Roberto Takashi Sudo
Formação:
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Wake Forest University
| Pós-Doutorado | 2015 - 2016
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Wake Forest University
| Pós-Doutorado | 2000 - 2000
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Wake Forest University
| Pós-Doutorado | 1995 - 1996
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Thomas Jefferson University
| Pós-Doutorado | 1989 - 1990
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Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Doutorado | 1984 - 1988
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Universidade Federal do Rio de Janeiro
Ciências Biológicas (Farmacologia e Química Medicinal) | Mestrado | 1978 - 1981
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Universidade do Estado do Rio de Janeiro
Residência Médica | Especialização | 1977 - 1978
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Universidade Federal do Rio de Janeiro
Farmacologia e Terapêutica Experimental | Especialização | 1976 - 1976
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Universidade Federal do Rio de Janeiro
Medicina | Graduação | 1971 - 1976
Laboratórios:
Nuvens de Palavras:
Artigos:
(19.34% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Cardiac electrical and contractile disorders promoted by anabolic steroid overdose are associated with late autonomic imbalance and impaired Ca2+ handling | 10.1016/j.steroids.2019.04.001 | 2019 |
| GPER agonist G1 improves diastolic function and attenuates cardiac RAS activation in estrogen-deficient hypertensive rats | 10.1097/FJC.0000000000000721 | 2019 |
| Reduction of cardiac and renal dysfunction by new inhibitor of DPP4 in diabetic rats | 10.1016/j.pharep.2019.07.005 | 2019 |
| Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats | 10.1371/journal.pone.0195047. eCollection 2018 | 2018 |
| Novel agonist of α4β2* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain | 10.2147/JPR.S169637 | 2018 |
| Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension | 10.1093/gerona/gly068 | 2018 |
| O -GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats | 10.1074/jbc.ra118.001746 | 2018 |
| Human Mesenchymal Stem Cell Therapy Reverses Su5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Mice | 10.3389/fphar.2018.01395 | 2018 |
| Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat | 10.1093/gerona/glw045 | 2017 |
| Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction | 10.2147/DDDT.S113289 | 2017 |
| The Hypnotic, Anxiolytic, and Antinociceptive Profile of a Novel µ-Opioid Agonist | 10.3390/molecules22050800 | 2017 |
| Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2 | 10.1177/1470320317722270 | 2017 |
| Antinociception induced by a novel α 2A adrenergic receptor agonist in rodents acute and chronic pain models | 10.1016/j.ejphar.2017.09.018 | 2017 |
| Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension | 10.3389/fphar.2017.00858 | 2017 |
| Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation | 10.1124/jpet.115.231241 | 2016 |
| Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats | 10.1016/j.bbrc.2016.05.040 | 2016 |
| Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents | 10.2147/DDDT.S108327 | 2016 |
| Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae) | 10.1590/0001-3765201620150821 | 2016 |
| Activation of GPER ameliorates experimental pulmonary hypertension in male rats | 10.1016/j.ejps.2016.11.009 | 2016 |
| Laceration in rat gastrocnemius. Following-up muscle repairing by ultrasound biomicroscopy (in vivo), contractility test (ex vivo) and histopathology | 10.1590/s0102-86502015001000003 | 2015 |
| Novel Orally Active Analgesic and Anti-Inflammatory Cyclohexyl-N-Acylhydrazone Derivatives | 10.3390/molecules20023067 | 2015 |
| Novel Agonist of Adenosine Receptor Induces Relaxation of Corpus Cavernosum in Guinea Pigs: An In Vitro and In Vivo Study | 10.1016/j.urology.2015.02.006 | 2015 |
| Prevention and Reversal of Morphine-Induced Tolerance by Novel Muscarinic Receptor Agonist in Rats with Neuropathic Pain | 10.4172/2155-9562.1000282 | 2015 |
