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human breast phosphate nitric oxide lithium estresse saccharomyces cerevisiae membrane atpase kidney proximal atpase clinical isolate fluconazole erythrocyte enzyme avaliacao characterization isoetes levedura saccharomyces radicular multidrug resistance skeletal muscle phosphofructo kinase plantulas milho mamoeiro resposta plasma membrane proximal tubule hydrostatic pressure phosphofructokinase inhibition renal