Luiz Eduardo Baggio Savio

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Biofísica Carlos Chagas Filho

Departamento:

Programa de Imunobiologia/Biof

ORCID:

https://orcid.org/0000-0002-6712-6885


Formação:
  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2016 - 2016
  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2016 - 2018
  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Doutorado | 2012 - 2016
  • Universidade Federal do Rio Grande do Sul

    Ciências Biológicas (Bioquímica) | Mestrado | 2010 - 2012
  • Pontifícia Universidade Católica do Rio Grande do Sul

    Ciências Biológicas | Graduação | 2006 - 2009
Laboratórios:
Nuvens de Palavras:
Artigos:

(100.00% artigos com DOI)

Titulo DOI Ano
P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-κB signaling favoring mononuclear cell adhesion in schistosomiasis 10.3389/fimmu.2023.1328897 2024
Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis 10.1016/j.bj.2024.100713 2024
ATP-P2X7 signaling mediates brain pathology while contributing to viral control in perinatal Zika virus infection 10.1016/j.bbi.2024.02.035 2024
High mobility group box 1, ATP , lipid mediators, and tissue factor are elevated in COVID -19 patients: HMGB1 as a biomarker of worst prognosis 10.1111/cts.13475 2023
The role of NOD-like receptors in innate immunity 10.3389/fimmu.2023.1122586 2023
SARS-CoV-2 spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID syndrome in mice 10.1016/j.celrep.2023.112189 2023
SARS-CoV-2 Spike protein alters microglial purinergic signaling 10.3389/fimmu.2023.115846 2023
P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice 10.3389/fphar.2023.1179723 2023
Cysteinyl-leukotrienes promote cutaneous Leishmaniasis control 10.3389/fcimb.2023.1192800 2023
Editorial: Inflammasome, purinergic signaling, and immunometabolism in oral health and disease 10.3389/froh.2023.1236507 2023
Effect of Quinolinic Acid on Behavior, Morphology, and Expression of Inflammatory/oxidative Status in Rats? Striatum: Is Coenzyme Q10 a Good Protector? 10.1007/s12640-023-00656-1 2023
Purinergic signaling in the battlefield of viral infections 10.1007/s11302-023-09981-8 2023
Folic acid supplementation during pregnancy alters behavior in male rat offspring: nitrative stress and neuroinflammatory implications 10.1007/s12035-022-02724-7 2022
P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism dependent on Pannexin-1 Hemichannels 10.3389/fimmu.2022.752105 2022
Extracellular Nucleotides on Lymphocyte Function 10.3389/fcell.2022.892303 2022
Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation? 10.1007/s12035-022-02871-x 2022
Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis 10.1016/j.bj.2021.06.003. 2022
P2X receptors in the balance between inflammation and pathogen control in sepsis 10.1007/s11302-022-09870-6 2022
The blockage of downstream P2Y2 receptor signaling inhibits the prostate cancer cell adhesion to endothelial cells 10.1016/j.lfs.2022.120793 2022
High-protein nutrition during pregnancy increases neuroinflammation and homocysteine levels and impairs behavior in male adolescent rats offspring 10.1016/j.lfs.2022.121084 2022
Targeting Purinergic Signaling in the Dynamics of Disease Progression in Sepsis 10.3389/fphar.2020.626484 2021
Ectonucleotidase Modulation of Lymphocyte Function in Gut and Liver 10.3389/fcell.2020.621760 2021
Hyperhomocysteinemia alters cytokine gene expression, cytochrome c oxidase activity and oxidative stress in striatum and cerebellum of rodents 10.1016/j.lfs.2021.119386 2021
Innate immune memory mediates increased susceptibility to Alzheimer?s disease-like pathology in sepsis surviving mice 10.1016/j.bbi.2021.04.001 2021
Purinergic signalling in host innate immune defence against intracellular pathogens 10.1016/j.bcp.2021.114405 2021
Purinergic signaling in the modulation of redox biology   10.1016/j.redox.2021.102137 2021
P2X7 receptor activation increases expression of caveolin-1 and formation of macrophage lipid rafts, thereby boosting CD39 activity 10.1242/jcs.237560 2020
Purinergic signaling in infectious diseases of the central nervous system 10.1016/j.bbi.2020.07.026 2020
P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion 10.1155/2020/2545682 2020
P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis 10.1007/s11302-020-09746-7 2020
Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 × 7 receptor 10.1002/eji.201847657 2019
Immunomodulatory effects of P2X7 receptor in intracellular parasite infections 10.1016/j.coph.2019.02.005 2019
