Yraima Moura Lopes Cordeiro

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Faculdade de Farmácia

Departamento:

Departamento de Biotecnologia Farmacêutica

ORCID:

https://orcid.org/0000-0003-4278-212X


Formação:

  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2005 - Agora

  • Universidade Federal do Rio de Janeiro

    Química Biológica | Doutorado | 2001 - 2005

  • Universidade Federal do Rio de Janeiro

    Química Biológica | Mestrado | 1999 - 2001

  • Universidade Federal do Estado do Rio de Janeiro

    Ciências Biológicas - Modalidade Médica | Graduação | 1995 - 1999

  • Escola Técnica Federal de Química do Rio de Janeiro

    Curso Técnico em Biotecnologia | Ensino Profissional de nível técnico | 1991 - 1994
Laboratórios:
Nuvens de Palavras:
Artigos:

(100.00% artigos com DOI)

Titulo DOI Ano
New mescaline-related N-acylhydrazone and its unsubstituted benzoyl derivative: Promising metallophores for copper-associated deleterious effects relief in Alzheimer's disease 10.1016/j.jinorgbio.2022.112033 2023
PRIMA-1 inhibits Y220C p53 amyloid aggregation and synergizes with cisplatin in hepatocellular carcinoma 10.3389/fmolb.2023.1165132 2023
(Dys)functional insights into nucleic acids and RNA-binding proteins modulation of the prion protein and α-synuclein phase separation 10.1007/s12551-023-01067-4 2023
Targeting Biomolecular Condensation and Protein Aggregation against Cancer 10.1021/acs.chemrev.3c00131 2023
How oxidized EGCG remodels α-synuclein fibrils into non-toxic aggregates: insights from computational simulations 10.1039/D3CP02261G 2023
Phase separation of the mammalian prion protein: Physiological and pathological perspectives 10.1111/jnc.15586 2023
Copper drives prion protein phase separation and modulates aggregation 10.1126/sciadv.adi7347 2023
Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation 10.1016/j.sbi.2022.102346 2022
Novel Method for the Production, Purification, and Characterization of Recombinant Lunasin: Identification of Disulfide Cross-Linked Dimers 10.1007/s10989-022-10466-2 2022
Prion protein complexed to a DNA aptamer induce behavioral and synapse dysfunction in mice 10.1016/j.bbr.2021.113680 2022
The interplay between a GC-rich oligonucleotide and copper ions on prion protein conformational and phase transitions 10.1016/j.ijbiomac.2021.01.097 2021
Rabbit PrP Is Partially Resistant to in vitro Aggregation Induced by Different Biological Cofactors 10.3389/fnins.2021.689315 2021
Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands 10.1039/d1sc01739j 2021
Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo 10.1016/j.ymthe.2021.04.035 2021
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases 10.3390/biom11050767 2021
Liquid-liquid phase separation and fibrillation of the prion protein modulated by a high-affinity DNA aptamer 10.1096/fj.20190 1897R 2020
Phase Separation and Disorder-to-Order Transition of Human Brain Expressed X-Linked 3 (hBEX3) in the Presence of Small Fragments of tRNA 10.1016/j.jmb.2020.02.030 2020
Challenges and Advances in Antemortem Diagnosis of Human Transmissible Spongiform Encephalopathies 10.3389/fbioe.2020.585896 2020
Accommodation of In-Register N-Linked Glycans on Prion Protein Amyloid Cores 10.1021/acschemneuro.0c00635 2020
Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells 10.1016/j.bioorg.2018.10.003 2019
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant 10.1080/14756366.2019.1571270 2019
Modulation of p53 and prion protein aggregation by RNA 10.1016/j.bbapap.2019.02.006 2019
RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction 10.1038/s41598-019-48883-x 2019
Synthesis and in silico and in vitro evaluation of trimethoxy-benzamides designed as anti-prion derivatives 10.1007/s00044-019-02441-2 2019
Diosmin induces caspase-dependent apoptosis in human glioblastoma cells 10.1590/0001-3765201920191031 2019
