Leonardo Freire-de-Lima
Instituição:
Universidade Federal do Rio de Janeiro
Centro:
Centro de Ciências da Saúde
Unidade:
Instituto de Biofísica Carlos Chagas Filho
Departamento:
Programa de Biologia Celular e Parasitária/Biof
Formação:
-
University of Washington, Pacific Northwest Research Institute
| Pós-Doutorado | 2014 - 2014
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2013 - 2014
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Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2012 - 2013
-
Pacific Northwest Diabetes Research Institute
Glycobiology of Cancer | Especialização | 2011 - 2011
-
Universidade Federal do Rio de Janeiro
| Pós-Doutorado | 2010 - 2012
-
University of Washington
| Pós-Doutorado | 2008 - 2010
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National Jewish Medical and Reseach Center.
Cellular and Molecular Immunology | Especialização | 2004 - 2004
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Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Doutorado | 2004 - 2008
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Universidade Federal do Rio de Janeiro
Ciências Biológicas (Biofísica) | Mestrado | 2002 - 2004
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Universidade do Grande Rio
Ciências Biológicas | Graduação | 1999 - 2002
Laboratórios:
Nuvens de Palavras:
Artigos:
(97.33% artigos com DOI)
| Titulo | DOI | Ano |
|---|---|---|
| Inhibition of Microbicidal Activity of Canine Macrophages DH82 Cell Line by Capsular Polysaccharides from Cryptococcus neoformans | 10.3390/jof10050339 | 2024 |
| Seasoning to Kill: the Example of the Natural Amide Piperine and Its Potential in the Design of New Antiparasitic Drugs | 10.21577/0103-5053.20240085 | 2024 |
| A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants | 10.3390/microorganisms12040720 | 2024 |
| Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages | 10.1007/s12026-022-09321-9 | 2023 |
| The Blessed Union of Glycobiology and Immunology: A Marriage That Worked | 10.3390/medicines10020015 | 2023 |
| Editorial: Drug-resistance in cancer cells: A new wine in an old bottle | 10.3389/fonc.2023.1161008 | 2023 |
| Non-self glycan structures as possible modulators of cancer progression: would polysaccharides from Cryptococcus spp. impact this phenomenon? | 10.1007/s42770-023-00936-0 | 2023 |
| Increased Expression of the Pathological O-glycosylated Form of Oncofetal Fibronectin in the Multidrug Resistance Phenotype of Cancer Cells | 10.1016/j.matbio.2023.03.002 | 2023 |
| ABCB1 and ABCC1 Function during TGF-β-Induced Epithelial-Mesenchymal Transition: Relationship between Multidrug Resistance and Tumor Progression | 10.3390/ijms24076046 | 2023 |
| Special Issue: -Parasitic Infection and Host Immunity-: Editorial | 10.3390/microorganisms11041027 | 2023 |
| Increased Trypanosoma cruzi Growth during Infection of Macrophages Cultured on Collagen I Matrix | 10.3390/life13041063 | 2023 |
| Bittersweet Sugars: How Unusual Glycan Structures May Connect Epithelial-to-Mesenchymal Transition and Multidrug Resistance in Cancer | 10.3390/medicines10060036 | 2023 |
| Resistance to cisplatin in human lung adenocarcinoma cells: effects on the glycophenotype and epithelial to mesenchymal transition markers | 10.1007/s10719-022-10042-2 | 2022 |
| Immune Responses in Leishmaniases: An Overview | 10.3390/tropicalmed7040054 | 2022 |
| Glycobiology of Cancer: Sugar Drives the Show | 10.3390/medicines9060034 | 2022 |
| The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation | 10.3390/medicines9060037 | 2022 |
| Cellular Stress and Senescence Induction during Trypanosoma cruzi Infection | 10.3390/tropicalmed7070129 | 2022 |
| Cryptococcus: History, Epidemiology and Immune Evasion | 10.3390/app12147086 | 2022 |
| SARS-CoV-2?s Variants of Concern: A Brief Characterization | 10.3389/fimmu.2022.834098 | 2022 |
| Pulmonary Fibrosis and Hypereosinophilia in TLR9-/- Mice Infected by Cryptococcus gattii | 10.3390/pathogens11090987 | 2022 |
| The History of the ABC Proteins in Human Trypanosomiasis Pathogens | 10.3390/pathogens11090988 | 2022 |
| O POTENCIAL DA XANTONA NATURAL α-MANGOSTINA NO DESENVOLVIMENTO DE NOVOS AGENTES ANTI-INFECCIOSOS: UMA REVISÃO | 10.21577/0100-4042.20170954 | 2022 |
| A Novel Protocol for the Synthesis of 1,2,4-Oxadiazoles Active against Trypanosomatids and Drug-Resistant Leukemia Cell Lines | 10.3390/tropicalmed7120403 | 2022 |
| Humoral response in Leishmaniasis | 10.3389/fcimb.2022.1063291 | 2022 |
| Intrinsic and Chemotherapeutic Stressors Modulate ABCC-Like Transport in Trypanosoma cruzi | 10.3390/molecules26123510 | 2021 |
| Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection | 10.1093/infdis/jiab425 | 2021 |
| X-linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection | 10.1038/s41598-021-97041-9 | 2021 |
| Autoimmune Disorders & COVID-19 | 10.3390/medicines8100055 | 2021 |
| COVID-19 Infection and Neuropathological Features | 10.3390/medicines8100059 | 2021 |
| Trypanosoma cruzi trans-Sialidase as a Potential Vaccine Target Against Chagas Disease | 10.3389/fcimb.2021.768450 | 2021 |
| Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias | 10.1074/jbc.RA120.013090 | 2020 |
| Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-related Events in Human Lung Adenocarcinoma Cells | 10.3390/medicines7040019 | 2020 |
| Resistance to paclitaxel induces glycophenotype changes and mesenchymal-to-epithelial transition activation in the human prostate cancer cell line PC-3 | 10.1177/1010428320957506 | 2020 |
| The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19) | 10.1038/s41598-020-76781-0 | 2020 |
| Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation | 10.3389/fimmu.2019.00164 | 2019 |
| Design, Synthesis, Trypanocidal Activity, and Studies on Human Albumin Interaction of Novel S-Alkyl-1,2,4-triazoles | 10.21577/0103-5053.20190033 | 2019 |
| Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host | 10.3389/fmicb.2019.00305 | 2019 |
| Editorial: Cancer Metabolism: Current Knowledge and Perspectives | 10.3389/fonc.2019.00287 | 2019 |
| Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans | 10.3389/fmed.2019.00129 | 2019 |
| Functional Characterization of ABCC Proteins from Trypanosoma cruzi and Their Involvement with Thiol Transport | 10.3389/fmicb.2018.00205 | 2018 |
| Circulating Plasma MicroRNA-208a as Potential Biomarker of Chronic Indeterminate Phase of Chagas Disease | 10.3389/fmicb.2018.00269 | 2018 |
| Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection | 10.3389/fmed.2018.00025 | 2018 |
| Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses | 10.3389/fonc.2018.00081 | 2018 |
| Antibody Repertoires Identify β-Tubulin as a Host Protective Parasite Antigen in Mice Infected With Trypanosoma cruzi | 10.3389/fimmu.2018.00671 | 2018 |
| NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis | 10.3389/fimmu.2018.00967 | 2018 |
| Immunomodulating role of IL-10-Producing B cells in Leishmania amazonensis infection | 10.1016/j.cellimm.2018.08.014 | 2018 |
| Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection | 10.1038/s41598-018-34649-4 | 2018 |
| Multiple Myeloma Cells Express Key Immunoregulatory Cytokines and Modulate the Monocyte Migratory Response | 10.3389/fmed.2017.00092 | 2017 |
| Role of Inactive and Active Trypanosoma cruzi Trans-sialidases on T Cell Homing and Secretion of Inflammatory Cytokines | 10.3389/fmicb.2017.01307 | 2017 |
| The Sweet Side of Immune Evasion: Role of Glycans in the Mechanisms of Cancer Progression | 10.3389/fonc.2016.00054 | 2016 |
| Modulation of Cell Sialoglycophenotype: A Stylish Mechanism Adopted by Trypanosoma cruzi to Ensure Its Persistence in the Infected Host | 10.3389/fmicb.2016.00698 | 2016 |
| Host resistance to visceral leishmaniasis: prevalence and prevention | 10.1586/14787210.2016.1160779 | 2016 |
| Glycosylation in Cancer: Interplay between Multidrug Resistance and Epithelial-to-Mesenchymal Transition? | 10.3389/fonc.2016.00158 | 2016 |
| Expanding the knowledge of the chemical structure of glycoconjugates from Trypanosoma cruzi TcI genotype. Contribution to taxonomic studies | 10.1590/0001-3765201620160386 | 2016 |
| Editorial: Glycosylation Changes in Cancer: An Innovative Frontier at the Interface of Cancer and Glycobiology | 10.3389/fonc.2016.00254 | 2016 |
| Macrophage Polarization in Infectious Diseases | 2015 | |
| The -sialidase, the major virulence factor: three decades of studies | 10.1093/glycob/cwv057 | 2015 |
| Sweet and Sour: The Impact of Differential Glycosylation in Cancer Cells Undergoing Epithelialâ--Mesenchymal Transition | 10.3389/fonc.2014.00059 | 2014 |
| Increase of O-Glycosylated Oncofetal Fibronectin in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Epithelial Cells | 10.1371/journal.pone.0060471 | 2013 |
| Design, Synthesis and Trypanocidal Evaluation of Novel 1,2,4-Triazoles-3-thiones Derived from Natural Piperine | 10.3390/molecules18066366 | 2013 |
| Inhibitory Effects of Trypanosoma cruzi Sialoglycoproteins on CD4+ T Cells Are Associated with Increased Susceptibility to Infection | 10.1371/journal.pone.0077568 | 2013 |
| Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin | 10.1016/j.febslet.2012.05.020 | 2012 |
| Sialic acid: a sweet swing between mammalian host and Trypanosoma cruzi | 10.3389/fimmu.2012.00356 | 2012 |
| Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis | 10.1016/j.phytochem.2011.08.006 | 2011 |
| Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process | 10.1073/pnas.1115191108 | 2011 |
| Leishmanicidal activity of Himathantus sucuuba latex against Leishmania amazonensis | 10.1016/j.parint.2010.01.002 | 2010 |
| The trans-Sialidase from Trypanosoma cruzi a Putative Target for Trypanocidal Agents | 2010 | |
| Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell response | 10.1074/jbc.M109.096305 | 2010 |
| A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence | 10.1093/glycob/cwq065 | 2010 |
| Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 vs. KB epidermoid tumor cells | 10.1016/j.carres.2009.04.032 | 2009 |
| Endothelial cell signalling induced by trans-sialidase from Trypanosoma cruzi | 10.1111/j.1462-5822.2007.01017.x | 2008 |
| Novel 1,3,4-Thiadiazolium-2-phenylamine ChloridesDerived from Natural Piperine as Trypanocidal Agents: Chemical and Biological Studies | 10.1016/j.bmc.2007.12.049 | 2008 |
| The toxic effects of piperine against Trypanosoma cruzi: ultrastructural alterations and reversible blockage of cytokinesis in epimastigote forms | 10.1007/s00436-008-0876-9 | 2008 |
| Toxic effect of piperine and derivates on epimastigotes and amastigotes forms of Trypanosoma cruzi | 10.1016/j.bmcl.2004.04.019 | 2004 |
| In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis | 10.1128/AAC.46.7.2111-2115.2002 | 2002 |
Eventos:
(0.00% eventos com DOI)