Alessandro Bolis Costa Simas
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Pesquisas de Produtos Naturais
Departamento:
Programa de Produtos Naturais/IPPN
Formação:
-
Stanford University
| Pós-Doutorado | 2003 - 2004
-
Columbia University
Química (Estágio Doutoral / Doutorado Sanduíche) | Doutorado | 1992 - 1994
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Universidade Federal do Rio de Janeiro
Química de Produtos Naturais | Doutorado | 1991 - 1995
-
Universidade Federal do Rio de Janeiro
Farmácia | Graduação | 1986 - 1990
Laboratórios:
Nuvens de Palavras:
Artigos:
(86.67% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway | 10.3390/ijms232012078 | 2022 |
| Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators | 10.1080/14756366.2021.1916009 | 2021 |
| Synthesis of lipase/silica biocatalysts through the immobilization of CALB on porous SBA-15 and their application on the resolution of pharmaceutical derivatives and on nutraceutical enrichment of natural oil | 10.1016/j.mcat.2021.111529 | 2021 |
| Acetylcholinesterase: The -Hub- for Neurodegenerative Diseases and Chemical Weapons Convention | 10.3390/biom10030414 | 2020 |
| Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate | 10.1016/j.cbi.2019.05.048 | 2019 |
| In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon | 10.3390/biom9100583 | 2019 |
| Nerve Agents? Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators | 10.2174/1385272823666190806114017 | 2019 |
| Lipase Regioselective O -Acetylations of a myo -Inositol Derivative: Efficient Desymmetrization of 1,3-Di- O -benzyl- myo -inositol | 10.1002/ejoc.201701417 | 2018 |
| Synthesis of reference compounds related to Chemical Weapons Convention for verification and drug development purposes - a Brazilian endeavour | 10.1088/1742-6596/975/1/012020 | 2018 |
| STRAIGHTFORWARD, ECONOMICAL PROCEDURES FOR MICROSCALE ELLMAN?S TEST FOR CHOLINESTERASE INHIBITION AND REACTIVATION | 10.21577/0100-4042.20170278 | 2018 |
| Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon | 10.3390/molecules23112954 | 2018 |
| One-Pot Synthesis of NEMP, a VX Surrogate, and Reactivation of NEMP-Inhibited Electrophorus Eel Acetylcholinesterase by Current Antidotes | 10.21577/0103-5053.20180246 | 2018 |
| Palladium on Layered Double Hydroxide: A Heterogeneous System for the Enol Phosphate Carbon-Oxygen Bond Activation in Aqueous Media | 10.1155/2017/8418939 | 2017 |
| Evaluation of the performance of differently immobilized recombinant lipase B from Candida antarctica preparations for the synthesis of pharmacological derivatives in organic media | 10.1039/c5ra22508f | 2016 |
| Accurel MP 1000 as a support for the immobilization of lipase from Burkholderia cepacia: Application to the kinetic resolution of myo-inositol derivatives | 10.1016/j.procbio.2015.06.023 | 2015 |
| Selectivity Studies Towards the Synthesis of Novel Biaryl Ureas by (Hetero)Nanocatalysis: Size Control and Support Effects | 10.1002/cctc.201500889 | 2015 |
| Preparation of core-shell polymer supports to immobilize lipase B from Candida antarctica | 10.1016/j.molcatb.2013.11.020 | 2014 |
| Efficient desymmetrization of 4,6-di-O-benzyl-myo-inositol by Lipozyme TL-IM | 10.1016/j.carres.2013.11.005 | 2014 |
| Kinetic resolution of a precursor for myo-inositol phosphates under continuous flow conditions | 10.1016/j.molcatb.2012.11.006 | 2013 |
| The use of aqueous potassium dichloroiodate for the synthesis of ureas | 10.1016/j.tetlet.2012.12.045 | 2013 |
| On the kinetic resolution of sterically hindered myo-inositol derivatives in organic media by lipases | 10.1016/j.tetasy.2012.01.005 | 2012 |
