Julio Scharfstein

Instituição:

Universidade Federal do Rio de Janeiro

Centro:

Centro de Ciências da Saúde

Unidade:

Instituto de Biofísica Carlos Chagas Filho

Departamento:

Programa de Imunobiologia/Biof

ORCID:

não disponível no Lattes


Formação:

  • Biortechnology Research Institute

    | Pós-Doutorado | 1991 - 1992

  • New York University

    | Mestrado | 1974 - 1976

  • New York University

    | Doutorado | 1974 - 1978

  • Israel Institute Of Technology

    Quimica | Graduação | 1969 - 1972
Laboratórios:
Nuvens de Palavras:
Artigos:

(49.57% artigos com DOI)

Titulo DOI Ano
Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy 10.3390/jcm12082888 2023
High mobility group box 1, , lipid mediators, and tissue factor are elevated in -19 patients: as a biomarker of worst prognosis 10.1111/cts.13475 2023
Pleiotropic antifibrotic actions of aspirin-triggered resolvin D1 in the lungs 10.3389/fimmu.2023.886601 2023
Sheltered in Stromal Tissue Cells, Trypanosoma cruzi Orchestrates Inflammatory Neovascularization via Activation of the Mast Cell Chymase Pathway 10.3390/pathogens11020187 2022
Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors 10.3390/ph14010056 2021
P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation 10.1007/s12015-021-10129-7 2021
Dietary Fiber Drives IL-1β-Dependent Peritonitis Induced by Bacteroides fragilis via Activation of the NLRP3 Inflammasome 10.4049/jimmunol.2000078 2021
Surface megalin expression is a target to the inhibitory effect of bradykinin on the renal albumin endocytosis 10.1016/j.peptides.2021.170646 2021
Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis 10.3389/fimmu.2020.574862 2020
IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection 10.1002/jlb.4ma0420-568r 2020
Kinins Released by Erythrocytic Stages of Plasmodium falciparum Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors 10.3389/fmed.2019.00075 2019
Subverting bradykinin-evoked inflammation by co-opting the contact system 10.1097/MOH.0000000000000444 2018
Oral infection of mice with Fusobacterium nucleatum results in macrophage recruitment to the dental pulp and bone resorption 10.1016/j.bj.2018.05.001 2018
P2-×-7-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation 10.1016/j.imbio.2018.10.008 2018
Computer-aided quantification of microvascular networks: Application to alterations due to pathological angiogenesis in the hamster 10.1016/j.mvr.2017.03.004 2017
Mast Cell Coupling to the Kallikrein-kinin System Fuels Intracardiac parasitism and Worsens Heart Pathology in Experimental Chagas Disease 10.3389/fimmu.2017.00840 2017
Effect of Anti-hypertensive Therapy with Angiotensin Converting Enzyme Inhibitors on Chronic Periodontitis: a Case-Control Study 10.1111/odi.12551 2016
A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection 10.1177/0022034515593465 2015
Porphyromonas gingivalis Fimbriae Dampen P2X7-Dependent Interleukin-1beta Secretion 10.1159/000363338 2014
C5a and Bradykinin Receptor Cross-Talk Regulates Innate and Adaptive Immunity in Trypanosoma cruzi Infection 10.4049/jimmunol.1302417 2014
Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B 2 and B 1 Receptors 10.1155/2014/143450 2014
The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi 10.3389/fimmu.2012.00396 2013
Novel Family of Insect Salivary Inhibitors Blocks Contact Pathway Activation by Binding to Polyphosphate, Heparin, and Dextran Sulfate 10.1161/atvbaha.113.302482 2013
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathyâ¿¿ 10.1111/j.1476-5381.2011.01609.x 2012
Bradykinin Enhances Sindbis virus Infection in Human Brain Microvascular Endothelial Cells 10.1016/j.virol.2011.10.003 2012
Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway 10.1016/j.mvr.2011.10.003 2012
Resistance to visceral leishmaniasis is severely compromised in mice deficient of Bradykinin B2-Receptors. 10.1186/1756-3305-5-261 2012
Infection-associated vasculopathy in experimental chagas disease pathogenic roles of endothelin and kinin pathways. 10.10106/B978-0-12-385895-5.00005-0 2011
Captopril increases the intensity of monocyte infection by Trypanosoma cruzi and induces human Th17 cells 10.1111/j.1365-2249.2010.04270.x/ 2010
Trypanosoma cruzi Cysteine Proteases, Acting at the Interface Between the Vascular and Immune Systems, Influence Pathogenic Outcome in Experimental Chagas Disease 10.2174/1874421401004010060 2010
Perspectives on the Trypanosoma cruzi¿host cell receptor interactions 10.1007/s00436-009-1383-3 2009
Back to the future in chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research 10.1590/S0074-02762009000900025 2009
Salivary gland homogenates of lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation 10.1159/000197866 2009
Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors 10.1189/jlb.1108693 2009
Kinin danger signals proteolytically released by gingipain induce fimbriae-specific IFN-y-and IL-17-producing T cells in mice infected intramucosally with porphyromonas gingivalis 10.4049/jimmunol.0900895 2009
Protease Activated Receptor Signaling Is Required for African Trypanosome Traversal of Human Brain Microvascular Endothelial Cells 10.1371/journal.pntd.0000479 2009
Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway 10.1515/BC.2008.126 2008
A recombinant form of chagasin fromTrypanosoma cruzi: inhibitory activity on insect cysteine proteinases 10.1002/ps.1553 2008
Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi 2008
The role of conserved residues of chagasin in the inhibition of cysteine peptidases 10.1016/j.febslet.2008.01.008 2008
The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of an Inhibitor Family 10.1016/j.str.2007.03.012 2007
Kininogens Coordinate Adaptive Immunity through the Proteolytic Release of Bradykinin, an Endogenous Danger Signal Driving Dendritic Cell Maturation 10.1111/j.1365-3083.2007.01983.x 2007
The propeptide of cruzipain???a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin?F 10.1111/j.1742-4658.2007.05666.x 2007
Bradykinin B2 Receptors of Dendritic Cells, Acting as Sensors of Kinins Proteolytically Released by Trypanosoma cruzi, Are Critical for the Development of Protective Type-1 Responses 10.1371/journal.ppat.0030185 2007
1 H, 15 N and 13C assignments of the cysteine protease inhibitor Chagasin from Trypanosoma cruzi 10.1007/s10858-006-0014-x 2006
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease 10.1172/JCI27798 2006
Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi 10.4049/jimmunol.177.9.6325 2006
The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi 10.1111/j.1574-6968.2006.00267.x 2006
Parasite cysteine proteinase interactions with ?2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids 10.1016/j.imbio.2005.10.014 2006
Solution Structure and Backbone Dynamics of the Trypanosoma cruzi Cysteine Protease Inhibitor Chagasin 10.1016/j.jmb.2006.01.064 2006
Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex 10.1016/j.micinf.2005.06.016 2006
Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa 10.1007/s00436-006-0195-y 2006
Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells 10.1242/jcs.01677 2005
Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzy and functional complementation of a Saccharomyces cerevisiae PGM null mutant 10.1093/glycob/cwj023 2005
A New Cruzipain-Mediated Pathway of Human Cell Invasion by Trypanosoma cruzi Requires Trypomastigote Membranes 10.1128/IAI.72.10.5892-5902.2004 2004
Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin-receptor (B1/B2) subtypes. FASEB Journal.17:73-75, 2003. 2003
Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens 10.1016/S0014-5793(03)00327-2 2003
Role of vasoactive mediators in the pathogenesis of chagas' disease. 2003. FRONTIERS BIOSCIENCE 8:E410-9 2003
Cutting Edge: Bradykinin Induces IL-12 Production by Dendritic Cells: A Danger Signal That Drives Th1 Polarization 10.4049/jimmunol.170.11.5349 2003
Review of the World Class Parasites Book series 2003
Congopain from Trypanosoma congolense: drug target and vaccine candidate. Biol. Chem.; 383:439:449 2002
Induction of B-and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection. Microbes and Infection; 4:805-813. 2002
Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors. Mol.Biochem. Parasitol. 2001 Apr 25;114(1):41-52. 2001
Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi 2001
Heparan Sulfate Modulates Kinin Release by Trypanosoma cruzi through the Activity of Cruzipain 10.1074/jbc.M108518200 2001
Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi.Eur J Biochem 268(24):6578-86.2001 2001
Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine proteinases. Mol Biochem Parasitol. 109(1):47-59., 2000 2000
Host cell Invasion by Trypanosoma cruzi is potentiated by activation of Bradykinin B2 receptors. 2000. J Exp Med. 192(9):1289-300 2000
Discrimination of cruzipain, the major cysteine proteinase of T. cruzi and mammalian cathepsin B and L, by a pH inducible fluorogenic substrate of trypamosomal cysteine proteinases.Eur J Biochem. 1999 Jan;259(1-2):275-80. 1999
A role for extracellular amastigotes in the immunopathology of Chagas disease 1999
Inhibition of trypanosomal cysteine proteinases by their propeptide 1998
Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay. D-amino acid inhbitors for cruzipain, cathepsin B and Cathepsin L 1998
Exploiting Trypanosoma cruzi as a source of natural protein inhibitors of cysteine-proteinases:the case of chagasin. 1998
