067 | 2015 |
| γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect | 10.1016/j.bmc.2015.06.028 | 2015 |
| Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor | 10.1016/j.pnpbp.2015.04.003 | 2015 |
| Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth | 10.1007/s00210-013-0935-3 | 2014 |
| Functional binding assays for estimation of the intrinsic efficacy of ligands at the 5-HT1A receptor: Application for screening drug candidates | 10.1016/j.vascn.2014.03.002 | 2014 |
| Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis | 10.1016/j.phymed.2014.08.009 | 2014 |
| 21-Benzylidene Digoxin: A Proapoptotic Cardenolide of Cancer Cells That Up-Regulates Na,K-ATPase and Epithelial Tight Junctions | 10.1371/journal.pone.0108776 | 2014 |
| Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine | 10.3390/molecules190914699 | 2014 |
| Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice | 10.1007/s13105-012-0203-x | 2013 |
| Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound | 10.1016/j.ejmech.2012.08.011 | 2013 |
| SERCA2 is present in the rat vas deferens and is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation | 2013 | |
| Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579 | 10.1016/j.ejmech.2013.05.027 | 2013 |
| The natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+/K+-ATPase-Src kinase pathway | 10.1152/ajprenal.00130.2011 | 2012 |
| Synthesis, Biological Evaluation, and Structure-activity Relationship of Clonazepam, Meclonazepam, and 1,4-Benzodiazepine Compounds with Schistosomicidal Activity | 10.1111/j.1747-0285.2012.01354.x | 2012 |
| New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia | 10.1016/j.bbr.2012.09.016 | 2012 |
| ?2,3 -Ivermectin ethyl secoester, a conjugated ivermectin derivative with leishmanicidal activity but without inhibitory effect on mammalian P-type ATPases | 10.1007/s00210-010-0578-6 | 2011 |
| Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation | 10.1016/j.lfs.2010.10.027 | 2011 |
| Discovery of LASSBio-772, a 1,3-Benzodioxole N-Phenylpiperazine Derivative with Potent Alpha 1A/D-Adrenergic Receptor Blocking Properties | 10.1016/j.ejmech.2011.04.032 | 2011 |
| Effect of Valepotriates Isolated from on Rat P-Type ATPases | 10.1055/s-0030-1271084 | 2011 |
| Increased Endothelial Cell-Leukocyte Interaction in Murine Schistosomiasis: Possible Priming of Endothelial Cells by the Disease | 10.1371/journal.pone.0023547 | 2011 |
| Ivermectin is a nonselective inhibitor of mammalian P-type ATPases | 10.1007/s00210-009-0483-z | 2010 |
| Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection | 10.1016/j.toxicon.2009.06.032 | 2010 |
| Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. | 10.1016/j.phytochem.2009.10.007 | 2010 |
| Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors | 10.1590/S0100-879X2010007500028 | 2010 |
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors | 10.1016/j.bmc.2010.01.040 | 2010 |
| Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581 | 10.1016/j.bmcl.2010.03.034 | 2010 |
| Descoberta de novos protótipos N-fenilpiperazínicos heteroarilazólicos candidatos a fármacos antipsicóticos atípicos | 2010 | |
| Mechanisms of adaptive supersensitivity in vas deferens | 10.1016/j.autneu.2009.01.002 | 2009 |
| The effects of 3-methylclonazepam on Schistosoma mansoni musculature are not mediated by benzodiazepine receptors | 10.1016/j.ejphar.2009.01.021 | 2009 |
| Inhibition of the ?1?1 Isoform of the Na, K-ATPase by 8-methoxycoumestrol Without Positive Inotropic Effect in Human Myocardium-Novel Aspects of Cardiac Glycoside Pharmacology | 10.1097/FJC.0b013e3181a95ab2 | 2009 |
| Pharmacokinetic/Pharmacodynamic Modeling of Psychomotor Impairment Induced by Oral Clonazepam in Healthy Volunteers | 10.1097/FTD.0b013e3181b1dd76 | 2009 |
| Identification and Characterization of Coumestans as Novel HCV NS5B Polymerase Inhibitors | 2008 | |