A promising antiprion trimethoxychalcone binds to the globular domain of PrP and changes its cellular location 10.1128/AAC.01441-17 2018
Association of high pressure and alkaline condition for solubilization of inclusion bodies and refolding of the NS1 protein from zika virus 10.1186/s12896-018-0486-2 2018
Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain 10.1074/jbc.M116.762096 2017
Unraveling Prion Protein Interactions with Aptamers and Other PrP-Binding Nucleic Acids 10.3390/ijms18051023 2017
Publish and perish in the hands of predatory journals 10.1590/0001-37652017892 2017
Mammalian prion amyloid formation in bacteria 10.1080/19336896.2016.1141859 2016
The 'Jekyll and Hyde' Actions of Nucleic Acids on the Prion-like Aggregation of Proteins 10.1074/jbc.r116.733428 2016
Nanoencapsulated Lecitase Ultra and lipase, a comparative structural study. 10.1021/acs.langmuir.6b00826 2016
Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core 10.1038/srep37990 2016
Stability and structural changes of horseradish peroxidase: Microwave versus conventional heating treatment 10.1016/j.enzmictec.2014.11.002 2015
New Approaches for the Selection and Evaluation of Anti-Prion Organic Compounds 10.2174/1389557515666150227111629 2015
Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles 10.1590/0001-3765201520140712 2015
Biophysical Studies on BEX3, the p75NTR-Associated Cell Death Executor, Reveal a High-Order Oligomer with Partially Folded Regions 10.1371/journal.pone.0137916 2015
Mammalian prion protein (PrP) forms conformationally different amyloid intracellular aggregates in bacteria 10.1186/s12934-015-0361-y 2015
Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseases 10.1007/s12551-013-0132-0 2014
Anti-Prion Activity of a Panel of Aromatic Chemical Compounds: In Vitro and In Silico Approaches 10.1371/journal.pone.0084531 2014
Conformational dissection of Thermomyces lanuginosus lipase in solution 10.1016/j.bpc.2013.12.001 2014
The effect of temperature on protein refolding at high pressure: Enhanced green fluorescent protein as a model 10.1016/j.procbio.2013.09.022 2014
Biophysical and morphological studies on the dual interaction of non-octarepeat prion protein peptides with copper and nucleic acids 10.1007/s00775-014-1115-8 2014
Heparin binding confers prion stability and impairs its aggregation 10.1096/fj.13-246777 2014
The importance of a gatekeeper residue on the aggregation of transthyretin: implications to transthyretin-related amyloidoses 10.1074/jbc.m114.563981 2014
An analysis of the factors that affect the dissociation of inclusion bodies and the refolding of endostatin under high pressure 10.1016/j.procbio.2012.12.017 2013
Continuous flow valorization of fatty acid waste using silica-immobilized lipases 10.1039/c2gc36674f 2013
Insights into the Intramolecular Coupling between the N- and C-Domains of Troponin C Derived from High-Pressure, Fluorescence, Nuclear Magnetic Resonance, and Small-Angle X-ray Scattering Studies 10.1021/bi301139d 2013
A Comprehensive Study on the Activity and Deactivation of Immobilized Lecitase Ultra in Esterifications of Food Waste Streams to Monoacylglycerols 10.1002/cssc.201300026 2013
Pressure-Temperature Folding Landscape in Proteins Involved in Neurodegenerative Diseases and Cancer 10.1016/j.bpc.2013.06.002 2013
Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor 10.1042/bsr20130065 2013
Kinetics and mechanism of lipase catalyzed monoacylglycerols synthesis 10.1016/j.molcatb.2013.06.008 2013
Intramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membrane 10.1074/jbc.M113.500926 2013
The role of RNA in mammalian prion protein conversion 10.1002/wrna.118 2012
Allosteric function and dysfunction of the prion protein. 10.1007/s00018-011-0847-7 2012