Inhibition of cruzipain visualized in a fluorescence quenched solid- phase inhibitor library assay. D-Amino acid inhibitors for cruzipain, cathepsin B and cathepsin L 1997
Human T cell responses against the major cysteine proteinase (cruzipain) of Trypanosoma cruzi: role of the multifunctional Alfa 2- macroglobulin receptor in antigen presentation by monocytes 1997
Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion mixing combinatorial library and fluorogenic peptides 1997
Molecular characterization of chagasin, a Trypanosoma cruzi inhibitor of papain-like cysteine-proteinases 1997
Plasma leakage induced in postcapillary venules by the major cysteine-proteinase from Trypanosoma cruzi and its modulation by H1-blocker mepyramin 1997
Kininogenase activity by the major cysteinyl proteinase(cruzipain) from Trypanosoma cruzi 1997
Proteasome activity is required for the stage-specific transformation of a protozoan parasite 1996
Biotin-labelled diazomethane inhibitors derived from the substrate-like sequence of cystatin: targeting of the active site of cruzipain, the major cysteine proteinase of Trypanosoma cruzi 1996
Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors 1996
The proliferative response of T cells against cruzipain in chronic chagasic cardiopathy 1996
Antigenicity of cystatin-binding proteins from parasitic protozoan: detection by a proteinase inhibitor based capture immunoassay (Pinc- Elisa) 1995
Trypanosoma cruzi: identification of a membrane cysteine proteinase linked through a GPI anchor 1994
Identification of new cysteine protease gene isoforms in Trypanosoma cruzi. 1994
The Mhc-Class Ii Restricted Immune Response Against Parasitic Proteinases:Clearance-Receptors As An Alternative Pathway For Their Endocytic Uptake Into Antigen Presenting Cells. 1994
Use of Trypanosoma cruzi purified glycoprotein (Gp57/51) Or trypomastigote-Shed Antigens to assess cure for human Chagas'disease 1993
Analysis and partial epitope mapping of human T cell responses to Trypanosoma cruzi cysteinyl proteinases 1993
Signal transduction in Trypanosoma cruzi: opposite effects of adenylcyclase and phopholipase C systems in growth control 1993
Structural and functional aspects of human immune responses against the major cysteine proteinase from Trypanosoma cruzi 1993
The major cysteinyl proteinase from Trypanosoma cruzi: Structural and functional properties 1993
Structural and enzymatic properties of the major cysteinyl proteinase from Trypanosoma cruzi 1992
Temperature-dependent substrate inhibition of the cysteine proteinase (Gp57/51) from Trypanosoma cruzi 1992
Inhibitors of the major cysteinyl proteinase (Gp57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro 1992
Molecular approaches to antithrombotic therapy 1992
Further characterization of Trypanosoma cruzi Gp 57/51 (cysteine proteinase) as the major antigen expressed by differentiating epimastigotes 1991
Interactions between CD3 and Thy-1 T cell activation pathways: blockade of CD3-mediated T lymphocyte activation induced by immobilized anti-Thy-1 antibodies 1991
Imunogenicity of Trypanosoma cruzi cysteine proteinase. 1991
Functional and antigenic properties of thee major cysteine proteinase (Gp57/51) of trypanosoma cruzi 1990
Structural and functional identification of Gp57/51 antigen of Trypanosoma cruzi as a cysteine proteinase 1990
Identification and partial characterization of T. cruzi antigens recognized by T cells and immune sera from patient with Chagas'disease 1990
Glycoprotein Gp57/51 of Trypanosoma cruzi: structural and conformational epitopes defined with monoclonal antibodies 1988
Identification of T. cruzi antigens recognized by T cells and immune sera from chagasic patients 1988
Trypanosoma cruzi: characterization and isolation of a 57/51,000 m. w. surface glycoprotein (GP 57/51) espressed by epimatigotes and bloodstream trypomatigotes 1986
Trypanosoma cruzi antibodies 1986
Amyloid P component is present in cultures In cultured human smooth muscle cells but not in cultured skin fibroblasts 1985
Chagas'disease: serodiagnosis with purified Gp25 antigen 1985
Chemical structure and antigenic aspects of complexes obtained from epimastigotes of Trypanosoma cruzi 1983
Trypanosoma cruzi: description of a highly purified surface antigen defined by human antibodies 1983
Human Antibody Response To A Surface Glycoprotein Isolated From Trypanosoma Cruzi. 1982
Induction of the acute -phase protein serum amyloid P in experimental Chagas'disease 1982
Human C4-binding protein. Association with immune complexes in vitro 1979
Cross-species contamination of commercial serum proteins. 1979
Human C4-Binding Protein. I. Isolation And Characterization.J.Exp.Med. 1978
Eventos:

(0.00% eventos com DOI)

Titulo DOI Ano
Mouse fibroblasts guide IL-23 induction by Porphyromonas gingivalis-stimulated Dendritic Cells in gingipain-dependent mannar 2012
Intracardiac injection of Dm28c Trypanosoma cruzi provides a model of infection-associated myocarditis and heart fibrosis that depends critically on cooperative activation of the kallikrein/kinin sistem and the endothelin pathway 2012
Esploring the inflammatory role of mast cell/kallikrein-kinin cell pathway in the modulation of t cell responses against Trypanosoma cruzi. 2012
Mast cells propagate inflammation in peripheral sites of Trypanosoma cruzi infection through the activation of the kallikrein-kinin cascade 2012
Bradykinin B2 receptor is not required for tumor growth regression by radiotherapy 2011
Trypanosoma cruzi invades host cells through the activation of endothelin and kinin receptors: A converging pathway leading to chagasic vasculopathy 2011
Kinin danger signals proteolytically released by gingipain induce fimbriae-specific-IFN-gamma and IL-17-producing T cells in mice infected intramucosally by porphyromonas gingivalis 2009
Efficacy of vaccination against experimental trypanosoma cruzi infection is harnessed by bradykinin, a dentritic cell maturation signal that promotes the accumulation of type 1 effector CD8+ T cells in the heart 2009
Activation of bradykinin B2 receptors: an innate pathway guiding Tcell development in mice orally infected by the periodontal bacteria porphyromon 2009
The Colombian strain of Trypanosoma cruzi activates cardiovascular cells, rendering them susceptible to invasion via triggering of the inducible (B1) subtype of kinin receptors 2009
G-protein coupled receptors with distinct pharmacological specificities exert differential temporal and spatial control on the invasion of human smooth muscle cells by Trypanosoma cruzi 2009
Differential roles for G-protein coupled endothelin receptor subtypes (ETbR and ETaR) during the temporal progression of human smooth muscle cell invasion by Trypanosoma cruzi 2009
African trypanosome traversal of the human blood-brain barrier: A role for protease activated receptor signaling? 2009
Salivary gland homogenates enhances plasma leakage induced by L.chagasi promastigotes 2009
Gingipain and LPS from Porphyromonas gingivalis induce type-1 adaptive immunity via TLR2 and G-protein coupled Bradykinin B2 receptors, an innate axis activated at early stages of infection. 2008
Vaccines Containinng Bradykinin, A Type-1-Polarizing Adjuvant, Induce Immunoprotective Type-1 CD-8+Effector T Cells Against Trypanosoma cruzi. 2008
Bradykinin Elicits Eosinophil Lipid Body Biogenesis via PGE2 Autocrine Activity: Roles in Allergic Inflammation. 2008
In vivo targeting of dendritic cells with synthetic bradykinin : a novel strategy improving vaccine adjuvanticity 2007
Gingipain and LPS from Porphyromonas gingivalis, acting synergistically, link TLR2/B2R - driven inflammatory responses to adaptive immunity 2007
Activation of the innate kinin pathway is critical for type-1 immunity development and host resistance to acute infection with Trypanosoma cruzi 2007
Adaptive immunity in subcutaneous Trypanosoma cruzi infection is modulated by an innate pathway involving interdependent signaling of dendritic cells by C5a anaphylatoxins and bradykinin. 2007
SECRETION OF CXC CHEMOKINES BY MACROPHAGES LINKS TLR-2DEPENDENT SENSING OF Trypanosoma cruzi TO MECHANISMS THAT STEER INNATE IMMUNITY VIA BRADYKININ RECEPTORS 2006
LUTZOMYIA LONGIPALPIS SALIVARY GLAND HOMOGENATES INDUCE VASODILATION AND VASCULAR PERMEABILITY INCREASE IN THE HAMSTER CHEEK POUCH 2006
PORPHYROMONAS GINGIVALIS GINGIPAINS AND LIPOPOLYSACCHARIDES, ACTING COOPERATIVELY, DRIVE TH1 - TYPE IMMUNITY THROUGH THE KININ PATHWAY 2006
KININS MODULATE ANTIGEN-SPECIFIC T CELL RESPONSES IN INFLAMMATORY DRAINING LYMPH NODES 2006
SECRETION OF CXC CHEMOKINES BY MACROPHAGES LINKS TLR2 - DEPENDENT SENSING OF Trypanosoma cruzi TO MECHANISMS THAT STEER INNATE IMMUNITY VIA BRADYKININ RECEPTORS 2006
Activation of the innate kinin pathway is critical for development of host resistance to acute intraperitoneal infection with Trypanosoma cruzi 2006
Lutzomyia longipalpis salivary gland homogenates induce vasodilation and vascular permeability increase in the hamster cheek pouch 2006
TRYPANOSOMATID DRUG RESISTANCE : SOME CELLULAR FACETS 2006
CELL INVASION BY Trypanosoma cruzi EXTRACELLULAR AMASTIGOTES:ROLE OF CRUZIPAIN AND BRADIKININ CELL RECEPTORS 2006
Distinct Pathways of Smooth Muscle Invasion by Trypanosoma cruzi Dm28 Trypomastigotes: Differential Roles of G Protein-Coupled Receptors, Adenlyl Cyclase and PI3 Kinase Mediated Signaling. 2006
African trypanosomes traversal of the human blood-brain barrier requires cysteine protease-mediated calcium signaling. 2006
Inhibitors of Angiotensin-Converting Enzyme modify signaling pathways underlying invasion of endothelial cells by Trypanosoma cruzi 2006
STRUCTURAL BASIS FOR THE INHIBITORY FUNCTION OF CHAGASIN : DIFERENT REQUIREMENTS FOR THE INHIBITION OF PARASITE VERSUS HOST CYSTEINE PROTEASES. 2006
Kinin receptors promote Trypanosoma cruzi uptake by human circulating monocytes and induce modulatory changes in expression of cytokines and co-stimulatory molecules 2006
SECRETION OF CXC CHEMOKINES BY MACROPHAGES LINKS TLR2-DEPENDENT SENSING OF Trypanosoma cruzi TO MECHANISMS THAT STEER INNATE IMMUNITY VIA BRADYKININ RECEPTORS 2006
Proteomic and Immunological Analysis of Trypanosoma cruzi Shed Vesicles Involved in Host Immunomodulation and Cell Invasion 2005
ALTERATIONS IN TRAFFIC AND PRO-CRUZIPAIN MATURATION IN Trypanosoma cruzi OVEREXPRESSING CHAGASIN 2005
THE SUBSTRATE SPECIFICITY OF THE CYSTEINE PEPTIDASE OF Trypanosoma b. brucei, BRUCIPAIN AND ITS INACTIVATION BY NATURAL CYSTEINE PEPTIDASE INHIBITORS 2005
POTENT INHIBITION OF CATHEPSIN F AND OF CYSTEINE PROTEASES FROM TRYPANOSOMES (CRUZIPAIN AND BRUCIPAIN) BY THE PROPEPTIDE OF CRUZIPAIN 2005
INTERPLAY BETWEEN PARASITE CYSTEINE PROTEASES AND THE HOST KININ SYSTEM MODULATES VASCULAR LEAKAGE AND MACROPHAGE INFECTION BY PROMASTIGOTES OF THE Leishmania donovani complex 2005
KININOGEN HIGHJACKING BY L. CHAGASI PROMASTIGOTES: A POTENTIAL PATHWAY FOR TARGETED ACTIVATION OF BRADYKININ RECEPTORS OF MACROPHAGES 2005
ACTIVATION OF BRADYKININ B2 RECEPTORS BY Trypanosoma cruzi TRYPOMASTIGOTES MODULATES CXC-CHEMOKINE PRODUCTION BY MACROPHAGES 2005
BRADYKININ ADJUVANT CONVERTS EPIMASTIGOTE EXTRACTS INTO PROTECTIVE IMMUNOGENS BY DRIVING EFFECTOR-MEMORY T CELL DIFFERENTIATION VIA IL-12 INSTRUCTIVE PATHWAY 2005
GENDER AND GENETIC BACKGROUND DIFFERENTIALLY MODULATE KININ - DRIVEN LINKAGE OF INFLAMMATION TO INNATE AND TYPE-1 ADAPTIVE IMMUNITY IN MICE INFECTED BY Trypanosoma cruzi 2005
ACTIVATION OF THE KININ PATHWAY INTEGRATES INFLAMMATION TO INNATE AND ADAPTIVE IMMUNITY IN Trypanosoma cruzi INFECTION 2004
CHRONIC HEART FIBROSIS IS ATTENUATED IN B1 KNOCKOUT MICE INFECTED BY Trypanosoma cruzi 2004
CHRONIC HEART FIBROSIS IS ATTENUATED IN B1 KNOCKOUT MICE INFECTED BY Trypanosoma cruzi 2004
Leishmania donovani PROMASTIGOTES ELICIT MICROVASCULAR LEAKAGE AND INFLAMMATION BY ACTIVATING THE KININ PATHWAY THROUGH THE ACTIVITY OF CYSTEINE PROTEINASES 2004
BRADYKININ - DRIVEN ACTIVATION OF DENDRITIC CELLS : NEW STRATEGIES FOR ADJUVANT DEVELOPMENT AND VACCINE PRODUCTION 2004
Insights into the molecular mechanisms of endothelial kinin-receptor activation by Trypanosoma cruzi. 2002
Obtention and molecular characterization of transgenic sugarcane plants expressing a new cysteine proteinase inhibitor. 2002
Targeting of Trypanosoma cruzi cysteine proteinases by synthetic inhibitors depends on endocytosis. 2002
Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain 2002
HEPARAN SULFATE MODULATE KININ-RELEASE BY TRYPANOSOMA CRUZI THROUGH THR ACTIVITY OF CRUZIPAIN 2001
ROLE OF CRUZIPAIN IN THE ACTIVATION OF THE KININ CASCADE BY TRYPANOSOMA CRUZI TRYPOMASTIGOTES 2001
CHARACTERIZATION OF CHAGASIN-LIKE CYSTEINE PROTEASE INHIBITORS IN LEISHMANIA AMAZONENSIS, LEISHMANIA DONOVANI AND TRITRICHOMONAS FOETUS 2001
INTRACELLULAR LOCALIZATION AND SECRETION OF ACID PHOSPHATASE ACTIVITY IN ACANTHAMOEBA POLYPHAGA TROPHOZOITES 2001
ACTIVATION OF THE INDUCIBLE B1-KININ RECEPTOR (B1) BY TRYPANOSOMA CRUZI : HOST CELL SUSCEPTIBILITY TO 2001
INVOLVEMENT OF THE B2 - KININ RECEPTOR SUBTYPE IN MICROVASCULAR RESPONSES INDUCED BY TRYPANOSOMA CRUZI TRYPOMASTIGOTES IN VIVO 2001
Expression of cruzipain and of a cathepsin B-like target (Tc-cb) is inverted in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases. 1999
Trypanosoma cruzi invasion of endothelial cells is potentiated by kinin-induced stimulation of G protein-coupled bradykinin receptors. 1999
Characterization of the substrate specificity of cysteine protease isoforms from T. cruzi: a comparative study between cruzipaina 2 and cruzain. 1999
Gene transfection of Trypanosoma cruzi with a minor cysteine-protease isoform (cruzipain 2), but not with cruzain, potentiates trypomastigote infectivity in mammalian cells in vitro. 1999
Cloning and expression of chagasin, a cysteine peptidase inhibitor of T. cruzi. 1st International Protein Society Meeting, Mackinac Island, MI, Sept. 25-30, 1999 1999
Immunochemical characterization, subcellular distribution and functional properties of chagasin, a Trypanosoma cruzi cysteine peptidase inhibitor. 1999
The transfection of T. cruzi cell lines with the gene of the cysteine protease isoform cruzipain 2 enhances parasite infectivity in host cells. 1998
Trypanosoma cruzi resistance to synthetic inhibitors of cysteine-proteinases correlates with changes in the expression of target enzymes and membrane permeability 1998
Trypanosoma cruzi inhibitor of cysteine proteases: biochemical characterization of natural form of chagasin 1998
Recombinant cysteine protease isoforms from Trypanosoma cruzi (cruzain and cruzipain 2) show marked differences to inhibitor sensitivity. 1998
R-chagasin, a potent inhibitor of papain-like cysteine-proteinases, reduces host-cell susceptibility to invasion by Trypanosoma cruzi trypomastigotes. 1998
Inhibition studies of cysteine proteases from trypanosoma cruzi by molecular modeling. 1998
Immunochemical characterization of cruzipain isoforms during T. cruzi development. Mem. Inst. Oswaldo Cruz. 1998
Exploiting Trypanosoma cruzi as a source of natural protein inhibitors of cysteine-proteinases: the case of chagasin 1998
Inhibition of trypanosomal cysteine proteinases by their pro-peptide. 1998
Molecular Modeling of the Inhibition of Cysteine-proteases from T. cruzi by E-64. 1998
Molecular characterization of chagasin, a T. cruzi inhibitor of papain-like cysteinyl-proteinases. 1998
Endothelial cell interactions with Trypanosoma cruzi cysteine proteinases: possible role in microvascular pathology. 1997
Biochemical characterization and subcellular localization of the endogenous T. cruzi inhibitor of cysteine proteases. 1997
Multiple mechanisms determine drug-resistance against peptidyl-based inhibitors of T. cruzi cysteine-proteases. 1997
Preliminary characterization of Trypanosoma cruzi cell lines transfected with genes encoding for the cysteine protease isoform cruzipain 2. 1997
Recombinant cruzipain induces T. cruzi specific Th1 and Mucosal IgA responses 1997
Characterization Of A Trypanosoma Cruzi Population Resistant To Synthetic Irrecersible Cysteine Protease Inhibitors. 1996
Cloning And Expression Of A Novel T.Cruzi Inhibitor Of Cysteinyl Proteinases. 1996
Chronic Chagasic Myocardiopahy In Humans: Identification Of Cruzipain Antigens In Inflammatory Sites. 1996
Cd8+ T Cells From Chronic Chagasic Patients Against Self Lisosomal Cathepsins: Molecular Mimicry? 1996
The Kinin Releasing Activity Of Cysteinyl Proteinases From Trypanosomacruzi: A Factor Of Parasite Virulence And Pathogenicity? 1996
In Vitro Study Of Natural Substrates Degradation By The Cysteine Proteinase From Trypanosoma Cruzi. 1996
Role Of Proteasomes In Remodeling Of A Protozoan Parasite. 1996
Trypanosoma Cruzi Cysteine-Proteinases (Cruzipains) Induced Plasma Leakage In Post-Capillary Venules. 1996
The major cysteine proteinase from Trypanosoma cruzi: phenotypic characterization of a parasite sub-population selected for resistance against irreversible synthetic inhibitors. 1996
Trypanosoma cruzi cysteine-proteinases (cruzipains) induced Plasma Leakage in post-capillary venules. 6th World Congress for Microcirculation, Munich, Germany, 25-20 de Agosto de 1996. 1996
Role of proteasomes in remodeling of a protozoan parasite. 1996
Alternative Cruzipain T Cell Epitopes Recognition During Infection By T.Cruzi. 1995
Investigation Of The Substrate Specificity Of Cruzipain Through The Use Of Cystatin-Derived Substrates. 1995
Affinity Labelling Of Cruzipain By Cystatin-Derived Peptidyl Diazomethylketones. 1995
The Minor Cysteine Proteinase From Trypanosoma Cruzi:Identification Inparasite Populations Selected For Resistance To Synthetic Inhibitors. 1995
Human T Cell Responses Against T.Cruzi Cysteine-Proteases (Cruzipain):Uptake By Monocyte 2-Macroglobulin Receptors Enhances Antigen- Presenting Cell Function. 1995
Isoform-Specific Or Conserved Cruzipain T Cell Epitopes Are Preferentially Recognized During Human Infection By T. Cruzi. 1995
Asma Bronquica:Caracterizacao Molecular dos Principais Alergenos de Acaros da Poeira Domiciliar. 1995
T Cell Responses Against Cruzipains: Specific And Conserved Epitopes Are Recognized During Human Infection By T.Cruzi. 1995
The Cysteinyl Proteinase Of Trypanosoma Cruzi Induces Murine Cd4+Th1 Cells To Produce Ifn-Y. 1995
Human T Cell Responses Against T.Cruzi Cysteine-Proteinases: Uptake By Monocyte,(2-Macroglobulin Receptors Enhances Antigen-Presenting Cell Function. 1995
Multiple Peptide Solid-phase Synthesis And Development Of Peptide Library For Mapping The Active Site Of Endoproteases. 1995
Synthesis Of Coumarin-Containing Peptides And Their Hydrolysis By Cysteine Proteases. 1995
Respostas de células T humanas contra a principal cisteíno-proteinase do T. cruzi: função do receptor de (2-macroglobulina. 1995
The cysteinyl proteinase of Trypanosoma cruzi induces murine CD4+ TH1 cells to produce IFN-(. 9th International Congress of Immunology, São Francisco, Califórnia, EUA, 23-29 de Julho de 1995 1995
T cell responses against cruzipains: specific and conserved epitopes are recognized during human infection by T.cruzi. 1995
The Major T.Cruzi Cysteine Proteinase (Cruzipain):Involvement Of The A2-Macroglobulin Receptor In Antigen Presentation To Human T Lymphocytes. 1994
Quantification Of Cruzipain-Reactive T Cell In The Blood Of Chronic Chagasic Patients. 1994
T Cell Responses Against T.Cruzi Cysteine Proteinases(Cruzipains): Isoform-Specific And Conserved Epitopes Are Recognized During Human Infection. 1994
Preliminary Characterization Of Recombinant Cruzipain 2, A New Cysteine Protease Isoform From Trypanosoma Cruzi. 1994
Inhibitors Of The Major Cysteine Proteinase From Trypanosoma Cruzi (Cruzipain): Selection Of Parasite Resistance To Peptidyl Diazomethylketones. 1994
Interaction Between The Major T.Cruzi Cysteine Proteinase (Cruzipain) Antigen And The Human Plasma Inhibitor X2-Macroglobulin. 1994
Immunodominant Antibody And T Cell Epitopes Map To Different Domains Of Cruzipain. 1994
Human T Cell Responses To Cruzipain: Frequency Analysis And Characterization Of Immunodominant Epitopes. 1994
Differential Localization Of The Major Cysteine Proteinase Of Trypanosoma Cruzi During Its Intracellular Cycle In Heart Muscle Cell. 1994
Inhibitors Of The Major Cysteine Proteinase From Trypanosoma Cruzi: Selection Of Parasite Resistamce To Peptidyl Diazomethyl Ketones. 1994
The Major Cysteine Proteinase Of Trypanosoma Cruzi: Biochemical Characterization With The Human Plasma Inhibitor A2-Macroglobulin. 1994
Protease-Inhibitor Based Capture Immunoassay (Pin-Elisa) Allows For The Detection Of Antigenic Cysteine Proteinases From Parasitic Protozoa. 1994
Identification Of New Cysteine Protease Gene Isoforms From Trypanosomacruzi. 1994
The major T. cruzi cysteine proteinase (cruzipain): involvement of the a2-macroglobulin receptor in antigen presentation to human T lymphocytes. 1994
Differential localization of the major cysteine proteinase of Trypanosoma cruzi during its intracellular cycle in heart muscle cells. 1994
Independence Of Antibody And Cystatin C Binding Sites On The Surface Of Cystenyl Proteinases From T.Cruzi And Leishmania As Defined By A Novel Protease Inhibitor Capture Immunoassay (Pin-Elisa). 1993
Pin-Elisa: A General Screening Method For The Identification Of Antigenic Cysteinyl Proteinases. 1993
Partial Mapping Of T Cell Epitopes On The Major T. Cruzi Cysteinyl Proteinase. 1993
Partial Mapping of T cell epitopes on the major T. cruzi cysteinyl proteinase. XVIII Congresso Brasileiro de Imunologia. Águas de Lindóia, SP, Setembro de 1993 1993
Partial Mapping of T cell epitopes on the major T. cruzi cysteinyl proteinase. 1993
Partial Mapping of T cell epitopes on the major T. cruzi cysteinyl proteinase. 1993
Temperature Dependent Substrate Inhibition Of The Cysteine Protease (GP57/51) From Tryopanosoma Cruzi. 1992
Trypanosoma cruzi proteinase (GP 57/51): Structural, functional and immunological properties. 1991
Expression of proteinases during Trypanosoma cruzi metacyclogenesis. 1991
Trypanosoma cruzi: inhibitors of major cysteinyl proteinase (GP 57/51) impair host cell invasion and arrest intracellular development in vitro. 1991
Preliminary analysis of epitopes mapped within the central domain of the major cysteinevproteinase (GP 57/51) of T. cruzi. 1991
T. cruzi cysteine proteinase (GP 57/51): cellular immune response against papain (Papaya latex Protease) among chagasic patients - A possible cross-reaction? 1991
T.Cruzi Cysteine Proteinase (Gp57/51): Celular Immune Cross Reactivitywith Papaya Latex Protease (Papain). 1990
Peptidyl diazomethyl ketonas inhibit T. cruzi infection of heart muscle cells in vitro. 1990
T.Cruzi Gp57/51 Autoproteolysis: An Expression Of Its Proteinase Function? 1989
Frequency Of Reactive T Cell To Various Leishmania Brasiliensis(L.B.B.) Antigen Fractions In The Lesion Of Human American Cutaneous Leishmaniasis (Acl). Preliminary Results. 1989
Gp57/51 Of Trypamosoma Cruzi: Antigenic Changes Associated With Auto- Proteolysis. 1989
Glicoproteina Gp57/51 do T.Cruzi: Influencia da Resposta Imune Especifica Sobre O Curso da Infeccao Chagasica Experimental. 1989
Alteracoes Na Antigenicidade da Gp57/51 de Trypanosoma Cruzi:Eviden- Cias A Favor de Um Mecanismo de Auto-Fragmentacao. 1989
Modulação por anticorpos anti-Thy 1 da ativação de linfócitos T mediada por anticorpos anti- CD3. 1989
Trypanosoma cruzi GP 57/51: antigenic changes associated with autolytic fragmentation are prevented by serine protease inhibitors. 1989
Partial characterization of phospholipases in T. cruzi. 1989
Tcell responses against T. cruzi GP57/51: characterization of the responding phenotype in immunized mice. 1989
GP57/51 of Trypanosoma cruzi: antigenic changes associated with auto-proteolysis. 1989
Correlation Between Gp57/51 And The Outative Adhesion Proteins From Differentiating Epimastigotes. 1988
GP51 of Trypanosoma cruzi: conformational epitope defined with monoclonal antibodies. 1988
Isolation And Characterizationof Phosphatidyl-Inositol Specific Phospholipase C (Pi-Plc) From Trypanosoma Cruzi. 1987
Gp51 Of Trypanosoma Cruzi: Epitope Analysis By Monoclonal Antibodies. 1987
Recognition Of Various Leishmania Braziliensis Brasiliensis(L.B.B.) Antigen Fractions By Homogeneous T Cell Populations Derived From Peripheral Blood Of Cutaneous And Mucosal Leishmaniasis Patients. 1987
Phosphatidylinositol Specific Phospholipase C (Piplc) In T.Cruzi Epimastigotes. 1986
Isolation Of Gp57/51 Antigen Of T.Cruzi By Fast Performance Liquid/ Chromatografy. 1986
Antigenic Properties Of Purified Gp 51 Of T.Cruzi 1986
Homogeneous Human T Cell Populations With Specificity For Leishmania Species. Responsiveness To Fractions Of Leishmania Antigen. 1985
Avaliacao da Fracao Semipurificada (E) e da Glicoproteina Go-25 do Trypanosoma Cruzi Comoantigenos No Teste Imunoenzimatico Para A Doen- Ca de Chagas. 1985
Identification Of T.Cruzi Trypanosomatids. 1985
Involvement Of Carbohydrate Structures In The Antigenicity Of T. Cruziglycoproteins Gp-25 And Gp-50/55. 1985
Characterization Of A Cross-Reactive Antigen Of T.Cruzi Defined With Sleeping Sickness Sera. 1985
Gp-25 Antigen Of T.Cruzi:Identification Of A 60kd Precursor With Monoclonal Antibodies. 1985
Homogeneous human T cell populations with specificity for Leishmania species. Responsiveness to fractions of Leishmania antigen. 1985
Trypanosoma Cruzi Infection Of Human Muscle Cell Is Inhibited By Antibodies To Parasite Surface Antigens. 1983
Antibodies To T.Cruzi Surface Glycoprotein G-25 Inhibit Infection Of Human Smooth Muscle Cells In Vitro. 1983
Conservation Of T. Cruzi Antigens: Evidence From Mrna In Vitro Translation. 1983
Antibodies to T. cruzi surface glycoprotein G-25 inhibit infection of human smooth muscle cells in vitro. 1983
Antibodies To G25k - Antigen Protect Human Muscle Cells From In Vitro Infection With Trypanosoma Cruzi. 1982
Molecular Characterization Of A Trypanosoma Cruzi Surface Antigen (25kdefined By Human Antibodies. 1982
The Effect Of Auronofin And Sodium Aurothiomalate On Casein Induced Experimental Amyloidosis. 1982
Isolation Of A Trypanosoma Cruzi Surface Antigen Defined By Human Antibodies. 1982
The effect of auronofin and sodium aurothiomalate on casein induced experimental amyloidosis. 1982
Characterization Of The Acute Phase Reaction In Experimental Chagas' Disease. 1980
Human C4-Binding Protein In Immune-Glomerulonephritis 1978
Presence Of A C4 Binding Protein In Human Serum. 1978
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