Herbert Leonel de Matos Guedes
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Campus de Xerém
Unidade:
Setor de Pessoal/Xerém
Departamento:
Docentes/Xerém
Formação:
-
University of Texas Medical Branch at Galveston
| Pós-Doutorado | 2013 - 2014
-
INSTITUTO DE BIOFÍSICA CARLOS CHAGAS FILHO - UFRJ
| Pós-Doutorado | 2009 - 2011
-
INSTITUTO DE BIOFÍSICA CARLOS CHAGAS FILHO - UFRJ
Ciências Biológicas - Biofísica (imunobiologia) | Doutorado | 2005 - 2009
-
INSTITUTO DE BIOFÍSICA CARLOS CHAGAS FILHO - UFRJ
Ciências Biológicas - Biofísica (imunobiologia) | Mestrado | 2003 - 2005
-
Universidade Federal do Rio de Janeiro
Farmácia | Graduação | 2000 - 2003
-
Escola Técica Federal de Química
| Ensino Médio (2o grau) | 1994 - 1999
Laboratórios:
Nenhum laboratório cadastrado
Nuvens de Palavras:
Artigos:
(93.06% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| INTRANASAL DELIVERY OF LaAg VACCINE IMPROVES IMMUNITY OF AGED MICE AGAINST VISCERAL LEISHMANIASIS | 10.1016/j.actatropica.2024.107125 | 2024 |
| Isopentyl caffeate as a promising drug for the treatment of leishmaniasis: An in silico and in vivo study | 10.1016/j.crbiot.2024.100209 | 2024 |
| Crosslinked chitosan microparticles as a safe and efficient DNA carrier for intranasal vaccination against cutaneous leishmaniasis | 10.1016/j.jvacx.2023.100403 | 2023 |
| Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors | 10.3390/microorganisms10020398 | 2022 |
| Subtilisin of Leishmania amazonensis as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor | 10.3390/cimb44050141 | 2022 |
| Ageing impairs protective immunity and promotes susceptibility to murine visceral leishmaniasis | 10.1017/S0031182022000828 | 2022 |
| Effects of a Serine Protease Inhibitor N-p-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on Leishmania amazonensis and Leishmania infantum | 10.3390/pharmaceutics14071373 | 2022 |
| Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum | 10.3389/fimmu.2022.884760 | 2022 |
| Intradermal Immunization of SARS-CoV-2 Original Strain Trimeric Spike Protein Associated to CpG and AddaS03 Adjuvants, but Not MPL, Provide Strong Humoral and Cellular Response in Mice | 10.3390/vaccines10081305 | 2022 |
| Pulmonary Fibrosis and Hypereosinophilia in TLR9-/- Mice Infected by Cryptococcus gattii | 10.3390/pathogens11090987 | 2022 |
| SARS-CoV-2 Is Persistent in Placenta and Causes Macroscopic, Histopathological, and Ultrastructural Changes | 10.3390/v14091885 | 2022 |
| The role of Toll-like receptor 9 in a murine model of Cryptococcus gattii infection | 10.1038/s41598-021-80959-5 | 2021 |
| COVID-19 and the challenges of chemotherapy: The failure case of hydroxychloroquine in the clinical treatment of SARS-CoV-2 infection | 10.2174/2666796702999210112202907 | 2021 |
| PF-429242, a Subtilisin Inhibitor, Is Effective in vitro Against Leishmania infantum | 10.3389/fmicb.2021.583834 | 2021 |
| Eosinophils increase macrophage ability to control intracellular Leishmania amazonensis infection via PGD2 paracrine activity in vitro | 10.1016/j.cellimm.2021.104316 | 2021 |
| PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis | 10.3389/fimmu.2021.632667 | 2021 |
| Anti-Leishmania Effects of Volatile Oils and Their Isolates | 10.1007/s43450-021-00146-5 | 2021 |
| MPLA and AddaVax® Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis | 10.3390/microorganisms9061272 | 2021 |
| Leishmania Parasites Drive PD-L1 Expression in Mice and Human Neutrophils With Suppressor Capacity | 10.3389/fimmu.2021.598943 | 2021 |
