Pedro Paulo Xavier Elsas

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Microbiologia

Departamento:

Departamento de Imunologia/IM

ORCID:

não disponível no Lattes


Formação:

  • Brigham and Women?s Hospital, Harvard Med.School

    | Pós-Doutorado | 2005 - 2006

  • Institut Pasteur

    | Pós-Doutorado | 1999 - 1999

  • Roche Research Gent

    | Pós-Doutorado | 1994 - 1994

  • Institut Pasteur

    | Pós-Doutorado | 1991 - 1991

  • Universidade Federal do Rio de Janeiro

    Ciências (Microbiologia) | Doutorado | 1990 - 1990

  • Harvard University

    | Pós-Doutorado | 1981 - 1984

  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Mestrado | 1980 - 1981

  • Universidade Federal do Rio de Janeiro

    Medicina | Graduação | 1974 - 1979
Laboratórios:
Nuvens de Palavras:
Artigos:

(85.45% artigos com DOI)

Titulo DOI Ano
5-lipoxygenase- and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice 10.1016/j.intimp.2021.107440 2021
Allergen challenge-induced changes in bone-marrow responses to leukotriene D 4 , nonsteroidal anti-inflammatory drugs and cytokines 10.1080/08923973.2020.1733598 2020
Potent stimulation of eosinopoiesis in murine bone-marrow by myriadenolide is mediated by cysteinyl-leukotriene signaling 10.1016/j.intimp.2019.04.002 2019
The need to consider context in the evaluation of anti-infectious and immunomodulatory effects of Vitamin A and its derivatives 10.2174/1389450120666181217095323 2018
Novel lineage- and stage-selective effects of retinoic acid on mouse granulopoiesis: Blockade by dexamethasone or inducible NO synthase inactivation 10.1016/j.intimp.2017.02.001 2017
Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy 10.5493/wjem.v7.i3.58 2017
Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis 10.5493/wjem.v7.i1.11 2017
The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors 10.1155/2015/495430 2015
α-Galactosyl Ceramide suppresses murine eosinophil production through IFN-γ-dependent induction of NO synthase and CD95 10.1111/bph.13126 2015
How reliable is online diffusion of medical information targeting patients and families? 10.5493/wjem.v5.i4.244 2015
Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation 10.1155/2015/968932 2015
5-Lipoxygenase-Dependent Recruitment of Neutrophils and Macrophages by Eotaxin-Stimulated Murine Eosinophils 10.1155/2014/102160 2014
Roles of 5-Lipoxygenase and Cysteinyl-Leukotriene Type 1 Receptors in the Hematological Response to Allergen Challenge and Its Prevention by Diethylcarbamazine in a Murine Model of Asthma 10.1155/2014/403970 2014
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure 10.1155/2013/474132 2013
Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents 10.1155/2013/208705 2013
Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective 10.1590/1516-3180.2013.1315519 2013
Essential roles of endogenous glucocorticoids and TNF/TNFR1 in promoting bone-marrow eosinopoiesis in ovalbumin-sensitized, airway-challenged mice 10.1016/j.lfs.2013.11.006 2013
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients 10.1016/j.humimm.2012.03.007 2012
G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production 10.1016/j.lfs.2011.03.001 2011
Inducible Nitric Oxide Synthase/CD95L-dependent Suppression of Pulmonary and Bone Marrow Eosinophilia by Diethylcarbamazine 10.1164/rccm.200905-0800OC 2010
Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow 10.1189/jlb.1108709 2010
Evidence for a regulatory role of ?4 - integrins in the maturation of eosinophils generated from the bone marrow in the presence of dexamethasone 10.1111/j.1365-2222.2009.03289.x 2009
Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection 10.1096/fj.08-124248 2009
Relationship of neutrophil phagocytosis and oxidative burst with the subgingival microbiota of generalized aggressive periodontitis 10.1111/j.1399-302X.2008.00484.x 2009
Leukotriene B4 is essential for selective eosinophil recruitment following allergen challenge of CD4+ cells in a model of chronic eosinophilic inflammation 10.1016/j.lfs.2008.06.004 2008
Cysteinyl leukotrienes mediate the enhancing effects of indomethacin and aspirin on eosinophil production in murine bone marrow cultures 10.1038/sj.bjp.0707586 2008
