Cristian Follmer

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências Matemáticas e da Natureza

Unidade:

Instituto de Química

Departamento:

Departamento de Físico-Química/IQ

ORCID:

https://orcid.org/0000-0001-6178-0432


Formação:

  • Weill Cornell Medical College - Cornell University

    | Pós-Doutorado | 2014 - 2015

  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2004 - 2006

  • Universidade Federal do Rio Grande do Sul

    Biologia Celular e Molecular | Doutorado | 2001 - 2004

  • Universidade Federal do Rio Grande do Sul

    Biologia Celular e Molecular | Mestrado | 1999 - 2001

  • Universidade Federal do Rio Grande do Sul

    Química | Graduação | 1995 - 1998
Laboratórios:
Nuvens de Palavras:
Artigos:

(97.67% artigos com DOI)

Titulo DOI Ano
Fibrillation of α-synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N-terminal acetylation and familial Parkinson's disease mutations 10.1111/febs.17027 2024
Alpha-synuclein in Parkinson's disease: a villain or tragic hero? A critical view of the formation of α-synuclein aggregates induced by dopamine metabolites and viral infection 10.1080/14737175.2023.2196014 2023
Nanomicelles of taurine inhibit the fibrillation and toxicity of amyloid β1-42 peptide 10.1016/j.jddst.2023.104721 2023
Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis 10.1016/j.bbadis.2023.166835 2023
Could the Urease of the Gut Bacterium Proteus mirabilis Play a Role in the Altered Gut-Brain Talk Associated with Parkinson?s Disease? 10.3390/microorganisms11082042 2023
The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers 10.1002/1873-3468.14263 2022
The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking 10.3390/biom12121816 2022
In Vitro Protective Action of Monomeric and Fibrillar α-Synuclein on Neuronal Cells Exposed to the Dopaminergic Toxins Salsolinol and DOPAL 10.1021/acschemneuro.0c00527 2020
Viral Infection-Induced Gut Dysbiosis, Neuroinflammation, and α-Synuclein Aggregation: Updates and Perspectives on COVID-19 and Neurodegenerative Disorders 10.1021/acschemneuro.0c00671 2020
Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID -19 on Parkinson's Disease 10.1002/mds.28231 2020
Role of Parkinson?s Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde 10.1021/acschemneuro.8b00498 2019
Formation of large oligomers of DOPAL-modified α-synuclein is modulated by the oxidation of methionine residues located at C-terminal domain 10.1016/j.bbrc.2018.12.128 2019
In vitro neurotoxicity of salsolinol is attenuated by the presynaptic protein α-synuclein 10.1016/j.bbagen.2018.08.022 2018
Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein 10.1016/j.bbrc.2018.09.111 2018
Conjugation with polyamines enhances the antitumor activity of naphthoquinones against human glioblastoma cells 10.1097/cad.0000000000000619 2018
A medical approach to the monoamine oxidase inhibition by using 7H-benzo[e]perimidin-7-one derivatives 10.2174/1568026616666160824120929 2016
Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro 10.1016/j.neuro.2014.11.006 2015
Oligomerization and Membrane-Binding Properties of Covalent Adducts Formed by the Interaction of Alpha-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL) 10.1074/jbc.m115.686584 2015
UV-induced selective oxidation of Met5 to Met-sulfoxide leads to the formation of neurotoxic fibril-incompetent α-synuclein oligomers 10.3109/13506129.2014.912208 2014
Monoamine oxidase and α-synuclein as targets in Parkinson¿s disease therapy 10.1586/14737175.2014.920235 2014
Structure-function studies on jaburetox, a recombinant insecticidal peptide derived from jack bean (Canavalia ensiformis) urease 10.1016/j.bbagen.2013.11.010 2014
Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity 10.1016/j.bmcl.2014.04.072 2014
Beyond Topoisomerase Inhibition: Antitumor 1,4-Naphthoquinones as Potential Inhibitors of Human Monoamine Oxidase 10.1111/cbdd.12255 2014
Fármacos multifuncionais: monoamina oxidase e α-sinucleína como alvos terapêuticos na doença de Parkinson 10.1590/S0100-40422013000200017 2013
Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein 10.1016/j.neuint.2012.10.001 2013
Catalytic properties of lipases immobilized onto ultrasound-treated chitosan supports 10.1007/s12257-013-0285-5 2013
α-Synuclein as an intrinsically disordered monomer: fact or artifact? 10.1111/febs.12471 2013
Echinococcus granulosus Antigen B Structure: Subunit Composition and Oligomeric States 10.1371/journal.pntd.0001551 2012
The Anti-Parkinsonian Drug Selegiline Delays the Nucleation Phase of ?-Synuclein Aggregation Leading to the Formation of Nontoxic Species 10.1016/j.jmb.2010.10.027 2011
Measuring the Strength of Interaction between the Ebola Fusion Peptide and Lipid Rafts: Implications for Membrane Fusion and Virus Infection 10.1371/journal.pone.0015756 2011
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: Evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO 10.1016/j.bmc.2011.10.049 2011
Ureases as a target for the treatment of gastric and urinary infections 10.1136/jcp.2009.072595 2010
Membrane-disruptive properties of the bioinsecticide Jaburetox-2Ec: Implications to the mechanism of the action of insecticidal peptides derived from ureases. 10.1016/j.bbapap.2009.09.001 2009
Insights into the role and structure of plant ureases. 10.1016/j.phytochem.2007.06.034 2008
Dopamine Affects the Stability, Hydration, and Packing of Protofibrils and Fibrils of the Wild Type and Variants of ?-Synuclein 10.1021/bi061871+ 2007
Germa-gamma-lactones as novel inhibitors of bacterial urease activity 10.1016/j.bbrc.2007.02.158 2007
Cysteine Based Novel Noncompetitive Inhibitors of Urease(s) - Distinctive inhibition susceptibility of microbial and plant ureases 10.1016/j.bmc.2006.05.078 2006
Effect of chemical modification of histidines on the copper-induced oligomerization of jack bean urease (EC 3.5.1.5). 10.1016/j.abb.2004.12.001 2005
Jackbean, soybean and B. pasteurii ureases: biological effects unrelated to ureolytic activity 10.1111/j.1432-1033.2004.04046.x 2004
Separation of jack bean (Canavalia ensiformis) urease isoforms by immobilized metal affinity chromatography and characterization of insecticidal properties unrelated to ureolytic activity 10.1016/j.plantsci.2004.03.019 2004
Jack bean urease (EC 3.5.1.5) aggregation monitored by dynamic and static light scattering. 10.1016/j.bpc.2004.03.009 2004
PIXE analysis of urease isoenzymes isolated from Canavalia ensiformis (jack bean) seeds 10.1016/s0168-583x(01)01128-4 2002
Canatoxin, a toxic protein from jack beans (Canavalia ensiformis), is a variant form of urease (EC 3.5.1.5): biological effets of urease independent of its ureolytic activity 2001
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
The expression of Cellular Prion Protein (PrPC) increases Parkinson's Disease neurodegeneration in mice 2024
The role of CCL21-CCR7 during neuron-microglia interaction in Parkinson`s Disease 2023
Intrastriatal injection of 1.4-dihydroxyphenylacetaldehyde (DOPAL) induces motor and non-motor Parkinson-like deficit in mice 2022
Neurotoxicity of the dopamine metabolite salsolinol is attenuated by protein α-synuclein in vitro 2019
Exploring the effect of familial Parkinson's disease mutations on the oligomerization of α-synuclein induced by 3,4-dihydroxyphenylacetaldehyde (DOPAL). 2019
N-terminal acetylation of alpha-synuclein affects the thermodynamic stability of fibrils and favors phospholipid membrane-induced fibrillation 2019
Molecular and cellular features of the interaction between alpha-synuclein and salsolinol in Parkinson ́s disease 2018
O papel dos astrócitos no modelo de Doença de Parkinson induzida por DOPAL (3,4- diidroxifenilacetaldeído) 2017
Análise da expressão de CCL21 em neurônios dopaminérgicos tratados com 3,4 dihidroxifenilacetaldeino (DOPAL) ? modelo da doenca de Parkinson in vitro 2017
Interação neurônio-microglia no contexto da doença de Parkinson: o papel da citocina CCL21 2017
The dangerous encounter between the toxic dopamine metabolite DOPAL and the presynaptic protein alpha-synuclein in Parkinson´s disease 2017
Selegilina e rasagilina como drogas multifuncionais para a doença de Parkinson 2016
Efeitos neuroprotetores das células gliais na doença de Parkinson 2016
Análise da expressão de CCL21 em neurônios dopaminérgicos tratados com alfa-sinucleína. 2016
Interactions of Monoamine Oxidases A and B with neurotransmitters and 1,4-naphthoquinones ligands by Docking and Molecular Dynamics Simulations 2014
Oligomerization but not Fibrillization of Alpha-Synuclein is Induced by Exposure to UV-Radiation 2013