| Experimental design of the kinetic resolution of a key precursor of high-value bioactive myo-inositols by an immobilized lipase | 10.1002/jctb.3806 | 2012 |
| Kinetic resolution of 1,3,6-tri-O-benzyl-myo-inositol by Novozym 435: Optimization and enzyme reuse | 10.1021/op300063f | 2012 |
| Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling | 10.2174/156802612804910241 | 2012 |
| Kinetic resolution of (R,S)-1,2-isopropylidene glycerol (solketal) ester derivatives by lipases | 10.1016/j.molcatb.2010.12.008 | 2011 |
| Kinetic resolution of (±)-1,2-O-isopropylidene-3,6-di-O-benzyl-myo-inositol by lipases: An experimental and theoretical study on the reaction of a key precursor of chiral inositols | 10.1016/j.molcatb.2011.02.001 | 2011 |
| Recent Progress in Transition-Metal-Catalyzed C-N Cross-Couplings: Emerging Approaches Towards Sustainability | 10.2174/157017911794407683 | 2011 |
| Hydrophilic cyclodextrin protected Pd nanoclusters: insights into their size control and hostâ¿"guest behavior | 10.1039/c1jm11962a | 2011 |
| Catalytic Applications of Heterogeneous Systems Based on Cyclodextrins | 10.2174/138527210791616939 | 2010 |
| Efficient kinetic resolution of (±)-1,2-O-isopropylidene-3,6-di-O-benzyl-myo-inositol with the lipase B of Candida antarctica | 10.1016/j.tetasy.2010.12.006 | 2010 |
| Direct selective and controlled protection of multiple hydroxyl groups in polyols via iterative regeneration of stannylene acetals | 10.1016/j.tetlet.2009.03.114 | 2009 |
| Acyclic Ketene Aminal Phosphates Derived from N,N-Diprotected Acetamides: Stability and Cross-Couplings | 10.1016/j.tetlet.2009.09.159 | 2009 |
| Hydroxypropyl-?-Cyclodextrin-Capped Palladium Nanoparticles: Active Scaffolds for Efficient Carbon-Carbon Bond Forming Cross-Couplings in Water | 10.1002/adsc.200900348 | 2009 |
| An Expeditious and Consistent Procedure for Tetrahydrofuran (THF) Drying and Deoxygenation by the Still Apparatus | 10.1590/S0100-40422009000900042 | 2009 |
| Palladium-Catalyzed Cross-Couplings of 2-Tributylstannyl-N-Boc-2,3- Dehydropiperidine, a Cyclic Enecarbamate | 10.2174/157017808785982149 | 2008 |
| Enantioselective Palladium-catalyzed Addition of Dicarbonyl Compounds to an Allene Derivative | 10.1002/chem.200500826 | 2005 |
| Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom | 10.1016/j.bmcl.2003.10.044 | 2004 |
| A More Convenient and General Procedure for O-Monobenzylation of Diols via Stannylenes: A Critical Reevaluation of the Bu2SnO method | 10.1021/jo026794c | 2003 |
| 4-Chromenesulfones: synthesis and transformation to isoflavonoid models | 10.1016/S0040-4039(02)01653-2 | 2002 |
| Regioselective lithiations of a pterocarpan skeleton: the first synthesis of 4'-dehydroxycabenegrin A-I | 2001 | |
| Regioselective Lithiation of Resorcinol Derivatives: Synthesis of Mono O-MOM and O-Benzylresorcinols Prenylated at C-2 or C-4 Positions | 1999 | |
| Formal Enantioselective Synthesis of (+)-Vincamine. The First Enantioselective Route to 3, 14 - Epivincamine and its Enantiomer | 1999 | |
| Stereocontrolled Elaboration of Quaternary Carbon Centers Involving Michael-type Alkylation of Chiral Imines: an Efficient Enantioselective Access to (+)-Vincamine | 1997 | |
| Heterocyclic Silyllithium Reagents as Precursors of Masked Hydroxyl Groups. Preliminary Results | 1996 | |
| A Convenient Synthesis of 4-Prenylpterocarpin | 1992 |
Eventos:
(8.33% eventos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Chemoenzymatic desymmetrization of a potential synthetic precursor of bioactive myo-inositol phosphates | 2018 | |
