Cláudia Lúcia Martins da Silva

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Ciências Biomédicas

Departamento:

Diretoria Adjunta de Graduação/ICB

ORCID:

https://orcid.org/0000-0001-9227-6036


Formação:

  • Universidade de São Paulo

    | Pós-Doutorado | 2005 - 2006

  • Universidade Federal do Rio de Janeiro

    Química Biológica | Doutorado | 1994 - 1999

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Farmacologia e Química Medicinal) | Mestrado | 1992 - 1994

  • Universidade Federal do Rio de Janeiro

    Farmacêutico Industrial | Especialização | 1991 - 1992

  • Universidade Federal do Rio de Janeiro

    Farmacêutico | Graduação | 1986 - 1991
Laboratórios:
Nuvens de Palavras:
Artigos:

(96.00% artigos com DOI)

Titulo DOI Ano
Altered purinergic P2X7 receptors signaling limits macrophage-mediated host defense in schistosomiasis 2024
P2X7 Receptor Modulation of the Gut Microbiota and the Inflammasome Determines the Severity of Toxoplasma gondii-Induced Ileitis 10.3390/biomedicines11020555 2023
Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gutlung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression 10.3389/fimmu.2023.1254762 2023
P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-κB signaling favoring mononuclear cell adhesion in schistosomiasis 10.3389/fimmu.2023.1328897 2023
The blockage of downstream P2Y2 receptor signaling inhibits the prostate cancer cell adhesion to endothelial cells 10.1016/j.lfs.2022.120793 2022
Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review 10.3390/jcm10010140 2021
Unveiling the Potential of Purinergic Signaling in Schistosomiasis Treatment 10.2174/1568026620666200924115113 2021
P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion 10.1155/2020/2545682 2020
In vitro and in silico studies for barbinervic acid, a triterpene isolated from Eugenia punicifolia that inhibits vasopressor tone 10.1080/14786419.2020.1739675 2020
Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension 10.1161/atvbaha.118.312038 2019
Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4 10.1371/journal.ppat.1007887 2019
Revisiting the pharmacodynamics uroselectivity of Alpha1-Adrenergic Receptor Antagonists 10.1124/jpet.119.260216 2019
The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by EGF receptor inhibition 10.1016/j.lfs.2019.117048 2019
The P2Y1 receptor-mediated leukocyte adhesion to endothelial cells is inhibited by melatonin 10.1007/s11302-017-9565-4 2017
CD39 Limits P2X7 Receptor Inflammatory Signaling and Attenuates Sepsis-Induced Liver Injury 10.1016/j.jhep.2017.05.021 2017
Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors 10.1016/j.vph.2016.02.005 2016
ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia 10.1590/1414-431x20165542 2016
Purinergic signaling in schistosomal infection 10.1016/j.bj.2016.06.006 2016
New Multi-target Antagonists of  1A-,  1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure 10.1124/jpet.115.227066 2015
Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF- 1 10.1155/2014/134974 2014
Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth 10.1007/s00210-013-0935-3 2014
Neutralization of Apis mellifera bee venom activities by suramin 10.1016/j.toxicon.2013.02.007 2013
Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid 10.1016/j.neuroscience.2012.11.048 2013
Endothelial P2X7 receptors? expression is reduced by schistosomiasis 10.1007/s11302-012-9332-5 2013
Schistosomiasis differentially affects vasoconstrictor responses: up-regulation of 5-HT receptor-mediated aorta contraction 10.1590/S0074-02762011000400012 2011
?2,3 -Ivermectin ethyl secoester, a conjugated ivermectin derivative with leishmanicidal activity but without inhibitory effect on mammalian P-type ATPases 10.1007/s00210-010-0578-6 2011
Increased Endothelial Cell-Leukocyte Interaction in Murine Schistosomiasis: Possible Priming of Endothelial Cells by the Disease 10.1371/journal.pone.0023547 2011
Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-Adrenergic receptor blocking properties 10.1016/j.ejmech.2011.04.032 2011
Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs? 10.1016/j.pharmthera.2010.02.009 2010
Ivermectin is a nonselective inhibitor of mammalian P-type ATPases 10.1007/s00210-009-0483-z 2010
Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors 10.1590/S0100-879X2010007500028 2010