Disruption of Purinergic Receptor P2X7 Signaling Increases Susceptibility to Cerebral Toxoplasmosis 10.1016/j.ajpath.2019.01.001 2019
The P2X7 receptor in inflammatory diseases: Angel or demon? 10.3389/fphar.2018.00052 2018
Intralesional uridine-5--triphosphate (UTP) treatment induced resistance to Leishmania amazonensis infection by boosting Th1 immune responses and reactive oxygen species production 10.1007/s11302-018-9606-7 2018
P2-×-7-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation 10.1016/j.imbio.2018.10.008 2018
P2X7 receptor promotes intestinal inflammation in chemically induced colitis and triggers death of mucosal regulatory T cells 10.1016/j.bbadis.2017.03.004 2017
CD39 Limits P2X7 Receptor Inflammatory Signaling and Attenuates Sepsis-Induced Liver Injury 10.1016/j.jhep.2017.05.021 2017
Potential role of P2X7R in esophageal squamous cell carcinoma proliferation 10.1007/s11302-017-9559-2 2017
Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor-Host Interaction and Therapeutic Perspectives 10.3389/fimmu.2017.01526 2017
Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death 10.18632/oncotarget.18595 2017
P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction 10.1007/s12035-016-0168-9 2017
Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis 10.1016/j.imbio.2016.12.007 2017
The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control 10.1007/s11302-016-9544-1 2017
Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors 10.1016/j.vph.2016.02.005 2016
Purinergic signaling in infection and autoimmune disease 10.1016/j.bj.2016.09.002 2016
Methionine Exposure Alters Glutamate Uptake and Adenine Nucleotide Hydrolysis in the Zebrafish Brain 10.1007/s12035-014-8983-3 2016
The role of P2X7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases 10.4103/2319-4170.127803 2014
Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF- β 1 10.1155/2014/134974 2014
Mild Hyperhomocysteinemia Increases Brain Acetylcholinesterase and Proinflammatory Cytokine Levels in Different Tissues 10.1007/s12035-014-8660-6 2014
The effect of exercise on the oxidative stress induced by experimental lung injury. 10.1016/j.lfs.2012.12.005 2013
Mild hyperhomocysteinemia reduces the activity and immunocontent, but does not alter the gene expression, of catalytic α subunits of cerebral Na+,K+-ATPase 10.1007/s11010-013-1598-6 2013
Proline-induced changes in acetylcholinesterase activity and gene expression in zebrafish brain: reversal by antipsychotic drugs 10.1016/j.neuroscience.2013.07.004 2013
Secondary metabolism in micropropagated Hypericum perforatum L. grown in non-aerated liquid medium 10.1007/s11240-011-0058-9 2012
Endotoxin-induced effects on nucleotide catabolism in mouse kidney 10.1016/j.ejphar.2011.11.002 2012
MK-801 alters Na+, K+-ATPase activity and oxidative status in zebrafish brain: reversal by antipsychotic drugs 10.1007/s00702-011-0745-z 2012
Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish 10.1016/j.pnpbp.2011.10.002 2012
Chronic mild hyperhomocysteinemia alters ectonucleotidase activities and gene expression of ecto-5¿-nucleotidase/CD73 in rat lymphocytes 10.1007/s11010-011-1141-6 2012
Long-term methionine exposure induces memory impairment on inhibitory avoidance task and alters acetylcholinesterase activity and expression in zebrafish (Danio rerio) 10.1007/s11064-012-0749-6 2012
Long-term proline exposure alters nucleotide catabolism and ectonucleotidase gene expression in zebrafish brain 10.1007/s11011-012-9321-y 2012
Mild Hyperhomocysteinemia Alters Extracellular Adenine Metabolism in Rat Brain 10.1016/j.neuroscience.2012.07.035 2012
Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes 10.1016/j.ejphar.2010.11.003 2011
Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age 10.1016/j.neuroscience.2011.01.065 2011
Endotoxemia alters nucleotide hydrolysis in platelets of rats 10.1080/09537100802657743 2009
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Cysteinyl leukotrienes participates in P2 receptor-mediated control of L. amazonensis infection in mice 2022
Homocysteine alters ectonucleotidase CD39 expression in BV-2 microglial cells 2022
Homocysteine increases P2X7 receptor expression and cytokine production in endothelial cells 2022
Implication of Purinergic P2X7 Receptor in M. leprae - Schwann Cell Infection: New Perspectives in Leprosy Neuropathy Study 2022
Implications of P2X7 receptor on neuroinflammatory and behavioral alterations in sepsis-surviving mice 2022
P2X7 receptor contributes to hyperhomocysteinemia-induced neuroinflammation 2022
