Marcelo Torres Bozza
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Microbiologia
Departamento:
Departamento de Imunologia/IM
Formação:
-
Fundação Oswaldo Cruz
Biologia Celular e Molecular | Doutorado | 1994 - 1998
-
Harvard University
| Pós-Doutorado | 1994 - 1996
-
Fundação Oswaldo Cruz
Biologia Parasitária | Mestrado | 1991 - 1993
-
Universidade do Estado do Rio de Janeiro
Medicina | Graduação | 1985 - 1990
Laboratórios:
Nuvens de Palavras:
Artigos:
(87.70% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Hemopexin and albumin inhibit heme-induced macrophage activation while also enabling heme-LPS synergistic promotion of TNF production | 10.1016/j.arres.2023.100069 | 2023 |
| Oligosymptomatic long-term carriers of SARS-CoV-2 display impaired innate resistance but increased high-affinity anti-spike antibodies | 10.1016/j.isci.2023.107219 | 2023 |
| Insights into the molecular basis and mechanism of heme-triggered |
10.1111/imm.13708 | 2023 |
| MIF is essential to the establishment of house dust mite-induced airway inflammation and tissue remodeling in mice | 10.1002/eji.202250016 | 2023 |
| Lipid Droplets Contribute to Sepsis-Associated Organ Dysfunction by Disrupting Tissue Tolerance Through the Amplification of Inflammation and Lipid Peroxidation | 10.2139/ssrn.3673486 | 2022 |
| Infection of Endothelial Cells by Dengue Virus Induces ROS Production by Different Sources Affecting Virus Replication, Cellular Activation, Death and Vascular Permeability | 10.3389/fimmu.2022.810376 | 2022 |
| Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants | 10.1084/jem.20220367 | 2022 |
| Arginase 1 is a marker of protection against illness in contacts of leprosy patients | 10.1038/s41598-022-11944-9 | 2022 |
| Intracerebral Injection of Heme Induces Lipid Peroxidation, Neuroinflammation, and Sensorimotor Deficits | 10.1161/strokeaha.120.031911 | 2021 |
| Chloroquine inhibits pro-inflammatory effects of heme on macrophages and in vivo | 10.1016/j.freeradbiomed.2021.07.028 | 2021 |
| c-MAF-dependent perivascular macrophages regulate diet-induced metabolic syndrome | 10.1126/sciimmunol.abg7506 | 2021 |
| Lipid droplet accumulation occurs early following Salmonella infection and contributes to intracellular bacterial survival and replication | 10.1111/mmi.14844 | 2021 |
| Congenital Zika syndrome is associated with maternal protein malnutrition | 10.1126/sciadv.aaw6284 | 2020 |
| Pro-inflammatory Actions of Heme and Other Hemoglobin-Derived DAMPs | 10.3389/fimmu.2020.01323 | 2020 |
| The Role of MIF on Eosinophil Biology and Eosinophilic Inflammation | 10.1007/s12016-019-08726-z | 2020 |
| Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance | 10.1371/journal.ppat.1008599 | 2020 |
| CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes | 10.1371/journal.ppat.1008230 | 2020 |
| Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis | 10.4049/jimmunol.1900886 | 2020 |
| Mayaro Virus Replication Restriction and Induction of Muscular Inflammation in Mice Are Dependent on Age, Type-I Interferon Response, and Adaptive Immunity | 10.3389/fmicb.2019.02246 | 2019 |
| ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart | 10.1371/journal.ppat.1006928 | 2018 |
| Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope | 10.1038/s41598-018-27855-7 | 2018 |
| Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection | 10.1038/s41467-018-05519-4 | 2018 |
| Heme oxygenase-1 and autophagy linked for cytoprotection. | 10.2174/1381612824666180727100909 | 2018 |
| Hemoglobin metabolism by-products are associated with an inflammatory response in patients with hemorrhagic stroke | 10.5935/0103-507x.20180003 | 2018 |
| RIPK1-RIPK3-MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils | 10.3389/fimmu.2018.01818 | 2018 |
| Heme and iron induce protein aggregation | 10.1080/15548627.2016.1271515 | 2017 |
| Indoleamine 2,3-dioxygenase and iron are required for Mycobacterium leprae survival | 10.1016/j.micinf.2017.06.006 | 2017 |
| Short-Term Regulation of Fc γ R-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products | 10.1155/2017/2086840 | 2017 |
