Paulo Roberto Ribeiro Costa

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Pesquisas de Produtos Naturais

Departamento:

Programa de Produtos Naturais/IPPN

ORCID:

https://orcid.org/0000-0001-9541-1707


Formação:

  • Université Pierre et Marie Curie

    | Pós-Doutorado | 1988 - 1988

  • Université Joseph Fourier - Grenoble I

    | Pós-Doutorado | 1988 - 1988

  • Université Joseph Fourier - Grenoble I

    | Pós-Doutorado | 1984 - 1984

  • Universidade Federal do Rio de Janeiro

    Química | Doutorado | 1978 - 1983

  • Universidade Federal do Rio de Janeiro

    Química de Produtos Naturais | Mestrado | 1972 - 1975

  • Universidade Federal do Rio de Janeiro

    Faculdade de Farmácia | Graduação | 1969 - 1972
Laboratórios:
Nuvens de Palavras:
Artigos:

(85.00% artigos com DOI)

Titulo DOI Ano
Microarray data analysis of antileukemic action of Cinnamoylated benzaldehyde LQB-461 in Jurkat cell line 10.1007/s11033-023-09030-y 2024
Advances in the synthesis of rearranged homoisoflavonoids 10.1039/d4ob00627e 2024
Flavonoids as Inspiration for the Design and Synthesis of New Antiproliferative, Antiparasitic and Antiviral Compounds: An Account 10.21577/0103-5053.20240056 2024
Flavonoids as Inspiration for the Design and Synthesis of New Antiproliferative, Antiparasitic and Antiviral Compounds: An Account 10.21577/0103-5053.20240056 2024
Advances in the synthesis of rearranged homoisoflavonoids 10.1039/D4OB00627E 2024
Low doses of 3-phenyl-lawsone or meglumine antimoniate delivery by tattooing route are successful in reducing parasite load in cutaneous lesions of Leishmania (Viannia) braziliensis-infected hamsters 10.3389/fcimb.2023.1025359 2023
Aurones: A Promising Scaffold to Inhibit SARS-CoV-2 Replication 10.1021/acs.jnatprod.3c00249 2023
Deacylative Allylation Reaction: A promising Approach for the Synthesis of Compounds Containing the Allyl Group at Quaternary Centers 10.21577/1984-6835.20230025 2023
LQB-118 Suppresses Migration and Invasion of Prostate Cancer Cells by Modulating the Akt/GSK3β Pathway and MMP-9/Reck Gene Expression 10.21873/anticanres.16171 2023
Aurones: A Promising Scaffold to Inhibit SARS-CoV-2 Replication 10.1021/acs.jnatprod.3c00249 2023
Low doses of 3-phenyl-lawsone or meglumine antimoniate delivery by tattooing route are successful in reducing parasite load in cutaneous lesions of Leishmania (Viannia) braziliensis-infected hamsters 10.3389/fcimb.2023.1025359 2023
Asymmetric hydrogenation and transfer hydrogenation in the enantioselective synthesis of flavonoids 10.1039/d1qo01503f 2022
The Isoflavanoid (+)-PTC Regulates Cell-Cycle Progression and Mitotic Spindle Assembly in a Prostate Cancer Cell Line 10.1002/cbdv.202200102 2022
Ru(II)-Catalyzed Asymmetric Transfer Hydrogenation of Chalcones in Water: Application to the Enantioselective Synthesis of Flavans BW683C and Tephrowatsin E 10.1021/acs.joc.2c01733 2022
Effects of anti- Leishmania compounds in the behavior of the sand fly vector Lutzomyia longipalpis 10.1002/ps.6900 2022
New 5-carba-pterocarpans: Synthesis and preliminary antiproliferative activity on a panel of human cancer cells 10.1016/j.bioorg.2020.104584 2021
Synthesis of new α-Aryl-α-tetralones and α-Fluoro-α-aryl-α-tetralones, preliminary antiproliferative evaluation on drug resistant cell lines and in silico prediction of ADMETox properties 10.1016/j.bioorg.2021.104790 2021
The pterocarpanquinone LQB-118 compound induces apoptosis of cytarabine-resistant acute myeloid leukemia cells 10.3892/ijo.2021.5204 2021
N - tert -Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles 10.3762/bjoc.17.86 2021
The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi 10.3389/fmicb.2021.617504 2021
Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity 10.1021/acsmedchemlett.1c00193 2021
Enantioselective synthesis of isoflavanones and pterocarpans through a RuII¿catalyzed ATH¿DKR of isoflavones 10.1002/cctc.202101252 2021
Synthesis and Biological Evaluation of Cyclic Analogues from Nitrone LQB-278: A New Potential Antileukemia Compound 10.21873/anticanres.15306 2021
Asymmetric Transfer Hydrogenation of Arylidene-Substituted Chromanones and Tetralones Catalyzed by Noyori-Ikariya Ru(II) Complexes: One-Pot Reduction of C-C and C-O bonds 10.1021/acs.joc.0c02981 2021
Synthesis of new α-Aryl-α-tetralones and α-Fluoro-α-aryl-α-tetralones, preliminary antiproliferative evaluation on drug resistant cell lines and in silico prediction of ADMETox properties 10.1016/j.bioorg.2021.104790 2021
