Mauro Sérgio Gonçalves Pavão

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Bioquímica Médica

Departamento:

Programa de Glicobiologia

ORCID:

não disponível no Lattes


Formação:

  • Washington University School Of Medicine

    | Pós-Doutorado | 1996 - 1998

  • Universidade Federal do Rio de Janeiro

    Biologia | Graduação | 1991 - 1997

  • Universidade Federal de São Paulo

    Ciências Biológicas (Biologia Molecular) | Doutorado | 1990 - 1993

  • Universidade Federal de São Paulo

    Ciências Biológicas (Biologia Molecular) | Mestrado | 1988 - 1990
Laboratórios:
Nuvens de Palavras:
Artigos:

(45.00% artigos com DOI)

Titulo DOI Ano
Continuous design and economic analysis of a Sargassum muticum biorefinery process 10.1016/j.biortech.2021.126152 2022
Effects of Dermatan Sulfate from Marine Invertebrate Styela plicata in the Wound Healing Pathway: A Natural Resource Applied to Regenerative Therapy 10.3390/md20110676 2022
Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice 10.3390/molecules27041194 2022
Prognostic significance of hedgehog signaling network-related gene expression in breast cancer patients 10.1002/jcb.29886 2021
Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro 10.1038/s41598-021-95190-5 2021
Vatairea guianensis lectin stimulates changes in gene expression and release of TNF -α from rat peritoneal macrophages via glycoconjugate binding 10.1002/jmr.2922 2021
Non-Anticoagulant Heparan Sulfate from the Ascidian Phallusia nigra Prevents Colon Carcinoma Metastasis in Mice by Disrupting Platelet-Tumor Cell Interaction 10.3390/cancers12061353 2020
HS2ST1-dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior 10.1111/cas.14539 2020
The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties 10.3389/fcell.2020.559554 2020
Metal ions and the extracellular matrix in tumor migration 10.1111/febs.14986 2019
Tunicate Heparan Sulfate Enriched in 2-Sulfated β-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin 10.3390/md17060351 2019
A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum 10.1590/0074-02760190088 2019
Marine Biotechnology in Brazil: Recent Developments and Its Potential for Innovation 10.3389/fmars.2018.00236 2018
Sulfated fucans and a sulfated galactan from sea urchins as potent inhibitors of selectin-dependent hematogenous metastasis 10.1093/glycob/cwy020 2018
Chondroitin sulfate isolated from the secretion of the venom-producing parotoid gland of Brazilian bufonid 10.1016/j.ijbiomac.2018.11.240 2018
Structural analysis of a sulfated galactan from the tunic of the ascidian Microcosmus exasperatus and its inhibitory effect of the intrinsic coagulation pathway 10.1016/j.ijbiomac.2017.08.166 2017
Biological function of unique sulfated glycosaminoglycans in primitive chordates 10.1007/s10719-016-9728-5 2016
Elemental biochemical analysis of the polysaccharides in the extracellular matrix of the yeast 10.1002/jobm.201400781 2015
Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration 10.1155/2015/453801 2015
Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules. 2015
Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14 10.1002/jcb.25127 2015
Fucosylated Chondroitin Sulfate inhibits Plasmodium falciparum cytoadhesion and merozoite invasion 10.1128/aac.00686-13 2014
Heparanase expression and localization in different types of human lung cancer 10.1016/j.bbagen.2014.04.010 2014
Extracellular Galectin-3 in Tumor Progression and Metastasis 10.3389/fonc.2014.00138 2014
modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression 10.1002/ijc.28921 2014
Glycosaminoglycans analogs from marine invertebrates: structure, biological effects, and potential as new therapeutics 10.3389/fcimb.2014.00123 2014
Methodologies to generate, extract, purify and fractionate yeast ECM for analytical use in proteomics and glycomics 10.1186/s12866-014-0244-0 2014
Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: effect on P-selectin, heparanase, metastasis and cellular recruitment 10.1093/glycob/cwu119 2014