Non-Specific Prion Protein-Nucleic Acid Interactions Lead to Different Aggregates and Cytotoxic Species 10.1021/bi300440e 2012
Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: Implications for cancer 10.1074/jbc.M112.340638 2012
Moniliophthora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Metastable Dimer in Solution: Structural and Functional Implications 10.1371/journal.pone.0045620 2012
Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species 10.1021/ja106725p 2011
Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion 10.1016/j.ymeth.2010.12.002 2011
Hydrophilic cyclodextrin protected Pd nanoclusters: insights into their size control and host¿guest behavior 10.1039/c1jm11962a 2011
Erratum to ¿Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors¿ [Int. J. Biochem. Cell Biol. 43 (1) (2011) 60¿64] 10.1016/j.biocel.2011.01.009 2011
PrP interactions with nucleic acids and glycosaminoglycans in function and disease 10.2741/3611 2010
Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins 10.1021/ar900179t 2010
The p53 Core Domain Is a Molten Globule at Low pH: FUNCTIONAL IMPLICATIONS OF A PARTIALLY UNFOLDED STRUCTURE 10.1074/jbc.M109.075861 2010
Subunit¿subunit interactions and overall topology of the dimeric mitochondrial ATP synthase of Polytomella sp. 10.1016/j.bbabio.2010.02.024 2010
Synthesis and anti-prion activity evaluation of aminoquinoline analogues 10.1016/j.ejmech.2010.07.054 2010
Enhanced prion protein stability coupled to DNA recognition and milieu acidification 10.1016/j.bpc.2008.12.011 2009
Effects of compressed fluids on the activity and structure of horseradish peroxidase 10.1016/j.supflu.2009.04.014 2009
Cognate DNA Stabilizes the Tumor Suppressor p53 and Prevents Misfolding and Aggregation 10.1021/bi9003028 2009
Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1 10.1096/fj.09-138974 2009
The intriguing nucleic acid-binding features of the mammalian prion protein 10.1016/j.tibs.2007.11.003 2008
Recognition mechanism of D- and L-tryptophan enantiomers by 2-hydroxypropyl-alpha- or betacyclodextrins 10.1016/j.tetasy.2008.04.035 2008
Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cells 10.1074/jbc.M802102200 2008
The peculiar interaction between mammalian prion protein and RNA 10.4161/pri.2.2.6988 2008
Protein Folding and Aggregation: Two sides of the same coin in the condensation of proteins revealed by pressure studies 10.1016/j.bbapap.2005.11.012 2006
Microbial reduction of alpha-acetyl-gamma-butyrolactone 10.1016/j.tetasy.2006.03.015 2006
FT-IR spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin 10.1529/biophysj.106.085928 2006
Structural insights into the interaction between prion protein and nucleic acid 10.1021/bi060532d 2006
The Hypothesis of the Catalytic Action of Nucleic Acid on the Conversion of Prion Protein 10.2174/0929866053587138 2005
Volume and energy folding landscape of prion protein revealed by pressure 10.1590/S0100-879X2005000800006 2005
The amino-terminal PrP domain is crucial to modulate prion misfolding and aggregation 10.1529/biophysj.105.067603 2005
Hydration and packing effects on prion folding and beta-sheet conversion: High-pressure spectroscopy and pressure perturbation calorimetry studies 10.1074/jbc.M404295200 2004
Fibrillar aggregates of the tumor suppressor p53 core domain 10.1021/bi034218k 2003
Modulation of Prion Protein Oligomerization, Aggregation, and  -sheet Conversion by 4,4'-Dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS) 10.1074/jbc.M312262200 2003
Pressure-induced Formation of Inactive Triple-shelled Rotavirus Particles is Associated with Changes in the Spike Protein VP4 10.1006/jmbi.2001.4512 2001
DNA Converts Cellular Prion Protein into the beta -Sheet Conformation and Inhibits Prion Peptide Aggregation 10.1074/jbc.M106707200 2001
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Copper ions modulate prion protein phase transitions 2023