Melatonin inhibits LPS-induced NO production in rat endothelial cells 10.1111/j.1600-079X.2008.00657.x 2009
Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity 10.1016/j.neurobiolaging.2007.04.008 2008
Noradrenaline-induced contraction of mice aorta is enhanced in shistosomiasis 10.1016/j.vph.2006.08.414 2007
Melatonin inhibits microvascular endothelial cell nitric oxide production in vivo and in vitro 10.1038/sj.bjp.0707225 2007
Schistosoma mansoni infection enhances host portal vein contraction: role of potassium channels and p38 MAP kinase 10.1016/j.micinf.2007.04.007 2007
Melatonin inhibits endothelial nitric oxide production in vitro 10.1111/j.1600-079x.2006.00366.x 2006
Role of calcium influx through voltage-operated calcium channels and of calcium mobilization in the physiology of Schistosoma mansoni muscle contractions 10.1017/s0031182006000023 2006
Adaptive expression pattern of different proteins involved in cellular calcium homeostasis in denervated rat vas deferens 10.1016/j.ejphar.2005.10.006 2005
Cellular mechanisms involved in the increased contraction of portal veins from Schistosoma mansoni infected mice 10.1007/s00436-002-0711-7 2003
Cyclic GMP-dependent vasosilatory properties of LASSBio 294 in rat aorta 10.1038/sj.bjp.0704473 2002
Control of calcium homeostasis in Schistosoma mansoni 10.1590/S0074-02762001000900012 2001
Portal veins of mice infected with Schistosoma mansoni exhibit an increased reactivity to 5-hydroxytryptamine 10.1590/s0074-02761998000700021 1998
Evidence for functional ryanodine receptors in Schistosoma mansoni 10.1016/S0006-2952(98)00219-6 1998
Evidence for functional ryanodine receptors in Schistosoma mansoni and their putative role in the control of calcium homeostasis 10.1590/S0074-02761998000700051 1998
Increased reactivity to 5-hydroxytryptamine of portal veins from mice infected with Schistosoma mansoni 10.1016/S1095-6433(98)10041-7 1998
Formation of a highly stable complex between BN 50730 and Platelet-Activating Factor receptor in rabbit platelet membranes 10.1016/0006-2952(95)02158-2 1996
Facilitation of the vasorelaxant action of calcium antagonists by basal nitric oxide in depolarized artery 10.1007/bf00168443 1996
Decrease in the ratio of high- to low-affinity isozymes of (Na+ K+)-ATPase during the development of rat cardiac ventricles 1995
Yangambin: a new naturally-occuring platelet-activating factor receptor antagonist: binding and in vitro functional studies 10.1055/s-2006-958025 1995
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Crosstalk between Endothelial Purinergic P2Y2/P2X7 Receptors Increases Leukocyte Adhesion favoring Mesenteric Inflammation during Schistosomiasis 2023
Role Of The Antiapoptotic C-iap2 On The Generation Of An Endothelial Memory In Schistosomiasis-associated Pulmonary Arterial Hypertension 2022
Tlr4/py14-Caveolin-1-Mediated Endothelial C-iap2 Expression During Schistosomiasis-Associated Pulmonary Arterial Hypertension 2022
Uncovering c-IAP2-Dependent Generation of an Endothelial Survival Memory in Schistosomiasis-Associated Pulmonary Arterial Hypertension 2022
Endothelial P2Y2 receptors signaling in primed cells contribute to leukocyte adhesion during chronic inflammation 2022
Mesenteric Endothelial Oxidative Stress and Antioxidant Profile during Schistosomiasis 2022
Endothelial oxidative stress and antioxidant profile during schistosomiasis 2021
The P2X7 receptor agonist ATP induces prostate cancer cells adhesion to human endothelial cells 2021
Endothelial P2Y2 receptor is involved in metastatic prostate cancer cell adhesion and its effect is inhibited by atorvastatin 2021
Endothelial P2Y2 receptors signaling in primed cells contribute to mesenteric inflammation in schistosomiasis 2021
DESENVOLVIMENTO DE MODELOS EXPERIMENTAIS PARA ESTUDOS DE HEMOSTASIA E INFLAMAÇÃO DURANTE A INFECÇÃO POR ARBOVIRUS 2020
Role of Caveolin-1 and Erk Phosphorylation in Schistosoma Mansoni- induced Shedding of Endothelial Cell Extracellular Vesicles 2020
Reduced macrophage P2X7 receptor function during schistosomiasis impairs host defense 2019
Atorvastatin blocked UTP-induced metastatic prostate cancer cells to endothelial cells 2019
TGF-Beta1 Modulates The binding of prazosin to human Alpha1A Adrenergic receptors in HEK-293 transfected cells 2018
Oxidative stress in mesenteric endothelium cells: Relevance on schistosomiasis endothelial dysfunction 2018
Effect of acetylcholine on the contractility of the ileum of wild type and P2X7-/- mice 2017
Increased ROS production and P2Y2 receptor-mediated leukocyte adhesion to mesenteric endothelial cells during schistosomiasis 2017
EGF receptor transactivation by alpha1 adrenoceptors on prostatic hyperplastic cells 2016
Investigation of the role of endothelial P2Y2 and P2Y6 receptors in leukocyte adhesion during mesenteric inflammation caused by schistosomiasis 2016
Hyperplastic prostate cell growth mediated through the transactivation of epidermal growth factor receptor by alpha1-adrenoceptor is inhibited by LDT5 2016
Comparison of LDT5, a multi-target lead compound for the treatment of benign prostatic hyperplasia, and tamsulosin binding at the D3 and 5-HT1A receptors 2016
P2Y1 receptor activation upregulates the endothelial cell ICAM-1 membrane expression and leukocyte adhesion 2015
LDT5 Prevents the increase of rat intra-urethral pressure without causing a hypotensive effect 2015
Purinergic signaling involving P2Y1 receptors and NTPDase 2 and 3 in mesenteric endothelial cells during schistosomiasis-related vascular inflammation 2014
Melatonin inhibits P2Y1 receptor-mediated leukocyte adhesion to endothelial cell 2014
LDT3 and LDT: pharmacological evaluation in human alpha-1 adrenoceptors 2014
Melatonin inhibits P2Y1 receptor-mediated leukocyte adhesion to endothelial cell 2014
Purinergic signaling involving NTPDase 2 and P2Y1 receptors contributes to endothelial leukocyte adhesion in schistosomal inflammation 2014
Purinergic signaling in mesenteric endothelial cells and peritoneal macrophages in chronic inflammation 2013
Leukocyte adhesion to mesenteric endothelial cells mediated by P2Y1 receptor activation during schistosomiasis 2013
MELATONIN INHIBITS P2Y1 RECEPTOR-MEDIATED LEUKOCYTE ADHESION TO ENDOTHELIAL CELL 2013
THE N-PHENYLPIPERAZINE LDT66 IS A COMPETITIVE ANTAGONIST OF ALPHA1A-ADRENOCEPTORS AND AN INHIBITOR OF HUMAN PROSTATE CELL PROLIFERATION 2013
Endothelial cell P2Y1 receptor purinergic signalling during chronic inflammation 2013
NEW N-PHENYLPIPERAZINE DERIVATIVES HAVE ANTI-PROLIFERATIVE EFFECT IN HUMAN 2013
PURINERGIC SIGNALING IN MESENTERIC ENDOTHELIAL CELLS FROM Schistosoma Mansoni-INFECTED MICE 2012
PURINERGIC SIGNALING IN MESENTERIC ENDOTHELIAL CELLS AND PERITONEAL MACROPHAGES FROM Schistosoma Mansoni-INFECTED MICE 2012
Regulation of purinergic signalling in endothelial cells during chronic inflammation 2012
PHARMACOLOGIC EVALUATION OF NEW ALPHA-1 ADRENOCEPTOR AND 5-HT1A ANTAGONISTS 2012
INTRINSIC ACTIVITY DETERMINATION OF THE DERIVATIVES N-PHENYLPIPERAZINICS FOR 5HT1A RECEPTORS 2012
Reduction in ATP-inducing permeabilization in macrophages and endothelial cells from schistosoma mansoni-infected mice 2011
Reduction in P2X receptor function in endothelial cells and macrophages from Schistosoma mansoni-infected mice 2011
Schistosomiasis decreases P2X function in murine mesenteric endothelial cells and peritoneal macrophages 2011
Phamacologic evaluation of new alpha-1 adrenoceptor antagonists: structural characteristics of the derivatives N-phenylpiperazinics that affect the affinity for alpha-1 adrenoceptors 2010
Pharmacologic evaluation of new alpha adrenoceptor antagonists. 2010
Ability of suramim to antagonize permeability alterations induced by honey bee venom. 2010
Pharmacologic evaluation of new alpha-adrenoceptor antagonists (MENÇÃO HONROSA) 2009
Cellular mechanisms involved in vascular alterations in schistosomiasis. 2009
Síntese e Avaliação Farmacológica de Derivados N1-Alquil-N4-2-Metoxifenilpiperazínicos: Contribuição ao Reconhecimento Molecular Pelos Receptores 5-HT1A, 5-HT2A e α1B 2009
PUTATIVE EFFECTT OF MELATONIN ON THE ENDOTHELIAL NITRIC OXIDE PRODUCTION BY iNOS 2008
Melatonin inhibits LPS-induced vasodilation 2008
Effect of ivermectin and synthetic derivatives on mammalian P-ATPases (MENÇÂO HONROSA) 2008
Pharmacological evaluation of new alpha adrenoceptor antagonists 2008
Melatonin inhibits lipopolysaccharide (LPS) induced relaxation of rat aorta by blocking activation of transcriptional factor NF-KB in endothelial cells 2008
Functional vascular alterations induced by schistosomiasis 2008
