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potencial extracellular epithelial cell herpetomonas samuelpessoai lung trypanosomatid toxoplasma gondii infection murine interaction marrow derived lung injury macrophage vitro mononuclear cell purinergic receptor mucociliary clearance pulmonary protease acute lung induced mice mesenchymal stromal diesel exhaust bone marrow allergic asthma group streptococci human endothelial aerobic exercise candida albicans