| Heme Drives Oxidative Stress-Associated Cell Death in Human Neutrophils Infected with Leishmania infantum | 10.3389/fimmu.2017.01620 | 2017 |
| Zika Virus Infects, Activates, and Crosses Brain Microvascular Endothelial Cells, without Barrier Disruption | 10.3389/fmicb.2017.02557 | 2017 |
| Red alert: labile heme is an alarmin | 10.1016/j.coi.2015.11.006 | 2016 |
| Inactivation of Dengue and Yellow Fever viruses by Heme, Cobalt-protoporphyrin IX and Tin-protoporphyrin IX | 10.1111/jam.13038 | 2016 |
| Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1 production in a murine model of acute gout | 10.1189/jlb.3MA0915-418R | 2016 |
| RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms | 10.4049/jimmunol.1502492 | 2016 |
| Molecular, Cellular and Clinical Aspects of Intracerebral Hemorrhage: Are the Enemies Within? | 10.2174/1570159X14666151230110058 | 2016 |
| Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice | 10.1038/ncomms13344 | 2016 |
| Resveratrol Reverses Functional Chagas Heart Disease in Mice | 10.1371/journal.ppat.1005947 | 2016 |
| Protein aggregation as a cellular response to oxidative stress induced by heme and iron | 10.1073/pnas.1608928113 | 2016 |
| Macrophage migration inhibitory factor promotes eosinophil accumulation and tissue remodeling in eosinophilic esophagitis | 10.1038/mi.2015.6 | 2015 |
| CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis | 10.1371/journal.pone.0133227 | 2015 |
| Immunology and Infection by Protozoan Parasites | 10.1155/2015/504951 | 2015 |
| Cryptococcus neoformans glucuronoxylomannan fractions of different molecular masses are functionally distinct | 10.2217/fmb.13.163 | 2014 |
| Heme on innate immunity and inflammation. | 10.3389/fphar.2014.00115 | 2014 |
| Hemolysis-induced lethality involves inflammasome activation by heme | 10.1073/pnas.1405023111 | 2014 |
| Bacterial Clearance in Septic Mice Is Modulated by MCP-1/CCL2 and Nitric Oxide | 10.1097/SHK.0b013e31827802b5 | 2013 |
| Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve | 10.1111/ejn.12161 | 2013 |
| Oral immunization with Lactococcus lactis secreting attenuated recombinant staphylococcal enterotoxin B induces a protective immune response in a murine model | 10.1186/1475-2859-12-32 | 2013 |
| Binding of the wheat germ lectin to Cryptococcus neoformans chitooligomers affects multiple mechanisms required for fungal pathogenesis | 10.1016/j.fgb.2013.04.005 | 2013 |
| Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania | 10.1038/nm.3221 | 2013 |
| Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation | 10.1182/blood-2013-05-504449 | 2013 |
| Design, Synthesis and Evaluation of Hydroxamic Acid Derivatives as Promising Agents for the Management of Chagas' disease | 10.1021/jm400902y | 2013 |
| Are ROS always detrimental to pathogens? | 10.1089/ars.2013.5447 | 2013 |
| Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1¿CXCR1/2-pathway | 10.1016/j.mvr.2011.10.003 | 2012 |
| Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production | 10.1182/blood-2011-08-375303 | 2012 |
| Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection | 10.4049/jimmunol.1103072 | 2012 |
| Oxidative stress fuels Trypanosoma cruzi infection in mice | 10.1172/JCI58525 | 2012 |
| Ketoprofen Impairs Immunosuppression Induced by Severe Sepsis and Reveals an Important Role for Prostaglandin E2 | 10.1097/SHK.0b013e318272ff8a | 2012 |
| Macrophage Migration Inhibitory Factor in Protozoan Infections | 10.1155/2012/413052 | 2012 |
| Leukotriene B4 Mediates Neutrophil Migration Induced by Heme | 10.4049/jimmunol.1002400 | 2011 |
| Cross-Talk between Macrophage Migration Inhibitory Factor and Eotaxin in Allergic Eosinophil Activation Forms Leukotriene C4-Synthesizing Lipid Bodies | 10.1165/rcmb.2010-0004OC | 2011 |
| MIF Participates in Toxoplasma gondii-Induced Pathology Following Oral Infection | 10.1371/journal.pone.0025259 | 2011 |
| Glycoconjugates and polysaccharides from the Scedosporium/Pseudallescheria boydii complex: structural characterisation, involvement in cell differentiation, cell recognition and virulence | 10.1111/j.1439-0507.2011.02105.x | 2011 |
