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vitro tcrho phosphatase activity herpetomonas samuelpessoai inhibitor trichomonas vaginalis cruzi epimastigote mineral host cell promastigote ecto atpase characterization trypanosomatid fonsecaea pedrosoi reservosome platelet activating characterization ecto atividade sterol biosynthesis estudo gene rato magnetosome uncultured magnetotactic cryptococcus neoformans possible role ultrastructural expression endocytosis anti