Alessandra Mendonça Teles de Souza

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Faculdade de Farmácia

Departamento:

Departamento de Fármacos e Medicamentos

ORCID:

https://orcid.org/0000-0001-9986-405X


Formação:

  • Istituto di Ricerche Farmacologiche Mario Negri - Milano

    | Pós-Doutorado | 2023 - 2024

  • Universidade Federal Fluminense

    Farmácia - habilitação em Bioquímica | Graduação | 2007 - 2008

  • Universidade Federal Fluminense

    Química | Doutorado | 2007 - 2011

  • Universidade Federal Fluminense

    Química | Mestrado | 2005 - 2007

  • Universidade Federal Fluminense

    Farmácia Industrial | Graduação | 2000 - 2005
Laboratórios:
Nenhum laboratório cadastrado
Nuvens de Palavras:
Artigos:

(95.38% artigos com DOI)

Titulo DOI Ano
Novel Naphthoquinone-1H-1,2,3-triazole Hybrids: Design, Synthesis and Evaluation as Inductors of ROS-Mediated Apoptosis in the MCF-7 Cells 10.1016/j.bmc.2024.117671 2024
Synthesis, in silico, and in vitro Evaluation of 7-chloro-quinolines Designed as Myeloperoxidase Inhibitors 10.1016/j.molstruc.2024.138528 2024
Quinoline derivatives as corrosion inhibitors for mild steel in acid medium: Deeper insights from experimental, ab initio density functional theory modeling, and in silico ecotoxicity investigations 10.1016/j.colsurfa.2024.134255 2024
4-oxoquinoline-3-carboxamide acyclonucleoside phosphonates hybrids: Human MCF-7 breast cancer cell death induction by oxidative stress-promoting and in silico ADMET studies 10.1016/j.molstruc.2022.134542 2023
Use of in silico and in vitro methods as a potential new approach methodologies (NAMs) for (photo)mutagenicity and phototoxicity risk assessment of agrochemicals 10.1016/j.scitotenv.2023.167320 2023
Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE/BuChE inhibitors for Alzheimer?s Disease 10.1002/jcb.30483 2023
Investigation of the Anti-asthmatic Activity of Solidagenone, In Vitro Toxicity Versus In Silico Studies 10.1007/s43450-023-00479-3 2023
Physiologically based pharmacokinetic modelling of semaglutide in children and adolescents with healthy and obese body weights 10.1111/bcp.15816 2023
Evaluation of biological activities of quinone-4-oxoquinoline derivatives against pathogens of clinical importance 10.2174/1568026622666220504124710 2022
Corrosion inhibition and ecotoxicological assessment of 1,2,3-triazolic alcohols 10.1016/j.matchemphys.2022.126508 2022
Alternative Methods for Pulmonary-Administered Drugs Metabolism: a Breath of Change 10.2174/1389557522666220620125623 2022
Toxicological assessment of SGLT2 inhibitors metabolites using in silico approach 10.1590/0001-3765202220211287 2022
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis 10.1016/j.bmc.2021.116506 2022
Evaluation of chloroquine and hydroxychloroquine as ACE-2 Inhibitors By In Silico Approaches: Cardiac Arrhythmia Cause? 10.1016/j.molstruc.2021.130946 2021
DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium 10.1007/s00775-021-01888-2 2021
Chalcones identify cTXNPx as a potential antileishmanial drug target 10.1371/journal.pntd.0009951 2021
Insights of Tris(2-pyridylmethyl)amine as anti-tumor agent for osteosarcoma: experimental and in silico studies 10.1016/j.molstruc.2020.129773 2021
Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents 10.3389/fchem.2020.624678 2021
Diterpenes isolated from Canistrocarpus cervicornis with virucidal activity against HIV-1: an in silico evaluation 10.1080/14786419.2021.2016745 2021
Structural insights into the allosteric site of Arabidopsis NADP-malic enzyme 2: role of the second sphere residues in the regulatory signal transmission 10.1007/s11103-021-01176-2 2021
Forced Degradation Studies of Norepinephrine and Epinephrine from dental anesthetics: Development of Stability-Indicating HPLC Method and Toxicity evaluation 10.1002/bmc.4832 2020
Nanoparticles Loaded with a New Thiourea Derivative: Development and In Vitro Evaluation Against Leishmania Amazonensis 10.2174/1567201817666200704132348 2020