Design, Synthesis And Pharmacologic Evaluation Of N1-Alkyl-N4-2-methoxyphenylpiperazines: Contribution For 5HT1A Receptor Recognition 2008
Effect of melatonin on nitric oxide production induced by lipopolysaccharide (LPS) in cultured endothelial cells 2007
Effect of artesunate and artemether on the Ca2+ATPase activity of Schistosoma mansoni 2007
The endothelial nitric oxide production induced by bradykinin and ATP is differently regulated by melatonin 2006
Melatonin inhibits the production of nitric oxide in bradykinin-stimulated endothelial cells 2006
Nitric oxide production in endothelial cell is inhibited by melatonin 2006
Investigação dos mecanismos celulares responsáveis pelo aumento da reatividade vascular a vasoconstrictores na esquistossomose mansônica 2005
Caracterização farmacológica de novo derivado cumestano com propriedade vasodilatadora 2005
Cation transport ATPases and (activated) MAP Kinases protein expression are not affected by heart hypertrophy induced by cardiac selective overexpression of mutant alpha1B adrenoceptors 2005
Antagonistas alfa 1 adrenérgicos N-fenilpiperazínicos: estudo sobre o reconhecimento molecular pelo adrenoreceptor alfa 1D 2004
INVESTIGAÇÃO DA PARTICIPAÇÃO DOS CANAIS DE Ca2+ VOLTAGEM-DEPENDENTES E CANAIS DE K+ NA HIPERREATIVIDADE VASCULAR INDUZIDA POR Schistosoma mansoni 2004
Pharmacological investigation of new alfa 1 adrenergic receptor antagonist 2004
Expression of Na+/K+ ATPase alpha subunit isoforms and activated MAP kinases in a model of hypertrophy by cardiac overexpression of mutant alpha1b adrenoceptors 2004
Ca2+ ATPases in hypertrophic hearts triggered by cardiac selective overexpression of mutant self-activated alpha1b adrenoceptors 2004
Adaptative expression of different proteins involved in cellular calcium homeostasis in denervated rat vas deferens 2003
Investigation of cellular mechanisms responsible for the increased vascular reactitivy to vasoconstrictors induced by Schistosoma mansoni 2003
Investigation of cellular mechanisms involved in the increased vasoconstriction response of vessels from Schistosoma mansoni infected mice 2002
Investigation of ryanodine and alpha-adrenergic receptors after denervation of rat vas deferens 2002
Functional changes of rat aorta after cardiac arrest and Wisconsin solution preservation 2002
5-HT supersensitivity of portal veins from S. mansoni infected mice: no role for increased sarcoplasmic reticulum Ca2+ release 2001
Schistosoma mansoni infection and portal vein contraction: investigation of mechanisms involved in the increased vasoconstriction response 2001
Agonist supersensitivity of portal veins from Schistosoma mansoni infected mice 2000
Protection against glutamate-induced neurotoxicity by LASSBio-294: possible involvement of cyclic nucleotides 2000
Vascular pharmacological characterization of a newly synthesized drug LASSBio-294 2000
LASSBio-294, a newly synthesized inotropic drug, has vasodilator properties 1999
Contribution to the pharmacological profile of PCALC19, a newly synthesized antiophidic drug 1999
5-Hydroxytryptamine-induced contraction of mice portal vein is increased by the presence of male Schistosoma mansoni 1999
Control of calcium homeostasis and contractility in Schistosoma mansoni 1999
Increased reactivity to 5-hydroxytryptamine of portal veins from mice infected unisexually with male Schistosoma mansoni 1998
Increase of Portal Vein Reactivity to 5-Hydroxytryptamine in Mice infected with Schistosoma mansoni 1997
Control of Calcium Homeostasis in the Human Flatworm Schistosoma mansoni 1997
Evidence for Functional Ryanodine Receptors in Schistosoma mansoni and their putative role in the control of calcium homeostasis 1997
Portal veins of mice infected with Schistososma mansoni exhibit an increased reactivity to 5-hydroxytryptamine 1997
Caracterização de sítios de ligação da [3H]-Rianodina em frações subcelulares do Schistosoma mansoni 1996
BN 50730 - an hetrazepine derivative - acts as an irreversible antagonist of PAF receptor 1994
Yangambin, a new naturally-occuring platelet-activating factor receptor antagonist: Biochemical and Pharmacological studies 1994
Competition of yangambin, a novel selective PAF antagonist, with [3H]-PAF for binding sites in rabbit platelet membranes 1993
Characterization of the furofuran lignan yangambin as a novel PAF antagonist 1992
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