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trypanosoma cruzi lung injury purinergic receptor cell derived mononuclear leishmania amazonensis ultrastructural thymic epithelial host cell desenvolvimento allergic asthma candida albicans cigarette smoke mice atividade epithelial cell trypanosomatid triiodothyronine herpetomonas samuelpessoai toxoplasma gondii growth hormone copd pseudallescheria boydii receptor endothelial cells lung pulmonary human endothelial activation characterization