Phase separation research applied to the study of the biological function of the prion protein 2023
MUTANT p53 AMYLOID AGGREGATES TRANSMISSION THROUGH EXTRACELLULAR VESICLES IN BREAST CANCER 2023
Phase separation research applied to the study of the biological function of prion protein 2022
Modulation of Alpha-Synuclein Aggregation by Organic Compounds 2022
A high-affinity DNA hairpin binds to the prion protein globular domain leading to partial unfolding and liquid phase separation 2019
New method for prion protein aggregation in vitro as a useful tool to select and study therapeutic compounds against prion diseases 2019
Brain expressed x-linked (BEX3) and its transitions from intrinsic disorder to the formation of ordered 3D fold and liquid-liquid phase separation 2019
Evaluation of recombinant prion protein interaction with Cu(II) and nucleic acids: insights into the pathophysiology of prion disorders 2019
Changes in phase transition in p53 induced by solvation and high pressure 2019
Liquid liquid phase separation and aggregation of the prion protein modulated by a high affinity DNA aptamer 2019
Heparin Binding Confers Prion Stability And Impairs Its Aggregation 2014
Identification Of Promising Anti-Prion Drug Candidates Through Ex-Vivo, In Vitro And In Silico Methodologies 2014
In Silico Evaluation of Pharmacodynamic and Pharmacokinetic Parameters and In Vitro Mutagenicity Analysis of Anti-Prion Compounds 2014
Intramolecular Dynamics Within the N-Cap-SH3-SH2 Regulatory Unit of the c-Abl Tyrosine Kinase Reveal Targeting to the Cellular Membrane 2014
Pathological Implications of Nucleic Acids Interactions With Prion Proteins: In Vitro and In Vivo Approaches 2014
CROSS-TALK BETWEEN PRION PROTEIN AND NUCLEIC ACIDS: PROTEIN MISFOLDING LEADING TO CYTOTOXICITY 2013
CONFORMATIONAL ENSEMBLES OF GLYCOSYLATED PRION PROTEIN: A STRATEGY FOR MAPPING INTERACTIONS WITH PHYSIOLOGICAL AND THERAPEUTIC LIGANDS 2013
ISOLATION AND CHARACTERIZATION OF RNA MOLECULES BOUND TO RECOMBINANT MOUSE PRION PROTEIN 2013
RABBITS AND THEIR RESISTANCE TO PRION INFECTION: A MATTER OF ALTERED PRP-NUCLEIC ACID INTERACTIONS? 2013
Parkinson's disease: evaluating the effects of possible anti-parkinsonian compounds on alpha-synuclein aggregation and neurotoxicity 2012
HEPARIN BINDING INCREASES MURINE PRION PROTEIN STABILITY 2012
Modulation of a Prion Peptide aggregation by Chalcones: Therapeutic Implication 2012
Non-Specific Prion Protein?Nucleic Acid Interactions Lead into Different Aggregates and Cytotoxic Species 2012
Commercial Enzymes in Reverse Micelles Nanosystems: Structure-Activity Relationship 2012
Time-Dependent Conformation Profile of c-Abl Protein Reveals New Insights on Its Regulation and Functionality 2012
Moniliophtora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Dimer in Solution: Structural and Functional Implications 2012
Allosteric Effect of Ligands in Prion Protein Studied through Teorical and Experimental Methods for Structural Prediction 2012
New Aminoquinoline Compounds Inhibit Aggregation of the Syrian Hamster Prion Peptide and are Potential Lead Compounds Against Prion Diseases 2010
MpNep2 from Moniliophthora perniciosa Recover Necrosis Activity after Exposure to Temperature 2010
Evaluation of the Effect of Copper in the Aggregation and Conformation 2010
Insights on PrP Interaction with RNA Molecules 2010
Prion Protein Interaction with Low Molecular Weight Heparin 2010
Structural and physiological implications of prion protein interaction with DNA 2009
Prion protein aggregation and toxicity: the contribution of RNA molecules 2009
Evaluation fo prion protein interaction with heparin reveals pH-dependent binding sites 2009
THE PECULIAR INTERACTION BETWEEN MAMMALIAN PRION PROTEIN AND RNA 2009
Tumor Suppressor p53 WT and R248Q Core Domain Aggregation at Low pH 2009
