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estudo tomatine novel candida albicans cancer parasite role growth inhibitor proteinase trypanosoma cruzi squalene synthase glycosylation activating factor glcnacylation multidrug resistance deteccao herpetomonas samuelpessoai vitro linked metabolism compound extracellular ultrastructure trypanosoma tomatidine trypanosomatid characterization fluconazole pseudallescheria boydii