Antiviral Drug Discovery and Development for Mayaro Fever - What do we have so far? 10.2174/1389557520666200316160425 2020
Structure-activity relationship, molecular docking, and molecular dynamic studies of diterpenes from marine natural products with anti-HIV activity 10.1080/07391102.2020.1845977 2020
Theoretical and experimental studies of a new aniline derivative corrosion inhibitor for mild steel in acid medium 10.1002/maco.201911065 2020
Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors 10.1016/j.ejmech.2020.112255 2020
In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension 10.1590/0001-3765202020191445 2020
Leishmania infantum arginase: biochemical characterization and inhibition by naturally occurring phenolic substances 10.1080/14756366.2019.1616182 2019
Synthesis and in silico and in vitro evaluation of trimethoxy-benzamides designed as anti-prion derivatives 10.1007/s00044-019-02441-2 2019
A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location 10.1128/aac.01441-17 2018
Tannic Acid Solution: A Better Fixative Solution Than Formalin for Elastin and Collagen-Toxic and Morphological Assessment 10.1002/ar.23894 2018
A comprehensive review of chalcone derivatives as antileishmanial agents 10.1016/j.ejmech.2018.03.047 2018
Identification, characterization and in silico ADMET prediction of Roflumilast degradation products 10.1016/j.jpba.2017.02.012 2017
Oligopeptidase B and B2: comparative modelling and virtual screening as searching tools for new antileishmanial compounds 10.1017/S0031182016002237 2017
Synthesis and mechanistic evaluation of novel N ?-benzylidene-carbohydrazide-1 H -pyrazolo[3,4 -b ]pyridine derivatives as non-anionic antiplatelet agents 10.1016/j.ejmech.2017.04.023 2017
Assessment of predictivity of volatile organic compounds carcinogenicity and mutagenicity by freeware in silico models 10.1016/j.yrtph.2017.09.030 2017
Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus 10.1007/s00705-017-3261-0 2017
Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor 10.1016/j.bmcl.2016.11.051 2017
Analysis of worldwide sequence mutations in Zika virus proteins E, NS1, NS3 and NS5 from a structural point of view 10.1039/c6mb00645k 2016
Antimycobacterial and Anti-Inflammatory Activities of Substituted Chalcones Focusing on an Anti-Tuberculosis Dual Treatment Approach 10.3390/molecules20058072 2015
Molecular modeling study of a series of amodiaquine analogues with antimalarial activity 10.1007/s00044-015-1403-z 2015
Probing insulin bioactivity in oral nanoparticles produced by ultrasonication-assisted emulsification/internal gelation 10.2147/IJN.S86313 2015
Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease 10.3390/molecules200610689 2015
Effect of 9-hydroxy-a- and 7-hydroxy-pyran Naphthoquinones on Trypanosoma cruzi and Structure-activity Relationship Studies 10.2174/1573406410666131229151303 2014
Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs 10.3390/molecules19056651 2014
Novel isomannide-based peptide mimetics containing a tartaric acid backbone as serine protease inhibitors 10.1007/s00044-014-1058-1 2014
Hologram quantitative structure–activity relationship and comparative molecular field analysis studies within a series of tricyclic phthalimide HIV-1 integrase inhibitors 10.2147/dddt.s47057 2013
Molecular Docking Studies of Marine Diterpenes as Inhibitors of Wild-Type and Mutants HIV-1 Reverse Transcriptase 10.3390/md11114127 2013
HIV-1 Reverse Transcriptase: a potential target for marine products 10.1590/S0102-695X2012005000084 2012
Novel peptide mimetics based on N-protected amino acids derived from isomannide as potential inhibitors of NS3 serine protease of Hepatitis C virus 2012
Hologram QSAR Models of 4-[(Diethylamino)methyl]-phenol Inhibitors of Acetyl/Butyrylcholinesterase Enzymes as Potential Anti-Alzheimer Agents 10.3390/molecules17089529 2012
