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respiratory distress mesenchymal stromal bone marrow alveolar concentration microcirculatory derived mononuclear acute obesity prefrontal subjects mechanical ventilation stromal cell minimum alveolar repetitive bupivacaina dysfunction propofol dexmedetomidine distress syndrome magnetic mecanica anesthesia neonatal transcranial lesao pulmonar intravenous allergic asthma interactions mechanics cortex immunomodulatory