Rafael Linden
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Biofísica Carlos Chagas Filho
Departamento:
Programa de Biofísica/I Biof
e-mail:
rlinden@biof.ufrj.br
Linkedin:
Google Scholar:
ORCID:
https://orcid.org/0000-0003-3287-336X
Formação:
-
Universidade de Oxford
| Pós-Doutorado | 1980 - 1982
-
Universidade Federal do Rio de Janeiro
Ciências Biológicas Biofísica | Especialização | 1976 - 1976
-
Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Doutorado | 1976 - 1979
-
Universidade Federal do Rio de Janeiro
Medicina | Graduação | 1970 - 1975
Laboratórios:
Nuvens de Palavras:
Artigos:
(50.57% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| rAAV-compatible human mini promoters enhance transgene expression in rat retinal ganglion cells | 10.1016/j.exer.2023.109758 | 2024 |
| HTLV-1 p12 modulates the levels of prion protein (PrPC) in CD4+ T cells | 10.3389/fmicb.2023.1175679 | 2023 |
| Novel approaches to glaucomatous neurodegeneration, based on the integrated stress response | 10.1016/j.omtn.2023.08.022 | 2023 |
| Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents | 10.3791/63442 | 2022 |
| Editorial: Multimorbidity in the context of neurodegenerative disorders | 10.3389/fnins.2022.1076486 | 2022 |
| Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration | 10.1167/iovs.63.2.5 | 2022 |
| Gene Therapy Strategies for Glaucomatous Neurodegeneration | 10.2174/1566523221666210126152000 | 2021 |
| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) | 10.1080/15548627.2020.1797280 | 2021 |
| Retinal Genomic Fabric Remodeling after Optic Nerve Injury | 10.3390/ genes12030403 | 2021 |
| Cell proliferation in the central nervous system of an adult semiterrestrial crab | 10.1007/s00441-021-03413-y | 2021 |
| Dissociation of genotype-dependent cognitive and motor behavior in a strain of aging mice devoid of the prion protein | 10.1016/j.bbr.2021.113386 | 2021 |
| Mitotherapy: Unraveling a Promising Treatment for Disorders of the Central Nervous System and Other Systemic Conditions | 10.3390/cells10071827 | 2021 |
| Roles of glutamate receptors in a novel in vitro model of early, comorbid cerebrovascular, and Alzheimer?s diseases | 10.1111/jnc.15129 | 2021 |
| Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina | 10.1016/j.bbadis.2020.165686 | 2020 |
| Rapid plasticity of intact axons following a lesion to the visual pathways during early brain development is triggered by microglial activation | 10.1016/j.expneurol.2018.10.002 | 2019 |
| De novo genesis of retinal ganglion cells by targeted expression of Klf4 in vivo | 10.1242/dev.176586 | 2019 |
| A subacute model of glaucoma based on limbal plexus cautery in pigmented rats | 10.1038/s41598-019-52500-2 | 2019 |
| Substrain-related dependence of Cu(I)-ATPase activity among prion protein-null mice | 10.1016/j.brainres.2019.146550 | 2019 |
| Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat | 10.1038/s41434-019-0100-9 | 2019 |
| Evidence of Müller Glia Conversion Into Retina Ganglion Cells Using Neurogenin2 | 10.3389/fncel.2018.00410 | 2018 |
| The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules | 10.3389/fnmol.2017.00077 | 2017 |
| Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | 10.1080/15548627.2015.1100356 | 2016 |
| Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean | 10.1016/j.aquatox.2015.12.025 | 2016 |
| A roadmap for investigating the role of the prion protein in depression associated with neurodegenerative disease | 10.1080/19336896.2016.1152437 | 2016 |
| The prion protein selectively binds to and modulates the content of purinergic receptor P2X4R | 10.1016/j.bbrc.2016.02.122 | 2016 |
| rAAV8-733-Mediated Gene Transfer of CHIP/Stub-1 Prevents Hippocampal Neuronal Death in Experimental Brain Ischemia | 10.1016/j.ymthe.2016.11.017 | 2016 |
| CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system | 10.3389/fncel.2014.00438 | 2015 |
| Antioxidant activity stimulated by ultraviolet radiation in the nervous system of a crustacean | 10.1016/j.aquatox.2015.01.008 | 2015 |
| Activation and function of murine primary microglia in the absence of the prion protein | 10.1016/j.jneuroim.2015.07.002 | 2015 |
| Prion protein modulates monoaminergic systems and depressive-like behavior in mice | 10.1074/jbc.m115.666156 | 2015 |
| A snapshot of gene therapy in Latin America | 10.1590/s1415-47572014000200015 | 2014 |
| Pleiotropic Functions of Pituitary Adenylyl Cyclase-Activating Polypeptide on Retinal Ontogenesis: Involvement of KLF4 in the Control of Progenitor Cell Proliferation | 10.1007/s12031-014-0299-2 | 2014 |
| The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles | 10.1007/s00018-013-1328-y | 2013 |
| Advances in Recombinant Adeno-Associated Viral Vectors for Gene Delivery | 10.2174/15665232113136660028 | 2013 |
| Advances in gene therapy technologies to treat retinitis pigmentosa | 10.2147/opth.s38041 | 2013 |
| Allosteric function and dysfunction of the prion protein | 10.1007/s00018-011-0847-7 | 2012 |
| Activation of c-Jun N-Terminal Kinase (JNK) during Mitosis in Retinal Progenitor Cells | 10.1371/journal.pone.0034483 | 2012 |
| Guidelines for the use and interpretation of assays for monitoring autophagy | 10.4161/auto.19496 | 2012 |
| Neuroimmunoendocrine Regulation of the Prion Protein in Neutrophils | 10.1074/jbc.m112.394924 | 2012 |
| Evidence for a role of calcineurin in the development of retinocollicular fine topography? | 10.1016/j.neulet.2010.09.071 | 2011 |
| Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin 1 chain | 10.1096/fj.10-161653 | 2011 |
| Platelet Activating Factor Blocks Interkinetic Nuclear Migration in Retinal Progenitors through an Arrest of the Cell Cycle at the S/G2 Transition | 10.1371/journal.pone.0016058 | 2011 |
| Early c-Jun N-terminal kinase-dependent phosphorylation of activating transcription factor-2 is associated with degeneration of retinal ganglion cells | 10.1016/j.neuroscience.2011.01.059 | 2011 |
| Protein kinases JAK and ERK mediate protective effect of interleukin-2 upon ganglion cells of the developing rat retina | 10.1016/j.jneuroim.2010.12.008 | 2011 |
| Paracrine Interaction between Bone Marrow-derived Stem Cells and Renal Epithelial Cells | 10.1159/000331739 | 2011 |
| Prion Protein: Orchestrating Neurotrophic Activities | 10.21775/cimb.012.063 | 2010 |
| ATP controls cell cycle and induces proliferation in the mouse developing retina | 10.1016/j.ijdevneu.2009.09.004 | 2010 |
| Pituitary adenylyl cyclase-activating polypeptide controls the proliferation of retinal progenitor cells through downregulation of cyclin D1 | 10.1111/j.1460-9568.2010.07286.x | 2010 |
| Caspase dependence of the death of neonatal retinal ganglion cells induced by axon damage and induction of autophagy as a survival mechanism | 10.1590/S0100-879X2010007500082 | 2010 |
| Terapia gênica:o que é, o que não é e o que será | 2010 | |
| Rod photoreceptor cell death is induced by okadaic acid through activation of PKC and L-type voltage-dependent Ca2+ channels and prevented by IGF-1 | 10.1016/j.neuint.2010.04.021 | 2010 |
| Interleukin-4 blocks thapsigargin-induced cell death in rat rod photoreceptors: Involvement of cAMP/PKA pathway | 10.1002/jnr.22026 | 2009 |
| Prion protein | 10.1038/mp.a003935.01 | 2009 |
| Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1 | 10.1096/fj.09-138974 | 2009 |
| Does the use of recombinant AAV5 in pulmonary gene therapy lead to lung damage? | 10.1016/j.resp.2009.06.016 | 2009 |
| Physiology of the prion protein | 10.1152/physrev.00007.2007 | 2008 |
| Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function? | 10.1016/j.resp.2007.09.002 | 2008 |
| DNA Damage Induced Cell Death: Lessons from the Central Nervous System | 10.1038/cr.2007.110 | 2008 |
| A role for CK2 upon interkinetic nuclear migration in the cell cycle of retinal progenitor cells | 10.1002/dneu.20613 | 2008 |
| Interleukin-4 blocks proliferation of retinal progenitor cells and increases rod photoreceptor differentiation through distinct signaling pathways | 10.1016/j.jneuroim.2008.03.003 | 2008 |
| Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1 | 10.1523/JNEUROSCI.1701-08.2008 | 2008 |
| Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage. | 10.1016/j.expneurol.2008.06.001 | 2008 |
| Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol | 10.1007/s00005-008-0027-0 | 2008 |
| A conserved domain of the gp85/trans-sialidase family activates host cell extracellular signal-regulated kinase and facilitates Trypanosoma cruzi infection. | 10.1016/j.yexcr.2006.10.008 | 2007 |
| Antifungal Pisum sativum Defensin 1 Interacts with Neurospora crassa Cyclin F Related to the Cell Cycle | 10.1021/bi061441j | 2007 |
| Signaling induced by hop/STI-1 depends on endocytosis | 10.1016/j.bbrc.2007.04.202 | 2007 |
| Hop/STI1 modulates retinal proliferation and cell death independent of PrPc | 10.1016/j.bbrc.2007.07.038 | 2007 |
| Development of a ligand blot assay using biotinylated live cells | 10.1177/1087057107307146 | 2007 |
| STI1 promotes glioma proliferation through MAPK and PI3K pathways | 10.1002/glia.20579 | 2007 |
| Detecção imunohistoquímica de células apoptóticas em glioblastoma recidivante de paciente tratado com álcool perílico por via inalatória. | 2007 | |
| Estudo exploratório da administração intranasal do monoterpeno álcool perílico em pacientes com glioma recidivante | 2007 | |
| Apoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia | 10.1007/s10495-006-3560-5 | 2006 |
| Requirement of p38 stress-activated MAP kinase for cell death in the developing retina depends on the stage of cell differentiation | 10.1016/j.neuint.2006.03.011 | 2006 |
| Glutamate Regulates Retinal Progenitor Cell Proliferation During Development | 10.1111/j.1460-9568.2006.04966.x | 2006 |
| Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B-92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways. | 10.1016/j.brainresbull.2006.08.014 | 2006 |
| Modulation of the expression of the transcription factor Max in rat retinal ganglion cells, using a recombinant adeno-associated viral vector | 10.1590/S0100-879X2005000300008 | 2005 |
| Control of programmed cell death by neurotransmitters and neuropeptides in the developing mammalian retina | 10.1016/j.preteyeres.2004.10.001 | 2005 |
| The cellular prion protein modulates phagocytosis and inflammatory response | 10.1189/jlb.1103531 | 2005 |
| The surfer wears a suit: A report on the II Symposium on Creativity, Imagination and Interactivity in Science Education | 10.1590/S0100-879X2005000300001 | 2005 |
| Phagocytosis of apoptotic cells: A matter of balance | 10.1007/s00018-005-4511-y | 2005 |
| Rapid and Long-Term Plasticity in the Neonatal and Adult Retinotectal Pathways Following a Retinal Lesion | 10.1016/j.brainresbull.2005.04.005 | 2005 |
| NMDA receptor activation modulates programmed cell death during early postnatal retinal development: A BDNF-dependent mechanism | 10.1111/j.1471-4159.2005.03360.x | 2005 |
| Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound | 10.1096/fj.05-3812com | 2005 |
| Interaction of cellular prion and stress inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways | 10.1523/JNEUROSCI.2313-05.2005 | 2005 |
| Early nuclear exclusion of the transcription factor Max is associated with retinal ganglion cell death independent of caspase activity | 10.1002/jcp.10404 | 2004 |
| PrPc on the road: trafficking of the cellular prion protein | 10.1046/j.1471-4159.2003.02199.x | 2004 |
| Radiation-Induced Apoptosis in Developing Mouse Retina Exhibits Dose-Dependent Requirement for ATM Phosphorylation of p53 | 10.1038/sj.cdd.4401366 | 2004 |
| Programmed cell deaths: Apoptosis and alternative deathstyles | 10.1111/j.1432-1033.2004.04084.x | 2004 |
| Biosynthesis and metabolism of sulfated glycosaminoglycans during Drosophila melanogaster development | 10.1093/glycob/cwh070 | 2004 |
| Selective involvement of the PI3K/PKB/Bad pathway in retinal cell death | 2003 | |
| Major glycosaminoglycan species in the developing retina: synthesis, tissue distribution and effects upon cell death | 2003 | |
| Changing sensitivity to cell death during development of retinal photoreceptors | 10.1002/jnr.10739 | 2003 |
| Hydrogen peroxide induces caspase activation and programmed cell death in the amitochondrial Tritrichomonas foetus | 2003 | |
| Towards cellular receptors for prions | 2003 | |
| Gap Junctions Mediate Bystander Cell Death in Developing Retina | 2003 | |
| Alternative Programs of Cell Death in Developing Retinal Tissue | 10.1074/jbc.M306547200 | 2003 |
| Herbimycin A induces sympathetic neuron survival and protects against hypoxia | 2003 | |
| Doenças por prions | 2003 | |
| Sympathetic neuronal survival induced by retinal trophic factor | 2002 | |
| Cellular prion protein: on the road for functions | 2002 | |
| Differential effects of cyclin-dependent kinase blockers upon cell death in the developing retina | 2002 | |
| Activation of p38 stress-activated kinase during normal mitosis in the developing retina. | 2002 | |
| Pituitary adenylyl cyclase-activating polypeptide prevents induced cell death in retinal tissue through activation of cyclic AMP-dependent protein kinase | 2002 | |
| Apoptosis underlies immunopathogenic mechanisms in acute silicosis | 2002 | |
| Cellular prion protein transduces neuroprotective signals. | 2002 | |
| The stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. | 2002 | |
| Cell death in the inner nuclear layer of the retina is modulated by BDNF | 2002 | |
| Cytoplasmic c-Jun N-terminal immunoreactivity: A hallmark of retinal apoptosis | 2002 | |
| Structure of Laminin Substrate Modulates Cellular Signaling for Neuritogenesis. | 2002 | |
| O triunfo de um verme | 2002 | |
| Effects of prenatal ionizing irradiation on the development of the ganglion cell layer of the mouse retina | 2001 | |
| Depletion of cortical target induced by prenatal ionizing irradiation: Effects on the lateral geniculate nucleus and on the retinofugal pathways | 2001 | |
| Paracrine neuroprotective effect of nitric oxide in the developing retina | 2001 | |
| Differentiation-dependent sensitivity to cell death induced in the developing retina by inhibitors of the ubiquitin-proteasome proteolytic pathway | 2001 | |
| Fas Ligand triggers pulmonay sillicosis | 2001 | |
| The anti-death league: Associative control of apoptosis in developing retinal tissue | 2000 | |
| Evidence that the bifunctional redox factor/AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina. | 2000 | |
| Chloramphenicol induces apoptosis in the developing brain | 2000 | |
| Laminin Modulates Neuritogenesis of Developing Rat Retinal Ganglion Cells through a PKC-Dependent Pathway. | 2000 | |
| Tissue biology of apoptosis: Ref-1 and cell differentiation in the developing retina | 2000 | |
| Fundamentos da comunicação entre células nervosas | 2000 | |
| Apoptosis in developing retinal tissue | 1999 | |
| Neurotrophins selectively modulate neurite outgrowth and pattern in developing retinal ganglion cells. | 1999 | |
| Activation of NMDA receptors protects against glutamate neurotroxicity in the retina: Evidence for the involvement of neurotrophins. | 1999 | |
| Evidence for an antiapoptotic role of dopamine in developing retinal tissue | 1999 | |
| Nuclear exclusion of transcription factors in retinal apoptosis | 1999 | |
| Selective sensitivity of early post-mitotic retinal cells to apoptosis induced by inhibition of protein synthesis | 1999 | |
| Gamma irradiation leads to two waves of apoptosis in distinct cell populations of the retina of newborn rats | 1999 | |
| Modulation of apoptosis in retinal tissue in vitro | 1999 | |
| Developmentally regulated release of intraretinal neurotrophic factors in vitro. | 1997 | |
| Protein kinases selectively modulate apoptosis in the developing retina in vitro | 1997 | |
| Contrasting effects of protein synthesis inhibition and of cyclic AMP on apoptosis in the developing retina | 1996 | |
| Target and afferents interact to control developmental cell death in the mesencephalic parabigeminal nucleus of the rat | 1996 | |
| Death in a dish: controls of apoptosis within the developing retinal tissue. | 1996 | |
| Apoptosis in the developing retina: Paradoxical effects of protein synthesis inhibition | 1994 | |
| Development of abnormal lamination and binocular segregation in the retinotectal pathways of the rat | 1994 | |
| Expression of alpha-1 integrin subunit in the mammalian retina | 1994 | |
| The survival of developing neurons: a review of afferent control | 1994 | |
| Dendritic competition in the developing retina: ganglion cell density gradients and laterally displaced dendrites | 1993 | |
| Neuron death and the neurotrophic theory - some open issues | 1993 | |
| Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro | 1993 | |
| Intraretinal neurotrophic activity prevents the degeneration of ganglion cells in retinal explants | 1993 | |
| Neuritogenesis of retinal ganglion cells is differentially promoted bytarget extract in vitro | 1993 | |
| Fatorres Neurotróficos: Moléculas de vida para células nervosas | 1993 | |
| Evidence for a developmentally regulated neurotrophic activity from chick retina affecting the survival of retinal ganglion cells from newborn rats | 1992 | |
| Evidence that the relative densities of afferents from both eyes control laminar organization and binocular segregation of retinotectalafferents in rats | 1991 | |
| Axon orientation and axo-dedritic polarity of retinal ganglion cells during postnatal development in the rat | 1991 | |
| Transplante de relógio biológico | 1991 | |
| The pearl mutation accelerates the schedule of cell death in the earlypostnatal retina | 1990 | |
| Control of neuronal survival by anomalous targets in the developing brain | 1990 | |
| Cell death and interocular interactions among retinofugal axons: lack of binocularly matched specificity | 1990 | |
| Interactive effects of deafferentation and target removal on cell death in the parabigeminal nucleus of developing rats | 1990 | |
| Development of abnormal lamination and binocular segregation of retinal afferents onto the rat superior colliculus | 1990 | |
| Survival of retinal ganglion cells in vitro: the effect of conditionedmedium from retinal cell aggregates | 1990 | |
| Afferent control of neuronal survival in the developing brain | 1988 | |
| Dual control by targets and afferents of developmental neuronal death in the mammalian central nervous system: a study in the parabigeminal nucleus of the rat | 1987 | |
| Displaced amacrine cells in the ganglion cell layer of the hamster retina | 1987 | |
| Displaced ganglion cells in the retina of the rat | 1987 | |
| Mononuclear phagocytes in the retinal of developing rats | 1986 | |
| Developmental genetics of the retina: evidence that the pearl mutationin the mouse affects the time course of natural neuronal death in the ganglion cell layer | 1985 | |
| Transient populations of presumptive macrophages in the developing hamster brain, as indicated by endocytosis of blood-borne horseradish peroxidase | 1985 | |
| Evidence for differential effects of terminal and dendritic competition upon developmental neuronal death in the retina | 1985 | |
| Observations on postnatal neurogenesis in the superior colliculus and the pretectum in the opossum | 1984 | |
| Organization of the visual thalamus: corticothalamic connections from the primary visual area in the opossum | 1983 | |
| Retrograde and anterograde transneuronal degeneration in the parabigeminal nucleus following tectal lesions in developing rats | 1983 | |
| Masive retinotectal projections in rats | 1983 | |
| Tectal ablation at different ages in developing rats has different effects on retinal ganglion cell density but not on visual acuity | 1983 | |
| Postnatal changes in retinal ganglion cell density and optic axon populations in the pigmented rat | 1983 | |
| Neurogênese: morte e vida de neurônios jovens | 1983 | |
| Ganglion cell death within the developing retina: a regulatory role for retinal dendrites? | 1982 | |
| Evidence for dendritic competition in the developing retina | 1982 | |
| The pretectal complex of the opossum: projections from the striate cortex and correlation with retinal terminal fields | 1981 | |
| Receptive field properties of single units in the opossum striate cortex | 1976 | |
| Receptive fields in the visual cortex of the opossum | 1973 |
Eventos:
Nenhum evento cadastrado