Guilherme Augusto Piedade de Oliveira
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Bioquímica Médica
Departamento:
Programa de Biologia Estrutural
Formação:
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University of Virginia
| Pós-Doutorado | 2016 - Agora
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Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do RJ
| Pós-Doutorado | 2015 - 2016
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2014 - 2015
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2013 - 2013
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Universidade Federal do Rio de Janeiro
Química Biológica | Doutorado | 2009 - 2013
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Sociedade Latino Americana de Biofísica
Biofísica | Doutorado | 2009 - 2013
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Universidade Federal do Rio de Janeiro
Química Biológica | Mestrado | 2008 - 2009
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Universidade Federal do Rio de Janeiro
Ciências Biológicas Modalidade Médica | Graduação | 2004 - 2007
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Colégio pH
| Ensino Médio (2o grau) | 1999 - 2002
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Universidade Federal do Rio de Janeiro
| Livre Docência | 0 - Agora
Laboratórios:
Nenhum laboratório cadastrado
Nuvens de Palavras:
Artigos:
(98.15% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Conformational stability of SARS-CoV-2 glycoprotein spike variants | 10.1016/j.isci.2022.105696 | 2023 |
| Water Leakage Pathway Leads to Internal Hydration of the p53 Core Domain | 10.1021/acs.biochem.2c00320 | 2023 |
| Targeting Biomolecular Condensation and Protein Aggregation against Cancer | 10.1021/acs.chemrev.3c00131 | 2023 |
| Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation | 10.1016/j.sbi.2022.102346 | 2022 |
| Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53 | 10.3389/fmolb.2022.944955 | 2022 |
| Evolutionary Role of Water-Accessible Cavities in Src Homology 2 (SH2) Domains | 10.1021/acs.jpcb.2c05409 | 2022 |
| The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer | 10.1042/ebc20220064 | 2022 |
| A finely tuned interplay between calcium binding, ionic strength and pH modulates conformational and oligomerization equilibria in the Respiratory Syncytial Virus Matrix (M) protein | 10.1016/j.abb.2022.109424 | 2022 |
| Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands | 10.1039/d1sc01739j | 2021 |
| Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy | 10.1039/d1sc01886h | 2021 |
| Cryo-EM to visualize the structural organization of viruses | 10.1016/j.coviro.2021.04.011 | 2021 |
| Exploring the polymorphism, conformational dynamics and function of amyloidogenic peptides and proteins by temperature and pressure modulation | 10.1016/j.bpc.2020.106506 | 2021 |
| Polyclonal F(ab?)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency | 10.1016/j.isci.2021.103315 | 2021 |
| Process intensification for the production of yellow fever virus-like particles (VLPs) as potential recombinant vaccine antigen | 10.1002/bit.27864 | 2021 |
| Oncogenic gain of function in glioblastoma is linked to mutant p53 amyloid oligomers | 10.1016/j.isci.2020.100820 | 2020 |
| The Status of p53 Oligomeric and Aggregation States in Cancer | 10.3390/biom10040548 | 2020 |
| Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi | 10.1016/j.jsb.2020.107536 | 2020 |
| High pressure studies on the misfolding and aggregation of p53 in cancer and of α-synuclein in Parkinson?s disease | 10.1080/08957959.2019.1576173 | 2019 |
| Loss of the p53 transactivation domain results in high amyloid aggregation of the -40p53 isoform in endometrial carcinoma cells | 10.1074/jbc.RA119.007566 | 2019 |
| An extensively glycosylated archaeal pilus survives extreme conditions | 10.1038/s41564-019-0458-x | 2019 |
| New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents | 10.3390/molecules24112154 | 2019 |
| Conformational isomerization involving conserved proline residues modulates oligomerization of the NS1 interferon response inhibitor from the syncytial respiratory virus | 10.1021/acs.biochem.8b01288 | 2019 |