| Small Angle X-ray Scattering, Molecular Modeling, and Chemometric Studies from a Thrombin-Like (Lmr-47) Enzyme of Lachesis m. rhombeata Venom | 10.3390/molecules26133930 | 2021 |
| Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8 + T cell immunosenescence signature linked to immunopathology | 10.1111/imm.13410 | 2021 |
| Intranasal immunization with chitosan microparticles enhances lack-dna vaccine protection and induces specific long-lasting immunity against visceral leishmaniasis | 10.1016/j.micinf.2021.104884 | 2021 |
| Polyclonal F(ab?)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency | 10.1016/j.isci.2021.103315 | 2021 |
| Yellow fever vaccine protects mice against Zika virus infection | 10.1371/journal.pntd.0009907 | 2021 |
| Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 + T cells in human cutaneous leishmaniasis | 10.1111/imm.13173 | 2020 |
| Soro convalescente contra a covid-19 | 2020 | |
| Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis | 10.1186/s13287-020-01889-z | 2020 |
| Vitamin D increases killing of intracellular independently of macrophage oxidative mechanisms | 10.1017/S0031182020001791 | 2020 |
| Leishmanicidal therapy targeted to parasite proteases | 10.1016/j.lfs.2019.01.015 | 2019 |
| Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis | 10.3389/fimmu.2018.03001 | 2019 |
| The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy | 10.1371/journal.pntd.0007146 | 2019 |
| Pam3CSK4 adjuvant given intranasally boosts anti-Leishmania immunogenicity but not protective immune responses conferred by LaAg vaccine against visceral leishmaniasis | 10.1016/j.micinf.2019.02.005 | 2019 |
| Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice | 10.3389/fcimb.2019.00088 | 2019 |
| Nanoencapsulated retinoic acid as a safe tolerogenic adjuvant for intranasal vaccination against cutaneous leishmaniasis | 10.1016/j.vaccine.2019.05.043 | 2019 |
| Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis | 10.3389/fmed.2019.00100 | 2019 |
| B-1 lymphocytes are able to produce IL-10, but is not pathogenic during Leishmania (Leishmania) amazonensis infection | 10.1016/j.imbio.2019.10.006 | 2019 |
| Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma | 10.1002/sctm.19-0120 | 2019 |
| Immunotherapy using anti-PD-1 and anti-PD-L1 in Leishmania amazonensis-infected BALB/c mice reduce parasite load | 10.1038/s41598-019-56336-8 | 2019 |
| How to B(e)-1 important cell during Leishmania sp infection | 10.3389/fcimb.2019.00424 | 2019 |
| Vaccination With Recombinant Filamentous fd Phages Against Parasite Infection Requires TLR9 Expression | 10.3389/fimmu.2018.01173 | 2018 |
| Immunomodulating role of IL-10-Producing B cells in Leishmania amazonensis infection | 10.1016/j.cellimm.2018.08.014 | 2018 |
| TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells | 10.3389/fimmu.2018.02281 | 2018 |
| VACINAÇÃO: ESTRATÉGIA PARA REDUZIR A DESIGUALDADE | 2018 | |
| Effects of Bone Marrow Mesenchymal Stromal Cell Therapy in Experimental Cutaneous Leishmaniasis in BALB/c Mice Induced by Leishmania amazonensis | 10.3389/fimmu.2017.00893 | 2017 |
| Intranasal vaccination with adjuvant-free S. aureus antigens effectively protects mice against experimental sepsis | 10.1016/j.vaccine.2016.04.018 | 2016 |
| Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice | 10.1186/s13071-016-1822-9 | 2016 |
| Diet-induced obesity promotes systemic inflammation and increased susceptibility to murine visceral leishmaniasis | 10.1017/S003118201600127X | 2016 |
