Fernanda Guarino De Felice
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Bioquímica Médica
Departamento:
Programa de Biologia Celular e Biofisica
Formação:
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Northwestern University
| Pós-Doutorado | 2005 - 2008
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Universidade Federal do Rio de Janeiro
Química Biológica | Doutorado | 1997 - 2001
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Universidade Federal do Rio de Janeiro
Química Biológica | Mestrado | 1994 - 1997
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Universidade Federal do Rio de Janeiro
Ciências Biológicas | Graduação | 1990 - 1994
Laboratórios:
Nuvens de Palavras:
Artigos:
(97.44% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Structural changes in the obese brain | 10.4103/NRR.NRR-D-23-01123 | 2024 |
| Leptin receptor reactivation restores brain function in early-life Lepr -deficient mice | 10.1093/brain/awae127 | 2024 |
| The ketamine metabolite ( 2R,6R )-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease | 10.1002/alz.14034 | 2024 |
| Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity | 10.1093/braincomms/fcad059 | 2023 |
| Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression | 10.1523/eneuro.0256-22.2023 | 2023 |
| Impaired insulin signalling and allostatic load in Alzheimer disease | 10.1038/s41583-022-00558-9 | 2022 |
| Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys | 10.1002/trc2.12289 | 2022 |
| Inflammation at the crossroads of COVID-19, cognitive deficits and depression | 10.1016/j.neuropharm.2022.109023 | 2022 |
| The emerging neuroprotective roles of exerkines in Alzheimer?s disease | 10.3389/fnagi.2022.965190 | 2022 |
| Irisin stimulates protective signaling pathways in rat hippocampal neurons | 10.3389/fncel.2022.953991 | 2022 |
| Lung inflammation induced by silica particles triggers hippocampal inflammation, synapse damage and memory impairment in mice | 10.1186/s12974-022-02662-0 | 2022 |
| Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia | 10.1002/alz.12893 | 2022 |
| AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models | 10.1016/j.ymthe.2022.11.002 | 2022 |
| Correction of elF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease | 10.1126/scisginal.abc5429 | 2021 |
| Dementia in Latin America: Paving the way toward a regional action plan | 10.1002/alz.12202 | 2021 |
| Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers | 10.1186/s12974-021-02099-x | 2021 |
| Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer?s disease | 10.1038/s41398-021-01349-z | 2021 |
| Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice | 10.1002/path.5674 | 2021 |
| Cerebrospinal Fluid Neurotransmitters, Cytokines, and Chemokines in Alzheimer?s and Lewy Body Diseases | 10.3233/JAD-210147 | 2021 |
| The crosstalk between brain and periphery: Implications for brain health and disease | 10.1016/j.neuropharm.2021.108728 | 2021 |
| Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α | 10.1016/j.celrep.2020.01.072 | 2020 |
| Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System | 10.1016/j.tins.2020.04.004 | 2020 |
| The effect of lumbar puncture on the neurodegeneration biomarker neurofilament light in macaque monkeys | 10.1002/dad2.12069 | 2020 |
| Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer?s disease | 10.1111/jnc.15039 | 2020 |
| Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease | 10.1016/j.neuropharm | 2020 |
| Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease | 10.1002/dad2.12034 | 2020 |
| Behavioral Abnormalities in Knockout and Humanized Tau Mice | 10.3389/fendo.2020.00124 | 2020 |
| The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response | 10.002/trc2.12092.eCollection | 2020 |
| Covid-19 in older people with cognitive impairment in Latin America | 10.1016/S1474-4422 | 2020 |
| Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer?s models | 10.1038/s41591-018-0275-4 | 2019 |
| The Link Between Tau and Insulin Signaling: Implications for Alzheimer?s Disease and Other Tauopathies | 10.3389/fncel.2019.00017 | 2019 |
| Long-term consequences of the absence of leptin signaling in early life | 10.7554/elife.40970 | 2019 |
| The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer?s Disease | 10.3389/fnins.2018.01027 | 2019 |
| Understanding the link between insulin resistance and Alzheimer?s disease: Insights from animal models | 10.1016/j.expneurol.2019.03.016 | 2019 |
| Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice | 10.1038/s41419-019-1529-x | 2019 |
| Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment | 10.3389/fnbeh.2019.00048 | 2019 |
| Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes | 10.3389/fpsyt.2019.00057 | 2019 |
| Extracellular vesicles derived from human Wharton?s jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers | 10.1186/s13287-019-1432-5 | 2019 |
| Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice | 10.1038/s41467-019-11866-7 | 2019 |
| Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants | 10.1016/j.pnpbp.2019.109720 | 2019 |
| The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease | 10.1002/path.5056 | 2018 |
| Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects | 10.3389/fnins.2018.00037 | 2018 |
| Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers | 10.1074/jbc.m117.807180 | 2018 |
| Brain STAT5 signaling modulates learning and memory formation | 10.1007/s00429-018-1627-z | 2018 |
| Acute and chronic neurological consequences of early-life Zika virus infection in mice | 10.1126/scitranslmed.aar2749 | 2018 |
| Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer?s disease-associated Aβ oligomers | 10.1016/j.jneumeth.2018.05.021 | 2018 |
| Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones? | 10.1016/j.neuropharm.2018.05.021 | 2018 |
| Metabolic Dysfunction in Alzheimer?s Disease: From Basic Neurobiology to Clinical Approaches | 10.3233/jad-179911 | 2018 |
| Metabolic Syndrome and cognitive decline in the elderly: A systematic review | 10.1371/journal.pone.0194990 | 2018 |
| Insulin Resistance in Alzheimer's Disease | 10.3389/fnins.2018.00830 | 2018 |
| Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer?s and Parkinson?s Diseases | 10.1007/s40263-018-0593-6 | 2018 |
| Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes | 10.1016/j.jpsychires.2018.10.020 | 2018 |
| Interaction of Aβ Oligomers with Neurexin 2α and Neuroligin 1 Mediates Synapse Damage and Memory Loss in Mice | 10.1074/jbc.m116.761189 | 2017 |
| Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer?s Therapy? | 10.3389/fnagi.2017.00007 | 2017 |
| Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons | 10.1074/jbc.m116.753525 | 2017 |
| Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice | 10.1016/j.bbi.2017.04.007 | 2017 |
| Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model | 10.1523/jneurosci.3351-16.2017 | 2017 |
| Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson’s disease-like symptoms in mice | 10.1016/j.bbr.2017.06.047 | 2017 |
| Impaired peripheral glucose homeostasis and Alzheimer's disease | 10.1016/j.neuropharm.2017.11.027 | 2017 |
| Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets | 10.1016/j.neuropharm.2017.11.014 | 2017 |
| Brain metabolic stress in Alzheimer's | 2017 | |
| Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers | 10.1091/mbc.e17-06-0416 | 2017 |
| Opportunities and challenges in developing relevant animal models for Alzheimer?s disease | 10.1016/j.arr.2016.01.006 | 2016 |
| Getting a ?GRiP? on hypothalamic endoplasmic reticulum stress to combat obesity | 10.2337/dbi16-0057 | 2016 |
| Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice | 10.1007/s12035-016-0307-3 | 2016 |
| Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid- Oligomers in Mice | 10.1523/jneurosci.1269-16.2016 | 2016 |
| Alzheimer-associated A oligomers impact the central nervous system to induce peripheral metabolic deregulation | 10.15252/emmm.201404183 | 2015 |
| Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease | 10.3389/fncel.2015.00191 | 2015 |
| Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer?s disease | 10.3389/fnagi.2015.00094 | 2015 |
| Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes | 10.1016/j.pneurobio.2015.03.003 | 2015 |
| A Key Role of Insulin Receptors in Memory: Figure 1 | 10.2337/dbi15-0011 | 2015 |
| How does brain insulin resistance develop in Alzheimer's disease? | 10.1016/j.jalz.2013.12.004 | 2014 |
| Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease | 10.1016/j.jalz.2013.12.010 | 2014 |
| Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease | 10.2337/db13-1954 | 2014 |
| Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via cam kinase II signaling | 10.1002/glia.22713 | 2014 |
| Alzheimer's Disease-Like Pathology Induced by Amyloid- Oligomers in Nonhuman Primates | 10.1523/jneurosci.1353-14.2014 | 2014 |
| Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice. Molecular Psychiatry, | 10.1038/mp.2012.168 | 2013 |
| Alzheimer-s disease and insulin resistance: translating basic science into clinical applications | 10.1172/JCI64595 | 2013 |
| Intranasal Insulin as a Treatment for Alzheimer¿s Disease: A Review of Basic Research and Clinical Evidence | 10.1007/s40263-013-0076-8 | 2013 |