| A conformational switch balances viral RNA accessibility and protection in a nucleocapsid ring model | 10.1016/j.abb.2019.06.005 | 2019 |
| Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson?s disease | 10.1038/s42003-019-0598-9 | 2019 |
| A packing for A-form DNA in an icosahedral virus | 10.1073/pnas.1908242116 | 2019 |
| The intrinsically disordered carboxy-terminus of troponin-T binds to troponin-C to modulate myocardial force generation | 10.1074/jbc.RA119.011177 | 2019 |
| Biophysical characterization of p53 core domain aggregates | 10.1042/bcj20190778 | 2019 |
| Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer | 10.1074/jbc.ra118.003285 | 2018 |
| The missing links within troponin | 10.1016/j.abb.2018.12.026 | 2018 |
| Allosteric transmission along a loosely structured backbone allows a cardiac Troponin C mutant to function with only one Ca2+ ion | 10.1074/jbc.m116.765362 | 2017 |
| Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C | 10.1038/s41598-017-00777-6 | 2017 |
| The push-and-pull hypothesis in protein unfolding, misfolding and aggregation | 10.1016/j.bpc.2017.03.007 | 2017 |
| Interactions of ruthenium(II) compounds with sulfasalazine and N , N --heterocyclic ligands with proteins | 10.1016/j.ica.2017.08.037 | 2017 |
| Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer | 10.1021/acs.accounts.7b00473 | 2017 |
| Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease? | 10.1101/cshperspect.a023614 | 2016 |
| Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds | 10.1038/srep32535 | 2016 |
| Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype | 10.3389/fphys.2016.00429 | 2016 |
| Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core | 10.1038/srep37990 | 2016 |
| A hypothesis to reconcile the physical and chemical unfolding of proteins | 10.1073/pnas.1500352112 | 2015 |
| Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer | 10.3389/fonc.2015.00097 | 2015 |
| The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role Against α-Synuclein Oligomers | 10.1074/jbc.m115.662254 | 2015 |
| High-Pressure Chemical Biology and Biotechnology | 10.1021/cr400204z | 2014 |
| Solution and high-pressure NMR studies of the structure, dynamics and stability of the cross-reactive allergenic cod parvalbumin Gad m 1 | 10.1002/prot.24664 | 2014 |
| Insights into the Intramolecular Coupling between the N- and C-Domains of Troponin C Derived from High-Pressure, Fluorescence, Nuclear Magnetic Resonance, and Small-Angle X-ray Scattering Studies | 10.1021/bi301139d | 2013 |
| Nep1-like protein from Moniliophthora perniciosa induces a rapid proteome and metabolome reprogramming in cells of Nicotiana benthamiana | 10.1111/ppl.12061 | 2013 |
| Full Inactivation of Human Influenza Virus by High Hydrostatic Pressure Preserves Virus Structure and Membrane Fusion While Conferring Protection to Mice against Infection | 10.1371/journal.pone.0080785 | 2013 |
| Fine Modulation of the Respiratory Syncytial Virus M2-1 Protein Quaternary Structure by Reversible Zinc Removal from its Cys3-His1 Motif. | 10.1021/bi401029q | 2013 |
| Intramolecular Dynamics within the N-Cap-SH3-SH2 Regulatory Unit of the c-Abl Tyrosine Kinase Reveal Targeting to the Cellular Membrane | 10.1074/jbc.m113.500926 | 2013 |
| Metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 are increased in vulvar lichen sclerosus | 10.1016/j.ejogrb.2011.12.003 | 2012 |
| Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils: IMPLICATIONS FOR CANCER | 10.1074/jbc.M112.340638 | 2012 |
| Moniliophthora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Metastable Dimer in Solution: Structural and Functional Implications | 10.1371/journal.pone.0045620 | 2012 |
| Positive response to imatinib mesylate therapy for childhood chronic myeloid leukemia | 10.1590/S0100-879X2010007500026 | 2010 |
| Expression of metalloproteinases and their tissue inhibitors in gingiva affected by hereditary gingival fibromatosis: analysis of three cases within a family | 10.1111/j.1600-0765.2008.01180.x | 2009 |
| Expression of metalloproteinases and their tissue inhibitors in inflamed gingival biopsies | 2008 |
Eventos:
(0.00% eventos com DOI)