Prion protein interaction with heparin 2009
Evaluation of Prion Protein Interaction with Quinoline Derivatives: Therapeutic Implications 2009
Structural and Physiological Implications of Prion Protein Interaction with DNA 2009
CHARACTERIZATION OF THE PRP:RNA COMPLEX: STRUCTURAL INSIGHTS AND TOXICITY STUDIES 2008
INVESTIGATION OF THE EFFECT OF HEPARIN ON PRION PROTEIN STRUCTURE 2008
BIOPHYSICAL STUDY AND SAXS-DERIVED LOW RESOLUTION MODEL OF PRION PROTEIN (PRP) COMPLEXED WITH THE CO-CHAPERONE HOP/STI-1 2008
CHARACTERIZATION OF WILD-TYPE P53 AND MUTANT R248Q INTERMEDIATE STATES 2007
PrP:RNA INTERACTION GENERATES TOXIC SPECIES 2007
EVALUATION OF PRION PROTEIN INTERACTION WITH DNA: CALORIMETRIC ANALYSES AND CELLULAR TOXICITY ASSAYS 2007
DISSECTION OF PRION PROTEIN AND HEPARIN INTERACTION SITES 2007
Structural Basis for Nucleic Acid Binding to the Prion Protein 2006
Volume and energy folding landscape of prion protein revealed by pressure and calorimetry 2006
RNA binding acivity of the n-terminal domain of prion protein 2006
RNA binding activity of prion protein and toxicity of PrP-RNA aggregates 2006
Characterization of the Molten Globule State of a p53 Oncogenic Mutant 2006
The amino-terminal PrP domain is crucial to modulate prion misfolding and aggregation 2005
Structural Basis for Nucleic Acid Binding and Conformational Conversion of Prion Protein 2005
Modulation of Prion Protein Oligomerization, Aggregation and beta-sheet Conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS) 2004
Specificity of Prion Protein Structure-Stability Relationship Probed by Lead Compounds and Thermodynamic Variables 2004
Effects of hydration and binding of nucleic acids and hydrophobic compounds on prion folding and beta-sheet conversion 2004
Hydration and packing effects on prion folding and beta-sheet conversion: High-pressure spectroscopy and pressure perturbation calorimetry studies 2004
Modulation of Hamster Prion Domains Aggregation by Naphthalene and Acridine Derivatives 2003
On the Reversibility of Prion Protein Aggregation 2003
Investigating the Stability of recPrP23-231 and recPrP(del 32-121) Against Pressure and Denaturing Agents 2003
Investigating the Stability of recPrP23-231 and recPrP(del 32-121) Against Pressure and Denaturing Agents 2003
DNA Converts Cellular Prion Protein into the Beta-sheet Conformation and Inhibits Prion Peptide Aggregation 2002
DNA Converts Cellular Prion Protein into the Beta-sheet Conformation and Inhibits Prion Peptide Aggregation 2002
DNA Converts Cellular Prion Protein into the Beta-sheet Conformation and Inhibits Prion Peptide Aggregation 2002
On the contributions of DNA binding on recombinant murine cellularPrP(23-231) stability 2002
Interaction of prion peptide and prion cellular protein with a hydrophobic probe and with nucleic acid 2001
Interaction of prion peptide and prion cellular protein with a hydrophobic probe and with nucleic acid 2001
?Inhibition of the Prion Peptide (PrP 109-149) Aggregation by a 2001
?Inhibition of the prion peptide PrP (109-149) aggregation by a hydrophobic compound 2000
Inhibition of Prion Peptides PrP (109-141) and PrP (109-149) Aggregation by a Hydrophobic Compound 2000
Study of the Effects of High Hydrostatic Pressure on the Simian Rotavirus SA11 Shell 1999
Nitric Oxide Production By Murine Spleen Cells After In Vivo Stimulation With Rotavirus Inactivated By High Pressure 1998
Nitric Oxide Production By Murine Spleen Cells After In Vivo Stimulation With Rotavirus Inactivated By High Hydrostatic Pressure 1998
High Pressure Inactivation of Simian Rotavirus: Evaluation of Nitric Oxide Production by Murine Spleen Cells 1998
Fluorescence Spectroscopy Properties of Rotavirus Subjected to High 1997
Studies of Brain Miosin V (BM V) Structure by Hydrostatic Pressure 1995
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