Syndecan-1 modulates β-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation 10.1111/febs.12111 2013
Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression 10.1155/2013/852093 2013
Thyroid hormone treated astrocytes induce maturation of cerebral cortical neurons through modulation of proteoglycan levels 10.3389/fncel.2013.00125 2013
Cellular Microenvironment in Human Pathologies 10.1155/2013/946958 2013
Ascidian (chordate-tunicate) and mammalian heparin enemas attenuate experimental diversion colitis 10.1016/j.surg.2013.06.057 2013
Glycosaminoglycans: key players in cancer cell biology and treatment 10.1111/j.1742-4658.2012.08529.x 2012
Challenges for heparin production: artificial synthesis or alternative natural sources? 2012
Effect of sulfated glycosaminoglycans on tumor invasion and metastasis 2011
Dermatan sulfate reduces Monocyte Chemoattractant Protein 1 and TGF- production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction 2011
Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [->4IdoA(2-Sulfate)beta-1->3GalNAc(4-Sulfate)beta-1->] motifs in dermatan sulfate on heparin cofactor II activity. 2011
Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin 10.1111/j.1538-7836.2011.04401.x 2011
Unique extracellular matrix heparan sulfate from the bivalve Nodipecten nodosus (Linnaeus, 1758) safely inhibits arterial thrombosis after photochemically induced endothelial lesion 2010
Fucosylated chondroitin sulfate attenuates renal fibrosis in animals submitted to unilateral ureteral obstruction. A P-selectin mediated event? 2010
Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats (publicado on line). 2009
Nitric oxide production by hemocytes of the ascidian Styela plicata 10.1007/s00441-009-0851-5 2009
Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density. 2008
The hemolymph of the ascidian styela plicata (chordata-tunicata) contains heparin inside basophil-like cells and an unique sulfated galactoglucan in the plasma. 10.1074/jbc.m604056200 2007
Isolation and characterization of a heparin with low antithrombin activity from the body of Styela plicata (Chordata-Tunicata). Distinct effects in venous and arterial models of thrombosis (Thrombosis Research, on line, doi:10.1016/j.thromres.2007.03.025 ). 2007
Chondroitin sulfate and keratan sulfate are the major glycosaminoglycans present in the adult zebrafish Danio rerio (Chordata-Cyprinidae) DOI 10.1007/s10719-007-9046-z) 2007
SELECTIN-BLOCKING ACTIVITY OF A FUCOSYLATED CHONDROITIN SULFATE GLYCOSAMINOGLYCAN FROM SEA-CUCUMBER: EFFECT ON TUMOR METASTASIS AND NEUTROPHIL RECRUITMENT 2007
Effects of low molecular weight heparin in obstructed kidneys: decrease of collagen, fibronectin and TGF-beta and increase in chondroitin/dermatan sulfate proteoglycan and macrophage migration. 2006
Co-localization of decorin-like dermatan sulfate proteoglycan and collagen in tissues of the primitive chordate Styela plicata. 2006
Antithrombotic properties of a heparin with low antithrombin activity from the test cells of Styela plicata evaluated by in vivo experimental models of thrombosis and bleeding. 2006
Selection and characterization of a unique phage display-derived antibody against dermatan. 2006
Biochemical and immunohistochemical analysis of glycosaminoglycans of inflamed and non-inflamed intestinal mucosa of patients with Crhon's disease. 2005
Selective cleavage and anticoagulant activity of a sulfated fucan. Stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolisis, preparation of oligosaccharides and heparin cofactor II-dependente anticoagulant activity. 2005
A functional dermatan sulfate epitope containing iduronate(2-O-sulfate)alpha1-3GalNAc(6-O-sulfate) disaccharide in the mouse brain: demonstration using a novel monoclonal antibody raised against dermatan sulfate of ascidian ascidia nigra. 2005
Biosynthesis and metabolism of sulfated glycosaminoglycans during Drosophila melanogaster development. 2004
Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice 2004
Molecular recognition and modulation of hepatocyte growth factor activity by heparan and dermatan sulfates 2004
Fine structure, immunocytochemistry and biochemical analysis of hemocytes from a primitive chordate: a possible ancestor of the mammalian mast cell 2004
Hepatocyte growth factor/scatter factor and its interaction with heparan sulphate and dermatan sulphate 2003
Oversulfated dermatan sulfate exhibits neurite outgrowth-promoting activity towards embryonic mouse hippocampal neuronns: implications of dermatan sulfate in neuritogenesis in the brain. 2003
Structural and anticoagulant properties of sulfated glycosaminoglycans from primitive chordates 2002
Co-localization of heparin and histamine in the intracellular granules of test cells from the invertebrate Styela plicata (Chordata) 2002
Medicinal plants contain polysaccharides with anticoagulant activity mediated by heparin cofactor II 2002
Unbalanced effects of dermatan sulfates with different sulfation patterns on coagulation, thrombosis and bleeding 2001
Structural analysis of anticoagulant glycosaminoglycans in the tissues of the primitive chordate Styela plicata (Chordata-Tunicata) 2000
Occurrence of heparin in the invertebrate Styela plicata is restricted to cell layers facing outside environment:a possible role in defence ? 2000
Isolation and preliminary characterization of sulfated glycosaminoglycans from ascidian test cells 1999
Highly sulfated dermatan sulfate from ascidians. Structure versus anticoagulant activity of these glycosaminoglycans 1998
Spectroscopic analysis of the products formed by chondroitinase ABC lyase digestion of an ascidian dermatan sulfate demostrate the occurrence of unusual 6-O-sulfo-2-acetamino-2-deoxy-3-O-(2-Osulfo-a-L-idopyranosyluronic acid)-b-D-galactose units 1997
Structure and anticoagulant activity of s fucosylated chondroitin sulfate from echinoderm: sulfated fucose branches on the polysaccharide account for its high anticoagulant action 1996
Unique sulfated polysaccharides from ascidians (Chordata-Tunicata) 1996
A unique dermatan sulfate-like glycosaminoglycan from ascidian. Its structure and the effect of its unusual sulfation pattern on anticoagulant activity 1995
Comparison between the sulfated polysaccharides from larval and adult ascidians 1994
Acidic polysaccharides of the ascidian Styela plicata. Biosynthetic studies on the L-galactans of the tunic, and preliminary characterization of a dermatan sulfate-like polymer in body tissues 1994
Sulfated polysaccharides in the tunic of the ascidian Styela plicata are synthesized by the epithelial cells 1993
Structural studies of a sulfated L-galactan from Styela plicata (Tunicate): analysis of the Smith degraded polysaccharide 1990
Structure of a unique sulfated a-L-galactofucan from the tunicate Clavelina 1990
L-galactose in sulfated polysaccharides from tunicates. Carbohydrate Research 1989
Structural heterogeneity among unique sulfated L-galactans from different species of ascidians (Tunicates) 1989
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Dual effects of unique dermatan sulfates from ascidians on tumor invasion: inhibition of epythelial to mesenchymal transition and hematogeneous metastasis 2011
Decorin-like proteoglycan co-localizes with collagen fibers in the extracellular matrix of the primitive invertebrate Styela plicata (CHORDATA-TUNICATA) 2005
Purification and characterization of a chondroitin sulfate glycosaminoglycan from the zebrafish Brachydanio rerio. 2005
Heparin cofactor II-independent antithrombotic activity of ascidian dermatan sulfates in an arterial thrombosis model in rats involves inhibition of thrombin-induced platelet activation. 2005
Isolation and anticoagulant activity of low molecular weight fractions obtained from the dermatan sulfate of the ascidian Styela plicata 2005
Glicobiologia do Câncer: a heparina como um agente anti-metastático 2005
Antinflammatory effect of Heparin and Dermantan sulfate obtained from the ascidian Styela plicata in an experimental model of inflammatory bowel disease in rats. 2005
Inhibition of the binding of P- and L-selectins to sialyl-Lewis and LS180 colon carcinoma cells by invertebrate glycosaminoglycans. 2005
Isolation, characterization and anticoagulant properties of a heparin-like glycosaminoglycan from the body of the ascidian Styela plicata(Chordata-Tunicata). 2005
Occurrence of heparin in immunologic cells in the primitive chordate Styela plicata 2003
Ascifian Glycosaminoglycans and their antithrombotic effect in different experimental models of thrombosis 2003
Preliminary biochemical analysis of the sulfated glycosaminoglycans from the zebrafish Danio rerio 2003
Evidence of decorin and collagen in the extracellular matrix of the primitive chordate Styela plicata (Chordata-Tunicata) 2003
Processing of sulfated glycosaminoglycans during the development of Drosophila melanogaster 2003
Glycosaminoglycans during the development of Drosophila melanogaster: evidence for the transfer of chondroitin sulfate and heparan sulfate from adult to larval tissues 2003
Glycosaminoglycans are involved in the early steps of vesicular stomatitis virus infection 2002
Expression of radiolabeled glycosaminoglycans in Drosophila melanogaster after metabolic incorporation with 35S-Sulfate 2002
Biochemical Characterization of glycosaminoglycans in intestinal inflamation 2002
Heparin proteoglycan in the ascidian Styela plicata 2002
In vivo properties of ascidian heparin 2001
Occurrence of heparinoids with anticoagulant activity in ascidian hemolymph 2001
Unbalanced effects of dermatan sulfates with different sulfation pattern on coagulation thrombosis and bleeding 2001
Characterization of the sulfated polysaccharides from Pectem maximums (Molusk - Bivalvea) and determination of their anticoagulant activity 2001
Occurrence of histamine and heparin in the tissues of the marine invertebrate Styela plicata (Tunicata) 2001
Unbalanced effect of dermatan sulfates with different sulfation pattern on coagulation, thrombosis and bleeding 2001
Biochemical and histochemical analysis of sulfated glycosaminoglycans in the tissues of the ascidian Styela plicata (Chordata - Tunicata) 2000
Antithrombotic activity of ascidian dermatan sulfates and their binding to heparin cofactor II 2000
NMR analysis and anticoagulant properties of a heparin-like polymer from ascidian test cells. 2000
Occurrence of heparin in the invertebrate Styela plicata is restricted to cell layers facing the outside environment: na ancient role in defence?, 2000
In vivo anticoagulant and antithrombotic activities of ascidian dermatan sulfate polymers and their effect on platelet aggregation 1999
Organ specific distribution of sulfated glycosaminoglycans in the ascidian Styela plicata (Chordata-Tunicata) 1999
Thrombin inhibition by the ascidian hemolymph in the presence of Heparin 1999
Isolation and characterization of a heparin-like polymer from ascidian test cells 1999
Sulfated polysaccharides are synthesized in ascidian's test cells 1998
Structural studies of heparin cofactor II - dermatan sulfate binding 1998
Isolation,fractionation and preliminary characterization of the sulfated polysaccharides from the test cells of the ascidian Styela plicata 1997
Sulfated fucose branches on a fucosylated chondroitin sulfate from echinoderm account for its anticoagulant action 1996
A dermatan sulfate-like glycosaminoglycan with anticoagulant activity from Styela plicata (Chordata-Tunicata) 1996
A unique dermatam sulfate-like glycosaminoglycan from ascidian: its structure and the effect of its unusual sulfation pattern on anticoagulant activity. 1996
Occurrence of a dermatan sulfate-like polymer in the viscera of ascidians composed by (idoA2S-GalNAc6S) disaccharide units 1995
Ascidic polysaccharides from marine organisms 1991
Publicações:
Minha Rede: