João Alfredo de Moraes Gomes da Silva

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Ciências Biomédicas

Departamento:

Departamento de Farmácologia Básica e Clínica

ORCID:

https://orcid.org/0000-0002-8563-6432


Formação:

  • Universidade do Estado do Rio de Janeiro

    | Pós-Doutorado | 2015 - 2016

  • Universidade do Estado do Rio de Janeiro

    | Pós-Doutorado | 2013 - 2015

  • Universidade do Estado do Rio de Janeiro

    | Pós-Doutorado | 2012 - 2013

  • Universidade do Estado do Rio de Janeiro

    Biologia (Biociências Nucleares) | Doutorado | 2008 - 2011

  • Universidade do Estado do Rio de Janeiro

    Biologia (Biociências Nucleares) | Mestrado | 2006 - 2008

  • Universidade do Estado do Rio de Janeiro

    Ciencias Biologicas | Graduação | 2002 - 2005

  • Pontifícia Universidade Católica do Rio de Janeiro

    Informatica | Graduação | 1999 - Agora
Laboratórios:
Nenhum laboratório cadastrado
Nuvens de Palavras:
Artigos:

(100.00% artigos com DOI)

Titulo DOI Ano
Extracellular vesicles as modulators of monocyte and macrophage function in tumors 10.1590/0001-3765202420231212 2024
Heparin prevents the cytotoxic activity of Bothrops jararacussu and Apis mellifera venoms in renal cells 10.1016/j.toxicon.2022.107011 2023
DESIGN, SYNTHESIS AND PHENOTYPIC PROFILING OF SIMPLIFIED GEDATOLISIB ANALOGUES 10.3390/ph16020209 2023
Pleiotropic antifibrotic actions of aspirin-triggered resolvin D1 in the lungs 10.3389/fimmu.2023.886601 2023
Extracellular Vesicles From Stored Red Blood Cells Convey Heme and Induce Spic Expression on Human Monocytes 10.3389/fimmu.2022.833286 2022
Extracellular vesicles derived from MDA-MB-231 cells trigger neutrophils to a pro-tumor profile 10.3390/cells11121875 2022
A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization 10.3390/toxins13010030 2021
Urine proteomic analysis reveals alterations in heme/hemoglobin and aminopeptidase metabolism during Lonomia obliqua venom-induced acute kidney injury 10.1016/j.toxlet.2021.01.012 2021
Melanoma¿derived extracellular vesicles skew neutrophils into a pro¿tumor phenotype 10.1002/jlb.3a0120-050rr 2021
Adipose Tissue-Derived Extracellular Vesicles and the Tumor Microenvironment: Revisiting the Hallmarks of Cancer 10.3390/ cancers13133328 2021
Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro 10.1038/s41598-021-95190-5 2021
Translational Application of Fluorescent Molecular Probes for the Detection of Reactive Oxygen and Nitrogen Species Associated with Intestinal Reperfusion Injury 10.3390/metabo11120802 2021
Effect of Lonomia obliqua Venom on Human Neutrophils 10.3390/toxins13120908 2021
Obese adipose tissue extracellular vesicles raise breast cancer cell malignancy 10.1530/erc-19-0507 2020
Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4 10.3390/nu12092828 2020
Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice 10.3390/ijms21249658 2020
Renal and vascular effects of kallikrein inhibition in a model of Lonomia obliqua venom-induced acute kidney injury 10.1371/journal.pntd.0007197 2019
Helicobacter pylori urease induces pro¿inflammatory effects and differentiation of human endothelial cells: Cellular and molecular mechanism 10.1111/hel.12573 2019
AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway 10.1016/j.intimp.2018.01.045 2018
Reactive oxygen species generation mediated by NADPH oxidase and PI3K/Akt pathways contribute to invasion of Streptococcus agalactiae in human endothelial cells 10.1590/0074-02760170421 2018
Recombinant and Chimeric Disintegrins in Preclinical Research 10.3390/toxins10080321 2018
Downregulation of Microparticle Release and Pro-Inflammatory Properties of Activated Human Polymorphonuclear Neutrophils by LMW Fucoidan 10.1159/000494220 2018
Effects of Lonomia obliqua Venom on Vascular Smooth Muscle Cells: Contribution of NADPH Oxidase-Derived Reactive Oxygen Species 10.3390/toxins9110360 2017
Nanocarriers as Phototherapeutic Drug Delivery System: Appraisal of Three Different Nanosystems in an In vivo and In vitro Exploratory Study 10.1016/j.pdpdt.2017.11.003 2017
Microparticles derived from obese adipose tissue elicit a pro-inflammatory phenotype of CD16+, CCR5+ and TLR8+ monocytes 10.1016/j.bbadis.2016.09.016 2017
ExoU-induced redox imbalance and oxidative stress in airway epithelial cells during Pseudomonas aeruginosa pneumosepsis 10.1007/s00430-015-0418-x 2015
Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease 10.1182/blood-2014-07-589283 2015
Rapid NOS-1-derived nitric oxide and peroxynitrite formation act as signaling agents for inducible NOS-2 expression in vascular smooth muscle cells 10.1016/j.phrs.2015.08.001 2015
Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells 10.1016/j.atherosclerosis.2015.09.026 2015
Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells 10.1016/j.dib.2015.11.053 2015
Reactive oxygen species involved in apoptosis induction of human respiratory epithelial (A549) cells by Streptococcus agalactiae 10.1099/mic.0.000202 2015
Redox Modulation of FAK Controls Melanoma Survival - Role of NOX4 10.1371/journal.pone.0099481 2014
Heme modulates intestinal epithelial cell activation: involvement of NADPHox-derived ROS signaling 10.1152/ajpcell.00078.2012 2013
Pro-inflammatory properties and neutrophil activation by Helicobacter pylori urease 10.1016/j.toxicon.2013.02.009 2013
A pro-inflammatory profile of endothelial cell in Lonomia obliqua envenomation 10.1016/j.toxicon.2012.03.016 2012
Heme modulates smooth muscle cell proliferation and migration via NADPH oxidase: A counter-regulatory role for heme oxygenase system 10.1016/j.atherosclerosis.2012.07.043 2012
Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease 10.1182/blood-2012-02-413138 2012
Leukotriene B4 mediates vascular smooth muscle cell migration through αvβ3 integrin transactivation 10.1016/j.atherosclerosis.2010.06.009 2010
α9β1 integrin engagement inhibits neutrophil spontaneous apoptosis: Involvement of Bcl-2 family members 10.1016/j.bbamcr.2010.03.012 2010
Eventos:
Nenhum evento cadastrado
Publicações:
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