| Oligopeptidase B and B2: comparative modelling and virtual screening as searching tools for new antileishmanial compounds | 10.1017/s0031182016002237 | 2016 |
| The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control | 10.1007/s11302-016-9544-1 | 2016 |
| Serine Proteases and Vaccines agaisnt Leishmaniasis: A Dual Role | 2015 | |
| Interactions between Neutrophils and Leishmania braziliensis Amastigotes Facilitate Cell Activation and Parasite Clearance | 10.1159/000373923 | 2015 |
| Intranasal vaccination with killed Leishmania amazonensis promastigotes antigen (LaAg) associated with CAF01 adjuvant induces partial protection in BALB/c mice challenged with Leishmania (infantum) chagasi. | 10.1017/s0031182015001250 | 2015 |
| The comparative genomics and phylogenomics of Leishmania amazonensis parasite | 10.4137/EBO.S13759 | 2014 |
| Intranasal vaccination with extracellular serine proteases of Leishmania amazonensis confers protective immunity to BALB/c mice against infection | 10.1186/1756-3305-7-448 | 2014 |
| The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis | 10.1590/s0074-02762012000300018 | 2012 |
| Peripheral expression of LACK-mRNA induced by intranasal vaccination with PCI-NEO-LACK defines the protection duration against murine visceral leishmaniasis | 10.1017/S0031182012000868 | 2012 |
| Intranasal immunization with LACK-DNA promotes protective immunity in hamsters challenged with L. chagasi | 10.1017/S0031182011001417 | 2011 |
| Serine proteases of Leishmania amazonensis as immunomodulatory and disease-aggravating components of the crude LaAg vaccine | 10.1016/j.vaccine.2010.04.109 | 2010 |
| Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom | 10.1016/j.bpc.2007.11.002 | 2008 |
| Oligopeptidase B-2 from Leishmania amazonensis with an unusual C-terminal extension | 10.2478/s11686-008-0026-7 | 2008 |
| Biological Function and Molecular Mapping of M Antigen in Yeast Phase of Histoplasma capsulatum | 10.1371/journal.pone.0003449 | 2008 |
| Protection against cutaneous leishmaniasis by intranasal vaccination with lipophosphoglycan. | 10.1016/j.vaccine.2006.05.093 | 2007 |
| Identification Of serine proteases from L. braziliensis | 2007 | |
| BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: ROLE OF N-GLYCOSYLATION | 10.1016/j.toxicon.2007.02.018 | 2007 |
| Identification and characterization of proteases from skin mucus of tambacu, a Neotropical hybrid fish | 10.1007/s10695-007-9128-7 | 2007 |
| Oligopeptidase B from L. amazonesis: Molecular cloning, gene expression analysis and molecular model | 10.1007/s00436-007-0630-8 | 2007 |
| BINDING OF EXTRACELLULAR MATRIX PROTEINS TO Paracoccidioides brasiliensis | 10.1016/j.micinf.2006.01.012 | 2006 |
| Optimization of sample preparation from skin mucus of a neotropical fish for two-dimensional substrate gel electrophoresis | 10.1016/j.ab.2006.07.030 | 2006 |
| TGF-beta-associated enhanced susceptibility to leishmaniasis following intramuscular vaccination of mice with Leishmania amazonensis antigens. | 10.1016/j.micinf.2005.04.016 | 2005 |
| ELISA for early diagnosis of histoplasmosis. | 10.1099/jmm.0.05469-0 | 2004 |
| Diagnostic PCR assay for identification of Histoplasma capsulatum based on the nucleotide sequence of the M antigen | 10.1128/jcm.41.2.535-539.2003 | 2003 |
| Aspartic proteinase in Dugesia tigrina (Girard) planaria | 2002 |
Eventos:
(0.00% eventos com DOI)