Ectopic lung transplantation induces the accumulation of eosinophil progenitors in the recipients' lungs through an allergen- and IL-5-dependent mechanism 10.1111/j.1365-2222.2006.02623.x 2007
Eosinophilopoiesis at the Cross-Roads of Research on Development, Immunity and Drug Discovery 10.2174/092986707781368487 2007
Anti-Inflamatory Drug Effects on Apoptosis of Eosinophil Granulocytes Derived from Murine Bone-Marrow: Cellular Mechanisms as Related to Lineage, developmental Stage and Hemopoietic Environment 10.2174/187152306775537274 2006
New tricks and old drugs: novel perspectives on the molecular and cellular mechanisms of action of drugs affecting leukocyte function and survival 10.2174/187152306775537265 2006
Impact of diet on the immunological microenvironment of the pregnant uterus and its relationship to allergic disease in the offspring: a review of the recent literature 10.1590/S1516-31802006000500013 2006
Increased spontaneous and endotoxin-induced TNF-a production in Whole blood Cultures of Children with Primary Malnutrition 10.1590/S0100-879X2005000200005 2005
Cells isolated from bone-marrow and lungs of allergic BALB/C mice and cultured in the presence of IL-5 are respectively resistant and susceptible to apoptosis induced by dexamethasone. 10.1016/j.intimp.2005.01.001 2005
Prostaglandin E2 and Dexamethasone regulate eosinophil differentiation and survival through nitric oxide- CD95-Dependent pathway. 10.1016/j.niox.2004.08.001 2004
Induction of Bone-marrow eosinophilia in mice submitted to surgery is dependent on stress-induced secretion of glucocorticoids 10.1038/sj.bjp.0705943 2004
Isolation and characterization of hemopoietic cells from lungs of allergic mice 10.1378/chest.123.3_suppl.345s-a 2003
Quantification and localization of Platelet-derived growth factor in gingiva of periodontitis patients 10.1902/jop.2003.74.3.323 2003
Preface [Hot topic: Hemopoiesis and Allergy (Guest Editor: P. Xavier Elsas)] 10.2174/1568010033484061 2003
The Effects of Allergen and Anti-Allergic Drugs on Murine Hemopoietic Cells: Moving Targets, Unusual Mechanisms, and Changing Paradigms 10.2174/1568010033484089 2003
Allergenic sensitization prevents upregulation of haemopoiesis by cyclooxygenase inhibitors in mice 10.1038/sj.bjp.0704580 2002
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice. 10.1038/sj.bjp.0703145 2000
Murine myeloid progenitor responses to GM-CSF and eosinophil precursor responses to IL-5 represent distinct targets for downmodulation by prostaglandin E2. 10.1038/sj.bjp.0703403 2000
Do glucocorticoids enhance eosinopoiesis? 10.1016/s0165-6147(00)01568-6 2000
Estudo de crianças com síndrome do desconforto respiratório agudo: correlação anatomoclínica radiológica 10.1590/S0037-86821999000500014 1999
Stimulation of early eosinophil progenitors by a heat stable alveolar macrophage product from ovalbumin-sensitized and non-sensitized guinea pigs 10.1111/j.1365-2222.1997.tb00695.x 1997
Rapid Increase In Bone-Marrow Eosinophil Production And Responses To Eosinopoietic Interleukins Triggerd By Intranasal Allergen Challenge 1997
Eosinophil cytotoxicity enhancing factor: purification, characterization and immunocytochemical localization on the monocyte surface 10.1002/eji.1830200530 1990
Selection Of U937 Histiocytic Lymphoma Cells Highly Responsive To PMA-Induced Differentiation Utilizing Monoclonal Antibodies To The EosinoPhil Cytotoxicity Enhancing Factor 1990
Monocytes Activate Eosinophils For Enhanced Helminthotoxicity And Increased Generation Of Leukotriene C4 1987
Recombinant Tumour Necrosis Factor (Rtnf-Alpha) Enhances Leukotriene Biosynthesis In Neutrophils And Eosinophils Stimulated With The Ca2+ Ionophore A23187 1987
Characterization Of A Factor From The U937 Cell Line That Enhances The Toxicity Of Human Eosinophils To Schistosoma Mansoni Larvae 1987
IgE antibody and resistance to infection II. Effect of IgE suppression on the early and late skin reaction and resistance of rats toSchistosoma mansoni infection 10.1002/eji.1830160602 1986
Ultrastructure Of The Attack Of Eosinophils Stimulated By Blood Monoculear Cell Products On Schistosomuia Of Schistosoma Mansoni. 1985
Enhancement By Monokine (S) Of Leukotriene Production By Human Eosinophils And Neutrophils Stimulated With The Ca2+ Ionophore A23187 1985
Controle Genetico do Reconhecimento Imunologico 1979
Eventos:

(6.45% eventos com DOI)

Titulo DOI Ano
Suppression of murine granulopoiesis by oral Allergen pretreatment of sensitized/challenged Mice 2012
Role of endogenous glucocorticoids in the regulation of eosinopoiesis in a murine model for allergic asthma 2012
IL-17A suppresses eosinophilopoiesis in murine bone-marrow through a novel iNOS- and CD95-dependent mechanism modulated by IFN- and IL-4 2012
IL-17 INTERACTIONS WITH IL-5, GM-CSF, IL-4, CYSTEINYL-LEUKOTRIENES AND DEXAMETHASONE IN REGULATION OF EOSINOPOIESIS 2012
5-lipoxygenase-dependent recruitment and activation of neutrophil and mononuclear phagocytes by murine eosinophils 2012
ENDOGENOUS GLUCOCORTICOIDS IN THE REGULATION OF EOSINOPOIESIS IN A MURINE MODEL FOR ALLERGIC ASTHMA 2011
ROLE OF ENDOGENOUS GLUCOCORTICOIDS IN THE REGULATION OF EOSINOPOIESIS IN A MURINE MODEL FOR ALLERGIC ASTHMA 2011
PS1-075. Alpha-galactosyl ceramide, An activator of invariant natural killer T cells, suppresses eosinopoiesis by an inducible no synthase- and CD95L-dependent mechanism 10.1016/j.cyto.2011.07.106 2011
PS2-052. Interleukin-17 A Suppresses Eosinopoiesis By An Inducible No Synthase- And CD95L-Dependent Mechanism 10.1016/j.cyto.2011.07.212 2011
CIS 2010 First North American Primary Immune Deficiency National Conference 10.1016/j.clim.2010.02.008 2010
iNOS/CD95L-dependent suppression of pulmonary and bone-marrow eosinophilia by Diethylcarbamazine 2009
A TOLERIZAÇÃO ORAL INIBE A EOSINOPOIESE "IN VITRO" NO MODELO EXPERIMENTAL DE ASMA NUM MECANISMO DEPENDENTE DE CÉLULAS T ESPLÊNICAS 2008
Neutrophilia and increased neutrophil function in healthy military during intensive training" 2008
"ROLE OF ENDOGENOUS GLUCOCORTICOIDS IN THE REGULATION OF EOSINOPOIESIS IN A MURINE MODEL FOR ALLERGIC ASTHMA" 2008
Glycoinositolphospholipid (GIPL) derived from Trypanosoma cruzi drives antigen response toward a TH-2 profile in a Toll-like receptor 4 (TLR4) -dependent process. 2008
STUDY OF THE SUPPRESSIVE EFFECT OF ISOPROTERENOL, ALL-TRANS RETINOIC ACID (ATRA) AND PROSTAGLANDIN E2 DURING THE DEVELOPMENT OF MURINE EOSINOPHILS IN CULTURE 2008
Th2 Antigen Response In Mice Can Be Enhanced By Glycoinositol-phospholipid From Trypanosoma cruzi, In A Toll-Like Receptor 4-Dependent Process 2008
Gluocorticoids and prostaglandin E2 control murine eosinophil adhesiveness and terminal differention through modulation of alfa-4 integrin expression 2007
Cysteinyl-leukotrienes mediate the effects of Cyclo-oxygenase inhibitors on murine bone marrow eosinopoiesis 2007
CYSTEINYL-LEUKOTRIENES MEDIATE THE EFFECTS OF CYCLO-OXYGENASE INHIBITORS ON MURINE BONE MARROW EOSINOPOIESIS AND PROTECT BONE-MARROW EOSINOPHILS AGAINST PGE2 PRO-APOPTOTIC EFFECTS. 2007
ALLERGIC LUNG GRAFTS INDUCE ACUMULATION OF HEMOPOIETIC CELLS IN LUNG AND INCREASE THE RESPONSE OF BONE-MARROW CELLS TO IL-5 IN A ECTOPIC TRANSPLANTATION 2006
Hematopoietic cells accumulate in murine lungs in response to ectopic grafts of lung tissue from allergic and from IL-5 trnsgenic mice 2005
Study of polymorphisms in the genes for TNF-α in pediatric patients in the ICU of Instituto Fernandes Figueira ? Fundação Oswaldo Cruz 10.1186/cc3549 2005
G-CSF treatment impairs eosinophils recruitment in allergic airway inflammation 2005
Effect of allergen sensitization on eosinophil precursor responses to cytokines and chemokines in bone marrow culture 2004
Macrophage migration inhibitory factor (MIF) is essential for eosinophil production on allergic pulmonary inflammation 2004
Modulation of the adaptative immunity after treatment with glycoinositolphospholipid (GIPL) extracted from Trypanosoma cruzi. 2004
