Debora Souza Faffe

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Biofísica Carlos Chagas Filho

Departamento:

Programa de Fisiologia e Biofísica Celular/Biof

ORCID:

https://orcid.org/0000-0001-5255-5938


Formação:

  • Harvard School of Public Health

    | Pós-Doutorado | 2003 - 2005

  • Harvard School of Public Health

    | Pós-Doutorado | 2001 - 2002

  • Universidade Federal do Rio de Janeiro

    Medicina (Cardiologia) | Doutorado | 1997 - 1998

  • Universidade Federal do Rio de Janeiro

    Medicina (Cardiologia) | Mestrado | 1994 - 1996

  • Hospital dos Servidores do Estado do Rio de Janeiro

    | Especialização - Residência medica | 1992 - 1994

  • Universidade Federal do Rio de Janeiro

    Medicina | Graduação | 1984 - 1990
Laboratórios:
Nuvens de Palavras:
Artigos:

(89.71% artigos com DOI)

Titulo DOI Ano
Mpox outbreak in Rio de Janeiro, Brazil: A translational approach 10.1002/jmv.29621 2024
Lessons from a Multilaboratorial Task Force for Diagnosis of a Fatal Toxoplasmosis Outbreak in Captive Primates in Brazil 10.3390/microorganisms11122888. 2023
Accuracy and ease-of-use of seven point-of-care SARS-CoV-2 antigen-detecting tests: A multi-centre clinical evaluation 10.1016/j.ebiom.2021.103774 2022
Evaluation of the Panbio COVID-19 Antigen Rapid Diagnostic Test in Subjects Infected with Omicron Using Different Specimens 10.1128/spectrum.01250-22 2022
Olfactory Dysfunction in Patients With Mild COVID-19 During Gamma, Delta, and Omicron Waves in Rio de Janeiro, Brazil 10.1001/jama.2022.11006 2022
A SARS-CoV-2 Negative Antigen Rapid Diagnostic in RT-qPCR Positive Samples Correlates With a Low Likelihood of Infectious Viruses in the Nasopharynx 10.3389/fmicb.2022.912138 2022
Multicenter Diagnostic Evaluation of a Novel Coronavirus Antigen Lateral Flow Test among Symptomatic Individuals in Brazil and the United Kingdom 10.1128/spectrum.02012-22 2022
Genomic Characterization of a Novel SARS-CoV-2 Lineage from Rio de Janeiro, Brazil 10.1128/jvi.00119-21 2021
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress 10.1038/s41598-021-88944-8 2021
COVID-19 diagnosis by RT-qPCR in alternative specimens 10.1590/0074-02760210085 2021
Performance of an alternative RT-PCR procedure using residual sample from the Panbio- Ag COVID-19 test 10.1016/j.bjid.2021.101630 2021
Epidemiological Dynamics of SARS-CoV-2 VOC Gamma in Rio de Janeiro, Brazil 10.1093/ve/veab087 2021
Intra-host evolution during SARS-CoV-2 prolonged infection 10.1093/ve/veab078 2021
Prolonged SARS-CoV-2 Positivity in Immunocompetent Patients: Virus Isolation, Genomic Integrity, and Transmission Risk 10.1128/spectrum.00855-21 2021
P2Y12 Receptor Antagonist Clopidogrel Attenuates Lung Inflammation Triggered by Silica Particles 10.3389/fphar.2020.00301 2020
Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients 10.1016/j.bbrep.2020.100814 2020
The anti-inflammatory and anti-oxidative actions of eugenol improve lipopolysaccharide-induced lung injury 10.1016/j.resp.2018.07.001 2019
Inflammatory and Oxidative Stress Markers in Experimental Allergic Asthma 10.1007/s10753-017-0560-2 2017
Time-dependency of mice lung recovery after a 4-week exposure to traffic or biomass air pollutants 10.1016/j.resp.2016.05.003 2016
Symbiont modulates expression of specific gene categories in Angomonas deanei 10.1590/0074-02760160228 2016
No correspondence between resistance mutations in the HCV-NS3 protease at baseline and early telaprevir-based triple therapy 10.1016/j.bbacli.2015.01.004 2015
Polymorphisms in IL-10 and INF-γ genes are associated with early atherosclerosis in coronary but not in carotid arteries: A study of 122 autopsy cases of young adults 10.1016/j.bbacli.2015.02.005 2015
Pulmonary functional and morphological damage after exposure to tripoli dust 10.1016/j.resp.2014.02.007 2014
P2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica 10.1371/journal.pone.0110185 2014
Respiratory toxicity of repeated exposure to particles produced by traffic and sugar cane burning 10.1016/j.resp.2013.11.004 2013
In vivo and in vitro lung mechanics by forced oscillations: effect of bleomycin challenge 10.1016/j.resp.2012.01.012 2012
Eugenol attenuates pulmonary damage induced by diesel exhaust particles 10.1152/japplphysiol.00764.2011 2012
Time-dependence of lung injury in mice acutely exposed to cylindrospermopsin 10.1016/j.toxicon.2012.06.009 2012
DYNAMIC NONLINEARITY OF LUNG TISSUE: FREQUENCY-DEPENDENCE AND HARMONIC DISTORTION 10.1152/japplphysiol.01487.2010 2011
Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice 10.3109/08958378.2011.566290 2011
LASSBio 596 per os avoids pulmonary and hepatic inflammation induced by microcystin-LR 10.1016/j.toxicon.2011.05.018 2011
Dynamic nonlinearity of lung tissue: effects of strain amplitude and stress level. 10. 1152/ japplphysiol. 01115. 2010 2011
Lipopolysaccharide-induced lung injury: Role of P2X7 receptor 10.1016/j.resp.2011.09.015 2011
On the crucial ventilatory setting adjustment from two- to one-lung ventilation 10.1016/j.resp.2011.08.006 2011
Residual oil fly ash worsens pulmonary hyperreactivity in chronic allergic mice 10.1016/j.resp.2011.07.011 2011
In vivo anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury 10.1152/japplphysiol.00560.2009 2010
Pulmonary function and histological impairment in mice after acute exposure to aluminum dust 10.3109/08958378.2010.489074 2010
Can LASSBio 596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR? 10.1016/j.toxicon.2010.06.005 2010
Does the use of recombinant AAV5 in pulmonary gene therapy lead to lung damage? 10.1016/j.resp.2009.06.016 2009
Lung Parenchymal Mechanics in Health and Disease 10.1152/physrev.00019.2007 2009
Recruitment maneuver: RAMP versus CPAP pressure profile in a model of acute lung injury 10.1016/j.resp.2009.08.010 2009
Composition of diesel particles influences acute pulmonary toxicity: an experimental study in mice 10.1080/08958370802112922 2008
Effects of amiodarone on lung tissue mechanics and parenchyma remodeling 10.1016/j.resp.2008.05.004 2008
Comparative respiratory toxicity of particles produced by traffic and sugar cane burning 10.1016/j.envres.2008.05.004 2008
Asthma: where is it going? 10.1590/S0100-879X2008005000031 2008
Microcrystalline cellulose induces time-dependent lung functional and inflammatory changes 10.1016/j.resp.2008.08.005 2008
Time course of lung parenchyma remodeling in pulmonary and extrapulmonary acute lung injury 10.1152/japplphysiol.00395.2005 2006
Mouse strain dependence of lung tissue mechanics: role of specific extracellular matrix composition 10.1016/j.resp.2005.08.008 2006
IL-13 and IL-4 induce vascular endothelial growth factor release from human airway smooth muscle cells: role of VEGF genotype 10.1165/rcmb.2005-0147OC 2006
Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma 10.1590/S0100-879X2006000200016 2006
Respiratory changes in a murine model of spontaneous systemic lupus erythematosus 10.1016/j.resp.2005.09.005 2006
Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats 10.1016/j.resp.2006.02.002 2006
Positive end-expiratory pressure prevents lung mechanical stress caused by recruitment/derecruitment 10.1152/japplphysiol.00118.2004 2005
Lung parenchyma remodeling in a murine model of chronic allergic inflammation 10.1164/rccm.200408-997OC 2005
Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13 10.1016/j.jaci.2004.11.033 2005
Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1 beta 10.1152/ajplung.00333.2004 2005
Transforming growth factor-beta 1 promoter polymorphism C-509T is associated with asthma 10.1164/rccm.200307-973OC 2004
Time course of respiratory mechanics and pulmonary structural remodelling in acute lung injury 10.1016/j.resp.2004.06.017 2004
What increases type III procollagen mRNA levels in lung tissue: stress induced by changes in force or amplitude? 10.1016/j.resp.2004.07.023 2004
On the preparation of lung strip for tissue mechanics measurement 2003
Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK 2003
Effect of corticosteroid on lung parenchyma remodeling at an early phase of acute lung injury 10.1164/rccm.200302-256OC 2003
Evaluation of respiratory mechanics and lung histology in a model of atelectasis 10.1016/S1569-9048(03)00125-3 2003
IL-13 and IL-4 promote TARC release in human airway smooth muscle cell: role of IL-4 receptor genotype 2003
Comparison of rat and mouse pulmonary tissue mechanical properties and histology 2002
Lung tissue mechanics and extracellular matrix composition in a murine model of silicosis 2001
Respiratory effects of lipopolysaccharide-induced inflammatory lung injury in mice 2000
Pulmonary morphofunctional effects of acute myocardial infarction 1999
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Gene Polymorphisms in IL-10, INF-γ and TGF-β are Associated with Early-Onset Coronary Artery Disease and Microvascular Function. 2015
Different MicroRNA Expression Profiles In Murine Aorta And Carotid Arteries. 2015
Polymorphisms associated with liver fibrosis and hepatocellular carcinoma in patients with chronic hepatitis C 2015
Resistance associated variants to NS5A and NS5B inhibitors in hepatitis C virus of naïve chronically infected patients 2015
Genetic variability of hepatitis virus NS3 protease from chronically infected patients submitted to telaprevir-based therapy. 2015
Isoproterenol treatment impairs pulmonary function associated with inflammation and apoptosis in rat lung 2013
Gene polymorphisms in IL-10 and IFN-γ are associated with early atherosclerosis in corronary but not in carotid arteries: a study of 122 autopsy cases of young adults. 2012
Lassbio 596 per os reduced lung inflammation and avoided pulmonary and mechanical impairment induced by Microcystin-LR 2011
Polymorphisms in candidate genes and early atherosclerosis: a study of 115 autopsy cases of young adults 2011
Downregulation of peroxisome proliferator-activated receptor-gamma (PPARγ) expression increases inflammation and impairs lung function in an experimental model of cardiac hypertrophy 2010
Aerobic exercise does not reverse pulmonary impairment caused by high doses of nandrolone decanoate 2010
Experimental model of papain-induced pulmonary emphysema. 2010
Protective role of PPARg activation in both acute and chronic phases in a murine model of silicosis 2010
Temporal effects of cigarette smoke exposure on lung mechanics. 2009
Role of purinergic P2X7 receptors in allergic inflammation 2009
Effects of eugenol in the acute pulmonary toxicity of diesel exhaust particles 2009
Pulmonary effects of fenofibrate in rats treated with isoproterenol for one week 2009
Pulmonary effects of rosiglitazone in rats treated with isoproterenol for one week 2009
Comparative respiratory toxicity of particles produced by urban pollution and sugar cane burning in a subchronic exposure model 2009
Anethole improves lipopolysaccharide (LPS)-induced lung injury 2009
Phosphodiesterase 4-5 inhibitor (LASSBio596) per os avoided pulmonary mechanical impairment and inflammation produced by microcystin-LR 2009
Pulmonary mechanical and histological impairments depend on time after exposure to cylindrospermopsin in mice 2009
Rosiglitazone impairs lung function in rats receiving isoproterenol and alone it decreases cardiac parasympathetic activity 2009
Lipopolysaccharide (LPS)-induced lung injury: role of purinergic P2X7 receptors 2008
Acute lung injury induced by cylindrospermopsin 2008
Pulmonary functional and morphological damage after exposure to Tripoli dust 2008
Acute lung injury caused by microcystin-LR in mice 2008
Phosphodiesterase 4 and 5 inhibitor and steroid actions on pulmonary injury induced by microcystin-LR 2008
Low doses of PM2.5 induce inflammation and oxidative stress with lung functional changes in mice 2008
Pulmonary mechanics and lung histology in a model of leptospirosis 2008
Anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury 2008
Acute exposure to aluminium dust induces respiratory changes in mice 2007
Lung inflammatory response after acute exposure to diesel particles in mice 2007
Acute exposure to very low dose of fine particulate matter increases lung impedance and induces inflammation in mice 2007
The role of purinergic P2X7 receptors on lipopolysaccharide(LPS)-induced lung injury 2007
Intranasal instillation of a very low dose of ROFA compromises lung mechanics and histology for 4 days 2007
Protective effects of phosphodiesterase 4 and 5 inhibitor on pulmonary damages induced by microcystin-LR 2007
Time course of mice lung mechanical and histological damage by microcystin-LR 2007
Composition of diesel particles influences their acute pulmonary toxicity: an experimental study in mice 2007
Modelo experimental de enfisema pulmonar induzido por papaina 2007
A composicão das partículas de diesel influencia a sua toxicidade pulmonar aguda: um estudo experimental em camundongos 2007
Alteracões pulmonares induzidas por exposição aguda a partículas finas 2007
Potencial terapêutico de LASSBio596 na intoxicação por microcistina-LR avaliado pela mecânica e histologia pulmonares de camundongos 2007
Efeitos pulmonares da exposição ao pó de Trípoli 2007
Ação anti-inflamat´roia do eugenol em um modelo de exposição aguda à fumaça de cigarro 2007
Ação anti-inflamatória do eugenol em modelo in vivo de lesão pulmonar aguda induzida por lipopolissacarídeo 2007
Papel dos receptores purinérgicos P2X7 na lesão pulmonar ainduzida por lipopolissacarídeo (LPS) 2007
Comparação entre os efeitos da exposição aguda à poluição urbana e de queima de biomassa em camundongos 2007
Lesão pulmonar aguda causada por cilindrospermopsina 2007
Lung inflammatory and mechanical responses after acute exposure to urban and biomass total suspended particles (TSP) in mice 2007
Anti-inflammatory effect of a phosphodiesterase 4 and 5 inhibitor in acute lung injury 2006
In vivo anti-inflammatory action of eugenol on lipopolysaccharide(LPS)-induced lung injury 2006
Ramp versus step: how to recruit air spaces? 2006
In vivo anti-inflammatory action of eugenol on lipopolysaccharide (LPS)-induced lung injury 2006
PEEP avoids ventilator-induced lung injury in independently ventilated lungs 2006
Acute lung inflammatory response after diesel particles exposure in mice 2006
Recruitment manouvre: ramp versus step technique 2006
Effects of residual oil fly ash (ROFA) in a murine modelo of chronic allergic inflammation 2006
Acute lung inflammatory response after urban and biomass total suspended particles (TSP) exposure in mice 2006
Acute lung inflammatory response in mice exposed to aluminium dust 2006
Direct effects of microcystin-LR on mice lung 2006
Time course of lung mechanics induced by residual oil fly ash 2006
Therapeutic potential of different phosphodiesterase inhibitors in acute lung injury 2006
Effect of IL-4R alpha genotype on IL-13 and IL-4-induced IL-6 release in human airway smooth muscle (HASM) cells 2005
Effect of beta-2 adrenoceptor polymorphisms on inflammatory gene expression in human airway smooth muscle (HASM) cells 2005
IL-13 and IL-4 cause VEGF production by human airway smooth muscle (HASM) cells: role of IL-4R alpha and VEGF genotype 2004
Comparisson of tissue mechanics and lung histology in two different strains of mice 2004
Lung tissue mechanics and extracellular matrix remodeling in a murine model of chronic asthma 2004
Lung mechanics and histology in a model of acute severe and fatal asthma 2004
Prone position in acute lung injury: understanding the mechanisms of oxygenation improvement 2004
A utilizacao de PEEP reduz o efeito lesivo pulmonar causado pela manobra de recrutamento alveolar em ratos 2004
Mecanica e histologia pulmonares em modelo murinico de asma severa e fatal 2004
Remodelamento do parenquima pulmonar em modelo murinico de asma cronica 2004
Role of MAP kinases and of NF-kappa b in TARC release from human airway smooth muscle cells 2004
IL-13 and IL-4 cause TARC expression in human airway smooth muscle (HASM) cells: role of IL-4 receptor polymorphisms 2003
Effects of IL-6 family cytokines on eotaxin and IL-8 release from HASM cells 2003
The TGFbeta1 C-509T promoter polymorphism is associated with asthma 2003
Beneficial effects of PEEP on parenchymal lesion caused by recruitment manoeuvrer 2003
Lung parenchyma remodelling in a murine model of asthma 2003
Alveolar and bronchial remodelling in a murine model of chronic asthma 2003
Different response of lung parenchyma remodelling in primary and secondary acute lung injury to corticosteroid 2003
Dinamic properties of lung tissue strip during mechanical stress in acute lung injury 2003
Effects of a new phosphodiesterase inhibitor in a murine model of asthma 2003
Effects of air pollution particles on the respiratory mechanics in mice 2003
Effects of different volumes in one lung ventilation 2003
Effects of low-dose corticoisteroid at an early phase of acute lung injury 2003
Effects of recruitment maneuvers in pulmonary and extrapulmonary ALI 2003
Lung tissue strip during mechanical stress 2003
Respiratory mechanics and lung histology in a murine model of fatal asthma 2003
Short versus prolonged small dose steroid therapy in acute lung injury 2003
Temporal evolution of respiratory mechanics in a model of acute lung injury induced by cecal ligation and puncture 2003
Effect of IL-4Ralfa polymorphisms on IL-4 and IL-13 induced eotaxin expression in human airway smooth muscle (HASM) cells. 2002
Pressão x volume: o que aumenta o nível de RNAm para colágeno no parênquima pulmonar? 2001
Efeito do extratato de Kalanchoe pinata na hiperreatividade brônquica 2001
Recrutamento alveolar em diferentes afecões respiratórias 2001
Evolucão temporal da mecânica respiratória e matriz extracelular na lesão pulmonar induzida por paraquat 2001
Lesão pulmonar aguda de etiologia pulmonar e extrapulmonar: efeitos do corticosteróide 2001
Efeito do extrato aquoso de Kalanchoe pinnata na lesão pulmonar aguda induzida por lipopolissacarídeo de E. coli 2001
Inibidores da fosfodiesterase podem impedir a lesão pulmonar aguda? 2001
Remodelamento do pulmão na fase precoce da lesão pulmonar aguda: efeito do corticosteróide 2001
Efeitos de diferentes bloqueadores neuromusculares na mecânica e histologia pulmonares 2001
O extrato aquoso de Kalanchoe pinnata pode vir a ser uma nova substância na profilaxia de asma brônquica? 2001
