Hilda Petrs Silva

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Biofísica Carlos Chagas Filho

Departamento:

Serviço de Biofísica Celular/I Biof

ORCID:

https://orcid.org/0000-0001-8961-2959


Formação:

  • University of Florida

    | Pós-Doutorado | 2019 - 2020

  • Weill Cornell Medical College

    | Pós-Doutorado | 2012 - 2012

  • Albert Einstein College of Medicine of Yeshiva University

    | Pós-Doutorado | 2011 - 2011

  • University of Gottingen Medical School

    | Pós-Doutorado | 2010 - 2010

  • Instituto de Biofísica Carlos Chagas Filho

    | Pós-Doutorado | 2009 - 2010

  • University of Florida

    | Pós-Doutorado | 2007 - 2009

  • Instituto de Biofísica Carlos Chagas Filho

    | Pós-Doutorado | 2006 - 2007

  • Instituto de Biofísica Carlos Chagas Filho

    | Pós-Doutorado | 2004 - 2006

  • Universidade Federal do Rio de Janeiro

    Doutorado em Ciência Biológicas (Biofísica) | Doutorado | 2000 - 2004

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas Modalidade Médica | Graduação | 1996 - 1999
Laboratórios:
Nenhum laboratório cadastrado
Nuvens de Palavras:
Artigos:

(93.94% artigos com DOI)