Macrophage migration inhibitory factor (MIF) is essential for eosinophil production on allergic pulmonary inflammation 2004
Corelação fisiopatologica dos casos de sepse com estudo do polimorfismo de mediadores da inflamação 2004
Ectopic grafts of allergic lung tissue iduce accumulation of hematopoietic cells in the graft recipient`s wn lungs by releasing IL-5 2004
dexamethasone and allergenic sensitization upregulate expression of alpha 4 integrins in eosinophil precurssors 2004
Relationship between neutrophil phagocytosis and subgingival microbiota in agressive periodontitis 2004
No and fasL are required for eosinophil apoposis induction by PGE2 2003
Allergen sensitization of high IgE-producting mice prevents upregulation of eosinophil production by dexamethasone productionby dexamethasone. 2003
Mobilização de Progenitores Hematopoiético para o Pulmão em um Modelo Experimental de Implante Ectópico de Tecido Pulmonar 2003
Allergic Lung induces Hemopoietic Cell Recruitment. 2002
Detecção de fator de necrose tumoral do tiopo alfa e dos seus receptores solúveis, em pacientes pediátricos com febre reumática 2002
EFEITOS DA DEXAMETASONA SOBRE A EXPRESSÃO DE PROTEÍNAS DE ADESÃO EM MEDULA ÓSSEA DE CAMUNDONGOS. In: XXXIV CONGRESSO BRASILEIRO DE FARMACOLOGIA E TERAPÊUTICA EXPERIMENTAL, 2002, 2002
ISOLATION AND CHARACTERIZATION OF HEMOPOIETIC CELLS FROM LUNGS 2002
Quantification and localization of platelet-derived growth factor in gingiva of periodontitis patients. 2002
SELECTIVE EOSINOPHIL MIGRATION TO THE PERITONEAL CAVITY IN MICE CARRYING EGG WHITE IMPLANTS (EWI): ROLE OF ANTIGEN, CD4+ LYMPHOCYTES AND LEUKOTRIENES. 2002
Quantificação de PDGF em Tecido Gengival imflamado 2001
Allergen sensitization prevents upergulation of hematopoiesis by indomethacin in mice 2001
Allergen sensitization prevents upregulation of hematopoiesis by indomethacin in mice. 2001
Downmodulation of eosinopoiesis E2 involves apoptosis 2000
TNF-alfa production by malnourished children 2000
Upregulation of eosinopoiesis by egg white implant: Role of glucocorticoids 2000
Produçao e Regulação de Citocinas Inflamatórias na Desnutrição Pluricarencial Infantil . 2000
Downmodulation of eosinopoiesis by Prostaglandin E2 involves apoptosis 2000
Papel dos glucocorticoides num modelo de eosinofilia cronica. 2000
Role of glucocorticoids in upregulation of eosinopoiesis. 2000
Role of Apoptosis in Downmodulation of eosinopoiesis by prostaglandin E2. 2000
Role of endogenous glucocorticoids in upregulation of eosinopoiesis. 2000
Upregulation by glucocorticoids and blockade Prostaglandin E2 of eosinopoiesis in bone-marrow from normal and allergic mice. 1999
Rapid increase in responsiveness to eosinopoietins triggered by allergen challenge 1997
Réponse augmentée de la moelle osseuse à l'IL-3 et à l'IL-5 après la provocation intranasale de souris sensibilisées à l'ovalbumine 1997
Eosinophil Cytotoxicity Enhancing Factor: Immunocytochemical Detection in Myeloid Progenitors, Hemopoietic Cell Lines And Activated Blood Cells 1994
Induction Of Eosinophil Production In Bone Marrow Culture By Heat Stable Products Of Guinea Pig Alveolar Macrophages 1992
Disturbances In The Establishment Of Long Term Bone Marrow Cultures From Syrian Hamsters During Leishmania Donovani Infection 1991
Eosinophil Cytotoxicity Enhancing Factor (Ecef): Purification, Characterization And Immunocytochemical Localization On The Cell Surface 1990
Possible Role Of A Cytokine That Regulares Eicosanoid Production In Pma-Induced Monocyte Differentiation 1990
A Monokine That Regulares Eosinophil Arachidonic Acid Metabolism Is A Myeloid Cell Surface Marker Associated With Monocyte Differentia- Tion 1990
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