| Hypoglicemic effect of the methanol flower extract of piper claussenianum and the major constituent 2',6'-dihydroxy-4'-methoxychalcone in streptozotocin diabetic rats. | 2015 | |
| Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Açaí) in a rodent model of acute and neuropathic pain | 10.1186/s12906-015-0724-2 | 2015 |
| Rats undernourished in utero have altered Ca 2+ signaling and reduced fertility in adulthood | 10.14814/phy2.12587 | 2015 |
| N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle | 10.1016/j.lfs.2013.11.012 | 2014 |
| N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity | 10.1016/j.ijcard.2014.02.022 | 2014 |
| Novel partial agonist of PPAR-gamma for treatment of diabetic neuropathy in rats | 2014 | |
| Oral treatment with Euterpe oleracea Mart. (acai) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction | 10.1186/1472-6882-14-227 | 2014 |
| Novel nicotinic receptor agonist reduces hyperalgesia and allodynia of neuropathic pain in diabetic rats | 2014 | |
| Adenosine A2A Receptor as a Target of Treatment for Pulmonary Arterial Hypertensio | 2014 | |
| Targeting of the Adenosine Receptors as a Novel Strategy for the Treatment of Arterial Hypertension | 2014 | |
| Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta | 10.3390/molecules18033072 | 2013 |
| Impairment of locomotor activity induced by the novel N-Acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice | 2013 | |
| Beneficial effects of a novel agonist of the adenosine A 2A receptor on monocrotaline-induced pulmonary hypertension in rats | 10.1111/bph.12193 | 2013 |
| Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta | 2013 | |
| A novel Ca²+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension | 10.1016/j.ejphar.2013.01.050 | 2013 |
| Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats | 10.1111/1440-1681.12090 | 2013 |
| A novel adenosine A2A receptor agonist attenuates the progression of monocrotaline-induced pulmonary hypertension in rats | 2013 | |
| Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound DOI 10.1111/j.1472-8206.2011.00999.X | 2012 | |
| Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model. DOI 10.1016/j.ejphar.2012.05.043 | 2012 | |
| Antihypertensive profile of 2-thienyl-3,4-methyleneddioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor | 2012 | |
| Docking, Synthesis and Anti-diabetic Activity of Novel Sulfonylhydrazone Derivatives Designedas PPAR-Gama Agonists | 2012 | |
| The Influence of Age on Bupivacaine Cardiotoxicity | 10.1213/ane.0b013e31820a9178 | 2011 |
| Pharmacological activity of novel 2-hydroxyacetophenone isatin derivatives on cardiac and vascular smooth muscle in rats. | 2011 | |
| Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneous hypertensive rats | 2011 | |
| Inhibition of L-type calcium current by tramadol and enantiomers in cardiac myocytes from rats | 2011 | |
| Na+-ATPase in Spontaneously Hypertensive Rats: Possible AT1 Receptor Target in the Development of Hypertension | 2010 | |
| Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine | 2010 | |
| Microwave-assisted synthesis and pharmacological evaluation of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives in sedation model | 2010 | |
| Pharmacological Characterization of (3-Thienylidene)-3,4-methylenedioxybenzoylhydrazide, a Novel Muscarinic Agonist with Antihypertensive Profile | 2010 | |
| Interaction of morphine with a new alfa2-adrenoceptor agonist in mice | 2010 | |
| Intravenous administration of azumolene to reverse malignant hyperthermia in Swine | 2010 | |
| Use of the caffeine-halothane contracture for malignant hyperthermia diagnosis in Brazil | 2010 | |
| Sedative and anticonvulsivant activity of methanol extract of Dorstenia arifolia in mice | 2010 | |
| Could an unsaturated high-fat acid diet impair the cardiovascular system? | 2010 | |
| Anesthetic Profile of a Non-lipid Propofol Nanoemulsion | 10.1016/S0034-7094(10)70059-3 | 2010 |
| LASSBio-294 a compound with inotropic and lusitropic activity decreases cardiac remodeling and improves Ca influx into SR after myocardial infarction | 10.1038/ajh.2010.157 | 2010 |
| Toxicological evaluation of azumolene after repeated intraperitoneal administration in rats | 2010 | |