Asymmetric Transfer Hydrogenation of Arylidene-Substituted Chromanones and Tetralones Catalyzed by Noyori-Ikariya Ru(II) Complexes: One-Pot Reduction of C-C and C-O bonds 10.1021/acs.joc.0c02981 2021
The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi 10.3389/fmicb.2021.617504 2021
LQB-118 compound inhibits migration and induces cell death in glioblastoma cells 10.3892/or.2019.7402 2020
The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro 10.1016/j.intimp.2020.106399 2020
Theoretical studies and NMR assay of coumarins and neoflavanones derivatives as potential inhibitors of acetylcholinesterase 10.1016/j.compbiolchem.2020.107293 2020
Synthesis of pterocarpans through palladium-catalyzed oxyarylation of alkoxy-2H-chromenes with o-iodophenols 10.1016/j.tet.2020.131638 2020
Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-Tumor Activity against MDR Leukemias 10.2174/1871520618666180420165128 2019
Enantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1-Azaspiro[4.5]decanes on Drug-Resistant Leukemias 10.1021/acs.joc.8b03203 2019
Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms 10.1371/journal.pone.0211229 2019
Enantioselective electrophilic fluorination of α-aryl-tetralones using a preparation of N-fluoroammonium salts of cinchonine 10.1016/j.jfluchem.2018.11.007 2019
Switching Diastereoselectivity in Catalytic Enantioselective (3+2) Cycloadditions of Azomethine Ylides Promoted by Metal Salts and Privileged Segphos-Derived Ligands 10.1021/acs.joc.9b00267 2019
The LQB-223 Compound Modulates Antiapoptotic Proteins and Impairs Breast Cancer Cell Growth and Migration 10.3390/ijms20205063 2019
Snake venom activities as a tool to develop new metalloproteinase inhibitors from synthetic derivatives of lapachol 10.1016/j.toxicon.2019.06.133 2019
Medicinal Electrochemistry of Halogenated and Nitrated Pterocarpanquinones 10.21577/0103-5053.20190161 2019
Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-tumor Activity against MDR Leukemias 10.2174/1871520618666180420165128 2019
The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress 10.1002/pros.23455 2018
New Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations 10.1590/0001-3765201820170858 2018
Second-generation pterocarpanquinones: synthesis and antileishmanial activity 10.1186/s40409-018-0174-7 2018
11a- N -tosyl-5-carbapterocarpans: synthesis, antineoplastic evaluation and in silico prediction of ADMETox properties 10.1016/j.bioorg.2018.07.004 2018
Interaction between bioactive compound 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) and Calf thymus DNA: Spectroscopic approach, electrophoresis and theoretical studies 10.1016/j.ijbiomac.2016.12.044 2017
Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone LQB-118 10.1002/chir.22696 2017
Solvent-Free Synthesis of Salen Ligands and Pd(II)- and Cu(II)-Salen Complexes: Their Use in the Oxidation of α-Tetralones to α-Naphthols 10.1055/s-0036-1588446 2017
Palladium-Catalyzed α-Arylation of Dimethyl Malonate and Ethyl Cyanoacetate with o-Alkoxybromobenzenes for the Synthesis of Phenylacetic Acid, Esters and Phenylacetonitriles 10.1055/s-0036-1588550 2017
Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl-t-Butylnitrone Derivative 10.1155/2017/2483652 2017
Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes 10.1016/j.tetasy.2015.12.004 2016
5-Carba-pterocarpens: A New Scaffold with Anti-HCV Activity 10.1016/j.ejmech.2016.02.010 2016
Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis 10.1128/aac.01787-15 2016
Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis 10.1128/aac.01545-16 2016
In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone LQB-118 10.1007/s10637-016-0359-2 2016
Reactive Oxygen Species Release, Alkylating Ability, and DNA Interactions of a Pterocarpanquinone: A Test Case for Electrochemistry 10.1002/celc.201600504 2016
Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice 10.1016/j.bmc.2016.07.046 2016
The syn-selective conjugate addition of amines to enoates derived from d-mannitol 10.1016/j.tetasy.2016.06.017 2016
Copper-versus palladium-catalyzed aromatization of 2-(methoxycarbonyl) tetralones: synthesis of methyl 1-hydroxy-2-naphthoates 10.1016/j.tet.2016.01.057 2016
Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery 10.1039/c6ra15143d 2016
Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities 10.21577/0103-5053.20160326 2016
Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis C virus inhibitors 10.1016/j.ejmech.2015.01.057 2015
NFκB Pathway and microRNA-9 and -21 are Involved in Sensitivity to the Pterocarpanquinone LQB-118 in Different CML Cell Lines 10.2174/18715206113139990108 2015
Palladium-Catalyzed Oxyarylation, Azaarylation and α-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues 10.2174/157017941206150828112502 2015
Abstract A51: Antineoplastic activity of novel synthetic compound pterocarpanquinone LQB-118 in lung cancer cells 10.1158/1557-3265.PMS14-A51 2015
Abstract A49: Efficiency of 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) in a panel of myeloid leukemia cell lines with different chemoresistance backgrounds 10.1158/1557-3265.PMS14-A49 2015
Synthesis of N-methylarylnitrones derived from alkyloxybenzaldehydes and antineoplastic effect on human cancer cell lines 10.1016/j.bmc.2015.03.014 2015
Synthesis of Chromen[4,3- b ]pyrrolidines by Intramolecular 1,3-Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol 10.1002/ejoc.201500434 2015
Synthesis of 11a-N-Arylsulfonyl-5-carbapterocarpans (Tetrahydro-5H-benzo[a]carbazoles) by Azaarylation of Dihydronaphthalenes with o-Iodo-N-(Arylsulfonyl)anilines in Poly(ethylene glycol) 10.1055/s-0034-1380757 2015
Ligand-Free Palladium-Catalyzed Oxyarylation of Dihydronaphthal­enes and Chromenequinone with o-Iodophenols and 3-Iodolawsone in PEG-400: An Efficient Synthesis of 5-Carbapterocarpans and Pterocarpanquinones 10.1055/s-0034-1378745 2015
Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro 10.1016/j.parint.2015.08.010 2015
Synthesis of 5-Carbapterocarpens by α-Arylation of Tetralones Followed by One-Pot Demethylation/Cyclization with BBr 3 10.1002/ejoc.201301505 2014
The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors 10.3892/ijo.2014.2615 2014
Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters 10.1371/journal.pone.0109672 2014
Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum 10.1371/journal.pone.0091191 2014
The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression 10.1016/j.bmc.2014.04.025 2014
The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway 10.1097/cad.0b013e3283592da8 2013
Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors 10.1111/cbdd.12105 2013
Palladium-Catalyzed Arylation of Enoates with Iodobenzene: Stereoselective Synthesis of Trisubstituted Olefins 10.5935/0103-5053.20130067 2013
The Therapeutical Potential of a Novel Pterocarpanquinone LQB-118 to Target Inhibitor of Apoptosis Proteins in Acute Myeloid Leukemia Cells 10.2174/1871520611313020019 2013
LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis 10.1093/jac/dks498 2013
Purification of a synthetic pterocarpanquinone by countercurrent chromatography 10.1590/s0103-50532012000600016 2012
A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro 10.1016/j.vetpar.2011.11.008 2012
Binap-silver salts as chiral catalysts for the enantioselective 1,3-dipolar cycloaddition of azomethine ylides and alkenes 10.1016/j.tetasy.2012.10.015 2012
214. Evaluation of the Antiophidic Activity of Lapachol and Synthetic Analogues 10.1016/j.toxicon.2012.04.215 2012
Microwave-Promoted Palladium-Catalysed Oxyarylation of Dihydronaphthalene and Chromenes by o-Iodophenols and Its Acetates 10.1002/ejoc.201100365 2011
LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells 10.1007/s10637-010-9453-z 2011
Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis 10.1093/jac/dkr158 2011
DBU as a catalyst for the synthesis of amides via aminolysis of methyl esters 10.1590/s0103-50532011001100023 2011
Synthesis of Coumarins and Neoflavones through Zinc Chloride Catalyzed Hydroarylation of Acetylenic Esters with Phenols 10.1055/s-0031-1289576 2011
Pterocarpanquinones, Aza-pterocarpanquinone and Derivatives: Synthesis, Antineoplasic Activity on Human Malignant Cell Lines and Antileishmanial Activity on Leishmania amazonensis 10.1016/j.bmc.2011.09.025 2011
1213 POSTER The New Synthetic Compound Pterocarpanquinone LQB-118 Induces Apoptosis in Acute Myeloid Leukemia Cells Through Survivin and XIAP Downregulation 10.1016/S0959-8049(11)70825-5 2011
A new and concise strategy to the enantioselective synthesis of (S)-2-amino-4-oxo-4-(pyridine-2-yl) butanoic acid from aspartic acid 10.1590/s0103-50532010000500002 2010
BINAP-AgSbF6 vs. BINAP-AgClO4 Complexes as Catalysts for the Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides and Alkenes 10.1055/s-0029-1219534 2010
Ability of a synthetic coumestan to antagonize Bothrops snake venom activities 10.1016/j.toxicon.2009.09.021 2010
Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry 10.1016/j.jorganchem.2010.05.014 2010
New pterocarpanquinones: Synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-α modulation in human PBMC cells 10.1016/j.bmc.2009.12.073 2010
Palladium-Catalyzed Tandem Heck-Lactonization from o -Iodophenols and Enoates: Synthesis of Coumarins and the Study of the Mechanism by Electrospray Ionization Mass Spectrometry 10.1021/jo1010922 2010
Comparison of the cytotoxic effect of lapachol, α-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells 10.1007/s10637-009-9231-y 2010
Antitumoral, Antileishmanial and Antimalarial Activity of Pentacyclic 1,4-Naphthoquinone Derivatives 10.1590/S0103-50532009000100026 2009
(±)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: Cytotoxic effect on human leukemia cell lines 10.1016/j.ejmech.2008.01.027 2009
N-tert-Butyl and N-Methyl Nitrones Derived from Aromatic Aldehydes Inhibit Macromolecular Permeability Increase Induced by Ischemia/Reperfusion in Hamsters 10.1016/j.bmc.2009.04.004 2009
Inhibition of the a1b1 Isoform of the Na, K-ATPase by 8-Methoxycoumestrol without Positive Inotropic Effect in Human Myocardium - Novel Aspects of Cardiac Glycoside Pharmacology 10.1097/FJC.0b013e3181a95ab2 2009
Iodination of Phenols in Water Using Easy to Hanle Amine-Iodine Complexes 10.1590/s0103-50532009001000021 2009
Synthesis of 5-Deoxypterocarpens,Pterocarpens and Coumestans by Intramolecular Heck Reaction. 10.1016/j.tetlet.2009.01.004 2009
Natural products as starting point for the discovery of new bioactive compounds: Drug candidates with antiophidic, anticancer and antiparasitic properties 10.5935/1984-6835.20090008 2009
Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors 10.1093/nar/gkm1178 2008
First stereoselective synthesis and assignment of the absolute configuration of the nebracetam eutomer and derivatives 10.1016/j.tetasy.2008.04.012 2008
Reação entre Nitrofenilmetanos e Enoato Derivado do D-manitol na Presença de TBAF ou DBU. Adição Conjugada Sin-Seletiva e Reação de Nef Consecutiva. 10.1590/S0100-40422008000400024 2008
Insights into the mechanism of Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan 10.1016/j.bmc.2008.09.007 2008
A tandem palladium-catalyzed Heck-lactonizationthrough the reaction of ortho-iodophenols with beta-substituted acrylates: synthesis of 4,6-substituted coumarins. 10.1016/j.tetlet.2008.03.037 2008
Synergistic interaction between ouabain and 8-methoxy-3,9-dihydroxy coumestan, a non-steroidal synthetic inhibitor of Na+,K+-ATPase 10.1016/j.lfs.2007.08.021 2007
Alfa-Phenyl-N-ter-butyl nitrone (PBN) derivatives:Synthesis and protective action against microvascular damages induced by ischemia/reperfusion 10.1016/j.bmc.2007.02.033 2007
Configuration assignment of stereogenic centers in a beta-pinene derivative by 1H NMR and molecular modeling. 10.1016/j.molstruc.2005.09.001 2006
Structure- activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na+,K+-ATPase and binding to the central benzodiazepine receptor. 10.1016/j.bmc.2006.07.053 2006
Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom 10.1016/j.bmcl.2003.10.044 2004
The First Synthesis of (+/-)-3,4-dihydroxy-8,9-methylenedioxypterocarpan, an Antitumoral Agente and its Cumestan Derivative 10.1590/S0103-50532004000600029 2004
Stereoselective preparation of pyrrolidin-2-ones from a Z-enoate derived from -(+)-mannitol 10.1016/j.tetasy.2004.06.013 2004
Stereoselective synthesis and preliminary evaluation of new d-3-heteroarylcarbonylalanines as ligands of the NMDA receptor 10.1016/j.bmcl.2004.06.062 2004
Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor 10.1016/j.ejphar.2004.05.026 2004
Crude D-( )-Glyceraldehyde Obtained from D-mannitol-diacetonide by Oxidative Cleavage with Sodium Periodate :Its Reactions with Nucleophilic Species. 10.1081/SCC-120027706 2004
Stereoselective conjugate addition of benzyl phenylsulfonyl carbanions to enoates derived from D-mannitol 10.1021/jo035427d 2004
Highly Stereocontrolled Synthesis of Natural Barbacenic Acid, Novel Bisnorditerpene From Barbacenia flava 10.1021/jo0340049 2003
