Eliezer Jesus de Lacerda Barreiro

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Ciências Biomédicas

Departamento:

Docentes/ICB

ORCID:

https://orcid.org/0000-0003-1759-0038


Formação:

  • Université Joseph Fourier - Grenoble I

    | Pós-Doutorado | 1987 - 1987

  • Université Joseph Fourier - Grenoble I

    Chimie Médicale | Doutorado | 1974 - 1978

  • Universidade Federal do Rio de Janeiro

    Química de Produtos Naturais | Mestrado | 1971 - 1973

  • Universidade Federal do Rio de Janeiro

    Faculdade de Farmácia | Graduação | 1967 - 1970
Laboratórios:
Nuvens de Palavras:
Artigos:

(45.52% artigos com DOI)

Titulo DOI Ano
Design, Synthesis and Phenotypic Profiling of Simplified Gedatolisib Analogues 10.3390/ph16020209 2023
Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent 10.3390/pharmaceutics15041282 2023
Comparative chemical and biological hydrolytic stability of homologous esters and isosteres 10.1080/14756366.2022.2027933 2022
Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs 10.3390/ph15080913 2022
Methyl Effect on the Metabolism, Chemical Stability, and Permeability Profile of Bioactive N -Sulfonylhydrazones 10.1021/acsomega.2c04368 2022
Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity 10.1371/journal.pone.0269447 2022
Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (M PRO ) through in silico screening supported by molecular docking and a fragment-based pharmacophore model 10.1039/d0md00282h 2021
Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514 10.3390/molecules26164828 2021
Supplementation with Spirulina platensis Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training 10.3390/nu13113763 2021
Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A2A Receptor 10.3390/molecules26237364 2021
LASSBio-596: a New Pre-clinical Candidate for Rheumatoid Arthritis? 10.1007/s10753-021-01564-2 2021
Novel VEGFR-2 inhibitors with an N -acylhydrazone scaffold 10.1002/ardp.202000130 2020

