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epithelial cell ultrastructural aerobic exercise pulmonary diesel exhaust group streptococcus desenvolvimento atividade murine derived mononuclear marrow derived macrophage triiodothyronine cigarette smoke receptor herpetomonas samuelpessoai protease mice trypanosoma cruzi stromal cell allergic asthma phytomonas serpens human endothelial mononuclear cell endothelial cells activation lung injury induced group streptococci infection