| Fungal Surface and Innate Immune Recognition of Filamentous Fungi | 10.3389/fmicb.2011.00248 | 2011 |
| Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection | 10.1096/fj.09-139469 | 2010 |
| Pro-inflammatory response resulting from sindbis virus infection of human macrophages: Implications for the pathogenesis of viral arthritis | 10.1002/jmv.21649 | 2010 |
| Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: A relevant role on viral replication | 10.1016/j.virol.2009.12.018 | 2010 |
| Heme Impairs Prostaglandin E2 and TGF- Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria | 10.4049/jimmunol.0904179 | 2010 |
| Schistosomal?Derived Lysophosphatidylcholine Are Involved in Eosinophil Activation and Recruitment through Toll?Like Receptor¿2¿Dependent Mechanisms | 10.1086/656477 | 2010 |
| TLR4 Recognizes Pseudallescheria boydii Conidia and Purified Rhamnomannans | 10.1074/jbc.M110.181255 | 2010 |
| Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation | 10.1074/jbc.M110.146076 | 2010 |
| Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction | 10.1189/jlb.0108009 | 2009 |
| Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells | 10.1016/j.chom.2008.12.011 | 2009 |
| Salivary Gland Homogenates of <i>Lutzomyia longipalpis</i> and Its Vasodilatory Peptide Maxadilan Cause Plasma Leakage via PAC1 Receptor Activation | 10.1159/000197866 | 2009 |
| Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection | 10.1096/fj.08-124248 | 2009 |
| TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection? | 10.1016/j.micinf.2009.04.025 | 2009 |
| The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation | 10.1016/j.bbrc.2009.10.129 | 2009 |
| CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection | 10.1189/jlb.0309187 | 2009 |
| Impact of lung remodelling on respiratory mechanics in a model of severe allergic inflammation | 10.1016/j.resp.2007.10.009 | 2008 |
| Trypanosoma cruzi Infection Is Enhanced by Vector Saliva through Immunosuppressant Mechanisms Mediated by Lysophosphatidylcholine | 10.1128/IAI.00683-08 | 2008 |
| Binding of Glucuronoxylomannan to the CD14 Receptor in Human A549 Alveolar Cells Induces Interleukin-8 Production | 10.1128/CVI.00296-06 | 2007 |
| Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation | 10.1002/eji.200635968 | 2007 |
| Unraveling the lethal synergism betweenTrypanosoma cruzi infection and LPS: A role for increased macrophage reactivity | 10.1002/eji.200636705 | 2007 |
| Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis | 10.1186/cc5783 | 2007 |
| Biochemical and biological characterization of the venoms of Bothriopsis bilineata and Bothriopsis taeniata (Serpentes: Viperidae) | 10.1016/j.toxicon.2007.03.020 | 2007 |
| Characterization of Heme as Activator of Toll-Like Receptor 4 | 10.1074/jbc.m610737200 | 2007 |
| Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors | 10.1074/jbc.m703570200 | 2007 |
| Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response. | 2007 | |
| Effects of the fish-oil supplementation on the immune and inflammatory responses in elite swimmers | 10.1016/j.plefa.2007.08.010 | 2007 |
| An -Glucan of Pseudallescheria boydii Is Involved in Fungal Phagocytosis and Toll-like Receptor Activation | 10.1074/jbc.M511417200 | 2006 |
| Hypothalamus¿pituitary¿adrenal axis during Trypanosoma cruzi acute infection in mice? | 10.1016/j.jneuroim.2005.08.015 | 2006 |
| Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles | 10.2174/157018006775789667 | 2006 |
| INCREASED SUSCEPTIBILITY TO SEPTIC AND ENDOTOXIC SHOCK IN MONOCYTE CHEMOATTRACTANT PROTEIN 1/CC CHEMOKINE LIGAND 2-DEFICIENT MICE CORRELATES WITH REDUCED INTERLEUKIN 10 AND ENHANCED MACROPHAGE MIGRATION INHIBITORY FACTOR PRODUCTION | 10.1097/01.shk.0000228801.56223.92 | 2006 |
| CALCITONIN GENE-RELATED PEPTIDE INHIBITS LOCAL ACUTE INFLAMMATION AND PROTECTS MICE AGAINST LETHAL ENDOTOXEMIA | 10.1097/01.shk.0000183395.29014.7c | 2005 |