| ChemoenzymaticEnantioselective Synthesis of Advanced Precursors of Bioactive myo-Inositols | 2015 | |
| Lipase-mediated Desymmetrization of 1,3-di-O-Benzyl-myo- Inositol | 10.5151/chempro-15bmos-BMOS2013_2013915195333 | 2013 |
| Selective mono-O-alkylation (protection) of carbohydrates catalyzed by stannylene acetals | 10.5151/chempro-14bmos-R0039-1 | 2013 |
| Chemoenzymatic Enantiospecific Synthesis of a Fluorinated myo-Inositol Analogue | 10.5151/chempro-15bmos-BMOS2013_2013915174810 | 2013 |
| Kinetic Resolution of myo-Inositols by Lipases: Organic Synthesis and Mollecular Modelling | 2009 | |
| Kinetic Resolution of Racemic 2,2-Dimethyl-1,3-dioxolane (Solketal) Ester Derivatives with Different Lipases | 2009 | |
| N-Substituted Dienes via Pd(0)-Catalyzed Cross-Coupling of Aliphatic Enol Phosphates | 2009 | |
| Cyclodextrin-capped Palladium Nanoparticles: Green Scaffolds for C-C-Bond Forming Cross-couplings in Water | 2009 | |
| Proteção Múltipla Direta Seletiva e Controlada de Grupos Hidroxila em Polióis via a Ativação Iterativa por Espécies Estanileno | 2009 | |
| Acoplamentos Cruzados de Enolfosfatos Alifáticos Catalisados por Pd(0) | 2009 | |
| Searching for suitable substrates to lipases in the kinetic resolution of racemic myo-inositols | 2007 | |
| On the optimization of Pd(0)-catalyzed cross-coupling reactions of a 2-stannylated enecarbamate | 2007 | |
| Estudo de acoplamentos cruzados catalisados por Pd(0) visando a síntese de beta-aminoálcoois | 2007 | |
| Aplicação de acoplamentos cruzados catalisados por Pd(0) na síntese de piperidinas funcionalizadas | 2007 | |
| Efeito antiofídico do edunol e seus derivados sintéticos | 2004 | |
| Estudo da síntese de desóxi-inositóis fluoretados, agentes potenciais para novas quimioterapias via interferência na sinalização celular | 2004 | |
| A busca de condições ótimas de monoalquilação de dióis via estanilenos em uma nova síntese de dois mio-inositóis tetrabenzilados | 2002 | |
| Acoplamentos catalisados de organometálicos derivados de enaminas cíclicas: dificuldades e perspectivas | 2002 | |
| Primeira síntese da 4'-desidroxicabenegrina A-I via um novo modo de substituição regiosseletiva em esqueletos pterocarpânicos | 2001 | |
| Novos desenvolvimentos na síntese do antitumoral elipticina | 2001 | |
| Rearranjo Carbaniônico Aromático 1,3-O-Si - C-Si Inédito de Grupo TBS | 2000 | |
| Uma Nova Estratégia para a Síntese do Antitumoral Elipticina | 1999 | |
| Enaminas e Aminas Cíclicas Litiadas como Precursores de Alcalóides | 1999 | |
| Regioselective lithiation of O-benzylresorcinols: Synthesis of monoprotected C-2 (or C-4)-prenylated resorcinols | 1998 | |
| Regioselective lithiation of Maackiain derivatives: A new approach to the total synthesis of prenylated pterocarpans | 1998 | |
| Etapas Finais da Síntese Enantiosseletiva da (+)-Vincamina | 1997 | |
| Estudo da prenilação de derivados resorcinólicos benzilados | 1997 | |
| 5-Methyl-2-furyl-dimethylsilyllithium, a novel precursor of masked hydroxyl group | 1996 | |
| Towards the synthesis of (+)-Vincamine | 1996 | |
| Efforts on the total synthesis of Cabenegrins A-I and A-II | 1996 | |
| Estudos visando a síntese da (+)-Vincamina | 1995 | |
| Preparação de um precursor isoprenílico para a Cabenegrina A-I | 1995 | |
| Studies on Epoxide Cyclisations | 1994 | |
| Studies towards the diastereoselective synthesis of lignans | 1990 | |
| Prenylated resorcinols as synthons in the synthesis of bioactive pterocarpans | 1989 |