2-Methoxy-3,8,9-trihydroxy coumestan: a new synthetic inhibitor of Na+,K+-ATPase with an original mechanism of action 10.1016/j.bcp.2003.08.005 2003
Stereoselective Mannich Reaction of Camphor Titanium Enolate 10.1016/S0957-4166(02)00260-4 2002
Selective Conjugate Addition of Nitromethane to Enoates Derived from D-Mannitol and L-tartaric acid 10.1016/S0957-4166(02)00230-6 2002
Synthesis and Preliminary Pharmacological Evaluation of new (+/-) 1,4-Naphthoquinones Structurally Related to Lapachol 10.1016/S0968-0896(02)00100-1 2002
NaBH4-MnCll2 for Improved Reduction of Beta-keto Esters Attached to a Chiral Auxiliary. Comparison with Zn(BH4)(2) 10.1080/00304940209355768 2002
4-Chromenesulphones: Synthesis and Transformation to Isoflavonoid Models 10.1016/S0040-4039(02)01653-2 2002
25 anos de Reações, Estratégias e Metodologias em Química Orgânica 10.1590/S0100-40422002000800012 2002
The 1,4-addition of organometallic reagents to enoates derived from pinanediol 10.1016/s0957-4166(02)00688-2 2002
The reaction of safrole derivatives with aluminum chloride improved procedures for preparation of catechols or their mono-o-methylated derivatives and a mechanistic interpretation. 10.1590/S0103-50532001000300005 2001
Synthesis and Preliminary Pharmacological Evaluation of Coumestans with Different Patterns of Oxygenation 10.1016/S0960-894X(00)00621-1 2001
Synthesis of beta -Amino Arylketones Through the Addition of ArLi Derivatives to beta-Aminoester 10.1016/S0040-4039(01)00358-6 2001
A Practical and Efficient Preparation of (-)-(4aS,5R)-4,4a,5,6,7,8-hexahydro-4a,5-dimethyl- 2(3H)-naphthalenone: A Key Intermediate in the Synthesis of (-)-Dehydrofukinone, 10.1016/S0957-4166(01)00089-1 2001
Regioselective lithiations of a Pterocarpan Skeleton: The First Synthesis of (+/-)-4 '-Dehydroxycabenegrin A-I 10.1016/S0040-4039(01)00682-7 2001
Safrol e Eugenol: Estudo da ReatividadeQuímica e uso em Síntese de Produtos Naturais Biológicamente ativos e seus Derivados 10.1590/S0100-40422000000300013 2000
The use of Chiral Auxiliaries Prepared From (-)- Beta - Pinene in stereoselective Reduction of Beta -Ketobutyrates 10.1080/00397910008087342 2000
Synthesis of Chiral Pyrrolidine and Pyrrole Derivatives Through the Chemoselective Dieckmann 10.1016/S0957-4166(00)00377-3 2000
The Regio- and Stereoselective Oxyamination of Pinenes and Camphene 10.1016/S0957-4166(00)00382-7 2000
Synthesis of new chiral auxiliares from carbohydrates for Et2AlCl-promoted Diels-Alder Reactions 10.1590/S0103-50532000000300012 2000
Formal Enantioselective Synthesis of (+)-Vincamine. The First Enantioselective Route to (+)-3,14-Epivincamine and Its Enantiomer, 10.1016/S0957-4166(98)00489-3 1999
Improved Method for the Esterification of Sugar Acetals With Dicyclocarbodiimide 10.1080/00304949909355350 1999
Syn or Anti Selective Michael Addition of Allyl Phenyl Sulphone and Phenyl Prenyl Sulphone to Enoates Derived From D-Mannitol, 10.1016/S0040-4039(98)01073-9 1998
New Carbohydrate-Based Chiral Auxiliaries in Diels-Alder Reaction 10.1016/S0957-4166(98)00286-9 1998
Carboxyl-Terminal Sequencing: New C-Terminal Peptidyl-ThioHydantoins Formation Conditions 1998
Synthesis and structural determination of new chiral auxiliaries derived from (-)-b-pinene 10.1016/S0957-4166(96)00523-X 1997
Stereocontrolled Elaboration of Quaternary Carbon Centers Involving the Asymmetric Michael-type Alkylation of Chiral Imines: an Efficient Enantioselective Access to (+)-Vincamine 10.1016/S0957-4166(97)00210-3 1997
Syn-selective Michael Addition of nitromethane derivatives to enoates derived from (R)-(+)-glyceraldehyde acetonide 10.1021/jo960788x 1997
Substâncias Enantiomericamente Puras (SEP): A questão dos fármacos quirais 10.1590/S0100-40421997000600014 1997
Asymmetric Friedel-Crafts Reactio Mediated by New Chiral Auxiliaries Derived From (1S)-(-)-(b)-Pinene: Enantioselective Synthesis of (-)-8-Norethyl, 1'-Normethyl Etodolac 10.1016/S0040-4039(97)01658-4 1997
One Pot Large Scale Procedure for the Production of 2-Ethyl and 2-Butyl-2-Carboethoxycyclopentanone frm Ethyl Adipate, 10.1080/00397919708005062 1997
Carbohydrates and Terpenes as Chiral Auxiliaries: the Stereoselective Synthesis of (+) or (-)-b-Piperonyl-g-butirolactone 1996
2,3;4,5-Bis-O-(1-methylethyledene)-b-D-fructopiranose as chiral auxiliary in asymmetric a-alkylation of ester enolates 10.1080/07328309608005685 1996
Asymmetric Friedel - Crafts Reaction: An Application to the Synthesis of an Etodolac Analogue 10.1080/00397919608003781 1996
Orthobromodiphenylmethane derivatives as starting material for the total synthesis of anthraquinones 10.1080/00397919608003853 1996
Snthesis of (-)-6,6-(ethylenedioxy)-1,10-dimethyl-1(9)-octal-2-one 1996
Variable Chemo-selective Electrophilic Attack on Silylated Aromatic Aldehydes 10.1055/s-1996-5530 1996
Total synthesis of pterocarpan: (?)-neorautenane 10.1039/P19950000949 1995
Stereoselective conjugate addition of Nitromethane to enolates derived from Glyceraldehyde acetonide 1994
Stereoselectivity of enolate formations: the effect of the substituent in the g-position of butirates 1994
Enantioselective synthesis of (R)-(+)-b-piperonil-Y-butirolactone 10.1016/0957-4166(94)80161-4 1994
Enantioselective synthesis of substituted octalones 10.1016/0957-4166(94)80104-5 1994
On the asymmetric induction involving lithium enolates of l-menthylpropionate 10.1016/S0957-4166(00)86253-9 1994
On the enantioselective formal synthesis of (+)-Vallesamidine, an Aspidospermae alkaloid, 1993
A convenient synthesis of (±)-4-prenylpterocarpin, 1992
Trans-2-arylcyclohexanols: use as auxiliaries in the Mukaiyama aldol-type condensation between silyl enol esters and aldehydes 10.1016/S0040-4039(00)61234-0 1992
Piperonal as starting material for the regioespecific and stereoselective synthesis of E and Z isomers of 3-methyl-2-hexenedioic acid-1-methyl ester, 10.1080/00397919108020839 1991
Synthesis of 6,7-methylenedioxylapachol 10.1080/00397919108020840 1991
Asymmetric Michael addition of chiral imines to phenylvinylsulphone: Preparation of key chiral building blocks for the synthesis of Aspidosperma and Hunteria alkaloids 10.1016/S0957-4166(00)82358-7 1991
New chiral auxiliaries derived from beta-pinene: their use in the asymmetric reduction of b-keto-esters 1991
Safrole as starting material for the synthesis of 7-methoxy-3'-4'-methylenedioxy isoflavone 1990
Vanillin (1) as starting material for the synthesis of isomeric phthalides 10.1080/00397918808081335 1988
Synthesis of Dimethoxyfuronaphthoquinones 10.1080/00397918808081336 1988
Expeditious, stereocontrolled synthesis of racemic and natural brasilenol through intramolecular symetry transfer. Absolute stereochemistry of brasilenol 10.1021/jo00382a042 1987
The synthesis of new hybrid prostanoids from natural safrole 1987
Eugenol as starting materials for the synthesis of 3-alkyl muconic acid dimethyl esteres and 3-alkyl adipic acid dimethyl ester 1986
Safrole as starting materials for the synthesis of 3-alkyl muconic acid monomethyl esters an 4,4-dialkylbutenolides 1986
The chemistry of phthalides. I. Synthesis of 2,3-dimethoxy-phthalide (Meconime) and 2-benzyloxyphthalide, 1986
A selective synthesis of brasilenol, a novel sesquiterpene from the sea hare Aplysia brasiliana and the red alga Laurencia obtusa 10.1021/jo00372a027 1986
Prostaglandin analogue: 2. The synthesis of new prostanoids derivatives from safrole isolated from sassafraz oil 1985
Eugenol and Safrole as starting materials for the synthesis of 3-alkyl-muconic acids mono and dimethyl ester and 4,4-dialkylbutenolids 10.1016/S0040-4039(00)98978-0 1985
The reaction of safrole with brominating agents. Differential trapping of the intermediates by bromide and water 1984
The nature of solvent effects in the reaction of safrole with bromine 1984
Efficient synthesis of cytotoxic quinones; 2-acetyl-4H,9H-naphtho [2,3-b] furan-4,9-dione, 6 and (+) 2-(1-hydroxy-ethyl)-4H,9H-naphtho [2,3-b] furan-4,9-dione, 7 10.1002/jhet.5570210274 1984
Prostaglandin analogues: The synthesis of new prostaglandins from natural safrole 1984
Prostaglandin analogues: the synthesis of new tromboxaxane derivatives from natural safrole 1984
Interaction of a nitro-group with adjacent cationic species to form nitronic lactones 1983
Eergia da ponte de hidrogênio entre moléculas S-trans na N-metil-formamida: cálculos pelo método CNDO/ 1983
A convenient method for the preparation of 6,7-methylenedio-xy-3-alkyl-2-hydroxy-1,4-naphthoquinones from natural safrole and carboxylic acids 10.1080/00397918308060351 1983
The Bayer-Villiger reactions in the synthesis of vicinal triphenol derivatives, 1982
An improved synthesis from natural safrole of indole related to indomethacin 1982
Preparação de aldeídos fenilacéticos oxigenados pela reação de ozonólise de alilbenzenos naturais - Utilização do homopiperonal como precursor de unidades C6-C2 1982