| Memantine rescues transient cognitive impairment caused by high molecular weight Aβ oligomers but not the persistent impairment induced by low molecular weight oligomers | 10.1523/JNEUROSCI.0482-13.2013 | 2013 |
| TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer?s β-Amyloid Oligomers in Mice and Monkeys | 10.1016/j.cmet.2013.11.002 | 2013 |
| Connecting Type 2 diabetes to Alzheimer¿s disease | 10.1586/14737175.2013.864824 | 2013 |
| Amyloid-Â Oligomers Induce Differential Gene Expression in Adult Human Brain Slices | 10.1074/jbc.m111.298471 | 2012 |
| An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer?s disease-associated Aβ oligomers | 10.1172/jci57256 | 2012 |
| Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid- Oligomers | 10.1074/jbc.M110.177790 | 2011 |
| Amyloid-beta oligomers increase the localization of prion protein at the cell surface | 10.1111/j.1471-4159.2011.07225.x | 2011 |
| N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer⿿s toxic amyloid-β peptide oligomers | 10.1111/j.1471-4159.2010.07058.x | 2010 |
| Expression Profile of Rat Hippocampal Neurons Treated with the Neuroprotective Compound 2,4-Dinitrophenol: Up-Regulation of cAMP Signaling Genes | 10.1007/s12640-009-9133-y | 2010 |
| Amyloid-? Triggers the Release of Neuronal Hexokinase 1 from Mitochondria | 10.1371/journal.pone.0015230 | 2010 |
| From the Cover: Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of AÂ oligomers | 10.1073/pnas.0809158106 | 2009 |
| Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal | 10.1016/j.taap.2009.07.018 | 2009 |
| Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers | 10.1016/j.neurobiolaging.2007.02.029 | 2008 |
| Soluble oligomers from a non-disease related protein mimic Aβ-induced tau hyperphosphorylation and neurodegeneration. | 10.1111/j.1471-4159.2007.04809.x | 2007 |
| Monoclonal antibodies that target pathological assemblies of Aβ | 10.1111/j.1471-4159.2006.04157.x | 2007 |
| Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer?s disease. | 10.2174/156720507781077287 | 2007 |
| Abeta Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine | 10.1074/jbc.m607483200 | 2007 |
| Soluble protein oligomers as emerging toxins in alzheimer's and other amyloid diseases | 10.1080/15216540701283882 | 2007 |
| Amyloid beta oligomers induce impairment of neuronal insulin receptors | 10.1096/fj.06-7703com | 2007 |
| Latin American Challenges (commentary) | 10.1038/nj7167-316b | 2007 |
| Small molecule inhibitors of lysozyme amyloid aggregation | 10.1385/CBB:44:3:549 | 2006 |
| Metastable, partially folded states in the productive folding and in the misfolding and amyloid aggregation of proteins | 10.1385/CBB:44:3:539 | 2006 |
| Mitochondrial Creatine Kinase Activity Prevents Reactive Oxygen Species Generation: ANTIOXIDANT ROLE OF MITOCHONDRIAL KINASE-DEPENDENT ADP RE-CYCLING ACTIVITY | 10.1074/jbc.m604123200 | 2006 |
| Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231) | 10.1074/jbc.M605367200 | 2006 |
| Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: The gentle face of Janus | 10.1080/15216540600702198 | 2006 |
| Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance | 10.1096/fj.201701352 | 2006 |
| Stabilization of partially folded intermediates in protein folding/misfolding transitions using hydrostatic pressure | 10.1590/S0100-879X2005000800009 | 2005 |
| Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons | 10.1016/j.neuropharm.2005.06.015 | 2005 |
| Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure | 10.1096/fj.03-1072fje | 2004 |
| Targeting the neurotoxic species in Alzheimer's disease: inhibitors of AÂ oligomerization | 10.1096/fj.04-1764com | 2004 |
| Mitochondrial bound hexokinase activity as a preventive antioxidant defense: Steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria. | 10.1074/jbc.M403835200 | 2004 |
| Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease | 2002 | |
| Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's | 10.1023/A:1021832302524 | 2002 |
| Inhibition of Alzheimer's disease b-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy | 10.1096/fj.00-0676fje | 2001 |
| Protein dynamics, folding and misfolding: From basic physical chemistry to human conformational diseases. | 10.1016/S0014-5793(01)02491-7 | 2001 |
| Inibidores da amiloidogênese e modulação da transmissão glutamatérgica como estratégias terapêuticas na doença de Alzheimer. | 2001 | |
| Selective glycosylation increases the structural stability of vicilin, the 7S storage globulin from pea seeds | 10.1006/abbi.2000.2024 | 2000 |
| Subunit dissociation and inactivation of pyruvate kinase by hydrostatic pressure: oxidation of sulfhydryl groups and ligand effects on enzyme stability | 10.1046/j.1432-1327.1999.00840.x | 1999 |
Eventos:
(0.00% eventos com DOI)