| Toxoplasma gondii Prevents Neuron Degeneration by Interferon-?-Activated Microglia in a Mechanism Involving Inhibition of Inducible Nitric Oxide Synthase and Transforming Growth Factor-?1 Production by Infected Microglia | 10.1016/S0002-9440(10)61191-1 | 2005 |
| Nod1 Participates in the Innate Immune Response to Pseudomonas aeruginosa | 10.1074/jbc.M501649200 | 2005 |
| MACROPHAGE MIGRATION INHIBITORY FACTOR LEVELS CORRELATE WITH FATAL OUTCOME IN SEPSIS | 10.1097/01.shk.0000140305.01641.c8 | 2004 |
| Soluble Factors Released by Toxoplasma gondii-Infected Astrocytes Down-Modulate Nitric Oxide Production by Gamma Interferon-Activated Microglia and Prevent Neuronal Degeneration | 10.1128/IAI.71.4.2047-2057.2003 | 2003 |
| Influence of first-wave derived T lymphocytes in the long term functional reconstitution of allogeneic T cell deficient hosts | 10.1078/0171-2985-00232 | 2003 |
| Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gammadelta T lymphocyte trafficking during inflammation induced by lipopolysaccharide Bacille Calmette-Guerin | 2003 | |
| The role of eicosanoids on Rhodnius heme-binding protein (RHBP) endocytosis by Rhodnius prolixus ovaries | 10.1016/S0965-1748(01)00132-1 | 2002 |
| Asymptomatic human carriers of Leishmania chagasi | 2002 | |
| Monocyte chemoatractant protein-1 and 5-lipoxigenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein | 2002 | |
| Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastic activity in chorioallantoic membrane model | 2002 | |
| Proinflammatory and Cytotoxic Effects of Hexadecylphosphocholine (Miltefosine) against Drug-Resistant Strains of Trypanosoma cruzi | 10.1128/AAC.46.11.3472-3477.2002 | 2002 |
| Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-gamma production | 10.1046/j.1365-2613.2002.00221.x | 2002 |
| Lipopolysaccharideinduced leukocyte lipid body formation in vivo: Innate immunity elicited intracellular loci involved in eicosanoid formation | 2002 | |
| Pituitary Adenylyl Cyclase-activating Polypeptide Prevents Induced Cell Death in Retinal Tissue through Activation of Cyclic AMP-dependent Protein Kinase | 10.1074/jbc.M110106200 | 2002 |
| Physalis angulata L. antineoplasic activity,in vitro, evaluation from it?s stems and fruit | 2002 | |
| Migration-Inhibitory Factor Gene-Deficient Mice Are Susceptible to Cutaneous Leishmania major Infection | 10.1128/IAI.69.2.906-911.2001 | 2001 |
| Novel nitroimidazoles with trypanocidal and cell growth inhibition activities | 2001 | |
| Targeted Disruption of Migration Inhibitory Factor Gene Reveals Its Critical Role in Sepsis | 10.1084/jem.189.2.341 | 1999 |
| Evidences of gentamicin resistance amplification in Klebsiella pneumoniae isolated from faeces of hospitalized newborns | 1999 | |
| The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-a and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor | 1998 | |
| The PACAP-type I receptor agonist maxadilan from sand fly saliva protects mice against lethal endotoxemia by a mechanism partially dependent on IL-10 | 10.1002/(SICI)1521-4141(199810)28:10<3120::AID-IMMU3120>3.0.CO;2-3 | 1998 |
| An oligonucleotide probe derived from kDNA minirepeats is specific for Leishmania (Viannia) | 1996 | |
| Characterization of 'Old World' Leishmania species using amplified minicircle variable regions as molecular probes | 10.1016/0035-9203(95)90569-3 | 1995 |
| Comparison of the Polymerase Chain Reaction (PCR) and Sorology for the Detection of Canine Visceral Leishmaniasis | 1995 | |
| Structural Characterization and Chromosomal Location of the Mouse Macrophage Migration Inhibitory Factor Gene and Pseudogenes | 10.1006/geno.1995.1071 | 1995 |
| Neutral endopeptidase modulation of septic shock | 10.1084/jem.181.6.2271 | 1995 |
| The Identity of Leishmania Isolated from Sand Flies and Vertebrate Hosts in a Major Focus of Cutaneous Leishmaniasis in Baturite, Northeastern Brazil. | 1994 | |
| Detection of Trypanosoma cruzi and Leishmania using PCR. | 1994 | |
| Use of Molecular Probes and PCR for Detection and Typing of Leishmania | 1994 |
Eventos:
Nenhum evento cadastrado