Osvaldo Andrade Santos Filho
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Pesquisas de Produtos Naturais
Departamento:
Programa de Produtos Naturais/IPPN
Formação:
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2008 - 2009
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The University of Illinois at Chicago
| Pós-Doutorado | 2002 - 2006
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2000 - 2002
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Instituto Militar de Engenharia
Química | Doutorado | 1996 - 2000
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Universidade Federal do Rio de Janeiro
Engenharia Econômica e Administração Industrial | Especialização | 1994 - 1995
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Instituto Militar de Engenharia
Química | Mestrado | 1994 - 1996
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Faculdade Béthencourt da Silva
Docência Superior | Especialização | 1993 - 1994
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Faculdades Reunidas Nuno Lisboa
Quimica Industrial | Graduação | 1988 - 1992
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Colégio Pedro II
| Ensino Médio (2o grau) | 1984 - 1986
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Colégio Pedro II
| Ensino Fundamental (1o grau) | 1980 - 1983
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Escola Municipal Suécia
| Ensino Fundamental (1o grau) | 1977 - 1979
Laboratórios:
Nuvens de Palavras:
Artigos:
(90.00% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway | 10.3390/ph17030273 | 2024 |
| Synthesis and evaluation of hybrid sulfonamide-chalcones with potential antileishmanial activity | 10.1002/ardp.202300440 | 2024 |
| Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic Activity | 10.1021/acsomega.4c03376 | 2024 |
| Novel Centratherin Derivatives: Molecular Docking Design, Asymmetric Synthesis, and Antitumoral Activity | 10.1016/j.tet.2024.134112 | 2024 |
| Aurones: A Promising Scaffold to Inhibit SARS-CoV-2 Replication | 10.1021/acs.jnatprod.3c00249 | 2023 |
| Identification of Potential Allosteric Site Binders of Indoleamine 2,3-Dioxygenase 1 from Plants: A Virtual and Molecular Dynamics Investigation | 10.3390/ph15091099 | 2022 |
| Identification of Potential Inhibitors of Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Main Protease from Non-Natural and Natural Sources: A Molecular Docking Study | 10.21577/0103-5053.20200139 | 2020 |
| Pharmacological profiling of JME-173, a novel mexiletine derivative combining dual anti-inflammatory/anti-spasmodic functions and limited action in Na+ channels | 10.1016/j.ejphar.2020.173367 | 2020 |
| Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking | 10.1016/j.bioorg.2020.104215 | 2020 |
| Solution and Solid State Nuclear Magnetic Resonance Spectroscopic Characterization of Efavirenz | 10.1016/j.xphs.2015.10.006 | 2016 |
| Aureonitol, a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin | 10.1371/journal.pone.0139236 | 2015 |
| 1,2,3-Triazolyl-4-oxoquinolines: A feasible beginning for promising chemical structures to inhibit oseltamivir-resistant influenza A and B viruses | 10.1016/j.bmc.2015.11.028 | 2015 |
| Design, synthesis, and antiviral activity of new 1H-1,2,3-triazole nucleoside ribavirin analogs | 2014 | |
| Synthesis of simple molecules prepared as arginase inhibitors and evaluated against Leishmania amazonensis | 2013 | |
| Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection | 10.1016/j.foodchem.2013.05.025 | 2013 |
| Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions | 10.1371/journal.pone.0078387 | 2013 |
| Synthesis of ß-Substituted Porphyrin Derivatives Containing Heterocyclic Moieties as Potential Photosensitizers Against Cutaneous Leishmaniasis | 10.1002/ejoc.201201501 | 2013 |
| New Trifluoromethyl Triazolopyrimidines as Anti-Plasmodium falciparum Agents | 10.3390/molecules17078285 | 2012 |
| CoMFA/CoMSIA 3D-QSAR of pyrimidine inhibitors of Pneumocystis carinii dihydrofolate reductase | 10.1007/s00894-012-1399-y | 2012 |
| Mapping the Protein Interaction Network in Methicillin-Resistant | 10.1021/pr100918u | 2011 |
| Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes | 10.3390/molecules16098083 | 2011 |
| In silico identification of anthropogenic chemicals as ligands of zebrafish sex hormone binding globulin | 10.1016/j.taap.2008.07.014 | 2009 |
| The Receptor-Dependent QSAR Paradigm: An Overview of the Current State of the Art | 2009 | |
| An Updated Steroid Benchmark Set and Its Application in the Discovery of Novel Nanomolar Ligands of Sex Hormone-Binding Globulin | 10.1021/jm7011485 | 2008 |
| Combined 4D-fingerprint and clustering based membrane-interaction QSAR analyses for constructing consensus Caco-2 cell permeation virtual screens | 10.1002/jps.21086 | 2008 |