Síntese de derivados do ácido 2,3-indoil-acético a partir do safrol 1982
Síntese do 2-acetil-4H,9H-nafto[2,3-b]furan-4,9-diona e (+) 2-(1-hidroximetil)-H,9H-nafto[2,3-b]furan-4,9-diona 1982
Utilização de sintons naturais na preparação de compostos biologicamente ativos. I. Prostanóides 1981
Utilização de sintons naturais na preparação de compostos biologicamente ativos. II. Antiinflamatórios 1981
Reações de Bayer-Villiger: aplicação na síntese de trifenóis vicinais e O-derivados 1981
Síntese de quinolinas a partir do safrol 1980
Ions carbônio não clássicos em reações de adição eletrofílica ao safrol 1975
Solvent Effects in the Reaction of Safrole with Bromine 10.1016/S0040-4039(00)91064-5 1975
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Metal-catalyzed synthesis of coumarins, coumestans, pterocarpans and pterocarpens 2012
Cytotoxic Potential of Lapachol Analogues 2011
Síntese de Novos Análogos do Lapachol Via Reações de Acoplamento Cruzado de Suzuki-Miyaura. Evolução Antitumoral 2011
Synthesis of Lapachol Analogues Through Suzuki-Miyaura Cross-Coupling. Antitumoral Evaluation. 2011
Palladium Catalyzed Heck Oxyarylation in Lawsone Derivatives 2011
Palladium Catalyzed Heck-Lactonization from Ortho-Iodophenols and Enoates: Synthesis of Coumarins and the Study of the Mechanism by Electrospray Ionization Mass Spectrometry 2011
Enantioselective Conjugate Addition of Aldehydes and Ketones to Maleimides Catalyzed by a Chiral Bifunctional n-Benzoimidazol-Cyclohexanediamine 2011
Synthesis of Coumarins Through Zinc Chloride-Catalyzed Hydroarylation of Acetylenic Esters by Phenols 2011
New Palladacycles Derived Acylhydrazones and Hydrazones as Pre-Catalyst in Mirozoki-Heck Coupling and Oxyarylations 2011
Synthesis of Azapterocarpan Analogues by Intramolecular 1,3-Dipolar Cycloaddition 2011
Improved Procedure for the Alfa-Arylation of Chromanones by o-Protected Ortho-Bromophenols 2011
Microwave Promoted Palladium-Catalyzed Oxyarylation of Dihydronaphthalene and Chromenes by o-Iodophenols and its Acetates 2011
Sínteses dos 5-desoxipterocarpenos, pterocarpeno e cumestano 2011
Construção de uma biblioteca de fragmentos moleculares para o desenvolvimento de novos fármacos. 2011
Estudo da Adição Conjugada de Aminas a Enoatos Derivados do D-Manitol 2011
Síntese e Avaliação da atividade Antineoplásica de Chalconas 2011
Novas Pterocarpanoquinonas: Síntese e Avaliação da Citotoxicidade. 2011
Novos paladaciclos derivaddos de acilhidrazonas e fenihidrazonas em Heck-Mizoroki e Oxiarilações 2011
Oxiarilação entre diidronaftalenos e cromenos por o-iodofenois em microondas 2011
Reações de Suzuki-Miyaura na Síntese de Análogos do Lapachol 2011
Seleção Rápida de Fragmentos Moleculares na Busca por Novos Fármacos 2011
Síntese de Cumarinas Catalisadas por Cloreto de Zinco: uma Reação de Hidroarilação de Ésteres Acetilênicos com Fenóis 2011
Síntese de Pterocarpanoquinonas Derivadas da LQB-118: Substâncias com Ação Antitumoral e Potencial Efeito Antiinflamatório 2011
Reação de Heck catalizada por Paládio entre Iodobenzeno e Enoatos E e Z 2010
Síntese de 2H-cromenos via formação de Cumarinas 2010
Síntese de 5-desoxipterocarpanos via reação de oxarilação de 1,2-dihidronaftalenos catalisada por paládio 2010
Síntese de Análogos do Lapachol via Reações de Acoplamento Cruzado Catalisado por Pd(0) 2010
Sínteses de Auronas bioativas 2010
Synthesis of Chalcones with Antineoplasic Activity 2010
New Pterocarpanquinones: Synthesis and Cytotoxicity Evaluation. 2010
Synthesis of New Lapachol Analogues trough Suzuki-Miyaura Cross-Coupling. Antitumoral Evaluation. 2010
Síntese de Análogos do Lapachol Via Reações de Acoplamento Cruzado Catalisado por Pd(0) 2009
Estudo da Reação de Oxa-Heck entre Orto-Iodofenóis e Cromenos: Etapa Chave na Síntese de Pterocarpanoquinonas Bioativas. 2009
Reações de Heck entre diidronaftaleno e orto-iodofenóis. Preparação de 5-desoxipterocarpanos 2009
Cicloadições 1,3-Dipolares Estereosseletivas entre Fumarato de di-Etila e Nitronas Derivados de Aldeídos Aromáticos. 2003
Stereoselective 1,3-Dipolar Cycloadditions Among Symmetrical Olefins and Nitrones Derivative of Aromatic Aldehydes. 2003
Preliminary Study on Catalytic Asymmetric Michael Reaction Promoted By a Lithium-Binol Complex to 1-Boc-1,5-Dithydro-Pyrrol-2-one 2003
Preparation of Chiral Substituted Pyrrolidin-2-ones from Enoates Derived from D-(+)-Mannitol - The First Enantioselective Synthesis of (S)-N-Benzyl-4-Hydroxymethyl Pyrrolidin-2-one, A Nootropic Agent. 2003
