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receptor induced characterization tritrichomonas foetus group streptococcus murine trypanosomatid activation interaction copd vitro expression group streptococci mesenchymal stromal endothelial cells avaliacao pulmonary phytomonas serpens protease ultrastructural herpetomonas samuelpessoai mononuclear cell diesel exhaust aerobic exercise lung chronic atividade pseudallescheria boydii cell candida albicans