| Categorical QSAR models for skin sensitization based on local lymph node assay measures and both ground and excited state 4D-fingerprint descriptors | 10.1007/s10822-008-9190-y | 2008 |
| Using Molecular Docking, 3D-QSAR, and Cluster Analysis for Screening Structurally Diverse Data Sets of Pharmacological Interest | 10.1021/ci8001952 | 2008 |
| Structure-Based QSAR Analysis of a Set of 4-Hydroxy-5,6-dihydropyrones as Inhibitors of HIV-1 Protease: An Application of the Receptor-Dependent (RD) 4D-QSAR Formalism | 10.1021/ci050326x | 2006 |
| Molecular dynamics simulations of a set of isoniazid derivatives bound to InhA, the enoyl-acp reductase fromM. tuberculosis | 10.1002/qua.21055 | 2006 |
| A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials | 10.1590/S0103-50532004000300019 | 2004 |
| Rational Design of New Antituberculosis Agents: Receptor-Independent Four-Dimensional Quantitative Structure?Activity Relationship Analysis of a Set of Isoniazid Derivatives | 10.1021/jm049913k | 2004 |
| Characterization of Skin Penetration Processes of Organic Molecules Using Molecular Similarity and QSAR Analysis | 10.1021/mp049924+ | 2004 |
| Modelagem de proteínas por homologia | 10.1590/S0100-40422003000200019 | 2003 |
| The 4D-QSAR Paradigm: Application to a Novel Set of Non-peptidic HIV Protease Inhibitors | 2002 | |
| Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR | 10.1016/S0301-4622(02)00077-7 | 2002 |
| Type 2 antifolates in the chemotherapy of falciparum malaria | 10.1590/S0103-50532002000600003 | 2002 |
| A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors | 10.1023/A:1011152818340 | 2001 |
| Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance | 10.1016/S0301-4622(01)00180-6 | 2001 |
| Free energy force field (FEFF) 3D-QSAR analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors | 10.1023/A:1013199108020 | 2001 |
| Molecular modeling of the interaction of trypanocide guanyl hydrazones with B-DNA | 10.1016/S0960-894X(97)00312-0 | 1997 |
Eventos:
(4.17% eventos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Virtual Screening and Drug Repurposing: Together Against Worm-Borne Diseases | 2022 | |
| Potential Inhibitors of helminths Cathepsin B1: Riboflavin | 2022 | |
| Evaluation of aryl amidines/benzimidazoles as potential anti-COVID-19 agents: A computational study | 10.3390/ECMC2020-07288 | 2020 |
| XXIX Annual Meeting of the Brazilian Society of Protozoology / XL Annual Meeting on Basic Research in Chagas' Disease | 2013 | |
| Investigação espectroscópica do efavirenz por RMN de solidos e em solução | 2012 | |
| Design, síntese e avaliação antimalárica de novos derivaos triazolopirimidínicos | 2011 | |
| Design e síntese de análogos de ribavirina com potencial antividade anti-HIV | 2011 | |
| Design e síntese de novos derivados sulfonamídicos com potencial atividade Leishmanicida | 2011 | |
| Design e Sintese de Novos Nucleosídeos como Antivirais Análogos da Ribavirina | 2010 | |
| Searching for new antileishmaniasis lead molecules: synthesis and molecular modeling of new ethyl 7-aryl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-5-carboxylate derivatives | 2010 | |
| 3D-QSAR CoMFA Study of pteridine derivatives inhibitors of Pneumocystis carinii dihydrofolate reductase | 2010 | |
| Modelagem comparativa e dinâmica molecular dos dominios transmembranares de VEGFR1, VEGFR2 e VEGFR3 | 2009 | |
| Constructing Protein Pruning Models to Perform Receptor-Dependent (RD) 4D-QSAR analysis of a Set of Diazaborine Derivatives | 2005 | |
| Planejamento Direto de Tuberculostaticos Potenciais 1. Aplicacao do Formalismo QSAR-4D em Derivados de Isoniazida | 2003 | |
| Planejamento Direto de Tuberculostaticos Potenciais 2. Aplicacao do Formalismo FEFF 3D-QSAR DR em Derivados de Isoniazida | 2003 | |
| Modelagem Molecular no Planejamento de Potenciais Antimalariais | 2001 | |
| 4D-QSAR Analysis: Application to a Set of HIV Protease Inhibitors | 2001 | |
| Generation and Topological Molecular Modeling Study of Wild-Type and Mutant Plasmodium falciparum DHFR | 2001 | |
| Homology Modeling of Dihydrofolate Reductase-Tymidilate Synthase of Plasmodium falciparum: Apotential Model to Design New Antimalarials | 2001 | |
| 4D-QSAR of Plasmodium falciparum Dihydrofolate Reductase Inhibitors | 2000 | |
| Homology Modeling of Plasmodium falciparum Dihydrofolate Reductase. A Tool for the Design of Antimalarial Drugs | 1999 | |
| Homology Modeling of Plsmodium falciparum Dihydrofolate Reductase | 1999 | |
| Molecular Modeling of the Interaction of Trypanocide Guanyl Hydrazones with B-DNA | 1996 | |
| Estudo Conformacional de Guanil Hidrazonas Potencialmente Ativas contra o Trypanossoma cruzi | 1995 |