Adição Conjugada do Dianion de a-N-benzoylaminoacetonitrile a Enoatos Preparados a partir do D (+)-Manitol Visando a Síntese de Pirrolidinas 2002
A Primeira Síntese do (±) 3,4-Diidroxi-8,9-Metilenodioxipterocarpano 2002
Síntese De Potenciais Inibidores da UDP-Gal Mutase: Iminociclitóis Derivados da Galactose 2002
Adições Conjugadas de Nitronatos a Cinamatos Quirais. Síntese Estereosseletiva de 4-Aril-2-Pirrolidinonas 2002
Síntese Estereosseletiva de 2-Pirrolidinonas via Adição Conjugada de Nitronatos a Enoatos Derivados do D-(+)-Manitol 2002
O efeito CIPE no controle da estereosseletividade da adição conjugada de organometálicos a enoatos derivados do pinenodiol 2002
A reação de Mannich estereosseletiva do enolato de titânio da cânfora. Aplicação na síntese de gama-aminoálcool 2002
Estudos Visando a Preparação Estereosseletiva de Butirolactonas Tetraidrofurânicas via Adição Conjugada a Enoatos Derivados do D-(+)-Manitol 2002
Estudo Teórico e por RMN de Ésteres Pró-Quirais Derivados do Pineno 2002
Síntese e Avaliação Farmacológica de Novas 1,4-Naftoquinonas Estruturalmente Relacionadas ao Lapachol 2002
A Pratical and Efficient Preparation of (-)-(4aS,5R)-4,4a,5,6,7,8-Hexahydro-4a,5-Dimethyl-2(3H)-Naphtalenone: A Key intermediate in the synthesis of (-)-Dehydrofukinone 2001
Aceptores g-oxigenados derivados do D-(+)-manitol como precursores na síntese enantiosseletiva de lignanas dibenzilbutirolactônicas bioativas. 2001
Particularidades reacionais do R-(+)-gliceraldeído frente a espécies nucleofílicas de diferentes pKa 2001
A reação de Mannich a partir da Nopinona e da Cânfora 2001
Primeira síntese da (±)-4´-desidroxicabenegrina A-I via um novo modo de substituição regiosseletiva em esqueletos pterocarpânicos 2001
Síntese e Avaliação Farmacológica de Cumestanos com diferentes padrões de oxigenação nos anéis A e D 2000
Síntese convergente de cromenos e organomercuriais: Intermediários na síntese de pterocarpanos e cumestanos 2000
RMN na Configuração absoluta de Centros Quirais em butirolactonas derivadas do D-(+)-Manitol 2000
Síntese Enantiosseletiva de alfa-Aminoácidos potencialmente ativos em receptores glutâmicos 2000
Uma Comparação entre os Usos deNaBH4-MnCl2 e de Zn(BH4)2-ZnCl2 na Redução estereosseletiva de Benzoilacetatos quirais 2000
Anelação de Robinson Assimétrica como ferramenta para construção de esqueletos eremofilanos 2000
Adiçaõ de Alilsulfona a Enoatos Derivados do Manitol Síntese enantiosseletiva de gama-Butirolactonas beta,gama- Disubstituidas 2000
Estudos Visanto a Síntese (+)-Retronecina 2000
Síntese de Pirrolidinas Via Reação de Dieckmann Regiosseletiva 2000
Síntese de D-Arilglicinas a Partir da N-(R)-gliceraldimina 2000
Rearanjo Carbaniônico Aromático 1,3 O Si _CSi Inédito de Grupo TBS 2000
Preparação de Aril Cetonas via adiçaõ de Aril-Lítio a Derivados de beta aminoésteres 2000
A Oxigenação Vicinal Estereosseletiva do (-)-alfa Pineno 2000
Estudos vuisando a Síntese Enantiossaletiva da (-)-Arctigenina 2000
Carbohydrates Derivatives as Chiral Auxiliares in Diels-Alder Reactions 1998
Designing new Chiral Auxiliaries from Carbohydrates 1998
Regiosselective Lithiation of O-Benzylresorcinols: Synthesis of Monoprotected C-2(OrC-4)- Prenylated Resorcinols 1998
Synthesis of Non- Proteic alfa-Aminoácidos 1998
Syn or Anti Selective Michael Addition ofAllyl and Phenyl Sulphones to Enoates Derived From D-Mannitol 1998
Determination of the configuration at C3 and C1'in adducts Originated from the Michael Addition of Allyl, Prenyl and Benzyl Sulphones to Enoates Derived from D-Mannitol 1998
Syn-Selective Addition of Nitromethane to Chiral Enoates Alkylated at the alfa -Position Derived From D-(+)-Mannitol 1998
Regioselective Lithiation of Maackiain Derivatives: A New Approach to the Total Synthesis of Prenylated Pterocarpans 1998
New Quiral Auxiliaries from Carbohydrates in Diels-Alder Reaction 1998
Synthesis of New Crhomenes and Organomercurials: Toward the Preparation of New Pterocapans With Diferent Paterns of Oxygenation at Rings A and D 1998
The use of Chiral Auxiliaries Prepared From (-)- Beta Pinene in Stereoselective Reduction of Beta-Ketobutyrates 1998
Syn-Selective Michael Addition of Phenyl Sulphones to Enoates Derived From D-Mannitol 1998
New Strategies for the Synthesis of Biologically Active Compounds. 1994
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