P2X7 receptor induces neuroinflammation and impairs brain development in Zika virus-infected mouse pups by inhibiting Akt/mTOR/p70S6K signaling pathway 2022
SARS-CoV-2 spike protein alters purinergic signaling parameters in microglial cells 2022
SARS-CoV-2 spike protein increases the ectonucleotidases activity in BV-2 microglial cells 2022
Study of the role of purinergic signaling in the development and/or recovery of liver damage and systemic impairment in chronic liver diseases 2022
The participation of oral bacteria in the aggravation of colitis: The role of purinergic signaling 2022
Implications of P2X7 receptor activation in sepsis-associated long-term cognitive impairment 2021
The role of purinergic signaling in Zika pathophysiology 2021
CD39 Limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury 2018
P2X7 RECEPTOR CONTRIBUTES TO LONG-TERM BRAIN ALTERATIONS IN SEPSISSURVIVING MICE 2018
THE P2X7 RECEPTOR CONTRIBUTES TO SEPSIS-INDUCED OXIDATIVE DAMAGE IN MICE LIVER. 2018
Role of adenosine in lung fibrosis caused by silica particles 2018
THE ROLE OF THE P2X7 RECEPTOR IN ZIKA VIRUS INFECTION 2018
ZIKA VIRUS INFECTION INCREASES CD39 EXPRESSION IN MICE BRAIN 2018
Simultaneous P2X7 receptor blockade and adenosine A2A receptor activation reduces liver damage and improves survival in sepsis 2017
Role of the P2X7 receptor in the acute kidney injury induced by sepsis 2017
ATP-gated P2X7 receptor contributes to sepsis-associated brain dysfunction 2016
THE P2X7 RECEPTOR MEDIATES CHRONIC TOXOPLASMOSIS RESISTENCE BY ROS PRODUCTION AND IL-1 AND IL-12 IN THE BRAIN 2016
P2X7 receptor deletion attenuates the sepsis-induced brain dysfunction 2015
Pyrimidinergic receptor agonists reduces in vivo L. amazonensis infection 2015
CD39/ENTPD1 expression on macrophages limits ATP-P2X7 receptor pro- inflammatory signaling responses in sepsis 2015
P2X7 RECEPTOR REGULATES INTESTINAL INFLAMMATORY RESPONSE IN MURINE CHEMICALLY INDUCED COLITIS 2015
CD39 expression on macrophage caveolae domains limits ATP-P2X7 receptor pro-inflammatory signaling responses in sepsis. 2015
Purinergic signaling involving P2Y1 receptors and NTPDase 2 and 3 in mesenteric endothelial cells during schistosomiasis-related vascular inflammation 2014
The involvement of methionine exposure in some parameters of purinergic system in zebrafish (Danio rerio) brain 2014
Purinergic receptor functionality controls murine infection by L. amazonensis 2013
P2X7 receptor orchestrates purinergic signaling in sepsis 2013
Endothelial cell P2Y1 receptor purinergic signalling during chronic inflammation 2013
P2X7 receptor modulates inflammatory response in sepsis 2013
Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish 2012
Hyperprolinemia alters nucleotide catabolism and ectonucleotidase gene expression in zebrafish brain 2012
Methionine exposure alters nucleotide hydrolysis and ectonucleotidase and P1 receptors gene expression in zebrafish (Danio rerio) brain 2012
Pro-inflammatory (deleterious) effect of the P2X7 in sepsis 2012
Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age 2011
Long-term proline exposure induces behavioral changes in zebrafish 2011
Chronic mild hyperhomocysteinemia alters ectonucleotidase activities and gene expression in rat lymphocytes: is there association with cerebro-cardiovascular diseases? 2011
Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes 2010
NTPDases role in the pathophysiology of cognitive impairment induced by seizure in early age 2010
Endotoxemia altera as atividades ectonucleotidásicas em membranas renais de camundongos 2010
Hiperprolinemia inibe a atividade da acetilcolinesterase em cérebro de zebrafish 2010
Efeitos do exercício físico sobre parâmetros de estresse oxidativo em ratos submetidos a lesão pulmonar aguda 2010
Prolina altera a atividade e a expressão gênica da acetilcolinesterase em cérebro de zebrafish 2010
Efeito do agonista do receptor A2A de adenosina (CGS-21680) sobre as ectonucleotidases de linfócitos de camundongos endotoxêmicos 2009
Efeito do agonista de receptor A2A sobre as atividades nucleotidásicas em membranas renais de camundongos endotoxêmicos 2009
Análise de compostos bioativos em plantas de Hypericum perforatum micropropagadas em meio de cultivo líquido 2008
Efeito do lipopolissacarídeo (LPS) sobre a hodrólise de nucleotídeos em plaquetas de ratos 2008
Otimização da micropropagação de Hipericum perforatum utilizando meio de cultivo líquido 2007
Publicações:
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