| Insights into the mechanism of Na+, K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan | 2008 | |
| Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae) | 2008 | |
| Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni | 2007 | |
| Noradrenaline-induced contraction of mice aorta is enhanced in schistosomiasis | 2007 | |
| Na+/K+-ATPase a isoforms expression in stroke-prone spontaneously hypertensive rat heart ventricles: effect of salt loading and lacidipine treatment | 2007 | |
| Murine portal vein hyperreactivity to 5-HT in schistosomiasis: evidence of the involvement of potassium channels and p38 MAP Kinase | 2007 | |
| Synergistic interaction between ouabain and 8-metoxy-3,9-dihydroxy coumestan, a non-steroidal synthetic inhibitor of Na+,K+-ATPase. | 2007 | |
| Role of calcium influx through voltage-operated calcium channels and of calcium mobilisation in the physiology of Schistosoma mansoni muscle contractions | 2006 | |
| Structure-Activity Relationship of Wedelolactone Analogues: Structural Requirements for Inhibition of Na+,K+-ATPase and Binding to the Central Benzodiazepine Receptor | 2006 | |
| Usefulness of serotoninergic challenge with oral citalopram | 2006 | |
| Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors | 2005 | |
| On-line solid phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE-HPLC-MS-MS) for quantification of bromazepam in human plasma: an automated method for bioequivalence studies | 2005 | |
| Adaptive expression pattern of different proteins involved in cellular calcium homeostasis in denervated rat vas deferens | 2005 | |
| Taurine prevents the neurotoxicity of b-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders | 2004 | |
| Characterization of a GABAergic neurotransmission in adult Schistosoma mansoni | 2004 | |
| In vitro/in vivo correlation of dissolution profiles of two L-thyroxine tablets with pharmacokinetics data obtained in patients with hypothyroidism. | 2004 | |
| Characterization of 2-Methoxy-3,8,9-Trihydroxy Coumestan, a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor | 2004 | |
| Stereoselective Synthesis and Preliminary Evaluation of New D-3-Heteroarylcarbonylalanines as Ligands of the NMDA Receptor | 2004 | |
| Cellular mechanisms involved in the increased contraction of portal veins from Schistosoma mansoni-infected mice. | 2003 | |
| Insights into the mechanism of erythrocyte Na+/K+ -ATPase inhibition by nitric oxide and peroxynitrite anion | 2003 | |
| 2-Methoxy-3,8,9-Trihydroxy Coumestan: a new synthetic inhibitor of Na+,K+-ATPase with an original mechanism of action. | 2003 | |
| Teste de bioequivalência para fármacos que apresentam farmacocinética altamente variável | 2003 | |
| Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta | 2002 | |
| Synthesis and Preliminary pharmacological Evaluation of New 1,4-Naphthoquinones Structurally Related to Lapachol | 2002 | |
| Influence of development on Na/K-ATPase expression: isoform and tissue dependency | 2002 | |
| Role of noradrenaline on the expression of the Na+/K+-ATPase a2 isoform and the contractility of cultured rat vas deferens | 2002 | |
| Evidence For The Presence Of Glutamatergic Receptors In Adult Schistosoma mansoni. | 2002 | |
| Characterization of subcellular fractions and distribution profiles of transport components involved in Ca2+ homeostasis in rat vas deferens | 2002 | |
| Synthesis and Preliminar Pharmacological Evaluation of Coumestanes Bearing Different Patterns of Oxygenation in Rings A and D | 2001 | |
| Radioligand binding assays in the drug discovery process: high throughput screening and the risk of false negative | 2001 | |
| Comparative Bioavailability of Two L-Thyroxine Formulations after Multiple Dose Administration in Patients with Hypothyroidism and its Relation with Dissolution Profiles | 2001 | |