New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis

 10.2147/dddt.s258459 2020
Carbamoyl- N -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate 10.1039/d0ra00287a 2020
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N -Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors 10.1021/acs.jmedchem.0c00508 2020
Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ) inhibitors discovered by virtual screening using free energy models 10.1007/s10822-020-00327-9 2020
β-lactam antibiotics: An overview from a medicinal chemistry perspective 10.1016/j.ejmech.2020.112829 2020
In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis 10.3389/fphar.2020.590544 2020
A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives 10.1038/s41598-018-36846-7 2019
Chemical Intuition in Drug Design and Discovery 10.2174/1568026619666190620144142 2019
Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis 10.1016/j.exppara.2019.04.003 2019
What is hidden in the biodiversity? The role of natural products and medicinal chemistry in the drug discovery process 10.1590/0001-3765201920190306 2019
Reduction of cardiac and renal dysfunction by new inhibitor of DPP4 in diabetic rats 10.1016/j.pharep.2019.07.005 2019
Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor 10.3389/fphar.2019.00628 2019
Gastroprotective effects of N-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the NO/cGMP/KATP pathway 10.1016/j.bcp.2019.113629 2019
LASSBio-596 protects gastric mucosa against the development of ethanol-induced gastric lesions in mice 10.1016/j.ejphar.2019.172662 2019
Discovery of naphthyl- N -acylhydrazone p38α MAPK inhibitors with in vivo anti-inflammatory and anti-TNF-α activity 10.1111/cbdd.13085 2018
Lung and liver responses to 1- and 7-day treatments with LASSBio-596 in mice subchronically intoxicated by microcystin-LR 10.1016/j.toxicon.2017.10.029 2018
Ru(II) Compounds: Next-generation anticancer metallotherapeutics? 10.1021/acs.jmedchem.7b01689 2018
Oxidative imbalance in mice intoxicated by microcystin-LR can be minimized 10.1016/j.toxicon.2018.02.008 2018
Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones 10.1590/0001-3765201820170796 2018
Synthesis, Aqueous Solubility, Metabolic Stability and Pharmacological Profile of Simplified Urea Derivatives 10.2174/1570180814666171012155204 2018
Synthesis, Pharmacological Evaluation and Docking Study of a New 2018
LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice 10.1371/journal.pone.0199009 2018
N-Acylhydrazones as drugs 10.1016/j.bmcl.2018.07.015 2018
Potent immunosuppressive activity of a phosphodiesterase-4 inhibitor N-acylhydrazone in models of lipopolysaccharide-induced shock and delayed-type hypersensitivity reaction 10.1016/j.intimp.2018.09.047 2018
The Bench of Science 10.21577/1984-6835.20180001 2018
The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D 4 receptor binding and toxicological assessment 10.1016/j.biopha.2018.02.120 2018
Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative 10.3390/ph11040119 2018
Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats 10.1371/journal.pone.0195047 2018
Recent Advances in Development of Polyphenols as Anticancer Agents 10.2174/1389557518666180220122113 2018
Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction 10.2147/dddt.s113289 2017
LASSBio-1422 10.1097/FBP.0000000000000267 2017
Structural and physicochemical characterization of sulfonylhydrazone derivatives designed as hypoglycemic agents 10.1039/C7NJ00074J 2017
Structural characterization and cytotoxicity studies of different forms of a combretastatin A4 analogue 10.1016/j.molstruc.2017.06.093 2017
A combined experimental and in silico characterization to highlight additional structural features and properties of a potentially new drug 10.1016/j.molstruc.2017.06.061 2017
The antithrombotic and haemostatic effects of LASSBio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats 10.1111/jphp.12771 2017
Multi-gram Preparation of 7-Nitroquinoxalin-2-amine 10.21577/0103-5053.20170018 2017
Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension 10.3389/fphar.2017.00858 2017
LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor 10.3389/fphar.2017.00778 2017
Discovery of naphthyl- N -acylhydrazone p38α MAPK inhibitors with in vivo anti-inflammatory and anti-TNF-α activity 10.1111/cbdd.13085 2017
LASSBio-1425, an analog of thalidomide, decreases triglyceride and increases HDL cholesterol levels by inhibition of TNF-α production 10.1016/j.ijcard.2015.09.071 2016
The total synthesis of calcium atorvastatin 10.1039/c5ob02546j 2016
Respiratory and Systemic Effects of LASSBio596 Plus Surfactant in Experimental Acute Respiratory Distress Syndrome 10.1159/000443037 2016
Synthesis, characterization, DNA binding, DNA cleavage, protein binding and cytotoxic activities of Ru(II) complexes 10.1016/j.ijbiomac.2015.09.045 2016
Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery 10.1039/c6ra15143d 2016
Synthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 Inhibitors 10.1371/journal.pone.0162895 2016
Design, synthesis, structural characterization and in vitro cytotoxic activity of mononuclear Ru(II)complexes 10.1007/s00044-016-1625-8 2016
Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation 10.1124/jpet.115.231241 2016
LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model 10.1097/FBP.0000000000000200 2016
Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents 10.2147/DDDT.S108327 2016
Investigating the therapeutic effects of LASSBio-596 in an in vivo model of cylindrospermopsin-induced lung injury 10.1016/j.toxicon.2014.12.004 2015
Novel Orally Active Analgesic and Anti-Inflammatory Cyclohexyl-N-Acylhydrazone Derivatives 10.3390/molecules20023067 2015
Novel Agonist of Adenosine Receptor Induces Relaxation of Corpus Cavernosum in Guinea Pigs: An In Vitro and In Vivo Study 10.1016/j.urology.2015.02.006 2015
Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor 10.1016/j.pnpbp.2015.04.003 2015
Design, synthesis and in vitro trypanocidal and leishmanicidal activities of novel semicarbazone derivatives 10.1016/j.ejmech.2015.05.046 2015
Structural features evolution - from fluids to solid phase - and crystal morphology study of LASSBio 1601: a cyclohexyl-N-acylhydrazone derivative 10.1039/c5ra02696b 2015
Design, synthesis, characterization, cytotoxic and structure activity relationships of novel Ru(II) complexes 10.1016/j.cclet.2015.03.011 2015
Prevention and Reversal of Morphine-Induced Tolerance by Novel Muscarinic Receptor Agonist in Rats with Neuropathic Pain 10.4172/2155-9562.1000282 2015
Synthesis and Biological Evaluation of Pyrazolo[3,4-b]pyridin-4-ones as a New Class of Topoisomerase II Inhibitors 10.2174/1573406411666141210141317 2015
In vivo effect of LASSBio-785, a lipid-lowering and anti-inflammatory agent, on cardiac Ca2+-ATPases from hypercholesterolemic rats 10.1016/j.ijcard.2015.08.091 2015
Therapeutic effects of LASSBio-596 in an elastase-induced mouse model of emphysema 10.3389/fphys.2015.00267 2015
Simple HPLC-UV for the quantification of a new leishmanicidal candidate (E)-1-4 (trifluoromethyl) benzylidene) - 5 - (2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment 10.1002/bmc.3646 2015
LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model 10.1097/fbp.0000000000000200 2015
Structural characterization of LASSBio-1289: a new vasoactive N-methyl-N-acylhydrazone derivative 10.1039/C4CE02011A 2015
Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors 10.1016/j.ejmech.2013.10.058 2014
N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle 10.1016/j.lfs.2013.11.012 2014
LASSBio-1135: A Dual TRPV1 Antagonist and Anti-TNF-Alpha Compound Orally Effective in Models of Inflammatory and Neuropathic Pain 10.1371/journal.pone.0099510 2014
In Vitro Microsomal Hepatic Metabolism of Antiasthmatic Prototype LASSBio-448 10.2174/1568026614666140506123718 2014
Pulmonary And Hepatic Injuries Caused By The Subchronic Exposure To Microcystin-lr: Role Of The Duration Of Treatment With LASSBio 596 2014
Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies 10.1371/journal.pone.0091660 2014
Docking, Synthesis and Antiproliferative Activity of N-Acylhydrazone Derivatives Designed as Combretastatin A4 Analogues 10.1371/journal.pone.0085380 2014
Vasodilator and antihypertensive effects of a novel N -acylhydrazone derivative mediated by the inhibition of L-type Ca 2+ channels 10.1111/j.1472-8206.2012.01076.x 2014
Synthesis, Antiproliferative and Anti-inflammatory Activities of Novel Simplified Imatinib Analogues 2014
Novel Partial Agonist of PPAR-Gamma for Treatment of Diabetic Neuropathy in Rats 2014
Toxicological in vitro and subchronic evaluation of LASSBio-596 10.1016/j.fct.2014.07.037 2014
Structural characterization of LASSBio-1289: a new vasoactive N-methyl-N-acylhydrazone derivative 10.1039/c4ce02011a 2014
N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity 10.1016/j.ijcard.2014.02.022 2014
Adenosine A2A Receptor as a Target of Treatment for Pulmonary Arterial Hypertensio 2014
Synchrotron X-ray powder diffraction data of LASSBio-1515: A new N-acylhydrazone derivative compound 10.1016/j.radphyschem.2013.02.014 2014
3-Aminothiophene-2-Acylhydrazones: Non-Toxic, Analgesic and Anti-Inflammatory Lead-Candidates 10.3390/molecules19068456 2014
Novel vasodilator prototype drug LASSBio 897 and its action on the cardiovascular system of dogs 2014
Pharmacological profile of the cardioactive prototype LASSBio-897: a preliminar study of its potencial vasodilatory activity 2014
Beneficial effects of a novel agonist of the adenosine A 2A receptor on monocrotaline-induced pulmonary hypertension in rats 10.1111/bph.12193 2013
A novel Ca²+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension 10.1016/j.ejphar.2013.01.050 2013
Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats 10.1111/1440-1681.12090 2013
Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates 10.1016/j.ejmech.2012.10.047 2013
Synchrotron X-ray powder diffraction data of LASSBio-1515: A new N-acylhydrazone derivative compound 10.1016/j.radphyschem.2013.02.014 2013
XII National Meeting of Pharmaceutical Chemistry Professors: could we have now a subarea of Pharmaceutical and Medicinal Chemistry in the CNPq Pharmacy Comittee? 10.1590/S1984-82502013000100001 2013
Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice 10.1590/1414-431X20122085 2013
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound 10.1016/j.ejmech.2012.08.011 2013
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579 10.1016/j.ejmech.2013.05.027 2013
Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet 10.1254/jphs.13016FP 2013
Oral Antithrombotic Effects of Acylhydrazone Derivatives 10.5551/jat.14886 2013
Desafios da indústria farmacêutica brasileira 10.1590/s0100-40422013001000012 2013
Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives 10.3390/molecules181011683 2013
Structure Re-determination of LASSBio-294 - a cardioactive compound of the N-acylhydrazone class - using X-ray powder diffraction data 10.1017/S0885715613000808 2013
As Longas Pernas do Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®;http://www.farmacia.ufrj.br/lassbio): Histórico e Perspectivas 2013
Opportunities and Challenges for Innovation in Pharmaceuticals: Now or Never. 2013
THIONYL CHLORIDE (CAS No 7719-09-7) - MÉTODO DE PREPARAÇÃO INDUSTRIAL DE SOLVENTES E REAGENTES QUÍMICOS 2013
A Novel Adenosine A2a Receptor Agonist Attenuates the Progression of Monocrotaline-induced Pulmonary Hypertension in Rats 2013
Novel vasodilator prototype drug LASSBio 897 and its action on the cardiovascular system of dogs 2013
Pharmacological profile of the ptototypes LASSBio-294 and LASSBio-897: a comparative preliminar study of their metabolites' effects on myocardial contraction. 2013
New oxidovanadium(IV) N-acylhydrazone complexes: Promising antileishmanial and antitrypanosomal agents 10.1016/j.ejmech.2012.12.036 2013
Novel furfurylidene N-acylhydrazones derived from natural safrole: discovery of LASSBio-1215, a new potent antiplatelet prototype 10.3109/14756366.2011.578575 2012
Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives 10.1016/j.bmc.2012.01.034 2012
Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production 10.1371/journal.pone.0046925 2012
Design, Synthesis, and Pharmacological Evaluation of N -Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors 10.1021/jm300514y 2012
Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model 10.1016/j.ejphar.2012.05.043 2012
Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor 10.1016/j.ejmech.2012.06.056 2012
Synthesis and characterization of the atropisomeric relationships of a substituted N-phenyl-bipyrazole derivative with anti-inflammatory properties 10.1002/chir.22016 2012
Synthesis, Biological Evaluation, and Structure-activity Relationship of Clonazepam, Meclonazepam, and 1,4-Benzodiazepine Compounds with Schistosomicidal Activity 10.1111/j.1747-0285.2012.01354.x 2012
Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors 10.1590/s0103-50532012000100023 2012
New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia 10.1016/j.bbr.2012.09.016 2012
Design, Synthesis, Antinociceptive and Anti-Inflammatory Activities of Novel Piroxicam Analogues 10.3390/molecules171214126 2012
Synthesis and Pharmacological Evaluation of Novel Phenyl Sulfonamide Derivatives Designed as Modulators of Pulmonary Inflammatory Response 10.3390/molecules171214651 2012
Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida 10.1590/s0102-695x2012005000007 2012
Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors 10.1016/j.ejmech.2012.05.006 2012
Potential Inhibitory Effect of LASSBio-596, a New Thalidomide Hybrid, on Inflammatory Corneal Angiogenesis in Rabbits 10.1159/000337137 2012
LASSBio-542: Novel Thalidomide Analog Distinctly Modulates IL-10 and Inhibits Angiogenesis 10.2174/157340712801784778 2012
Docking, Synthesis and Anti-Diabetic Activity of Novel Sulfonylhydrazone Derivatives Designed as PPAR-Gamma Agonists 10.2174/156802612804910205 2012
Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazone 10.1007/s00894-011-1219-9 2012
CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes 10.1016/j.ejmech.2010.11.024 2011
The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinson?s Disease 2011
Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of I?B kinase-? 10.1016/j.ejmech.2011.01.045 2011
Discovery of LASSBio-772, a 1,3-Benzodioxole N-Phenylpiperazine Derivative with Potent Alpha 1A/D-Adrenergic Receptor Blocking Properties 10.1016/j.ejmech.2011.04.032 2011
The Methylation Effect in Medicinal Chemistry 10.1021/cr200060g 2011
Binuclear zinc(II) complexes with the anti-inflammatory compounds salicylaldehyde semicarbazone and salicylaldehyde-4-chlorobenzoyl hydrazone (H2LASSBio-1064) 10.1016/j.poly.2011.04.024 2011
Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes 10.3390/molecules16086902 2011
LASSBio 596 per os avoids pulmonary and hepatic inflammation induced by microcystin-LR 10.1016/j.toxicon.2011.05.018 2011
MAOS and Medicinal Chemistry: Some Important Examples from the Last Years 10.3390/molecules16119274 2011
Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of lubg inflammation 2011
Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazone 10.1007/s00894-011-1219-9 2011
Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LCâ¿¿MS/MS: Application for a pharmacokinetic study 10.1016/j.jpba.2011.02.031 2011
Therapeutic approaches for tumor necrosis factor inhibition 2011
Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound 10.1111/j.1472-8206.2011.00999.x 2011
Microwave-assisted synthesis and structure¿activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives 10.1016/j.bmcl.2009.11.038 2010
Characterization of the conformational ensemble from bioactive N-acylhydrazone derivatives 10.1016/j.jmgm.2009.10.004 2010
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors 10.1016/j.bmc.2010.01.040 2010
Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581 10.1016/j.bmcl.2010.03.034 2010
LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation 10.1111/j.1476-5381.2010.00672.x 2010
Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294 10.1016/j.bmcl.2010.04.073 2010
Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition 10.1016/j.ejphar.2010.04.003 2010
A Theoretical Investigation on the Pleiotropic Effects of Statins as p38 2010
Can LASSBio 596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR? 10.1016/j.toxicon.2010.06.005 2010
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates 10.1016/j.bmc.2010.06.002 2010
Cardiovascular effects induced by N-(4'-dihydro)-piperoylthiomorpholine in normotensive rats 10.1111/j.2042-7158 2010
LASSBio-294, A Compound With Inotropic and Lusitropic Activity, Decreases CardiacRemodeling and Improves Ca2+ InfluxSarcoplasmic Reticulum After Myocardial Infarction Into 2010
Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi 10.1590/S0102-695X2010005000017 2010
2-Acetylpyridine thiosemicarbazones: Cytotoxic activity in nanomolar doses against malignant gliomas 10.1016/j.ejmech.2010.09.021 2010
Descoberta de novos protótipos N-fenilpiperazínicos heteroarilazólicos candidatos a fármacos antipsicóticos atípicos 2010
Espectalina, cassina e análogos semissintéticos como potenciais candidatos a fármacos para o tratamento da doença de Alzheimer 2010
LASSBio - 596: da descoberta aos ensaios pré - clínicos 2010
Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes 10.1016/j.bmc.2008.11.018 2009
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates 10.1016/j.bmc.2008.11.065 2009
Biodiversidade: fonte potencial para a descoberta de fármacos 2009
Synthesis, pharmacological evaluation and docking studies of new sulindac analogues 10.1016/j.ejmech.2008.11.012 2009
Synthesis and pharmacological evaluation of N-phenyl-acetamide sulfonamides designed as novel non-hepatotoxic analgesic candidates 10.1016/j.ejmech.2009.02.026 2009
Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives 10.1016/j.ejmech.2009.04.044 2009
Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH) 10.1016/j.bmcl.2009.07.075 2009
Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates 10.1016/j.bmc.2008.12.045 2009
From nature to drug discovery:the indole scaffold as a 'privileged structure' 2009
Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors 10.1016/j.pbb.2009.07.008 2009
Structural insights into IKK? inhibition by natural products staurosporine and quercetin 10.1016/j.bmcl.2009.10.076 2009
Pharmacological Characterization of (3-Thienylidene)-3,4-Methylenedioxybenzoylhydrazide: A Novel Muscarinic Agonist With Antihypertensive Profile 10.1038/ajh.2009.238 2009
Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: Discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole 10.1016/j.bmc.2009.08.009 2009
Cytotoxic Guanidine Alkaloids from Pterogyne nitens - 10.1021/np800612x 2009
New Insights for Multifactorial Disease Therapy: The Challenge of the Symbiotic Drugs 2008
Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581 10.1016/j.pbb.2007.10.018 2008
Synthesis and anti-platelet activity of novel arylsulfonate-acylhydrazone derivatives, designed as antithrombotic candidates 10.1016/j.ejmech.2007.03.032 2008
Improved solvent-free Dakin oxidation protocol 10.1080/00397910701820673 2008
CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline 10.1016/j.ejphar.2007.11.035 2008
Antinociceptive Profile of 2,3,6-Trisubstituted Piperidine Alkaloids:3-O-Acetyl-spectaline and Semi-synthetic Derivatives of (-)-Spectaline 2008
Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors 10.1016/j.phytochem.2008.01.006 2008
NSAIDs revisited: Putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPAR?) 10.1016/j.ejmech.2007.11.031 2008
Pharmacokinetic evaluation of LASSBio-579: an N-phenylpiperazine antipsychotic prototype 2008
Constituintes Químicos das Flores de Pterogyne nitens 2008
Studies of trypanocidal (inhibitory) power of naphthoquinones:Evaluation of quantum chemical molecular descriptors for structureeactivity relationships 10.1016/j.ejmech.2007.12.023 2008
1-Methyl-7-(4-nitrophenyl)-3-phenylpyrazolo[3,4- b ]pyrrolo[3,4- d ]pyridine-6,8(3 H ,7 H )-dione 10.1107/s1600536808037240 2008
Pharmacokinetic evaluation of LASSBio-579: an N -phenylpiperazine antipsychotic prototype 10.1211/jpp.60.6.0004 2008
Development and validation of a LC-MS/MS method with electrospray ionization for determination of LASSBio-579 in rat plasma 10.1016/j.jpba.2006.07.052 2007
Synthesis, Pharmacological Evaluation and Electrochemical Studies of Novel6-Nitro-3,4-Methylenedioxyphenyl-N-Acylhydrazone Derivatives: Discovery ofLASSBio-881, a New Ligand of Cannabinoid Receptors 10.1016/j.bmc.2007.01.013 2007
Molecular Hybridization: A usful tool in the design of new drug prototypes 2007
A Descoberta Racional de Fármacos 2007
The molecular basis of COX-2 versus COX-1 selectivity of lumiracoxib bymolecular docking studies 2007
Privileged Structures: A Useful Concept for the Rational Design of New Lead Drugs Candidates 2007
High performance liquid chromatography method for quantification of the N-phenylpiperazine derivative LASSBio-579 in the rat plasma 2007
Uma visão da Química Bioinorgânica Medicinal 2007
Medicinal chemistry of N-acylhydrazones: New lead-compounds of analgesic, antiinflammatory ad antithrombotic drugs 2006
Thalidomide and analogs as antiinflammatory and immunomodulator drug candidates 2006
Protective Effects of Phosphodiesterase Inhibiors on Lung Function and Remodeling in a Murine Model of Chronic Asthma 2006
Os Produtos Naturais e a Química Medicinal Moderna 2006
New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies 10.1016/j.bmc.2005.07.072 2006
Molecular docking study and development of na empirical binding free energy model for phosphodiesterase 4 inhibitors 10.1016/j.bmc.2006.05.017 2006
Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phhalimide-containing TNFalpha modulators 10.1016/j.bmc.2006.06.042 2006
Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties 10.1016/j.bmc.2006.07.046 2006
ASPECTOS QUÍMICOS, BIOLÓGICOS E ETNOFARMACOLÓGICOS DO GÊNERO Cassia 2006
Design, Synthesis and Pharmacological Evaluation of Neuroactive Pyrazolo[3,4-d]pyridine derivatives 10.1016/j.bmc.2005.08.042 2006
Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma 10.1590/s0100-879x2006000200016 2006
LASSBio-468, a new achiral thalidomide analogue which modulates TNF-alpha and NO production and inhibits endotoxic ahock and arthitis in an animal model 10.1016/j.intimp.2004.10.017 2005
Bioisosterism: A Useful Strategy for Molecular Modification and Drug Desing 2005
Um Paradigma Da Quimica Medicinal: A Flexibilidade Dos Ligantes E Receptores 2005
Desing, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide 10.1016/j.bmcl.2004.12.012 2005
Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats 10.1016/j.ejphar.2005.02.011 2005
Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues 10.1016/j.bmc.2005.03.003 2005
Design, synthesis and pharmacological evaluation of new nonsteroidal antiinflammatory 1,3,4-thiadiazole derivatives 2005
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids 10.1016/j.bmc.2005.04.030 2005
New anti-Alzheimer drugs from biodiversity: the role of the natural acetylcholinestarse inhibitors 2005
Pharmacokinetis and tissue distribuition of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats 10.1016/j.ejps.2005.06.002 2005
Aplicação de análise de componentes principais para verificação de atribuições de sinais nos espectros de RMN 1H. O caso dos 3-aril(1,2,4)-oxadiazolil-5-carboidrazida 2005
Hydrolisis of new phthalimide-derived esters catalyzed by immobilized lipase 2005
Chemo-selective hydrolisis of the iminic moiety in salicylaldehyde semicarbazone promoted by ruthenium 10.1016/j.ica.2005.04.021 2005
Electronspray ionization mass and tandem mass spectra of a series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines: new dopaminergic ligands with potential antipsychotic properties 2005
The molecular basis for coxib inhibition of p38alpha MAP kinase 10.1016/j.bmcl.2005.05.107 2005
A proposed molecular basis for the selective resveratrol inhibition of the PGHS-1 peroxidase activity 10.1016/j.bmc.2005.07.028 2005
New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: Quantitative structure-activity relationship studies. 2005
A questão da inovação em fármacos no Brasil: proposta de criação do programa nacional de fármacos (Pronfar). 2005
Cysteinyl Leukotriene Receptor Antagonists and Thromboxane Synthase Inhibitors: New targets to treat Asthma 2004
Studies on diastereoselective reduction of cyclic beta-ketoesters with boron hydrides. Part 4: The reductive profile of functionalized cyclohexanone derivatives 2004
A novel 3D-QSAR comparative molecular field analysis (CoMFA) model of imidazole and quinazolinone functinalized p38 MAP kinase inhibitor 2004
Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis 2004
Esquizofrenia, Quarenta Anos da hipotese Dopaminergica Sob A Otica da Quimica Medicinal 2004
Selective PGHS-2 Inhibitors, A Rational Approach for Treatment of the Inflammation 2004
New optimized piperamide analogues with potent in vivo hypotensive properties 2004
Produtos Naturais Como Candidatos a Farmacos Uteis No Tratamento Do Mal De Alzheimer 2004
New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives 2004
Enzymatic hydrolysis by immobilized lipase applied to a new prototype anti-asthma drug 2004
Agentes Dopaminergicos e o Tratamento da Disfuncão Eretil 2004
Studies of Chiral GC Separation of gamma-Butyrolactone Derivatives on 2,3-di-O-Methyl-6-O-t-Butyldimethylsilyl-beta-cyclodextrin 2003
Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors 2003
Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives 2003
Highly Stereocontrolle Synthesis of Natural Barbacenic Acid. Novel Bisnorditerpene from Barbacenia flava 2003
Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury 2003
Dopaminergic Profile of New Heterocyclic of N-phenylpiperazine Derivatives 2003
Novas Estratégias Terapêuticas para o Tratamento da Depressão: Uma Visão da Química Medicinal 2003
Thienylhydrazone derivative increases sarcoplasmatic reticulum Ca+2 release in mammalian skeletal muscle. 2003
The Medicinal Chemistry and Drug Discovery: A new cardioactive lead-compound, LASSBio-294. 2003
Antinociceptive Profile of (-) ¿ Spectaline: A Piperidine Alkaloid From Cassia Leptophylla 2003
Validated HPLC method for determination of LASSBio-581, a new heterocyclic N-phenylhydrazine derivative, in rat plasma 2003
Desing, Synthesis and Pharmacological Profile of New Tacrine Isosteres: A New Class of Potent and Selective Acetycholonesterase Inhibitors 2003
Desing, Synthesis and Pharmacological Profile of Novel Doámine D2 Receptor Ligands 2003
Design,Synthesis and Pharmacological Evaluation of Novel Pyrazolo [3,4-b ]thieno [2,3-d ]pyridine Acid Derivatives:A New Class of Anti-in flammatory and Anti-platelet Agents 2002
Vasodilatory Properties of LASSBio 294 and its Dependence on cGMP Increase 2002
A Química Medicinal de N-acilidrazonas: Novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e antitrombóticos 2002
Highly Diastereoselective mercury mediated synthesis of funstionalyzed 2-azabicyclo[3.3.0]octane derivatives 2002
Molecular Modeling of New Derivatives 1H-Pyrazolo[3,4-b]pyridine Designed as Isosters of Antimalarial Mefloquine 2002
New isoxazole derivatives designed as nicotinic acetylcholine receptor ligand candidates 2002
Local intersection volume: a new 3D descriptor applied to develop a 3D-QSAR pharmacophore model for benzodiazepine receptor 2002
Studies on the diastereoselective reduction of 2-acetyl-2-alkyl-gama-butyrolactones with boron hydrides 2002
Novel Phthalimide Derivatives, Designed as Leukotriene D4 Receptor Antagonists 2002
Structure-Activity Relationship of the Antimalarial Agent Artemisinin. 6 . The Development of Predictive in Vitro Potency Models Using CoMFA and HQSAR Methodologies 2002
Molecular Modeling of novel 1H-pyrazolo[3,4-b»pyridine Derivatives Designed as Isosters of the Antimalarial Mefloquine 2002
Selective PGHS-2 inhibitors: A rational approach for treatment of the inflammation 2002
Synthesis and Anti-inflammatory Activity of phthalimide derivatives, esigned as new thalidomide analogues 2002
Agentes Antiasmaticos Modernos: Antagonistas de receptores de leucotrienos cisteínicos 2002
Synthesis and biological evaluation of new imidazo[1-2a]pyridine derivatives designed as mefloquine analogues 2002
Estratégica de Simplificação Molecular no Planejamento Racional de Fármacos: A Descoberta de Novo Agente Cardioativo 2002
Synthesis and pharmacological evaluation of novel antinociceptive N-substituted-phenylimidazolyl-4-acylhydrazone derivatives 2002
Synthesis of Natural Amide Alkaloid Piperdardine and a New Bioactive Analogue 2001
Synthesis and Pharmacological Evaluation of new 2-azabicyclo[3.3.0]octane derivative 2001
Sobre a Química dos Remédios, dos Fármacos e dos Medicamentos 2001
A Importância da Síntese de Fármacos 2001
O Renascimento de um Fármaco: Talidomida 2001
LASSBio 294, a Novel Cardionotropic Agent, Increases the Calcium Content in the Sarcoplasmatic Reticulum of Saponin-Skinned Cardiac Fibres 2001
A novel thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine, increases inotropism and decreases fatigue of skeletal muscle 2001
Estratégias em Química Medicinal para o planejamento de fármacos 2001
Asymmetric synthesis of 3beta-angeloyloxy-4beta-hydroxyeudesman-8-one, purported sesquiterpene from Puchea quitoc 2000
Synthesis and non-addictive analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole 2000
Electron impact mass spectrometry of some 3-[3-(4-aryl)-1,2,4-oxadiazole-5-yl]acyl arylaldehyde hydrazone derivatives 2000
A possible molecular mechanism for the inhibition of cysteine proteases by salicilaldehyde N-acylhydrazones and related compounds 2000
Chiral gas chromatographic separation of 2-oxabicyclo[3.3.0]octane derivatives and their synthetic precursors 2000
O-Alkylation of bioactive phthalimide derivatives under microwave irradiation in dry media 2000
Synthesis of Functinalized g-Spirolactone and 2-oxabicyclo[3.3.0]octane Derivatives from Nuclephilic Oxirane Ring Opening 2000
Synthesis and Biological Activity of New Potential Antimalarial: 1H-pyrazolo[3,4-b]pyridine derivatives 2000
Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolyl N-Acylarylhydrazones Derivatives 2000
Synthesis and Evaluation of Novel Heterotricyclic Acylhydrazones Derivatives, Designed as PAF Antagonist Candidates 2000
A New Nicotinic Pseudoreceptor Model: A Theoretical Thermodynamic Analysis of Simultaneous Cation-p and Hydrogen Bond Interactions 2000
Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole##This paper represents contribution # 36 of the LASSBio, UFRJ (Br.) (LASSBio, http://acd.ufrj.br/≈pharma/lassbio); For contribution # 35, see [24]. 10.1016/s0223-5234(00)00120-3 2000
Studies on Antiplatelet Agents from Natural Safrole. II. Synthesis and Pharmacological Properties of Novel; Functionalized Oxime O-benzylether Derivatives 1999
A Utilização do Safrol, Principal Componente Químico do Óleo de Sassafrás, na Síntese de Substancias Bioativas na Cascata do Ácido Araquidônico: Anti-inflamatórios, Analgésicos e Anti-trombóticos 1999
Synthesis and Analgesic Pofile of Novel N-Containing Heterocycle Derivatives: Arylidedne 3-Phenyl-1,2,4-oxadiazole-5-carbohydrazine 1999
New Antithrombotic Aryl-semicarbazide Derivative Synthesized from Natural Safrole 1999
Toward a Platelet-activating Factor Pseudo-receptor 2. A Three Dimensional Semiempirical Model for Agonist and Antagonist Binding 1999
"Synthesis of New Isosteric Heterocyclic Derivatives: Pyrazolo[3,4-b]thieno[2,3-e]pyridine, Pyrazolo[3,4-b]pyrrolo[2,3-b]pyridine and Pyrazolo[3,4-b]furo[2,3-e]pyridine 1999
Síntese de Novos Análogos de Piperamidas Hipotensoras 1999
Proposal of a New PAF Pharmacophoric Map by the AM1 Method 1999
Synthesis and Anti-platelet Evaluation of Novel Aryl-sulfonamides Derivatives, from Natural Safrole 1999
Anti-inflammatory Profile of N-Phenylpyrazole Arylhydrazones Derivatives 1999
Synthesis of Piperamides from Natural Safrole 1999
Synthesis and Antinociceptive Profile of Novel Acidic Sulfonylhydrazone Derivatives, from Natural Safrole 1999
Planning and Synthesis of novel 2-oxabicyclo[3.3.0]octane derivatives as potencial lead-compounds with anti-platelet properties 1999
Synthesis And Pharmacological Evaluation Of New Flosulide Analogues, Synthesized From Natural Safrole 1998
Diastereomeric Analysis Of Bioactive N-Phenylpyrazole-4-Acylhydrazone Derivatives By High Resolution Gas Chromatography 1998
Synthesis Of New Benzylic Ethers Of Oximes Derived From 1-Phenyl Pyrazole Compounds 1998
Toward A Platelet-Activating Factor Pseudoreceptor: Semiempirical Modeling Of Cation-Pi And Hydrogen Bond Interactions In Agonist Binding 1998
Synthesis And Analgesic Properties Of New 5-Thioaryl Pyrazole Derivatives 1998
Synthesis Of New 2-Pyridinylarylhydrazones And Evaluation Of Their Analgesic, Antiinflammatory And Antiplatelet Profile 1998
Synthesis And Analgesic Profile Of New Planned Imidazo[1,2-A]Pyridine Acylaryl Hydrazones Derivatives 1998
Synthesis Of New 1,2-Benzothiazin-3-One Derivatives, Designed As Dual Cyclooxigenase And 5-Lipoxigenase Inhibitors Candidates 1998
Synthesis And Pharmacological Profile Of A New Class Of Bicyclic Phospholipids Analogues, Designed As Platelet Activating Factor Antagonist Candidates 1998
Inibidores Seletivos de Prostaglandina Endoperoxido Sintase-2 (Pghs-2): Nova Estratégia Para O Tratamento da Inflamação 1998
1H And 13C Of New Bioactive Isochromanylacylhydrazone Derivatives 1998
Four-Dimensional Quantitative Structure-Activity Relationship Analysis Of A Series Of Interphenylene 7-Oxabicycloheptane Oxazole Thromboxane A2 Receptor Antagonists 1998
Studies on Diastereoselective Synthesis of 3-Vinyl-5-Carbomethoxy-2-Oxabicyclo{3.3.0]Octane Derivatives Employing Palladium II Oxidative Cyclization 1998
1H and13C NMR of bioactive isochromanylacetylarylhydrazone derivatives 10.1002/(SICI)1097-458X(199807)36:7<533::AID-OMR328>3.0.CO;2-V 1998
Reduction Of 2-Allyl-2-Carbomethoxycyclopentanone Derivatives With Sodium Borohydride. Part 2. The Elucidation Of Diastereoselective Control. 1997
Improvement Of Enantioselective Synthesis And Chiral High Resolution Gas Chromatography Analysis Of (+)-2-Allyl-2-Carbethoxycyclopentanol 1997
The Synthesis Of New Isochromanylacetylhydrazones Designed As Probable Non-Addictive Analgesic Agents 1997
On The Modeling Of Some Active Antiinflammatory And Antithrombotic Drugs By Am1 1997
Modelagem Molecular, Ferramenta Para O Planejamento Racional de Fármacos 1997
Síintese de Beta-Ceto-Ésteres Ciclícos: Novo Procedimento Para Ciclizações de Dieckman Empregando Alcl3 e Trietilamina 1997
Substâncias Enantiomericamente Puras (Sep): A Questão dos Fármacos 1997
2-Pyridylhydrazone Derivatives, A New Class Of Platelet Aggregation Inhibitors 1996
Synthesis And Anti-Platelet Evaluation Of New Tricyclic Paf Antagonists, Designed As Structurally Related To Hetrazepines Class - Web 2086 1996
Synthesis Of Condensed Tricyclic Pyrazolo[2,3-B]Thieno[2,3-D]Pyridine And Related Isostere Derivatives 1996
Synthesis And Analgesic Properties Of New 4-Arylhydrazone 1h-Pyrazolo[3,4-B]Pyridine Derivatives 1996
A Semiempirical Study Of Pyrazole Acylhydrazones As Potential Antimalarial Agents 1996
Enantiofacial Selective Reduction Of 2-Allyl-2-Carbethoxycyclopentanone Madiated By Baker'S Yeast 1996
Design And Synthesis Of A New 4-Oxa-8w-11-Deoxy-5,6-Dihydroprostacyclin Analogue 1996
Asymmetric Friedel-Crafts Reaction: An Application To The Synthesis Of An Etodolac Analogue 1996
Cardiotônicos: Histórico & Perspectivas de Uma Antiga e Importante Classe de Agentes Terapêuticos 1996
Noções Sobre Metabolismo de Fármacos 1996
Molecular Modeliing On Paf And New Proposed Paf Antagonists 1996
Crystal Structure Of Pyrazole Derivatives. Iv. 5-Chloro-4-Chlorosulfonyl-3-Methyl-1-Phenylpyraazole 1996
Studies Toward The Diastereoseleective Reduction Of 2-Alkoxycarbonyl-2-Allylcyclopentanone Derivatives With Sodium Borohydrides 1995
The Synthesis And Analgesic Properties Of New Spiro-Isochromanyl Acid Derivatives Synthesized From Natural Safrole 1995
Semiempirical Calculations On The Mechanism Of Stereoselective Nabh4 Reduction Of 2-Methoxycarbonyl-2-Allyl-Cyclopentanone 1995
Design Of New Potential 5-Lipoxigenase Inhibitors, Dual Thromboxane Synthase Inhibitors And Thromboxane A2 Receptor Antagonists By Am1 1995
Síntese, Avaliação das Propriedades Antiedematogênicas e Relação Estrutura Atividade de Derivados 5-Arilidrazonil-N-Fenil Pirazolas 1995
Synthesis And Analgesic Properties Of 5-Acylarylhydrazone 1-H Pyrazole (3,4-B}Pyridine Derivatives 1994
Analgesic and Antiinflammatory Effects of 3-[3-(Phenyl)-1,2,4-Oxadiazol-5-yl]Propionic Acid 1994
Structures of Pyrazole Derivatives.III. 5-amino-4-ciano-1-phenylpyrazole 1994
Perspectivas Terapêuticas de Fármacos que Atuem na Cascata do Ácido Araquidônico 1994
New Pyrazolylhydrazono Derivatives Inhibitors Of Platelet Aggregation 1993
The Synthesis And Antiinflammatory Activity Of 1-Alkyl-Isochroman- 1-Yl Acetic Acids Derivatives 1993
Structures Of Pyrazole Derivatives.1 A Potential Bioisoster Of Thromboxane Synthetase Inhibitor 1993
Structures Of Pyrazole Derivatives.II.A Potential Bioisoster Of Acetazolamide. 1993
Sintese e Atividade Antiinflamatória de Novos Derivados Pirazolicos Funcionalizados. Parte 1. 5-Amino Pirazolas 1993
Agentes Antiinflamatórios Não Esteróides. Parte 1. 1993
Agentes Antiinflamatórios Não Esteróides. Parte 2. 1993
Agentes Antiinflamatórios Não Esteróides. Parte 3. 1993
Structures of pyrazole derivatives. I. A potential bioisoster of thromboxane synthetase inhibitors 10.1107/s0108270192008527 1993
The Synthesis And Antiinflammatory Properties Of A New Sulindac Analogue Synthesized From Natural Safrole. 1992
Pyrazole, An Alcohol Dehydrogenase Inhibitor Has Dual Effects On N-Methyl-D-Aspartate Receptors Of Hippocampal Pyramidal Cells: Agonist And Nomcompetitive Antagonist 1992
Synthesis Of Pyrazole Derivatives As Potential Bioisosteres Of Thromboxane-Synthetase Inhibitors 1992
Synthesis of a New Benzothiazine Derivative, Related to Oxicams, Synthesized from Natural Safrole 1992
A Importancia da Sintese de Farmacos Na Producao de Medicamentos 1991
Bioisosterismo:Importante Estrategia de Modificacao Molecular Para O Plenejamento Racional de Farmacos. Parte 1. 1991
Substituted Pyrazolylhydrazones: A New Class Of Platelet Aggregation Inhibitors 1991
Investigation Of The Lipophilicity Of Antiphlogistic Pyrazole Derivatives: Relationships Between Log Kw And Log P Values Of 5-Arylamino And Arylhydrazone-3-Methyl-4-Nitro-1-Phenylpyrazoles 1991
Antinoceptive Property Of New 4-Acyl-Arylhydrazone Pyrazolic Compounds 1991
Bioisosterismo:Importante Estrategia de Modificacao Molecular Para O Plenejamento Racional de Farmacos. Parte 2. 1991
Produtos Naturais Bioativos de Origem Vegetal e O Desenvolvimento de Farmacos 1990
Anti-Inflammatory Properties Of New Bioisosteres Of Indomethacin Synthesized From Natural Safrole Which Are Sulindac Analogues 1989
The Synthesis Of A New 8-Azaprostanoid 1989
Síntese Total de um Sesquiterpeno Natural Isolado de Aplysia brasiliana. Síntese Enantioespecífica do (+)-Brasilenol 1989
Eicosanóides. Parte 2 1988
The Synthesis Of New Hybrid Prostanoid From Natural Safrole 1987
Expeditious, Stereocontrolled Synthesis Of Racemic And Natural Brasilenol Through Intramolecular Asynetry Transfer. Absolute Stereochemistry Of Brasilenol 1987
The Synthesis of a New Prostanoid from Natural Safrole 1987
Eicosanóides.Parte1 1987
A Selective Synthesis Of Brasilenol, A Novel Sesquiterpene From The Sea Hare Aplysia Brasiliana And The Red Alga Laurencia Obtusa 1986
Sintese Estereosseletiva de 2-Oxa Biciclo[3.3.0]Octanos Funcionalizado 1985
Prostaglandin Analogues. Part 2. Synthesis Of New Derivatives From Safrole Isolated From Sassafraz Oil. 1985
Prostaglandin Analogues. The Synthesis of New Aromatic Prostanoides from Natural safrole 1984
Prostaglandin Analogues. The Synthesis of New Thromboxanes Derivatives from Natural Safrole 1984
Síntese de Análogos de Prostaglandinas a Partir do Ácido Hidnocárpico 1984
Prostaglandin Analogues. Synthesis Of Tetrahomoprostaglandin Derivatives From Natural Hydnocarpic Acid Isolated From Sapucainha Oil. 1983
The Synthesis of 6,7-dehydro-1-methyl-5H-pyrrolizidine-7-one (Danaidone) from pyrrolizidine alkaloid 1983
Nova Síntese da Sarcomicina-Via da Alfa Tropolona 1983
Utilização de Produtos Naturais Abundantes na Síntese de Substâncias Biologicamente Ativas: Resultados 1983
A New Synthesis Of Sarkomycin 1982
The Total Synthesis Of Prostaglandins By Tropolone Route 1982
An Improved Synthesis From Natural Safrole Of Indole Derivatives Related To Indomethacin 1982
Síntese de Derivados do Ácido 2,3-Indolilacético a Partir do Safrol 1982
Síntese de Prostaglandinas a Partir de Produtos Naturais Abundantes 1982
A Química Orgânica Sintética 1982
Síntese de Compostos Biologicamente Ativos a Partir de Produtos Naturais Abundantes 1981
Síntese de Potenciais Agentes Antiinflamtórios Não-Esteróides do Grupo dos Ácidos Heteroaril Carboxílicos 1981
Constituintes Químicos de Barbacenia Bicolor Mart 1980
Carbon-13 Nuclear Magnetic Resonance of Pyrrolizidines Alkaloids 1980
Synthesis of New Allenic Prostanoid 1979
Prostaglandinas 1979
Voies Nouvelles en Synthese de Prostaglandines 1977
The Use of Cyclo (3.2.0)Heptanones in The Synthesis of Natural Products and Modified Natural Products 1977
Tetracyclic Triterpenes of Barbecenia Biocolor Mart 1976
Controlled Formation of Allenes 1976
New Synthesis of Prostaglandins 1976
Reactions of Aldehydes with Lithium Dimethylcopper 1975
Asymmetric Induction in Addition of Organocuprates 1975
Formation of Allenes by Reaction of Lithium Diorganacuprates 1975
Pequena Contribuição para a Síntese Estereoespecífica de Olefinas 1973
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Study of leishmanicidal activity of derivatives from combretastain A4 2013
Novel Sulfonylhydrazone derivative reduces diabetic neuropaty in streptozotocin- injected rats 2013
Anti-amastigote activity of novel analogues of LASSBio-1064 2013
Relação estrutura-atividade de análogos de LASSBio-1586 2013
CoMFA, Síntese e Avaliação Farmacológica de Novos AINES Desenhados como Inibidores de Proteína Quinase Ativada por Mitógeno p38 2005
Novos Compostos Candidatos a Inibidores da trans-Sialidase de Trypanossoma cruzi 2005
Bases Moleculares para a Inibição Seletiva da Atividade Peroxidásica da PGHS-1 pelo Resveratrol 2005
Avaliação do Comportamento Eletroquímico de LASSBio-881, Candidato a Fármaco Analgésico e Antiimflamatório com Propriedades Antioxidantes 2005
Planejamento, síntese e avaliação farmacológica de novos derivados heterotricíclicos candidatos a protótipos de agentes neuroativos 2005
Planejamento, Síntese e Avaliação Farmacológica de Novos Derivados 2-benzoila-4,5-metilenodioxitolueno substituídos, Candidatos a Protótipos de Fármacos Analgésicos e Antiinflamatórios. 2005
ESTUDO DA ATIVIDADE ANALGÉSICA E ANTIINFLAMATÓRIA DA SUBSTÂNCIA MRC A2 ISOLADA DE MAYTENUS RIGIDA (CELASTRACEAE) 2005
ESTUDO DO PERFIL ANTIINFLAMATÓRIO E ANALGÁSICO DE DERIVADOS TIENILACILIDRAZÔNICOS ANÁLOGOS AO LASSBIO 294. 2005
ESTUDO DO MECANISMO DE AÇÃO ANTIAGREGANTE PLAQUETÁRIO DE DERIVADOS TIENILACILIDRAZÔNICOS 2005
Estudo comparativo da S-alquilação de derivados ftalimídicos candidatos a protótipos de fármacos antiinflamatórios na presença versus ausência de solvente orgânico 2005
A DFT Study for the Inhibition Mechanism of Carbonic Anhydrase by N-Acylhydrazones Derivatives 2004
A DFT study of the cordination behavior of N-acylhydrazone derivates proposed as inhibitors of angiotensin converting enzyme. 2004
Antagonistas alfa1-adrenérgicos N-fenilpiperazínicos: estudo sobre o reconhecimento molecular pelo adrenoceptor alfa1D 2004
Asymmtric Synthesis of a New Prototype Anti-asthma Drug Catalysed by Lipase 2004
Efeito de Derivados Tienilhidrazonas na Função Contrátil de Corpo Cavernoso de Cobaio 2004
Enzymatic hydrolysis by immobilized lipase applid to new prototypes phthlimidic anti-asthma drug 2004
Estudos Teórico de N-acilidrazonas: Novos compostos protótipos de fármacos anti-maláricos, antiinflamatórios e anti-trombóticos 2004
New semi-synthetic piperidine alkaloids active as brain cholinesterase inhibitors with low toxicity 2004
Novos candidatos a fármacos anticolinesterásicos planejados a partir de alcalóides piperidínicos de Senna spectabilis (Leguminoase) 2004
Pharmacological Investigation of New a1-Adrenergic Receptor Antagonists 2004
Synthesis and evaluation of the cardiovascular properties of new acylhydrazone derivatives structurally related to LASSBio-294 2004
Potencial terapeutico de diferentes inibidores de fosfodiesterases em um modelo de lesão pulmonar aguda 2004
Perfil farmacocinético pré-clínico de um novo derivado heterocíclico N-fenilpiperazínco (LASSBio-581). 2003
Atividade analgésica e estudos de SAR de 2,6-alquil-piperidin-3-óis isolados de Cassia leptophylla (Leguminosae). 2003
Construção de um modelo de QSAR-3D pelo o Método CoMFA para derivados Diarilpizazólicos com atividade antiinflamatória. 2003
Síntese e avaliação farmacológica de uma nova classe de carbamatos e ésteres planejados como antagonistas do PAF, derivados do Cardanol. 2003
Novos derivados N-acilidrazonas do núcleo Tieno[2',3',4,5]benzo[d][1,3]dioxala, desenhados a partir do Protótipo LASSBio 294. 2003
Modelo CoMFA de derivados fenilpiperazínicos com atividade antagonista-adrenérgica 2003
Efeito hipotérmico de novos derivados N-fenilpiperazínicos candidatos a protótipo de agentes dopaminérgicos. 2003
Análogos amídicos do sulindaco sulfona, desenhados como candidatos à novos antiinflamatórios de segunda geração. 2003
Caracterização do atropoisomerismo de antiinflamatórios N-fenil-bispirazólicos. 2003
Plamejamento, síntese e avaliação farmacológica de novos derivados heterotriciclicos candidatos a protótipos de agentes ansiolóticos. 2003
Validação de metodologia analítica para quantificação de um novo derivado heterocíclico N-fenilpiperazínico (LASSBio-581). 2003
Modelagrm molecular como ferramenta de elucidação do perfil diaestereosseletivo de reduções de ceto-ésteres por boroidretos. 2003
Nova metodologia sintética de obtenção One-Pot de derivados hidrazínicos e hidrazônicos a partir de ácidos carboxílicos. 2003
Monitoração da Publicidade e Propaganda de Medicamentos do Estado do Rio de Janeiro 2003
Studies Toward the diastereoselective Synthesis of gem-6-Oxarosaprostol, a New Antiulcer Drug Candidate. 2003
New Synthetic Methodology to the One-Pot Synthesis of Hydrazides and Hydrazones from Carboxylic acids. 2003
A novel phenoxi-phtalimid acid derivative LASSBio 552 caused a selective inhibition of allergen-evoked eosinophil recruitment in sensitized rats 2003
Planejamento, Síntese e Avaliação Farmacológica de novos antagonistas alfa-Adrenérgicosderivados de Safrol 2002
Novos Análogos da Talidomida Desenhados por Hibridação molecular como Inibidores da Enzima PGHS da Modulação do TNF-alfa 2002
Planejamento, Síntese e Avaliação Farmacológica de Novos Derivados 1,3,4-Tiadiazólicos, Candidatos a Inibidores Seletivos de PGHS-2 2002
Novos Candidatos a Protótipos de Farmacos Algésicos, Desenhados como Agonistas Canabinoides 2002
Avaliação Analgésica e Antinflamatória da (-)-Espectalina : Um Alcalóide Piperidínico isolado de cassia leptophylla(Leguminosae) 2002
Novos Alcalóides piperidínicos Isolados das Flores de Cássia Leptophylla (Leguminosae) 2002
Redução Enantiosseletiva de 2-Acetil-2-alil-gama-butirolactona com Fermento de Pão 2002
Diastereosseletividade em Reações de heteromercuração 2002
Planejamento e Síntese de Novos Candidatos a Protótipos de Agentes Neuroativos 2002
Malarial cysteine protease inhibitors based on mefloquine and chloroquine. 2002
Prophylatically Therapeutic Potential of PL596 in a Model of Acute Lung Injury 2001
Síntese de Avalçiaçaõ farmacológica e Desenvolvimento de Modelo Farmacofórico de novos Análogos da Talidomida 2001
Síntese, Avaliação Farmacológica e Desenvolvimento de Modelo Farmacofórico de Novos Derivados Fenilpiperazínicos, Candidatos a agentes antidepressivos 2001
Síntese de Novo Derivado Acilidrazônico Benzo-[C][1,2,5]-Tiadizólico como Agente Analgésico 2001
Planejamento , Síntese e Atividade Analgésica de Novos Derivados N-Acilidrazônicos Pirazólicos 2001
Planejamento, Sintese e avaliação Farmacológica d Novos Comostos Heterocíclicos Candidatos a Protótipos de Agentes Anti-psicóticos. 2001
Planejamento Síntese e Atividade Antiinflamatória e Analgésica de uma Série Congênere de Derivados N-Acilidrazônicos Imidazólico 2001
Modelagem Molecular de novos mode los Heteroc´clicos Isosteros ao Antimalárico Mefloquina 2001
Estudos da Interação Cox-2/Ligantes: O Papel do Encaixe induzido na Proposição de Novos Candidatos a Agentes Antiinflamatórios 2001
Estudos Fitoquímicos de Cassia Leptophylla Biomopnitorado por Ligantes Transgênicos 2001
Estudos Visandoa Redução Diastereosseletiva dos Derivados 2-Alil-2-Carboalcoxicicloexanonas com Hidretos de Boro 2001
Síntese de Alcalóides Amído piperdardina e de um Novo Análogo Bioatívo 2001
Cardiovascular Actions of a Novel Synthetic Analogues of Natural Piperamides 2001
Diastereoselective reduction of beta-keto-esters with boron hydrides: an efficient and inexpensive strategy to the preparation of new bioactive compounds 2001
Antiinflammatory Effect of Thalidomide-Derived Compounds on LPS-Induced Inflammation in Mouse Lung 2001
Prophilatically Therapeutic Potential of PL596 in a Model of Acute Lung Injury 2001
Síntese de Derivados Piridinil[1,2-a] Midazólicos Candidatos a Novos Agentes Antimaláricos 2000
Planejamento e Síntese de Novos Candidatos a Protótipo de Agente anti-Psicótico 2000
Planejamento Síntese e Avaliação das Propriedades Antiinflamatória de novos Derivados Ftalimídicos Piperazínicos Desenhados por Hibridação molecular como Inibidores de Fosfodiesterases 2000
Planejamento Síntese e Avaliação Farmacológica de Novos Candidatos a Agentes Antiinflamatórios não Esteroidais de segunda Geração, Derivados do Safrol 2000
Modelagem Molecular de Derivados N-Acilidrazônicos Com Ação Antinoceptiva 2000
Planejamento Síntese e Atividade Antiinflamatória de Novas Sulfolidrazonas Fenilacéticas 2000
Planejamento, Síntese e Avaliação farmacológica a Novos Candidatos a Protótipos de Agentes Antiinflamatórios, Desenhados como Inibidores de PGHS-2 por Simplificação Molecular 2000
Dinâmica Molecular das Interações de Novos Análogos da Tacrina (THA) com a Acetilcolinesterase 2000
Síntese de Novas N-Acilidrasonas Imidazólicas Planejadas como Novos Candidatos de Agentes Analgésicosa 2000
Síntese Modelagem Molecular e Avaliação Farmacológicade Novos Análogos de Piperamidas Naturais , Planejados Como Novos Agentes Cardiodepressivos 2000
Síntese de Novos Análogos Bicíclicos do Nebracetam Derivados do Sistema 2-Azabiciclo[3.3.0]Octano 2000
Platelet anti-aggregatimg activity of a new series of acylarylhydrazone-phenothiazine derivatives 2000
Anti-inflammatory and analgesic profile of new phenyl-imidazolic acylarylhydrazone derivatives planned as 5-LO and PGHS inhibitors 2000
Analgesic and anti-inflammatory activities of new molecules rationally planned as selective inhibitors of PGHS-2 enzyme 2000
Synthesis and assay of tacrine-like analogs with cholinesterase inhibition properties 2000
Vascular pharmacological characterization of a newly synthesized drug LASSBio-294 2000
Analgesic and antiinflammatory activities of new molecules rationally planned as selective inhibitors of PGHS-2 enzyme 2000
Inhibition of LPS-induced TNF-alfa and neutrophil influx into mouse lung by treatment with new potentially phosphodiesterase inhibitors 2000
Estudos e Dinâmica Molecular de Inibidores Seletivo de PGHS-2 em Modelos de Sítio Ativo 1999
Proposta de um Novo Modelo Farmacofórico 3D para o Receptor do Raf 1999
Estudos Semi-Empíricos de Ligantes Nicotínicos, Novo Modelo 3D; Pseudo-Receptor de nAChR 1999
Novo Modelo Farmacofórico 3D para Antagonistas de Receptor de Leucotriênios(cysLT1) 1999
Modelagem Molecular de Derivados Pirazolo(3,4-b) Piridina Candidatos a Agentes Antimaláridos 1999
Avaliação de Afinidade Relativa de Trombina usando tecnicas de Dinâmica Molecular 1999
Métodos de QSAR- Análise Comparativa de Campo Molecular (CoMFA) e Fragmentos Estruturais (HQSAR) de Drivados Acilhidrazona com Inibidores de Cruzaína 1999
Planejamento e Síntese de Novos Derivados Isoxazólicos Neuroativos 1999
Planejamento e Síntese de Novos Padrões de Derivados N-acilidrazônicos, Propostos Como Novos Candidatos a Agentes Anti-Inflamatórios 1999
Síntese de Novas Indolil-N-Acilidrazonas, Planejadas Racionalmente Como Agentes Analgésicos, a partir do Safrol 1999
Síntese de Novos derivados Tieno(2,3-c) Pirazolo 2-N-Acilidrazônicos, Candidatos a Analgésicos de Ação Periférica 1999
Síntese de novos drivados Pirazolo[2,3-d] Piridínicos Candidatos a Antagonistas de Receptores de LTD4 1999
Síntese de novos Isosteros de N-Acilidrazonas Trizólicas Funcionalizadas 1999
Síntese de Novos N-Acilarilidrazônico-Fenotiazínicos, Candidatos a Inibidores Duais de 5-Lipoxigenase/ciclooxigenase 1999
Síntese de Novos Heterocíclicos Derivados Como Candidatos a Agentes Neuroativos de Interesse Terapêutico 1999
Análise Conformacional por AM1 e Cosmo de Derivados 4-Acil-5-Metil-Imidazolilidrazonas com Atividade Analgésica e Anti-Inflamatórias 1999
Modelo de Qsar-3d Para Receptor Diazepínico: Uma Nova Metodologia de Descrição da Afinidade 1999
Uitlização de Microondas em Reação de O-Alquilação de Derivados Ftalimídicos Funcionalizados , Planejados como Potenciais Agentes Anti-Asmáticos. 1999
Estudos de Redução Diastereosseletiva de Derivados 2-Acetil-2-Alquil-Butirolactonas com Hidretos de Boro 1999
Síntese de Novos Síntons Isósteros de Heterotricíclicos Funcionalizados: Pirazolo[3,4-b] Furano[2,4-e]Piridina e Pirazolo[3,4b] e Pirrolo[2,3-e]piridina 1999
Síntese de Novos Análogos de PiperidinaS Hipotensoras 1999
Caracterização dos produtos Biciclicos cis[4.3.0]nonano, Cis[3.3.0]octano e gama -espiro Lactonas [4.4]nonano por RMN1He RMN13C 1999
Investigação Teórica da Relação Diastereoiomérica observada na Formação de Derivados Acil-Hidrazonas 1999
Mecanismos Envolvidos na Atividade Depressora Cardíaca Induzida por Novas Piperamidas 1999
Pharmacological Profile of new thieno-pyrazole-pyridine derivatives with anti-platelet and anti-inflammatory effects. 1999
Synthesis of a cis-Bicyclo[4.3.0]nonane Ring System as Intermediate for a 4-Oza-5,6-dihydro-11-deoxy-8w-Homoprostacyclin 1999
Acompanhamento da síntese da nova N-acilidrazona bioativa por RMN 13C no estado sólido In: VII Encontro de Usuários de Ressonância Magnética Nuclear 1999
Hologram QSAR (HQSAR) od Artemisinin Analogs 1999
Estudos de Modelagem Molecular de Inibidores Seletivos de PGHS-2: Proposta de um Modêlo Tridimensional de Sítio Farmacofórico 1998
Modelagem Molecular de Receptor Nicotínico e Antagonistas de Receptor GABAA Visando a Doença de Alzheimer 1998
Síntese de Novos Ácidos Pirazolo[3,4-b]tieno[2,3-d]piridina Alquil Carbocílicos, Planejados Racionalmente como Agentes anti-asmáticos 1998
Modelagem Molecular de Análogos Benzodiazepínicos 1998
QSAR-3D de Antagonistas de Receptor TP 1998
Interações Hidrofóbicas: Um Modêlo Semi-empírico 1998
Síntese de Novas Sulfonamidas Heterociclícas Derivadas do Safrol, Planejadas como Antagonistas-Protótipos de Receptores de Endotelinas 1998
Síntese e Avaliação Farmacológica de Novos Derivados Bipirazólicos, Planejados como Inibidores Seletivos de PGHS-2 1998
Síntese Diastereosseletiva de Novos derivados Hidrazônicos, Planejados como Novos Protótipos de Agentes Anti-inflamatório 1998
Síntese de 4-Acil-5-metil-imidazolil-hidrazonas com Atividade Analgésica 1998
Síntese de Piparamidas Hipotensoras e Isósteros, a Partir do Safrol 1998
Síntese de Novas 4-Arilacil-(1-fenil-1,2,3-triazolil0-hidrazonas Funcionalizadas 1998
Estudos Sobre a Síntese e Reações de Adição ao Epóxido Derivado da 2-Alil-2-carbometoxiciclopentanona 1998
Construção de um Modêlo Farmacofórico 3D de Antagonistas de Receptore de LTD4: Parte 1 - Estudos Conformacionais 1998
Síntese e Avaliação Farmacológica de Novos Derivados Aril-etilsulfonamídicos, Candidadtos a Antagonistaas de Receptores de Tromboxana: Anti-trombóticos 1998
Síntese e Avaliação Farmacológica de Novos Derivados N-Sulfonilarilidrazônicos: Analgésicos 1998
Planejamento, Síntese e Avaliação Farmacológica de Novos Protótipos de Inibidores Seletivos de Prostaglandina-H Sintase (PGHS-2) 1998
Atividaade Cardiodepressora de Novas Piperamidas 1998
Atividade Analgésica e Antinflamatória deNovos Derivados 4-Acil-5-metil- imidazolilacilidrazono 1998
Atividade Famaacológica de Novos Possíveis Agentes Duplos: Antagonistas de Receptores de Leucotrienos e Inibidores de Tromboxana Sintase 1998
Atividade Antiinflamatória de Novos Derivados Benzotiazínicos Sintetizados como Inibidores de PGHS- 2 e 5-LO 1998
Inibição da Pleurisia Alérgica em Ratos por Compostos ArilHidrazônicos Hidroxi-Metoxi Substituídos 1998
Um Novo Análogo Estrutural dos Benzodiazepínicos Bloqueia o Efeito Potencializador do Diazepam sobre Correntes Macroscópicas Ativadas pelo GABA em Neurônios Hipocampais 1998
Um Novo Derivado Pirazolo 4-acilhidrazono Aumenta a Liberação Es[pontanêa e Evocada de GABA em Neurônios Hipocampais 1998
Um Novo Análogo do GABA Potencializa a Neurotransmissão Gabaérgica e Inibea Glutamatérgica em Neurônios Hipocampais 1998
Um Novo Análogo Estrutural do GABA Atua como Antagonista dos Receptores GABA-A em Neurônios Hipocampais 1998
Determinação do Potencial Analgésico de Duas Diferentees Séries de Derivados Acilidrazônicos 1998
Ações do LASSBio-294 na Regulação do Cálcio em Fibras Cardíacas Desnudas 1998
Estudo do Mecanismo da Atividade Antiagregante Plaquetária de Derivados Aacilidrazônicos 1998
Studies on the Mechanism of Anti-platelet Activity of Furyl-hydrazones and Acylhydrazones Derivatives, Archives of Pharmacology (Suppl 2), 358, R719 1998
Antiinflammatory Profile of New Flosulide Analogues Synthesized as COX-2 Inhibitors from Natural Safrole,Archives of Pharmacology 1998
Desenvolvimento de um Pseudoreceptor para o Fator de Ativacao Plaquetaria (PAF) com o Metodo Semi-empirico AM1 1997
Modelagem Molecular de Novos Derivados Antagonistas do Receptor do PAF 1997
Sintese e Avaliacao Farmacologica de Novos Analogos de Inibidores Seletivos de PGHS-2, Derivados do Safrol 1997
Síntese de Novas Sulfonilidrazonas, Planejadas Racionalmente como Agentes Antitrombóticos, a Partir do Safrol 1997
Estudo AM1 de Derivados Pirazo[2,3-a]lopiridina como Provaveis Agentes Antimaláricos 1997
Sintese de Novos Derivados Imidazo[1,2-a]piridinil-N-alquilacilidrazônicos 1997
Sintese Diastereosseletiva de Derivados 3a,b-vinil 5-cabetoxi-2-oxabiciclo[3.3.0.]octano 1997
Síntese Diastereosseletiva de Novos Derivados Benzotiazínicos com Possíveis Inibidores Seletivos de PGHS-2 1997
Sintese de Novos Eteres de Oxima Analogos do Ridogrel a Partir do Safrol 1997
Sintese Diastereosseletiva do cis-2-Alil-2-carbometoxi-cciclopentanol, Utlizando Iodeto de Samário (SmI2) 1997
Derivados de b-Ciclodestrinas. Avaliação Enantiosseletiva e uma Contribuição para o estudo do Mecanismo de Separação Quiral 1997
Análise Diatereoisomérica de Acilidrazonas por Cromatografia Gasosa de Alta Resolução 1997
ATIVIDADE ANTIAGREGANTE PLAQUETÁRIA DE NOVOS ANÁLOGOS DE INIBIDORES DUPLOS TXS E TPant 1997
ATIVIDADE ANTINFLAMATÓRIA DE NOVOS DERIVADOS INIBIDORES SELETIVOS DA COX-2 1997
AVALIAÇÃO DAS PROPRIEDADES ANTIINFLAMATÓRIAS DE NOVOS DERIVADOS 4-HIDROXI-PIRAZOLO[3,4-b]PIRIDINA-4-CARBOXAMIDAS (COMO INIBIDORES DUPLOS COX/5-LO) 1997
Semiempirical Study of Pyrazole Acyl-Hydrazones as Potential Antimalarial Agents 1996
Diastereomeric Separation of 3a,b-O-alkyl-hydroxymethl-5-carbocy-2-oxabicyclo[3.3.0]octane Derivatives Using Selective Lactonization 1996
Synthesis and Antimalarial Properties of 4-aminoalcohol Pyrazolo[3,4-b]pyridine Derivatives 1996
Molecular Modeling on PAF and New Proposed PAF Antagonists 1995
Drug Design of New Potential 5-Lipoxigenase Inhibitors and Dual Thromboxane Synthase Inhibitors and Thromoboxane A2 Receptor Antagonists by AM1 1995
N-HETEROCYCLIC HYDRAZONE DERIVATIVES, A NEW CLASS OF ANTI-PLATELET AGENTS 1995
Ä New Series of Platelet Aggregation Inhibitors: 4-Acyl-pyrazolylhydrazone Derivatives 1994
Studies Towards the Enantioselective Synthesis of Etodolac 1994
Ënantioselective Reduction of 2-Allyl-2-carbethoxycyclopentanone Mediated by Baker's Yeast 1994
Synthesis of New Analogues of Tenidap 1994
Synthesis and Pharmacological Evaluation of Heterocyclic Hydrazones, Acylhydrazones and Amides: A New Class of Antiinflammatory and Antithrombotic Compounds 1994
Molecular Modeling Studies on Drugs Related to tha Therapy of Inflammation and Cardiovascular Diseases 1994
Relação Estrutura Química Atividade Analgésica de 2-Hydrazonopiridina 1994
Determinação do Carater Lipofiflico de Derivados 4-acilidrazonopirazóis por HPLC e Relação entre Log Kw e Valores de Log P 1994
Sintese de Arilidrazonas Com Potencial Atividade Antiinflamatoria 1993
An Am1 Study Of 1-Phenylpyrazole-4-Alkenyl Carboxylic Acid Derivative Of Biological Interest. 1993
Sintese de Novos Derivados 3-[(3-Aril0-1,2,4-Oxadiazol-5-Il] Propano- (N-Aril)-Amida. 1993
Sintese de Derivados 4-Arilamido Pirazolicos Com Atividade Antiinfla- Matoria, Analgesica e Anti-Agregante Plaquetario. 1993
Atividade Antinoceptiva de Derivados Pirazoli[3,4-B]Piridina 1993
Atividade dos Derivados Pirazolo 4-Acilidrazono Na Agregacao Plaquetaria In Vitro de Prp Humano. 1993
Sintese e Avaliacao Antiinflamatoria e Analgesica do Acido 1-Fenil-3-Metil Pirazolo[3,4-B]Piridina-4-Acetico. 1993
Relacao Entre Aestrutura e Atividade Analgesica de Derivados 5-Acil-Arilidrazono Pirazolo[3,4-B]Piridinicos. 1993
Estudo dos Parametros Estereoeletronicos Sobre A Ativida Analgesica de Derivados Hidrazono-Pirazolicos 1993
Sintese e Atividade Analgesica de Novos Derivados 4-Arilamino Pirazolo[3,4-B]Piridina 1993
Um Estudo Conformacional da 5-Hidrazonopirazola 1993
Analise Conformacional de Um Derivado do Safrol Por Mecanica Molecular 1993
Sintese de Novos Agentes Nsai A Partir do Safrol 1993
Sintese de Arilidrazonas com Potencial Atividade Antiinflamatoria 1993
Atividade Antimicrobiana de novos Derivados 5-Arilamina-N-fenilpirazolas 1993
Synthesis and Biological Activity of 8w-11-Deoxy Analogue of Prostacyclin 1992
QSAR in N-Phenylpyrazoles 1991
Synthesis and preliminar Pharmacological Evaluation of Arachidonic Acid Cascade Enzymes Inhibitors 1990
Preliminar Results in the Synthesis of a New Analogue of Sulindac 1989
Synthesis and Preliminar Pharmacological Evaluation o New 5-amino and 5-hidrazinopyrazoles as Antiinflammatory and Analgesic Agents 1989
Síntese de Macrolactonas Relacionadas com a Brefeldina-A 1987
Resultados Preliminares na Síntese do Derivado 4-Oxa-11-desoxi PGI 1987
Síntese de Derivados Pirazólicos com Potencial Atividade Inibitória da Quimiotaxia de Leucócitos 1987
Derivados Pirazólicos com Potencial Atividade Inibitória da Tromboxana-Sintetase 1987
Potenciais Agentes Anti-Inflamatórios Não-Esteroidais do Safrol. Parte 1 1986
Potenciais Agentes Anti-Inflamatórios Não-Esteroidais do Safrol. Parte 2. 1986
Progress in the Synthesis of (4Z)-11-Deoxy-8w, 6 PGI1 1985
Diastereoisomeric Selection in the Oxidative Cyclization of 2-Carbethoxy-2-allyl cyclopentanol 1985
Síntese Total do Brasilenol 1984
Síntese do 1-etoxi-1-tertbutildimetilsililoxi-4-isopropil-butadieno 1984
Utilização do Eugenol como Matéria-prima para a preparação de Derivados do Ácido Mucônico e do Ácido Adípico 1984
A Biomimetic Transformation of a Pyrrolizidine Alkaloid into a Pheromone of Danaid 1982
Studies Directed Towards the Synthesis of Prostaglandins Analogs from Natural Products 1980
Síntese Total de Nova Prostaglandina Alênica 1978
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