| FKBP12 Depletion Leads to Loss of Sarcoplasmic Reticulum Ca2+ Stores in Rat Vas Deferens | 2009 | |
| The lignan eudesmin extracted from Piper truncatum induced vascular relaxation via activation of endothelian H1 receptors | 2009 | |
| Relaxation of tracheal smooth muscle independent on functional epithelium cells induced by lidocaine, bupivacaine and isomers in rats | 2009 | |
| Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives | 2009 | |
| Synergistic Interaction between Morphine and Maprotiline after Intrathecal Injection in Rats | 2009 | |
| Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors. | 2009 | |
| Multigenerational Brazilian family with Malignant Hyperthermia | 2009 | |
| Effects of azumolene on normal and malignant hyperthermia susceptible skeletal muscle | 2008 | |
| Comparative effects of tramadol on vascular reactivity in normotensive and spontaneously hyperthensive rats (Doi 10.1111/j.1440-1681.2008.04979) | 2008 | |
| Vasodilatory activity of novel carbamate derivatives of isatin | 2008 | |
| Sedative-Hypnotic Profile of Novel Isatin Ketals | 2007 | |
| Regulation of intracellular calcium by bupivacaine isomers in cardiac myocytes from Wistar rats | 2006 | |
| Design, Synthesis and Pharmacological Evaluation of New Neuroactive Pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine Derivatives with in vivo Hypnotic and Analgesic Profile | 2006 | |
| Activity of Cecropia lyratiloba extract on contractility of cardiac and smooth muscles in Wistar rats | 2006 | |
| In vitro and in vivo vasodilator activity of racemic tramadol and its enantiomers in Wistar rats | 2006 | |
| Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats | 2005 | |
| Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues | 2005 | |
| Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea pigs. | 2005 | |
| Emulsão lipídica de isoflurano para administração intravenos | 2004 | |
| Emulsão lipídica de desflurano: efeitos anestésicos e hemodinâmicos em ratos | 2004 | |
| Administração venosa de emulsão lipídica de sevoflurano | 2004 | |
| Estereosseletividade da vasodilatação induzida pelos isômeros do tramadol | 2004 | |
| Descoberta de uma nova mutação no receptor da rianodina em família brasileira portadora de hipertermia maligna | 2004 | |
| Ação cardiodepressora da bupivacaína é menor em ratos jovens | 2004 | |
| Thienylhydrazone increases sarcoplasmic reticulum Ca2+ release in mammalian skeletal muscle | 2003 | |
| Alterations in contractility of skinned cardiac fibers induced by S(-) ropivacaine | 2003 | |
| Analogues of a new positive inotropic agent, LASSBio 294: Effects on cardiac and vascular smooth muscle | 2003 | |
| Anesthetic-sparing effect of dexmedetomidine on spinal anesthesia induced by isobaric solution of levobupivacaine | 2003 | |
| Systemic administration of dexmedetomidine increased the duration of spinal anesthesia induced by levobupivacaine | 2003 | |
| Epidural injection of tramadol isomers prolonged sensitive and motor nerves block induced by S(-)bupivacaine in rats | 2003 | |
| Administração sistêmica da dexmedetomidina aumenta a duração da anestesia subaracnóidea induzida pela levobupivacaína isobárica em cobaias | 2003 | |
| Efeito da dexmedetomidina associada a levobupivacaína na anestesia subaracnóidea em cobaias | 2003 | |
| Importância da estimulação de receptores alfa2-adrenérgicos e mu-opióides pelo tramadol no prolongamento do bloqueio sensitivo e motor da S(-)bupivacaína) administrada pela via peridural em ratos | 2003 | |
| Novel Skeletal Muscle Ryanodine Receptor Mutation in a Large Brazilian Family with Malignant Hyperthermia | 2002 | |
| Comparative effects of dantrolene and azumolene on the contractility of skeletal and cardiac muscles | 2002 | |
| Comparative toxicity between ropivacaine and racemic and non-racemic (75S:25R) mixtures | 2002 | |
| Regulation of intracellular calcium concentration by bupivacaine and enantiomers in cardiac myocytes | 2002 | |
| Dexmedetomidina prolonga o bloqueio motor induzido pela injeção subaracnóide de S(-) bupivacaína a 0,5% em cobaias | 2002 | |