| Testes de bioequivalência para fármacos com meia-vidas longa | 2001 | |
| Control of calcium homeostasis in Schistosoma mansoni | 2001 | |
| Testes de bioequivalência para fármacos que apresentem baixo índice terapêutico. | 2001 | |
| Selective destruction of nigro-striatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum | 2000 | |
| Down-regulation of Na/K-ATPase alpha2 isoform in denervated rat vas deferens | 2000 | |
| Dantrolene has no effect on [3H]-ryanodine binding | 1999 | |
| Quantitative Analysis Of The High-Affinity Binding Sites For [3h] Ouabain In The Rat Vas Deferens And Their Immunological Identificationas The Alpha2 Isoform Of Na/K-Atpase | 1998 | |
| Increased reactivity to 5-hydroxytryptamine of portal veins from mice infected with Schistosoma mansoni | 1998 | |
| Evidence for ryanodine receptors in Schistosoma mansoni | 1998 | |
| Portal veins from mice infected with Schistosoma mansoni exhibit an increased reactivity to 5-hydroxytryptamine | 1998 | |
| Evidence for functional ryanodine receptors in Schistosoma mansoni and their putative role in the control of calcium homeostasis | 1998 | |
| Ca-Mg ATPase in Schistosoma mansoni: evidence for heterogeneity and resistance to praziquantel | 1998 | |
| Praziquantel Has No Direct Effect On (Na+K)-Atpases And (Ca-Mg)Atpasesof Schistosoma Mansoni | 1997 | |
| Na/K-Atpase Density Is Sexually Dimorphic In The Adult Rat Kidney | 1997 | |
| Characterization Of An Isoform Of Na/K-Atpase With High Affinity For 3h-Ouabain In The Rat Vas Deferens | 1997 | |
| Evidence For The Presence Of Two (Ca-Mg)Atpases With Different Subcel Lular Distributions In The Human Flatworm Schistosoma Mansoni | 1996 | |
| Formation Of A Highly Stable Complex Between Bn 50730 And The Plateletactivating Factor Receptor In Rabbit Platelet Membranes | 1996 | |
| Decrease In The Ratio Of High- To Low-Affinity Isozymes Of (Na+K)- Atpase During The Development Of Rat | 1995 | |
| Time-Course Of The Effect Of Praziquantel On Schistosoma Mansoni Attachment, In Vitro: Comparison With Its Effect On Worm Length And Motility | 1995 | |
| Yangambin A New Naturally-Occuring Platelet-Activating Factor Antago Nist: Binding And In Vitro Functional Studies | 1995 | |
| Heterogeneity Of Ouabain Binding Sites In Schistosoma Mansoni: First Evidence For The Presence Of Two (Na,K)-Atpase Isoforms In Platyhelminths. | 1994 | |
| A (Ca-Mg)Atpase From Schistosoma Mansoni Is Coupled To An Active Transport Of Calcium | 1992 | |
| Distribution Of Alpha1 And Alpha2 (Na,K)-Atpase Isoforms Between The Junctional (T-Tubular) And Non-Junctional Sarcolemmal Domains Of Rat Ventricles | 1991 | |
| Praziquantel Inhibits Schistosoma Mansoni Attachment In Vitro | 1990 | |
| A Comparison Of The Affinities Of Rat (Na+K)-Atpase Isozymes For Cardioactive Steroids, Role Of Lactone Ring, Sugar Moiety And Kcl Concentration. | 1990 | |
| Vanadate Sensitivity Of (Na-K)Atpase From Schistosoma Mansoni And Its Modulation By Na, K And Mg | 1989 | |
| Use Of A Non-Linear Regression Approach For The Analysis Of The Ouabain-K Interaction With (Na+K)-Atpase From Guinea-Pig And Rat Hearts | 1989 | |
| Mg-Independent Ca-Stimulated Atpase Activity In The Tegument Of Schistosoma Mansoni | 1988 | |
| A Ca-Stimulated, Mg-Dependent Atpase Activity In Subcellular Fractionsfrom Schistosoma Mansoni | 1988 | |
| Schistosoma Mansoni: Preparation And Characterization Of (Na+K)Atpase From Tegument And Carcass | 1986 | |
| Heterogeneity Of Ouabain Specific Binding Sites And (Na + K) - Atpase Inhibition In Microsomes Form Rat Heart | 1984 | |
| The Inotropic Effect Of Ouabain And Its Antagonism By Dihydroouabain In Rat Isolated Atria And Ventricles In Relation To. | 1983 | |
| Inotropic Effects And Binding Sites Of Ouabain To Rat Heart | 1982 | |
| Sodium Activation Of Heart (Na+K)-Atpase From Normotensive And Hypertensive Rats | 1980 |
Eventos:
(0.00% eventos com DOI)