A Critical View of the Oligomeric State of Alpha-Synuclein, a Protein Linked to Parkinson´s Disease Pathogenesis. 2013
Unveiling the role of the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) on alpha-synuclein aggregation, a hallmark of Parkinson´s disease 2013
Membrane-disturbing Properties of Urease and Derived Recombinant Peptides 2012
Ação Antitumoral de Poliaminas Conjugadas a 1,4-naftoquinonaem Glioblastomas Multiforme 2012
Modulação cinética e estrutural da formação de fibras de alfa-sinucleína pelas toxinas agrícolas: paraquat e rotenona 2012
Propriedades catalíticas de lipases imobilizadas em partículas de quitosana 2012
Busca de Fármacos Multifuncionais para a Doença de Parkinson: Modulação da Formação de Fibras e Protofibras de Alfa-Sinucleína por 2012
Efeito de derivados naturais de 1,4-naftoquinonas na atividade de monoamino oxidase 2011
Modulação da formação de fibras de alfa-sinucleína: efeito de derivados de 1,4-naftoquinona 2011
Interação da MAO-A e MAO-B com menadiona e 1,4-naftoquinona via Docking e Dinâmica Molecular 2011
Propriedades Físico-Químicas de Lipases Imobilizadas em Particulas de Quitosana 2011
Desenvolvimento de Fármacos Multifuncionais para a Doença de Parkinson 2011
Propriedades Físico-Químicas de Lipases Imobilizadas em Partículas de Quitosana 2011
Ação antitumoral de Poliaminas conjugadas a 1,4-naftoquinona em Glioblastomas 2011
Structural Analysis of Echinococcus granulosus Antigen B Oligomers and High-Molecular-Weight Aggregates 2009
The anti-parkinsonian drug selegeline (R(-)-deprenyl) interacts with a-synuclein and inhibits its nucleation phase of aggregation. 2009
Characterization of Interaction between Ebola Fusion Peptide and Lipid Membranes 2008
The anti-parkinsonian drug selegeline (R(-)-deprenyl) inhibs the nucleation phase of a-synuclein aggregation 2008
Modelagem molecular do peptídeo inseticida Jaburetox. 2008
Selegilina ((R-) deprenyl), um composto anti-parkinsoniano, que inibe a agregação in vitro da proteína alfa-sinucleína, envolvida na Doença Parkinson, através do alongamento da fase de nucleação. 2008
Dissociação por pressão hidrostática revela diferenças na estabilidade de agregados de alfa-sinucleina: implicações na doença de Parkinson 2007
Effect of selegiline on the in vitro aggregation of A30P alpha-synuclein:new perspectives in the Parkinson´s therapy 2007
Dopamine affects the stability, hydration and packing of protofibrils and fibrils of wild-type and variants of synuclein 2006
Chemical modification of jack bean urease promoting differences in its biological activities 2006
Parkinson´s disease neuropathogenesis: high hydrostatic pressure reveals that dopamine stabilizes the intermediate of the synuclein´s mutants 2005
The Dark Side of Protein Folding 2005
Urease Isoforms from Jack beans (Canavalia ensiformis): separation by immobilized metal affinity and characterization of insecticidal properties unrelated to ureolytic activity 2003
Study of Jack bean urease association by light scattering spectroscopy: effect of buffers, reducing agents and freeze-thawing cycles on protein oligomerization 2003
Trisialogangliosides GT1b binding to Canavalia ensiformis ureases: development of pressue-assisted frontal analysis capillary electrophoresis method 2003
Aspectos físico-químicos e biológicos de ureases vegetais 2003
Study of jack bean urease by light scattering spectroscopy - effect of buffers, reducing agents and freeze-thawing cycles on protein oligomerization 2003
Insecticidal properties of jack bean urease isoenzymes 2002
Physicochemical characterization of canatoxin - an urease isoform from jack beans (Canavalia ensiformis) 2001
Canatoxin and urease as a novel group of multifuncional proteins with insecticidal properties 2001
Physicochemical characterization of canatoxin - an isoform from jack beans urease (EC 3.5.1.5) 2001
Urease family in Canavalia ensifromis seeds : immobilized metal affinity chromatography (IDA-Co+2), toxicity assay and metal determination by particle induced ray-X emission 2000
Partial sequence determination of Canatoxin (CNTX) - an insecticidal protein isolated from Canavalia ensiformis 1999
Solubilização de Mercúrio por Ácidos Húmicos e Ânions Orgânicos 1997
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