| Efeitos da bupivacaína racêmica e seus isômeros na regulação da concentração intracelular de cálcio em miócitos cardíacos de ratos | 2002 | |
| S(+) e R(-) tramadol: analgesia em camundongos e efeito nos bloqueios sensitivo-motor induzido pela injeção peridural de S(-) bupivacaína em ratos | 2002 | |
| Reversão da crise de hipertermia maligna suína pelo azumolene: um análogo hidrossolúvel do dantrolene | 2002 | |
| Is comparative cardiotoxicity of S(-) and R(+) bupivacaine related to enantiomer-selective inhibition of L-type Ca2+ channel | 2001 | |
| Avaliação do bloqueio motor e sensitivo dos isômeros da ropivacaína e suas misturas | 2001 | |
| Comparative motor nerve block between bupivacaine enantiomers and S(-)ropivacaine | 2001 | |
| Efeito comparativo do dantrolene e do azumolene na contratilidade de músculo esquelético | 2001 | |
| Estudo comparativo da toxicidade e do bloqueio motor entre os isômeros, mistura racêmica e não-racêmica (75S:25R) da bupivacaína | 2001 | |
| Potência, duração de efeito e alterações hemodinâmicas comparativas entre atracúrio e cisatracúrio | 2001 | |
| Ropivacaína: toxicidade comparativa entre os isômeros | 2001 | |
| Toxicidade cardíaca do dantrolene e do azumolene | 2001 | |
| The new compound, LASSBio294, increases the contractility of intact and saponin-skinned cardiac muscle from Wistar rats. | 2001 | |
| Comparative cardiac effect of R(+) and S(-) bupivacaine with S(-) ropivacaine | 2000 | |
| Lethal dose of S(+) ketamine is reduced by pre-treatment with propranolol | 2000 | |
| Inhibition of L-type Ca2+ current by bupivacaine enantiomers in rat cardiac myocytes | 2000 | |
| Efeitos da cetamina e seus isômeros na regulação de [Ca2+]i em fibras ventriculares desnudas | 1999 | |
| Ações intracelulares do dantrolene sódico na regulação da concentração mioplasmática de cálcio | 1999 | |
| Enantiômeros da bupivacaína e S(-) ropivacaína: estudo comparativo na musculatura lisa | 1999 | |
| Análise comparativa da hipnose e analgesia entre os estereoisômeros da cetamina | 1999 | |
| Importância da estimulação adrenérgica na toxicidade cardiovascular do isômero da cetamina | 1999 | |
| A new association of Kabuki Make-up syndrome and malignant hyperthermia | 1999 | |
| Potência bloqueadora da atividade do nervo ciático pelos isômeros da bupivacaína e S(-) ropivacaína: modelo experimental e análise comparativa | 1999 | |
| Avaliação dos efeitos arritmogênicos da ropivacaína e dos enantiômeros da bupivacaína em coração de rato | 1998 | |
| Análise das doses convulsivantes e letal média dos isômeros da bupivacaína e da S(-) ropivacaína | 1998 | |
| Bloqueio da corrente de cálcio pelos isômeros da bupivacaína em miócitos cardíacos de rato | 1998 | |
| Dose letal média (DL50) e dose hipnótica (DH50) dos isômeros R(-) e S(+) cetamina em camundongos | 1998 | |
| Rianodina: nova droga para o diagnóstico de hipertermia maligna? | 1998 | |
| Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells | 1997 | |
| Calcium sensitizing function for the dipeptide carnosine in skeletal muscle contractility | 1997 | |
| Changes in ryanodine-induced contractures by stimulus frequency in MHS and MHN dog skeletal muscle | 1997 | |
| Optimização do teste in vitro com rianodina para o diagnóstico de hipertermia maligna em cães | 1997 | |
| Dantrolene sódico: efeitos na contratilidade cardíaca de ratos | 1997 | |
| Contratura induzida pela rianodina em fibras humanas isoladas e desnudas de pacientes normais e portadores de hipertermia maligna | 1997 | |
| Estudo das ações dos enantiômeros da bupivacaína em feixes de músculos cardíacos de ratos | 1997 | |
| Reversão ou potencialização da contratura muscular provocada pela rianodina pleo aumento da concentração de potássio extracelular | 1997 | |
| Seletividade do efeito depressor do dantrolene sódico me músculos esqueléticos | 1997 | |
| Hipertermia maligna pós succinilcolina: relato de caso | 1997 | |
| Hipertermia maligna diagnosticada por teste de contratura muscular à cafeína e halotano: atualização de dado | 1997 | |
| Dantrolene sodium can increase or attenuate activity of skeletal muscle ryanodine receptor calcium release channel: clinical implications | 1996 | |
| Ryanodine contractures in human single, skinned skeletal muscle fibers are rapid in onset and offset | 1996 | |
| MH diagnostic test: effect of stimulus frequency on ryanodine contracture in MHS and normal dog skeletal muscle | 1996 | |
| Endogenous dipeptide carnosine opens calcium channel in malignant hyperthermia and normal skeletal muscle | 1996 | |
| Carnosine´s inotropic actions are mediated via changes in intracellular calcium | 1996 | |
| Endogenous peptide carnosine is cardioinotropic, release SR Ca++ and modulates the RyR2 calcium release channel | 1996 | |
| Alterations in contractility of skinned cardiac fibers induced by chronic infarction | 1996 | |
| Diagnóstico de hipertermia maligna no Brasil | 1993 | |
| Sensibilidade de fibras musculares desnudas de pacientes não-portadores e portadores de hipertermia maligna ao Sr2+ e a cafeína | 1993 | |
| Anestesia para biópsia muscular em pacientes susceptíveis à hipertermia maligna | 1993 | |
| Comparative pharmacokinetics of different oral nifedipine preparation in healthy brazilian volunteers | 1992 | |
| Effect of chronic intraventricular sodium on blood pressure and fluid balance | 1991 | |
| Halothane-cooling contractures and regulation of the myoplasmic Ca2+ concentration in skeletal muscle | 1991 | |
| Halothane cooling contractures of skinned mammalian muscles fibers | 1990 | |
| Potentiation of the halothane-cooling contractures of mammalian muscles by denervation | 1990 | |
| Alteration in the functional properties of skinned fibers from denervated rabbit skeletal muscle | 1990 | |
| Pharmacokinetics of oral ciprofloxacin in healthy young brazilian subjects | 1990 | |
| Studies of the halothane-cooling contractures of skeletal muscle | 1987 | |
| The temperature dependence of halothane-cooling contractures of skeletal muscle | 1986 | |
| Halothane-cooling contractures of mammalian muscles | 1986 | |
| Halothane-cooling contractures in mammalian skeletal muscles | 1985 | |
| Halothane-cooling contractures in mammalian skeletal muscle | 1985 | |
| Effects of salicylates on the halothane-cooling contractures | 1985 | |
| Halothane-cooling contractures of human skeletal muscle | 1985 | |
| Efeito hemodinâmico da lidocaína em cães | 1984 | |
| Halothane-cooling contractures of skeletal muscle: an experimental model for the malignant hyperthermia syndrome | 1984 | |
| Influence of temperature on halothane-induced contracture | 1984 | |
| Uso del verapamil en arritmias durante la anestesia general con halothano: anlisis hemodinamico | 1981 | |
| verapamil em arritmias durante anestesia geral pelo halotano: análise hemodinâmica | 1980 | |
| Alterações hemodinâmicas pelo verapamil durante anestesia geral com halotano | 1980 | |
| Propafenona em arritmias de fundo adrenérgico durante anestesia geral pelo halotano | 1980 | |
| Cálcio reverte e protege do efeito cardiodepressor da lidocaína | 1980 | |
| Efeito do verapamil na arritmia por anestésicos gerais | 1979 | |
| Análise hemodinâmica do efeito antiarritmico do verapamil durante anestesia geral com halotano | 1979 | |
| Efeitos do cálcio na cardiodepressão provocada pela lidocaína | 1979 | |
| Effect of calcium on the hemodynamic changes induced by intravenous lidocaine infusion | 1978 | |
| Cardiovascular effects of propafenon and verapamil during halothane anethesia | 1978 | |
| Efeito do fentanil na pressão arterial e na resposta as catecolaminas em ratos tratados pelo hexametônio ou suprarrenalectomizados | 1977 | |
| Efeitos hemodinâmicos da infusão venosa de lidocaína e bupivacaína em cães sob ventilação espontânea e artificial | 1977 | |
| Bloqueio em oftalmologia | 1977 | |
| Estudos comparativo do efeito amnésico do lorazepam e do diazepam | 1977 | |
| 5-hydroxytryptamine and narcotic-analgesics interactions in the intestine | 1976 | |
| Bloqueio pela ciclazocina da resposta contrátil in vivo do intestino do cão a 5-hidroxitriptamina | 1976 | |
| Bloqueio pela nalorfina e ciclazocina da potencialização produzida pela dextromoramida sobre o efeito contraturante intestinal da 5-hidroxitriptamina (5-HT) | 1975 | |
| Efeito do enfluorano na atividade elétrica espontânea do sistema límbico e tálamo ventral | 1975 |
Eventos:
(0.00% eventos com DOI)