Effect of IL-4Ralfa polymorphisms on IL-4 and IL-13 induced eotaxin expressiion in human airway smooth muscle (HASM) cells 2001
A comparative study of rat and mouse lung tissue mechanics and extracelular matrix 2000
Lung tissue mechanics and extracelular matrix in a murine model of silicosis 2000
On the techincs of lung tissue preparation for micromechanics measurement 2000
Tissue mechanics in a murine model of lung inflammation induced by microcrystalline cellulose 2000
Respiratory changes in a murine model of spontaneous Systemic Lupus Erythematosus 2000
Mecanica tecidual na síndrome do desconforto respiratório agudo pulmonar e extrapulmonar 2000
Mecânica e morfometria tecidual em modelo de inflamação pulmonar por celulose microcristalina 2000
Mecânica respiratória e histologia pulmonar após uso crônico de anabolizante hormonal 2000
Repercussões respiratórias do uso crônico de anabolizante hormonal 2000
Efeitos do extrato de Kalanchoe pinnata na mecânica respiratória de camundongos com hiperreatividade brônquica 2000
Efeitos da amiodarona sobre a mecânica respiratória 2000
Efeito protetor do corticosteróide na fase precoce da lesão pulmonar aguda 2000
Mecânica tecidual na fase precoce da lesão pulmonar aguda: efeitos da terapêutica com metilprednisolona 2000
Mecânica respiratória na lesão pulmonar aguda induzida por paraquat 2000
Amiodarona: repercussões morfofuncionais pulmonares 2000
Complicações respiratórias decorrentes do uso de anabolizante hormonal 2000
Alterações morfofuncionais na lesão pulmonar aguda de etiologia pulmonar e extrapulmonar 2000
Mechanical Behavior And Structural Composition Of Lung Parenchymal Strip In A Murine Model Of Silicosis 1999
Estudo comparativo das propriedades mecânicas do tecido pulmonar de ratos e camundongos 1999
Diferentes formas de acomodação interferem na mecânica tecidual? 1999
Alteracoes morfofuncionais em tecido pulmonar de um modelo experimental de silicose 1999
Alterações respiratórias em modelo de Lupus Eritematoso Sistêmico em camundongos 1999
Mecânica tecidual em presença de diferentes amplitudes e tensões 1999
Importancia da interface ar-liquido na medida da mecanica tecidual in vitro 1999
Respiratory Effects Of Lipopolysaccharide-Induced Inflammation Of Mouse Lung 1998
Repercussões Morfo-Funcionais da Lesão Pulmonar Aguda Induzida Por Inalação de Lipopolissacarídeo de Escherichia Coli 1998
Mecânica Respiratória Após Inalação de Lps 1997
Mecânica Respiratória Em Ratos Submetiods À Toracoscopia 1997
Análise da Evolução Temporal da Mecânica Respiratória e Histopatologia Em Um Modelo de Inflamação Pulmonar Induzido Por Lipopolissacarídeo Inalado 1997
Mecânica Respiratória No Infarto Agudo do Miocárdio Em Ratos Pré-Tratados Com Propranolol 1996
Mecânica Respiratória Na Fase Aguda do Infarto Agudo do Miocárdio Em Ratos 1996
Pressão Motriz do Sistema Respiratório Em Ratos Submetidos À Frenicotomia Uni- Ou Bilateral 1996
Propriedades Mecânicas Ativas e Passivas do Sistema Respiratório Em Ratos Submetidos À Frenicotomia Uni- Ou Bilateral 1996
Decaimento da Pressão dos Músculos Inspiratórios Durante A Expiração Em Ratos Submetidos À Frenicotomia Uni- Ou Bilateral 1996
Alterações Respiratórias e Histopatológicas No Infarto Agudo do Miocárdio Com e Sem Pré-Tratamento Com Beta-Bloqueador 1996
Mecânica Respiratória e Controle da Ventilação Na Frenicotomia Uni- e Bilateral 1996
O Significado do Edema de Membros Inferiores Em Pacientes Com Doença Pulmonar Estabelecida - A Propósito de 4 Casos 1995
Complicações Cardiovasculares No Pós-Operatório de Cirurgia Vascular 1994
Infarto Sem Onda Q: Incidência Em Unidade Coronariana, Evolução Hospitalar e Pós-Alta 1993
Publicações:
Minha Rede: