Leonardo Freire-de-Lima

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Biofísica Carlos Chagas Filho

Departamento:

Programa de Biologia Celular e Parasitária/Biof

ORCID:

https://orcid.org/0000-0003-3013-3173


Formação:
  • University of Washington, Pacific Northwest Research Institute

    | Pós-Doutorado | 2014 - 2014
  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2013 - 2014
  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2012 - 2013
  • Pacific Northwest Diabetes Research Institute

    Glycobiology of Cancer | Especialização | 2011 - 2011
  • Universidade Federal do Rio de Janeiro

    | Pós-Doutorado | 2010 - 2012
  • University of Washington

    | Pós-Doutorado | 2008 - 2010
  • National Jewish Medical and Reseach Center.

    Cellular and Molecular Immunology | Especialização | 2004 - 2004
  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Doutorado | 2004 - 2008
  • Universidade Federal do Rio de Janeiro

    Ciências Biológicas (Biofísica) | Mestrado | 2002 - 2004
  • Universidade do Grande Rio

    Ciências Biológicas | Graduação | 1999 - 2002
Laboratórios:
Nuvens de Palavras:
Artigos:
Nenhum artigo cadastrado
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
TH17 axis activation in the immune response against Cryotococcus gatti and the influence of IL-22 and IL-23 cytokines in the systemic experimental infection 2023
Design and synthesis of bis-chalcones as curcumin analogues and evaluation of their toxic activities against Trypanosoma cruzi amastigotes 2023
Design, synthesis and in silico evaluation of 4,6 styryl-pyrimidines as curcumin analogs with potential activity in breast cancer 2023
Glyucophenotipic analysis of human lung adenocarcinoma cell line treated chronically with nicotine 2023
pp-GalNAc-T6 but not pp-GalNAc-T3 participates in the synthesis of O-glycosylated oncofetal fibronectin and maintenance of their MDR Phenotype in breast cancer cells 2023
Modulation of Glycosphingolipids Biosynthesis in lung cancer cells treated with nicotine 2023
Immunomodulatory role of purified capsular polysaccharides from Cryptococcus neoformans on macrophages infected with Leishmania major 2023
Immunomodulatory activities of capsular polysaccharides (GXM and GXMGAL) on murine macrophages infected by Trypanosoma cruzi 2023
Atividade qanti-Trypanosoma cruzi de análogos estruturalmente simplificados e conformacionalmente restritos da curcumina 2023
Involvement of pp-GalNAc-T6 and O-glycosylated oncofetal fibronectin in human multiresistant breast cancer cell lines 2022
Avaliação do glicofenótipo da fibronectina celular em macrófagos humanos polarizados 2022
Envolvimento da pp-GalNAc-T6 e de glicanas O-ligadas no fenótipo de resistência a drogas em células tumorais 2022
Changes in the sweetening of cancer cells: Involvement of pp-GalNAc-T6 and O-linked glycans in the multidrug resistance phenotype 2021
Resistance to cisplatin in A549 cells: Effect on cell glycophenotype and epithelial to mesenchymal transition markers 2021
X-linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection 2021
A participação da pp-GalNAc-T6 e de glicanas O ligadas no fenótipo de resistência a drogas em células tumorais 2019
Expression of O-glycosylated oncofetal fibronectin in M-2 like differentiated macrophages 2019
Immunomodulation and pro-carcinogenic properties of cisplatin resistant human macrophages 2019
Estrogen related receptors (ERRs) alpha and gamma and their role in the definition of the glycophenotype in lung cancer cell lines during epithelial mesenchymal transition (TEM) 2017
The polypeptide N-acetylgalactosaminyltransferase 6 and its involvement on drug resistance phenotype in cancer cells 2017
Epithelial mesenchymal transition in adenocarcinoma cell line of human prostate PC-3 after the induction of resistance to paclitaxel 2017
Targeting the glycosphingolipid biosynthesis pathway for overcoming the multi drug resistance phenotype in chronic myeloid leukemias 2017
Doses sub-letais de quimioterápicos: Alterações no glicofenotipo e quimioresistencia. 2016
Expressão de fibronectina O-glicosilada em macrofagos alternativamente ativados 2016
Evaluation of glycophenotype and chemoresistance in breast cancer cell lines treated with sub-lethal concentrations of chemotherapeutic agentes 2016
Expression of O-glycosylated oncofetal fibronectin in M2-like differentiated human macrophages 2016
Hyposialylated N-glycans predominate in human serum glycoproteins during the chronic phase of Chagas disease 2016
First description of ABCC-like activity in Trypanosoma cruzi 2016
Expressão de fibronectina O-glicosilada em macrófagos, e sua possível participação na polarização macrofágica 2014
Piperina, uma amida isolada da pimenta-do-reino, é tóxica para linhagens de carcinoma e adenocarcinoma humanos; e, em concentrações não letais, inibe a transição epitélio-mesenquimal 2014
Modificações no glicofenótipo celular durante a indução de resistência tumoral 2014
Possible involvement of tumor-associated leukosialin CD43 in epithelial-mesenchymal transition 2013
Transição Epitélio-Mesenquimal Associada a Alterações na Expressão da Sialomucina CD43 2013
Increase of O-glycosylated oncofetal fibronectin in high glucose-induced epithelial-mesenchymal transition of cultured human epithelial cells 2012
The influence of 0-glcnacylation in the motility of alveolar ephithelial cancer cells 2012
CD43 interaction with actin regulatory proteins regulates T cell trafficking to cardiac tissue during Trypanosoma cruzi infection 2011
Induction of Epithelial-Mesenchymal Transition in Human Lung Epithelial Cells with O-glycosylated Fibronectin 2011
INVOLVEMENT OF CD43-MEDIATED T CELL HOMING IN PATHOGENESIS OF CHAGASIC CARDIOMIOPATHY 2009
Involvement of CD43 (Leukosialin) in pathogenesis of chagasic cardiomiopathy 2009
Glycosylation with O-linked α-GalNAc, associated with expression of oncofetal fibronectin, defines epithelial-mesenchymal transition in human prostate epithelial cells 2009
Trypanosoma cruzi explores CD8+ T cell sialylation to dampen Ag-specific CD8+ T cell response 2009
Involvement of CD43-mediated T cell homing in pathogenisis of experimental of experimental chagasic cardiomiopathy: elucidation of a mechanism to exploit as a therapeutical target during Trypanosoma cruzi infection 2009
Alteration of CD8+ cell surfacesialylation by trans-sialidase activity during Trypanosoma cruzi infection 2008
of CD43 modulates immune response and compromise T cells homing to heart during Trypanosoma cruzi infection 2008
Anti-Leishmanial activity of piperine and their analogues on Leishmania amazonensis 2008
Inactive trans-sialidase compromises T cell migration to heart of Trypanosoma cruzi infected mice 2008
Proteins from Trypanosoma cruzi trans-sialidase play distinct roles during parasite infection 2007
The Lectin and enzymatic activity of Trypanosoma cruzi trans-Sialidase (TS) proteins have distinct effects on cardiac inflammation and host immune responses 2007
Enzymatically active and inactive trans-sialidase from Trypanosoma cruzi express distinct pathogenic effects during the acute phase of infection 2007
Effects of trans-sialidase on the co-stimulation and traffic of T cells during Trypanosoma cruzi infection 2006
Effects of the active and inative trans-sialidase from Trypanosoma cruzi on the costimulation and traffic of T cells in vivo 2006
Síntese e Avaliação da Atividade Tóxica Sobre Trypanosoma cruzi de Novos Derivados 1,3,4-Tiadiazólio-2-amidinas, Análogos à Piperina 2006
Synthesis and Evaluation of Novel Mesoionic Compounds Against Trypanosoma cruzi 2006
Trypanosoma cruzi trans-sialidase play distinct roles in the pathogenesis of infection 2006
trans-sialidase ativa e inativa do Trypanosoma cruzi desencadeiam diferentes efeitos no tráfego de células T in vivo 2006
Trans-sialidase from Trypanosoma cruzi promotes alterations on T-cell subsets in the hearts of infected mice 2005
Effects of the miltefosine in the Na+-APase activity of the Trypanosoma cruzi through protein kinase C 2005
Trans-sialidase do Trypanosoma cruzi induz alterações fenotípicas em sub-populações de células T presentes no coração de camundongos infectados 2005
Morphological and ultrastructural changes in Trypanosoma cruzi epimastigotes induced by piperine, a natural amide isolated from Piper nigrum 2004
Characterization and cellular distribution of phosphofructokianse of Trypanossoma rangeli 2004
Piperine and it?s derivates: Possible mechanisms against Trypanosoma cruzi. A comparative study involving chemical structure and biological activity 2003
Piperina e derivados avaliacao da atividade toxica sobre Trypanosoma cruzi e possiveis mecanismos de acao 2003
Piperina e Derivados: Possíveis mecanismos de ação em Trypanosoma cruzi 2003
Piperine, an amide iisolated from Piper nigrum is toxic against Trypanosoma cruzi and inhibit the parasite malate dehydrogenase 2002
Activity of 18-methoxycoronaridine in a mouse cutaneous leishmaniasis model 2002
Effect of the natural alkaloid piperine on Trypanosoma cruzi: Citotoxicity and possible mechanisms of action 2002
Leishmanicidal activity of synthetic indole alkaloids 2001
Atividade antiparasitária de piperina e derivados sobre formas amastigotas de Leishmania amazonensis 2001
Potential antileishmanial activity of a fraction of Peschiera affinis 2001
Leishmanicidal activity of piperine and its derivatives 2001
Leishmanicidal and macrophage modulation effects of the indole alkaloids coronaridine and 18-methoxy-coronaridine 2000
Evaluation of antileishmanial activity of the Brazilian plant Himatanthus sucuuba. 2000
Antileishmanial effect of synthetic indole alkaloids and its role on macrophage modulation. 2000
Potential leishmanicidal activity of Himatanthus sucuuba (Apocynaceae) 2000
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