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antigen trypanosoma cruzi chronic cruzipain induced cysteine proteinase rato chronic chagasic efeito scintigraphy anabolic steroid technetium modulate inhibitor cysteine protease chagasic patients junction bone marrow blood cell arrhythmia mononucleares medula marrow mononuclear embryonic stem medula ossea model cardiopatia chagasica cell stroke electrical infection