Titulo DOI Ano
rAAV-compatible human mini promoters enhance transgene expression in rat retinal ganglion cells 10.1016/j.exer.2023.109758 2024
The Healthy and Diseased Retina Seen through Neuron-Glia Interactions 10.3390/ijms25021120 2024
Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues 10.3390/ cells12172155 2023
Novel approaches to glaucomatous neurodegeneration, based on the integrated stress response 10.1016/j.omtn.2023.08.022 2023
Tyrosine-Mutant AAV8 Vector Mediated Efficient and Safe Gene Transfer of Pigment Epithelium-Derived Factor to Mouse Lungs 10.33594/000000660 2023
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents 10.3791/63442 2022
Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration 10.1167/iovs.63.2.5 2022
The Role of Axonal Transport in Glaucoma 10.3390/ ijms23073935 2022
Gene Therapy Strategies for Glaucomatous Neurodegeneration 10.2174/1566523221666210126152000 2021
Optic Nerve Crush Activates the Genomic Fabrics of the Complement Cascade and Delta-Notch Signaling 10.3390/genes12030403 2021
Mitotherapy: Unraveling a Promising Treatment for Disorders of the Central Nervous System and Other Systemic Conditions 10.3390/cells10071827 2021
Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina 10.1016/j.bbadis.2020.165686 2020
Effects of a combinatorial treatment with gene and cell therapy on retinal ganglion cell survival and axonal outgrowth after optic nerve injury 10.1038/s41434-019-0089-0 2019
Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat 10.1038/s41434-019-0100-9 2019
A subacute model of glaucoma based on limbal plexus cautery in pigmented rats 10.1038/s41598-019-52500-2 2019
Self-complementary and tyrosine-mutant rAAV vectors enhance transduction in cystic fibrosis bronchial epithelial cells 10.1016/j.yexcr.2018.09.015 2018
Tyrosine Mutation in AAV9 Capsid Improves Gene Transfer to the Mouse Lung 10.1159/000445646 2016
rAAV8-733-Mediated Gene Transfer of CHIP/Stub-1 Prevents Hippocampal Neuronal Death in Experimental Brain Ischemia 10.1016/j.ymthe.2016.11.017 2016
CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system 10.3389/fncel.2014.00438 2015
Single Tyrosine Mutation in AAV8 Vector Capsid Enhances Gene Lung Delivery and Does Not Alter Lung Morphofunction in Mice 10.1159/000363033 2014
Advances in Recombinant Adeno-Associated Viral Vectors for Gene Delivery 10.2174/15665232113136660028 2013
Advances in gene therapy technologies to treat retinitis pigmentosa 10.2147/opth.s38041 2013
Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina 10.1038/mt.2010.234 2010
Does the use of recombinant AAV5 in pulmonary gene therapy lead to lung damage? 10.1016/j.resp.2009.06.016 2009
Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function? 10.1016/j.resp.2007.09.002 2008
High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors 10.1038/mt.2008.269 2008
Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage 10.1016/j.expneurol.2008.06.001 2008
Detecção imunohistoquímica de células apoptóticas em glioblastoma recidivante de paciente tratado com álcool perílico por via inalatória 2007
Modulation of the expression of the transcription factor Max in rat retinal ganglion cells by a recombinant adeno-associated viral vector 10.1590/S0100-879X2005000300008 2005
Early nuclear exclusion of the transcription factor max is associated with retinal ganglion cell death independent of caspase activity 10.1002/jcp.10404 2004
Biosynthesis and metabolism of sulfated glycosaminoglycans during Drosophila melanogaster development 10.1093/glycob/cwh070 2004
Evidence that the bifunctional redox factor / AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina 10.1038/sj.cdd.4400639 2000
Modulation of apoptosis in retinal tissue in vitro. 1999
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Comparison of common methods for cell transfection and rAAV2 purification with commercially available options 2024
Double thermal cauterization of the limbal plexus as an inducible model of glaucoma in rats. 2023
Comparison of rat retinal ganglion cell transduction with different amounts of rAAV vector. 2022
Construction of dead-Cas9 machinery for activation of endogeous neuroprotective transcription factor MAX in vitro 2022
Comparison of rat retinal ganglion cells transduction using different human mini-promoters compatible with rAAV 2022
Increased transgene expression in rat retinal ganglion cells by using human mini-promoters compatible with rAAV 2021
Increased transgene expression in rat retinal ganglion cells by using human mini-promoters compartible with rAAV 2020
Análise de mini-promotores para expressão em células ganglionares da retina de ratos adultos 2019
Análise de mini-promotores para expressão em células ganglionares da retina de ratos adultos 2019
Modulation of gene transduction by rAAV2 in the rat retina after intravitreal injection. 2018
Neuroprotection by overexpression of the transcription factor Max in experimental glaucoma 2018
Gene and cell therapy: combining two approaches to promote neuroprotection and neuroregeneration in a model of optic nerve injury 2017
Análise de mini-promotores para expressão em células ganglionares da retina de ratos adultos. 2017
Impacto da modulação de barreiras intra e extracelulares sobre a eficiência de transdução gênica mediada pelo vetor viral rAAV2 na retina de ratos após injeção intravítrea. 2017
Neuroprotective effect of gene therapy in rodent models of glaucoma using rAAV2-hMAX 2017
Thermal cauterization of the limbal plexus as a new inducible model of glaucoma in rats. 2017
Gene and cell therapy: combining two approaches to promote neuroprotection and neuroregeneration in a model of optic nerve injury 2016
Evaluations of olfactory unsheathing glia gene reprogramming by recombinant adeno-associated viral vector type 2 in vitro and in vivo 2015
CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system 2014
GENE AND CELL THERAPY: TWO APPROACHS TO PROMOTE NEUROPROTECTION AND NEUROREGENERATION IN A MODEL OF CNS INJURY 2014
Co-chaperone CHIP attenuates neuronal death upon ER stress 2013
Supplementation of Rds in rds/+ Mice Model for Gene Therapy Using Hirbp Promoter In an AAV Vector 2011
Neuroprotective Gene Expression with AAV8 for Oxygen-Glycose Deprivation in Organotypic Hippocampal Culture: A Model of Ischemic Stroke 2011
Suppression of rds Expression by siRNA and Gene Replacement Strategies for Gene Therapy Using AAV Vector 2010
Tyrosine Mutations in the Capsid of AAV Vectors Alters Transduction Properties in the Retina 2010
Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using AAV vector 2009
Highly Efficient Subretinal Gene Transfer in the Mouse by AAV Vectors with Capsid Tyrosine Mutations 2009
Dose- Dependent Humoral Immune Responses to Intravitreal Delivery of AAV Vectors and Strategies to Circumvent 2009
Transcription Factor Max Is Neuroprotective for Retinal Ganglion Cells: On the Road to Gene Therapy for Glaucoma 2008
Improving Retinal Ganglion Cell Transduction by Using scAAV Type 8 or Type 9 Vectors Containing Capsid Mutations 2008
Transduction and Tropism of an Abbreviated Form of CMV?Chicken ß?Actin Promoter (CBA) With AAV in Mouse Retina 2006
Self?Complementary AAV Vectors Promote Fast and Efficient Transduction of Mouse Retina 2006
Neuroprotection by gene transfer of transcription factor Max 2005
Does Adeno-associated virus (AAV-2) utilization in the pulmonary genetics therapy cause damages in the pulmonary function? 2005
A utilização do adenovírus-associado (AAV-2) na terapia gênica pulmonar causa danos na função pulmonar? 2005
Modulation of the transcription factor Max expression in rat retinal ganglion cells, using a recombinant adeno-associated viral vector 2004
Nuclear exclusion of the transcription factor Max: a novel event associated with retinal ganglion cell death 2003
Nuclear exclusion of the transcription factor Max during programmed cell death 2002
Exclusão nuclear do fator de transcrição Max durante a morte celular programada 2002
Nuclear exclusion of the transcription factorsc-Myc and Max during programmed cell death 2001
Nuclear exclusion of the transcription factors c-Myc and Max during programmed cell death 2001
Nuclear exclusion of transcription factors and Ref-1 during programmed cell death 2000
Associative control of apoptosis in the developing retina: evidence that Ref-1 is an anti-apoptotic protein associated with neuronal differentiation in retinal tissue 2000
Modelo para estudos do papel de Myc/Max e da exclusão nuclear durante a apoptose 2000
Modulation of apoptosis in retinal tissue in vitro 1999
Expression and subcellular localization of transcription factors and heat shock proteins in retinal apoptosis 1999
Localização subcelular anômala de proteínas nucleares precede a apoptose 1999
Modulação da apoptose de células proliferantes e diferenciadas da retina 1999
Modelo para estudo do papel de Myc/Max e exclusão nuclear durante a apoptose 1999
Nuclear exclusion of transcription factors in retinal apoptosis 1998
Association of c-Jun, c-Fos, c-Myc and Ref-1 with apoptosis and differentiation in the developing retina 1998
Exclusão nuclear dos fatores de transcrição Max e Myc durante a apoptose neuronal 1998
Association of c-Jun, c-Fos, c-Myc and Ref-1 with apoptosis and differentiation in the developing retina 1998
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