Molecular Modeling Studies of the Structural, Electronic and UV Absorption Properties of Benzophenone Derivatives 10.1021/jp306130y 2012
4-(1H-Pyrazol-1-yl) Benzenesulfonamide Derivatives: Identifying New Active Antileishmanial Structures for Use against a Neglected Disease 10.3390/molecules171112961 2012
Trypanosoma cruzi: Insights into naphthoquinone effects on growth and proteinase activity 10.1016/j.exppara.2010.07.007 2011
Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones 10.1016/j.ejmech.2011.01.066 2011
Identification of Nor-beta-Lapachone Derivatives as Potential Antibacterial Compounds against Enterococcus faecalis Clinical Strain 10.1007/s00284-010-9763-6 2011
Brown Seaweed Defensive Chemicals: a Structure-activity relationship Approach for the Marine Environment 2009
Sistema De Distribuição Individualizado: A Importância Da IDentificação Dos Pontos Críticos Nos Processos De Dispensação E Devolução De Materiais E Medicamentos 2009
Leishmania amazonensis Growth Inhibitors: Biological and Theoretical Features of Sulfonamide 4-Methoxychalcone Derivatives 10.1007/s00284-009-9447-2 2009
Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity 10.1016/j.ejmech.2008.04.016 2009
Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1,2,3-triazole derivatives of carbohydrates 10.1016/j.ejmech.2008.02.047 2009
Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series 10.1016/j.bmc.2006.09.067 2007
HIV-1 Reverse Transcriptase: A Therapeutical Target in the Spotlight 10.2174/092986706775476089 2006
Trypanocidal agents with low cytotoxicity to mammalian cell line: A comparison of the theoretical and biological features of lapachone derivatives 10.1016/j.bmc.2006.04.046 2006
Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives 10.1016/j.bmc.2006.08.019 2006
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Oligopeptidase B from Trypanosoma cruzi: homology modeling and docking studies 2010
In Silico Structure Activity Relationship and Toxicity Studies of Chalcones Derivatives with Antitumoral Profile 2010
Analysis of the binding mode of naphthoquinones derivatives into cruzain active site using molecular modeling approach 2010
SAR and molecular Docking studies of 1H-pyrazole-4-carbohydrazides derivatives as potential trypanocidal agents 2009
Análise por modelagem molecular da interação de derivados da lapachona no sítio ativo da cruzaína. 2009
In silico structure activity relationship and toxicity studies of chalcones derivatives with antitumoral profile 2009
In silico analysis of the binding mode of lapachone derivatives into cruzain. 2008
Computational Studies of 1H-pyrazole-4-carbohydrazides derivatives with potential trypanocidal activity 2008
Docking of the anti-retroviral dolabelladienetriol into wild-type and Y181C mutant HIV-1 reverse transcriptase 2008
Theoretical Evaluation of 1H-pyrazole-4-carbohydrazides derivatives as trypanocidal agents 2008
Lapachone derivatives as tripanocidal and low citotoxicity agents: a molecular modeling study 2007
Relação Estrutura-Atividade de derivados da lapachona como agentes tripanossomicidas de baixa toxicidade 2006
Estudo por SAR de compostos candidatos a antibióticos contra Staphylococcus aureus 2006
SAR studies of a new antibacterial candidate against Staphylococcus aureus 2006
Docking of a Dolabellane Diterpene Derivative on the Non-Nucleoside Binding Site of the HIV-1 Reverse Transcriptase 2005
Identification of a new series of acylhydrazone derivatives presenting antiplatelet activity 2004
Snake venom Lectins: structure-function inferences based on a bioinformatic approach 2004
Síntese e Avaliação da Atividade Farmacológica de 4-Acil-Hidrazona-1-H-Pirazolo[3,4-b]piridinas como Agentes Antitrombóticos 2004
MOLECULAR MODELING OF ANTICHAGASIC AGENTS USING AB INITIO METHODS AND SAR 2004
Construção de Modelos de QSAR-4D de Pirazil-N-Acil-Hidrazonas com Atividade Tripanocida 2004
Publicações:
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